Genome Biology | Volume 1 Issue 1

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	Volume 1 Issue 1
	Comment
	Editorial Editorial Genome Biology 2000, 1:comment001-comment001.2 (9 June 2000) Full text \| Editor’s summary These are exciting times for biology. The changes genomics brings to the way research is done in biological laboratories promise to be as profound as those triggered by the advent of recombinant DNA technology in the 1970s. It is in recognition of these changes that GenomeBiology is named and launched.
	Comment The Grail problem Gregory A Petsko Genome Biology 2000, 1:comment002-comment002.2 (9 June 2000) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Holy Grail is a familiar metaphor in science. A current Holy Grail is the complete sequence of the human genome, but there seems to be one for every field of biology.
	Opinion Whither genomics? Andrew W Murray Genome Biology 2000, 1:comment003-comment003.6 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individual biological pathways and to use the resulting information to yield knowledge about general principles that explain the functions and evolution of life.
	Review
	Review An overview of the structures of protein-DNA complexes Nicholas M Luscombe, Susan E Austin, Helen M Berman, Janet M Thornton Genome Biology 2000, 1:reviews001-reviews001.37 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.
	Minireview Molecular mechanisms of spindle function Claire E Walczak Genome Biology 2000, 1:reviews101-reviews101.4 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusions about the central role of microtubule nucleation and dynamics and of kinesin-related motor proteins in spindle function.
	Minireview What initiates actin polymerization? Anne Ridley Genome Biology 2000, 1:reviews102-reviews102.4 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [http://www.faseb.org/ascb/meetings/am99/main99mtg.htm] (Washington DC, December 11-15, 1999) was the elucidation of how actin polymerization is initiated. The emphasis was on the regulation and localization of the Arp2/3 complex, which over the last two years has been shown to stimulate actin nucleation, and on the identification of additional proteins that interact with actin and Arp2/3 in a variety of organisms.
	Minireview A cultivated taste for yeast Charles Brenner Genome Biology 2000, 1:reviews103-reviews103.4 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define protein function, to define drug targets, and to discover and characterize drugs.
	Minireview Membrane traffic between genomes John Armstrong Genome Biology 2000, 1:reviews104-reviews104.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Proteins of the Rab and SNARE families target vesicles to their intracellular destinations. A comparison of these families from the budding yeast, fission yeast, nematode and fruitfly genomes has implications for the organization of membrane traffic in different organisms.
	Minireview Measuring a cell's response to stress: the p53 pathway D Paul Harkin, Peter A Hall Genome Biology 2000, 1:reviews105-reviews105.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The characterization of complex cellular responses to diverse stimuli can be studied by the use of emerging chip-based technologies.
	Minireview Fly immunity: great expectations Ruslan Medzhitov, Charles Janeway Jr Genome Biology 2000, 1:reviews106-reviews106.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems.
	Minireview The many hues of plant heterochromatin Jeffrey L Bennetzen Genome Biology 2000, 1:reviews107-reviews107.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent sequence and cytogenetic analyses of heterochromatin in Arabidopsis, together with other results from Arabidopsis and maize, indicate that plant heterochromatin can have very different origins, compositions and dynamics. Shared features that must determine and/or be a result of its unique biological properties are also revealed.
	Minireview Chaotic actin Dennis Bray Genome Biology 2000, 1:reviews108-reviews108.3 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Living cells organize their internal contents by coordinating the chaotic thermal motion of protein molecules. A recent study, combining experiment with stochastic simulation, shows how this might be achieved in the case of actin polymerization.
	Report
	Web report A definitive source of HLA molecule sequences and nomenclature Christopher J Thorpe Genome Biology 2000, 1:reports201 (17 March 2000) Abstract \| Full text
	Web report A high-quality database of molecules of the immune system Christopher J Thorpe Genome Biology 2000, 1:reports202 (17 March 2000) Abstract \| Full text \| Editor’s summary This integrated immunogenetics database specializes in immunoglobulins, T-cell receptors and major histocompatibility complex (MHC) molecules.
	Web report A database of MHC-peptide interactions Christopher J Thorpe Genome Biology 2000, 1:reports203 (17 March 2000) Abstract \| Full text \| Editor’s summary SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC molecule specificities and references to the published literature.
	Web report Jobs and grants for junior researchers Bryony Wiseman Genome Biology 2000, 1:reports204 (17 March 2000) Abstract \| Full text \| Editor’s summary A new, free-access part of Science's main website, devoted to career advice for junior scientists.
	Web report Emerging online forum for life scientists Bryony Wiseman Genome Biology 2000, 1:reports205 (17 March 2000) Abstract \| Full text
	Web report Mammary glands explained Bryony Wiseman Genome Biology 2000, 1:reports206 (17 March 2000) Abstract \| Full text
	Web report Online reference book for biological topics Ines Chyla Genome Biology 2000, 1:reports207 (17 March 2000) Abstract \| Full text
	Web report Ribozymes as tools for the analysis of gene function Ines Chyla Genome Biology 2000, 1:reports208 (17 March 2000) Abstract \| Full text
	Web report How to design experiments logically Ines Chyla Genome Biology 2000, 1:reports209 (17 March 2000) Abstract \| Full text
	Web report Fugu: the small genome of a puffed-up fish Aengus Stewart Genome Biology 2000, 1:reports210 (17 March 2000) Abstract \| Full text \| Editor’s summary The puffer fish Fugu rubripes is perhaps better known as a Japanese delicacy, but its gene-rich, relatively small genome makes the puffer fish a suitable vertebrate for comparative mapping.
