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An RNA tertiary switch by modifying how helices are tethered

Laura R Ganser1, Anthony M Mustoe2 and Hashim M Al-Hashimi1*

Author Affiliations

1 Department of Biochemistry and Chemistry, Duke University Medical Center, Durham 27710, NC, USA

2 Department of Biophysics, University of Michigan, Ann Arbor 48109, MI, USA

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Genome Biology 2014, 15:425  doi:10.1186/s13059-014-0425-z

Published: 30 July 2014

Abstract

A viral tRNA-like structure has evolved a unique strategy to undergo a tertiary structure conformational switch that may help regulate viral regulation.