	Web report Xenopus: from tadpole to model organism Aengus Stewart Genome Biology 2000, 1:reports211 (17 March 2000) Abstract \| Full text \| Editor’s summary Developmental biology, primarily work with the embryos of Xenopus species X. laevis and X. tropicalis, is the focus of this site.
	Web report Fish development in black and white, and color too Aengus Stewart Genome Biology 2000, 1:reports212 (17 March 2000) Abstract \| Full text
	Web report An introduction to genetic diseases Basil Safwat Genome Biology 2000, 1:reports213 (17 March 2000) Abstract \| Full text
	Web report The implications of genetic research Basil Safwat Genome Biology 2000, 1:reports214 (17 March 2000) Abstract \| Full text
	Web report The human genome project explained Basil Safwat Genome Biology 2000, 1:reports215 (17 March 2000) Abstract \| Full text
	Web report The official repository for human genome mapping data Matthew Betts Genome Biology 2000, 1:reports216 (17 March 2000) Abstract \| Full text
	Web report Database of publicly available nucleotide sequences Matthew Betts Genome Biology 2000, 1:reports217 (17 March 2000) Abstract \| Full text
	Web report Biological and genetic information about the laboratory mouse Matthew Betts Genome Biology 2000, 1:reports218 (17 March 2000) Abstract \| Full text
	Web report Linked graphical maps of major signal transduction pathways Iain Gilfillan Genome Biology 2000, 1:reports219 (17 March 2000) Abstract \| Full text
	Web report A database of proteins that are known to interact Iain Gilfillan Genome Biology 2000, 1:reports220 (17 March 2000) Abstract \| Full text
	Web report Signaling molecules put into context Iain Gilfillan Genome Biology 2000, 1:reports221 (17 March 2000) Abstract \| Full text \| Editor’s summary Data are collected from Nature, Science, Cell, and Nature Cell Biology to form a database and resource for the signaling pathways of human cells.
	Web report Identification of complete gene structures in genomic DNA Todd Richmond Genome Biology 2000, 1:reports222 (17 March 2000) Abstract \| Full text
	Web report Prediction of intron splice sites Todd Richmond Genome Biology 2000, 1:reports223 (17 March 2000) Abstract \| Full text \| Editor’s summary The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegans and humans.
	Web report Topology prediction of membrane proteins Todd Richmond Genome Biology 2000, 1:reports224 (17 March 2000) Abstract \| Full text
	Web report Analysis of protein sequences Mar Albà Genome Biology 2000, 1:reports225 (17 March 2000) Abstract \| Full text \| Editor’s summary Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
	Web report Analysis of microarray expression data Paul Kellam Genome Biology 2000, 1:reports226 (17 March 2000) Abstract \| Full text
	Web report Chick pre-B cell encyclopedia Julie Curran Genome Biology 2000, 1:reports227 (17 March 2000) Abstract \| Full text
	Web report A 'handy' site for calcium-binding proteins Julie Curran Genome Biology 2000, 1:reports228 (17 March 2000) Abstract \| Full text
	Web report All you need to know about genetic mapping Julie Curran Genome Biology 2000, 1:reports229 (17 March 2000) Abstract \| Full text
	Web report Transcript mining Colin Semple Genome Biology 2000, 1:reports230 (17 March 2000) Abstract \| Full text
	Web report The structure of genomes Shuba Gopal Genome Biology 2000, 1:reports231 (17 March 2000) Abstract \| Full text
	Web report A database of restriction endonuclease buffers Todd Richmond Genome Biology 2000, 1:reports232 (17 March 2000) Abstract \| Full text
	Web report Gene recognition via spliced alignment Todd Richmond Genome Biology 2000, 1:reports233 (17 March 2000) Abstract \| Full text
	Web report A simple modular architecture research tool for the identification of signaling domains Todd Richmond Genome Biology 2000, 1:reports234 (17 March 2000) Abstract \| Full text
	Web report Links to molecular biology databases Mar Albà Genome Biology 2000, 1:reports235 (27 April 2000) Abstract \| Full text \| Editor’s summary Finding the relevant database is not always easy, and for some years Nucleic Acids Research has dedicated its first issue of the year to information about the most important existing databases.
	Web report Clustering of protein families Mar Albà Genome Biology 2000, 1:reports236 (27 April 2000) Abstract \| Full text \| Editor’s summary The Protomap program classifies proteins into clusters according to sequence similarity.
	Web report Expressed sequence tag (EST) clustering database Paul Kellam Genome Biology 2000, 1:reports237 (27 April 2000) Abstract \| Full text
	Web report Integrated chromosomal maps Kathryn Evans Genome Biology 2000, 1:reports238 (27 April 2000) Abstract \| Full text
	Web report Phylogenetic classification of proteins encoded in complete genomes Todd Richmond Genome Biology 2000, 1:reports239 (27 April 2000) Abstract \| Full text
	Web report Designing degenerate PCR primers Todd Richmond Genome Biology 2000, 1:reports240 (27 April 2000) Abstract \| Full text \| Editor’s summary The purpose of CODEHOP is to help in the design of degenerate PCR primers from protein sequence.
	Web report Precompiled codon-usage tables Todd Richmond Genome Biology 2000, 1:reports241 (27 April 2000) Abstract \| Full text
	Web report Identification of homology in human and mouse genomes Kathryn Evans Genome Biology 2000, 1:reports242 (27 April 2000) Abstract \| Full text
	Web report Variations on a gene Colin Semple Genome Biology 2000, 1:reports243 (27 April 2000) Abstract \| Full text
	Paper report Yersinia perturbs host cell signaling Jonathan B Weitzman Genome Biology 2000, 1:reports001 (17 March 2000) Abstract \| Full text \| Editor’s summary YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host defense mechanisms.
	Paper report Gadd45a knockout mice resemble p53 knockouts Jonathan B Weitzman Genome Biology 2000, 1:reports002 (17 March 2000) Abstract \| Full text \| Editor’s summary Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.
	Paper report Secretion by bacterial flagella William Deakin Genome Biology 2000, 1:reports003 (17 March 2000) Abstract \| Full text
	Paper report All the motifs in all known proteins Rachel Brem Genome Biology 2000, 1:reports004 (17 March 2000) Abstract \| Full text
	Paper report How aminoacyl-tRNA synthetase recognizes tRNA Rachel Brem Genome Biology 2000, 1:reports005 (17 March 2000) Abstract \| Full text \| Editor’s summary Can the selection by aminoacyl-tRNA synthetases for the correct tRNA substrate happen during binding? The results of equilibrium experiments suggest that it can.
	Paper report Axon guidance gene screen Alan Shirras Genome Biology 2000, 1:reports006 (17 March 2000) Abstract \| Full text
	Paper report A lectin receptor for rhizobial nodulation William Deakin Genome Biology 2000, 1:reports007 (17 March 2000) Abstract \| Full text \| Editor’s summary The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.
	Paper report Classifying tumors by gene expression profiling Jonathan B Weitzman Genome Biology 2000, 1:reports008 (17 March 2000) Abstract \| Full text
	Paper report Predicting protein interactions from sequence Paul Kellam Genome Biology 2000, 1:reports009 (17 March 2000) Abstract \| Full text
	Paper report Perturbing gene expression with baculovirus Alan Shirras Genome Biology 2000, 1:reports012 (17 March 2000) Abstract \| Full text \| Editor’s summary A novel baculovirus misexpression system is shown to be functional in insect and vertebrate embryos.
	Paper report Plants recognize bacterial flagella William Deakin Genome Biology 2000, 1:reports013 (17 March 2000) Abstract \| Full text \| Editor’s summary Plant defense responses are induced by recognition of a conserved epitope of the major protein of the bacterial flagellum. This could represent a general perception mechanism for plants to detect infection by eubacteria.
	Paper report Polymorphisms suggest mitochondrial recombination Gilean McVean Genome Biology 2000, 1:reports014 (17 March 2000) Abstract \| Full text
	Paper report How many genes does it take to make a fly? Gilean McVean Genome Biology 2000, 1:reports015 (17 March 2000) Abstract \| Full text \| Editor’s summary The largest contiguous stretch of DNA yet sequenced in Drosophila suggests that fruit-flies have only half as many genes as Caenorhabditis elegans.
	Paper report Dispatched protein releases Hedgehog from cells Alan Shirras Genome Biology 2000, 1:reports017 (17 March 2000) Abstract \| Full text \| Editor’s summary A novel Drosophila segment polarity gene is identified and shown to be required for release of Hedgehog protein from secreting cells.
	Paper report Generation of Arabidopsis transposon lines Farhah Assaad Genome Biology 2000, 1:reports018 (17 March 2000) Abstract \| Full text \| Editor’s summary Positive and negative selection for unlinked transposition has been used to generate a large collection of Arabidopsis transposon lines.
	Paper report Unraveling chromosome 22 Jonathan B Weitzman Genome Biology 2000, 1:reports019 (17 March 2000) Abstract \| Full text
	Paper report Using gene chips to count DNA copy numbers Aude Fahrer Genome Biology 2000, 1:reports011 (17 April 2000) Abstract \| Full text
	Paper report Global gene expression patterns in rice Philippe Reymond Genome Biology 2000, 1:reports010 (27 April 2000) Abstract \| Full text
	Paper report Genome-wide analysis of bacterial metabolic pathways Mary Wildermuth Genome Biology 2000, 1:reports016 (27 April 2000) Abstract \| Full text \| Editor’s summary Systems analysis of the complete genome sequence combined with biochemical information on metabolic pathways has been used to define and elucidate the relationship between genotype and phenotype for Haemophilus influenzae Rd.
	Paper report How is the human signal peptide recognized? Rachel Brem Genome Biology 2000, 1:reports020 (27 April 2000) Abstract \| Full text \| Editor’s summary The crystal structure of human SRP54M from the signal recognition particle (SRP) reveals a homodimer interaction, which may be a model for the way signal sequences on nascent proteins recognize and activate the SRP.
	Paper report Sequence of the major histocompatibility complex Jonathan B Weitzman Genome Biology 2000, 1:reports021 (27 April 2000) Abstract \| Full text
	Paper report Predicting protein phosphorylation sites Rachel Brem Genome Biology 2000, 1:reports022 (27 April 2000) Abstract \| Full text
	Paper report Predicting global protein-protein interactions Rachel Brem Genome Biology 2000, 1:reports023 (27 April 2000) Abstract \| Full text
	Paper report Calcium dynamics in single plant cells Kath Carr, Alistair Hetherington Genome Biology 2000, 1:reports024 (27 April 2000) Abstract \| Full text \| Editor’s summary A new noninvasive technique has been developed that successfully measures calcium dynamics in single Arabidopsis guard cells.
	Paper report Mutagenesis of a large MYB gene family in Arabidopsis Seung Yon Rhee Genome Biology 2000, 1:reports025 (27 April 2000) Abstract \| Full text \| Editor’s summary PCR screening five collections of mutagenized Arabidopsis lines to find those that have T-DNA or transposon insertions in 73 members of the R2R3 MYB gene family has identified 47 insertions into 36 genes.
	Paper report A census of E. coli sequence repeats Rachel Brem Genome Biology 2000, 1:reports026 (27 April 2000) Abstract \| Full text \| Editor’s summary A statistical analysis of simple repeat motifs in DNA across the Escherichia coli genome is described.
	Paper report Mouse chromosomal deletions Paul Denny Genome Biology 2000, 1:reports027 (27 April 2000) Abstract \| Full text
	Paper report More efficient transposon mutagenesis in Arabidopsis? Leonore Reiser Genome Biology 2000, 1:reports028 (27 April 2000) Abstract \| Full text \| Editor’s summary A maize transposable element has been used to generate a tool for identifying gene function in Arabidopsis thaliana.
	Paper report Arabidopsis chromosome 2 sequence Todd Richmond Genome Biology 2000, 1:reports029 (27 April 2000) Abstract \| Full text \| Editor’s summary Members of the Arabidopsis Genome Initiative, primarily from The Institute for Genomic Research, have completed sequencing one of the first two plant chromosomes.
	Paper report Arabidopsis chromosome 4 sequence Todd Richmond Genome Biology 2000, 1:reports030 (27 April 2000) Abstract \| Full text \| Editor’s summary Members of the Arabidopsis Genome Initiative, including the European Union Arabidopsis Genome Sequencing Consortium and The Cold Spring Harbor, Washington University in St Louis and PE Biosystems Arabidopsis Sequencing Consortium, have completed sequencing one of the first two plant chromosomes.
	Paper report What transcripts are found in a human cell? Hamish Scott Genome Biology 2000, 1:reports031 (27 April 2000) Abstract \| Full text
	Paper report Improved oligonucleotides for microarrays Elaine Mardis Genome Biology 2000, 1:reports032 (27 April 2000) Abstract \| Full text \| Editor’s summary A novel method for the synthesis of 5'-attached oligonucleotides that eliminates truncated sequences may improve microarray construction.
	Paper report Predicting genes associated with prostate cancer Zach Perlman Genome Biology 2000, 1:reports033 (27 April 2000) Abstract \| Full text \| Editor’s summary A sensitive coexpression algorithm detects new genes associated with markers of prostate cancer.
	Paper report Profiling the flavonoid pathway Leonore Reiser Genome Biology 2000, 1:reports034 (27 April 2000) Abstract \| Full text
	Paper report Mapping replication origins Shuba Gopal Genome Biology 2000, 1:reports035 (11 May 2000) Abstract \| Full text
	Paper report Cholera virulence gene expression William Deakin Genome Biology 2000, 1:reports036 (11 May 2000) Abstract \| Full text \| Editor’s summary Expression patterns of Vibrio cholerae virulence genes determined during an infection differ dramatically from those observed in conventional in vitro analyses.
	Paper report Mycobacterium drug responses Zachary Perlman Genome Biology 2000, 1:reports037 (11 May 2000) Abstract \| Full text
	Paper report Drosophila genome sequence Alan Shirras Genome Biology 2000, 1:reports038 (11 May 2000) Abstract \| Full text \| Editor’s summary The nucleotide sequence of the 120 megabase euchromatic region of the Drosophila melanogaster genome is reported.
	Paper report Identifying plant centromeres Todd Richmond Genome Biology 2000, 1:reports039 (9 June 2000) Abstract \| Full text \| Editor’s summary Clever use of a mutation that allows tetrad analysis in a higher plant has enabled researchers to map the centromeres of Arabidopsis genetically with high precision.
	Paper report Polymorphic Toll-like receptors Ann-Marie Mallon Genome Biology 2000, 1:reports040 (9 June 2000) Abstract \| Full text
	Meeting report How will knowing genome sequences affect the life of the average cell biologist? Janet Rossant Genome Biology 2000, 1:reports401-reports401.2 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
	Meeting report Regulated secretion Colin Jamora Genome Biology 2000, 1:reports402-reports402.4 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the minisymposium on regulated secretion at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999 Conference website: http://www.faseb.org/ascb/meetings/am99/main99mtg.htm
	Meeting report Chemical approaches to understanding biological mechanisms Jason Swedlow Genome Biology 2000, 1:reports403-reports403.2 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work with small-molecule inhibitors of cellular processes presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
	Meeting report Cell motility and the formation of lamellipodia Louise Cramer Genome Biology 2000, 1:reports404-reports404.1 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
	Meeting report Determining the cellular function of myosin VI Lousie Cramer Genome Biology 2000, 1:reports405-reports405.2 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work presented at the 39th Annual Meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999
	Meeting report From sequence to consequence Gregory A Petsko Genome Biology 2000, 1:reports406-reports406.1 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the "Quantitative challenges in the post-genomic sequence era" workshop and symposium, San Diego, January 11-15, 2000
	Meeting report Dynamics of the nucleus Jason Swedlow Genome Biology 2000, 1:reports407-reports407.3 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report of work on the structure and function of the nuclear envelope and nuclear pores, presented at the 39th annual meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999.
	Meeting report Complexities of protein kinase C regulation David Stokoe Genome Biology 2000, 1:reports408-reports408.2 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Keystone Protein kinase C: structure, regulation and cellular function meeting, New Mexico, February 5-10, 2000.
	Meeting report Cardiovascular genomics: recent progress, current challenges, future promise Christopher J O'Donnell Genome Biology 2000, 1:reports409-reports409.3 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the second Annual Cardiovascular Genomics Meeting, Sponsored by Cambridge Healthtech, Inc., Miami, January 31-February 1, 2000.
	Meeting report The growing utility of microbial genome sequences Nigel J Saunders, Alex C Jeffries Genome Biology 2000, 1:reports410-reports410.3 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Genome Biology session of the 4^th annual conference on microbial genomes, Virginia, February 12-15, 2000.
	Meeting report Genomics and the renaissance of generalism Andrew JG Simpson Genome Biology 2000, 1:reports411-reports411.2 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A meeting report of the sessions on human, eukaryotic and bacterial genome sequencing at the American Society for Microbiology and Institut Pasteur joint conference: Genomes 2000 International Conference on Microbial and Model Genomes, Paris, April 11-15, 2000
	Research news How now, young cow William Wells Genome Biology 2000, 1:spotlight-20000428-01 (28 April 2000) Abstract \| Full text \| Editor’s summary Calves cloned from senescent cells have a surprising advantage: their cells look younger than cells from normal calves.
	Research news Plant interference William Wells Genome Biology 2000, 1:spotlight-20000428-03 (28 April 2000) Abstract \| Full text \| Editor’s summary A simple method for generating loss-of-function plant mutants
	Research news Microarrays for secreted proteins William Wells Genome Biology 2000, 1:spotlight-20000428-02 (28 April 2000) Abstract \| Full text \| Editor’s summary Secreted and membrane-associated proteins
	Research news Introns everywhere William Wells Genome Biology 2000, 1:spotlight-20000504-01 (4 May 2000) Abstract \| Full text \| Editor’s summary Self-splicing group II introns can home to the correct place in their host gene by reverse splicing into DNA.
	Research news GASPing for genes William Wells Genome Biology 2000, 1:spotlight-20000504-02 (4 May 2000) Abstract \| Full text \| Editor’s summary In the Genome Annotation Assessment Project (GASP), 12 groups tested their ability to identify genes in 3 million base pairs of Drosophila DNA.
	Research news Cell memory William Wells Genome Biology 2000, 1:spotlight-20000508-01 (8 May 2000) Abstract \| Full text \| Editor’s summary Binding of an extra dose of the chromatin protein Swi6 can shut down kilobases of DNA - and the alteration is heritable.
	Research news Double-promoting transcription William Wells Genome Biology 2000, 1:spotlight-20000508-02 (8 May 2000) Abstract \| Full text \| Editor’s summary Tandem promoters in a fly gene allow for regulation by both a TATA-binding protein (TBP) and a TBP-related protein.
	Research news Eat the dead William Wells Genome Biology 2000, 1:spotlight-20000508-03 (8 May 2000) Abstract \| Full text \| Editor’s summary Apoptosis eliminates the asymmetry of plasma membrane phospholipids and exposes phosphatidylserine on the outside of cells.
	Research news Sequence of human chromosome 21 William Wells Genome Biology 2000, 1:spotlight-20000509-01 (9 May 2000) Abstract \| Full text \| Editor’s summary The completed sequence of chromosome 21 reveals a paucity of genes - perhaps explaining why children with Down's syndrome survive.
	Research news E. coli: the computer William Wells Genome Biology 2000, 1:spotlight-20000509-03 (9 May 2000) Abstract \| Full text \| Editor’s summary A computer-encoded set of E. coli metabolic enzymes, linked up in the correct configuration and with a few absolute constraints, can qualitatively predict the growth potential of most mutant strains.
	Research news Sequencing on chips William Wells Genome Biology 2000, 1:spotlight-20000509-02 (9 May 2000) Abstract \| Full text \| Editor’s summary Sixteen channels, sixteen minutes, and a wafer 10 cm in diameter yield up to 500 base-pairs of 99% accurate DNA sequence per channel.
	Research news A classy RNA switch William Wells Genome Biology 2000, 1:spotlight-20000516-01 (16 May 2000) Abstract \| Full text \| Editor’s summary An RNA-DNA hybrid is essential for switching from one antibody class to another.
	Research news Big DNA, small channels William Wells Genome Biology 2000, 1:spotlight-20000516-02 (16 May 2000) Abstract \| Full text \| Editor’s summary Long DNA molecules can be separated, rapidly and without gel matrices, using channels made by lithography.
	Research news Down with diversity William Wells Genome Biology 2000, 1:spotlight-20000518-01 (18 May 2000) Abstract \| Full text \| Editor’s summary United by their genetic homogeneity, invading Argentinian ants are dominating their genetically diverse but infighting Californian counterparts.
	Research news Methylated but noisy William Wells Genome Biology 2000, 1:spotlight-20000518-02 (18 May 2000) Abstract \| Full text \| Editor’s summary Mutation of a plant gene relieves gene silencing but leaves methylation intact.
	Research news Guesses, anyone? William Wells Genome Biology 2000, 1:spotlight-20000523-01 (23 May 2000) Abstract \| Full text \| Editor’s summary How many genes are there in the human genome? The latest estimates still range from 30,000 to 120,000.
	Research news Transfecting with antibodies William Wells Genome Biology 2000, 1:spotlight-20000523-02 (23 May 2000) Abstract \| Full text \| Editor’s summary Antibody-coated beads that rip holes in cell membranes allow DNA transfection into specific subsets of cells.
	Research news Forty million years of solitude William Wells Genome Biology 2000, 1:spotlight-20000526-01 (26 May 2000) Abstract \| Full text \| Editor’s summary A bizarre pattern of sequence divergence shows that the bdelloids really have survived without sex.
	Research news An inchworm unwinds William Wells Genome Biology 2000, 1:spotlight-20000526-02 (26 May 2000) Abstract \| Full text \| Editor’s summary The RecBC DNA helicase has a binding domain that leaps ahead in 23-nucleotide bounds, and a DNA-unwinding domain that slithers up behind it.
	Research news For B cells, less is more William Wells Genome Biology 2000, 1:spotlight-20000531-01 (31 May 2000) Abstract \| Full text \| Editor’s summary The transcription factor PU.1 is needed for the formation of both macrophages and B cells. High PU.1 makes macrophages, whereas low PU.1 makes B cells.
	Research news Imprinting with insulation William Wells Genome Biology 2000, 1:spotlight-20000531-02 (31 May 2000) Abstract \| Full text \| Editor’s summary Methylation can dismantle a chromatin boundary, thus awakening the paternal copy of the Igf2 gene.
	Research news Don't blame the translocations William Wells Genome Biology 2000, 1:spotlight-20000602-01 (2 June 2000) Abstract \| Full text \| Editor’s summary A survey of translocations in related yeast strains shows that translocations aren't a requisite element of speciation.
	Research news Microbead expression arrays William Wells Genome Biology 2000, 1:spotlight-20000606-01 (6 June 2000) Abstract \| Full text \| Editor’s summary Massively parallel decoding of cDNAs immobilized in microbead arrays allows for fast and accurate expression profiling.
	Research news A lot of bloody genes William Wells Genome Biology 2000, 1:spotlight-20000607-01 (7 June 2000) Abstract \| Full text \| Editor’s summary Global transcription analysis reveals the substantial redundancy between two major transcription complexes in yeast.
	Research news Gene, regulate thyself William Wells Genome Biology 2000, 1:spotlight-20000607-03 (7 June 2000) Abstract \| Full text \| Editor’s summary Negative feedback can decrease the inherent variability of gene expression more than threefold.
	Research news Stem cells branch out William Wells Genome Biology 2000, 1:spotlight-20000607-02 (7 June 2000) Abstract \| Full text \| Editor’s summary Global transcription analysis reveals the substantial redundancy between two major transcription complexes in yeast.
	Research news Genome evolution goes local William Wells Genome Biology 2000, 1:spotlight-20000609-01 (9 June 2000) Abstract \| Full text \| Editor’s summary The variation in retrotransposon number and genome size in barley, which correlates with local microclimates, may serve an adaptive purpose.
	Research news No iron in Lyme William Wells Genome Biology 2000, 1:spotlight-20000609-02 (9 June 2000) Abstract \| Full text \| Editor’s summary The Lyme disease pathogen has no need for iron, and thus is not affected by host efforts to sequester it.
	Research news The birth of AIDS William Wells Genome Biology 2000, 1:spotlight-20000613-01 (13 June 2000) Abstract \| Full text \| Editor’s summary According to a new phylogenetic analysis, the subtype of HIV that causes the majority of AIDS cases started diverging around 1931.
	Research news Sharing transcription duties William Wells Genome Biology 2000, 1:spotlight-20000613-02 (13 June 2000) Abstract \| Full text \| Editor’s summary Global transcription analysis reveals the substantial redundancy between two major transcription complexes in yeast.
	Research news Diversity in axon guidance William Wells Genome Biology 2000, 1:spotlight-20000616-01 (16 June 2000) Abstract \| Full text \| Editor’s summary Thousands of alternatively spliced forms of an axon guidance receptor may contribute to the specificity of neuronal connections.
	Research news Two breaks make a translocation William Wells Genome Biology 2000, 1:spotlight-20000616-02 (16 June 2000) Abstract \| Full text \| Editor’s summary DNA with a single double-stranded break (DSB) is repaired, but two DSBs can result in a translocation.
	Research news Knockout flies William Wells Genome Biology 2000, 1:spotlight-20000621-01 (21 June 2000) Abstract \| Full text \| Editor’s summary Hope for mutation-on-demand in flies comes from a system that combines a recombinase and an endonuclease.
	Research news Sticky switches William Wells Genome Biology 2000, 1:spotlight-20000621-02 (21 June 2000) Abstract \| Full text \| Editor’s summary Put a hole in each of two proteins that bind each other, fill the combined hole with a chemical, and you have a switch for protein-protein interactions.
	Research news Choosing a smell William Wells Genome Biology 2000, 1:spotlight-20000622-01 (22 June 2000) Abstract \| Full text \| Editor’s summary The selection of a single odorant receptor gene is controlled locally within the genome.
	Research news Lymphocytes in lampreys? William Wells Genome Biology 2000, 1:spotlight-20000622-02 (22 June 2000) Abstract \| Full text \| Editor’s summary The presence of a lymphoid transcription factor in lampreys suggests that jawless vertebrates may have started constructing an immune system.
	Research news The day of the genome William Wells Genome Biology 2000, 1:spotlight-20000622-03 (22 June 2000) Abstract \| Full text \| Editor’s summary A semblance of peace is being restored to the human genome sequencing race as a joint announcement is planned for the coming week.
	Research news Who said what? Robert Walgate Genome Biology 2000, 1:spotlight-20000627-01 (27 June 2000) Abstract \| Full text \| Editor’s summary Read a few of the key points made by the pundits at the release of the draft human genome, 26 June, which took place via two separate press conferences.
	Research news Who has finished what? Robert Walgate Genome Biology 2000, 1:spotlight-20000627-02 (27 June 2000) Abstract \| Full text \| Editor’s summary The 'first draft' of the human genome sequence has been 'finished', but discussions continue about what is meant by finished, and who can patent what portions of the genome sequence and its annotation.
	Research news We're finished! William Wells Genome Biology 2000, 1:spotlight-20000627-03 (27 June 2000) Abstract \| Full text \| Editor’s summary Celera and the Human Genome Project have jointly announced the completion of a draft human genome sequence.
	Research news Gene targeting in sheep William Wells Genome Biology 2000, 1:spotlight-20000629-00 (29 June 2000) Abstract \| Full text \| Editor’s summary Making transgenic sheep need no longer be a hit-and-miss affair in terms of gene targeting, although cloning them remains an inefficient process.
	Research news Watch out for aneuploidy William Wells Genome Biology 2000, 1:spotlight-20000629-01 (29 June 2000) Abstract \| Full text \| Editor’s summary An analysis of both new and old microarray data reveals that results are frequently skewed by aneuploidy.
	Research news Replicating both ways William Wells Genome Biology 2000, 1:spotlight-20000629-02 (29 June 2000) Abstract \| Full text \| Editor’s summary An archeon uses homologs of eukaryotic DNA replication proteins to drive a bacterial mode of replication.
	Research news Transforming mosquitoes William Wells Genome Biology 2000, 1:spotlight-20000629-03 (29 June 2000) Abstract \| Full text \| Editor’s summary A method for introducing DNA into mosquitoes may lead to a mosquito that is incapable of transmitting the malaria parasite.
	Research
	Research Are plant formins integral membrane proteins? Fatima Cvrcková Genome Biology 2000, 1:research001-research001.7 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Formins are implicated in cellular morphogenesis and in communication between the actin cytoskeleton and the cell surface. Eight putative formin-coding genes have been found in the Arabidopsis genome sequence. Some lack parts of the conserved formin-homology 2 (FH2) domain and most have signal sequences and putative transmembrane segments that are not found in yeast or animals formins, placing plant formins in a distinct subfamily
	Research Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4) Irina Smirnova, Alexander Poltorak, Edward KL Chan, Colleen McBride, Bruce Beutler Genome Biology 2000, 1:research002-research002.10 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Toll-like receptor 4 gene (Tlr4) is thought to bind lipopolysaccharide and mediate lipopolysaccharide signal transduction in immune system cells. The Tlr4 genes of humans and mice have been sequenced, as well as the coding region and splice junctions of Tlr4 from 35 mouse strains, the chimpanzee and the baboon, revealing highly variable domains that may reflect differences in evolutionary selection and may underlie the magnitude of the response to lipopolysaccharide within a species.

	Volume 1 Issue 1
	Comment
	Editorial Editorial Genome Biology 2000, 1:comment001-comment001.2 (9 June 2000) Full text \| Editor’s summary These are exciting times for biology. The changes genomics brings to the way research is done in biological laboratories promise to be as profound as those triggered by the advent of recombinant DNA technology in the 1970s. It is in recognition of these changes that GenomeBiology is named and launched.
	Comment The Grail problem Gregory A Petsko Genome Biology 2000, 1:comment002-comment002.2 (9 June 2000) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Holy Grail is a familiar metaphor in science. A current Holy Grail is the complete sequence of the human genome, but there seems to be one for every field of biology.
	Opinion Whither genomics? Andrew W Murray Genome Biology 2000, 1:comment003-comment003.6 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The flood of data from genome-wide analysis is transforming biology. We need to develop new, interdisciplinary approaches to convert these data into information about the components and structures of individual biological pathways and to use the resulting information to yield knowledge about general principles that explain the functions and evolution of life.
	Review
	Review An overview of the structures of protein-DNA complexes Nicholas M Luscombe, Susan E Austin, Helen M Berman, Janet M Thornton Genome Biology 2000, 1:reviews001-reviews001.37 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary On the basis of a structural analysis of 240 protein-DNA complexes contained in the Protein Data Bank (PDB), we have classified the DNA-binding proteins involved into eight different structural/functional groups, which are further classified into 54 structural families. Here we present this classification and review the functions, structures and binding interactions of these protein-DNA complexes.
	Minireview Molecular mechanisms of spindle function Claire E Walczak Genome Biology 2000, 1:reviews101-reviews101.4 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The key molecules involved in regulating the assembly and function of the mitotic spindle are shared by evolutionarily divergent species. Studies in different model systems are leading to convergent conclusions about the central role of microtubule nucleation and dynamics and of kinesin-related motor proteins in spindle function.
	Minireview What initiates actin polymerization? Anne Ridley Genome Biology 2000, 1:reviews102-reviews102.4 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary For those working on the actin cytoskeleton, a major theme of the 39th annual meeting of the American Society for Cell Biology [http://www.faseb.org/ascb/meetings/am99/main99mtg.htm] (Washington DC, December 11-15, 1999) was the elucidation of how actin polymerization is initiated. The emphasis was on the regulation and localization of the Arp2/3 complex, which over the last two years has been shown to stimulate actin nucleation, and on the identification of additional proteins that interact with actin and Arp2/3 in a variety of organisms.
	Minireview A cultivated taste for yeast Charles Brenner Genome Biology 2000, 1:reviews103-reviews103.4 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The availability of complete genomic sequences of Saccharomyces cerevisiae has catalyzed a cultural change in the practice of yeast biology, providing opportunities to develop high throughput techniques to define protein function, to define drug targets, and to discover and characterize drugs.
	Minireview Membrane traffic between genomes John Armstrong Genome Biology 2000, 1:reviews104-reviews104.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Proteins of the Rab and SNARE families target vesicles to their intracellular destinations. A comparison of these families from the budding yeast, fission yeast, nematode and fruitfly genomes has implications for the organization of membrane traffic in different organisms.
	Minireview Measuring a cell's response to stress: the p53 pathway D Paul Harkin, Peter A Hall Genome Biology 2000, 1:reviews105-reviews105.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The characterization of complex cellular responses to diverse stimuli can be studied by the use of emerging chip-based technologies.
	Minireview Fly immunity: great expectations Ruslan Medzhitov, Charles Janeway Jr Genome Biology 2000, 1:reviews106-reviews106.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems.
	Minireview The many hues of plant heterochromatin Jeffrey L Bennetzen Genome Biology 2000, 1:reviews107-reviews107.4 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent sequence and cytogenetic analyses of heterochromatin in Arabidopsis, together with other results from Arabidopsis and maize, indicate that plant heterochromatin can have very different origins, compositions and dynamics. Shared features that must determine and/or be a result of its unique biological properties are also revealed.
	Minireview Chaotic actin Dennis Bray Genome Biology 2000, 1:reviews108-reviews108.3 (9 June 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Living cells organize their internal contents by coordinating the chaotic thermal motion of protein molecules. A recent study, combining experiment with stochastic simulation, shows how this might be achieved in the case of actin polymerization.
	Report
	Web report A definitive source of HLA molecule sequences and nomenclature Christopher J Thorpe Genome Biology 2000, 1:reports201 (17 March 2000) Abstract \| Full text
	Web report A high-quality database of molecules of the immune system Christopher J Thorpe Genome Biology 2000, 1:reports202 (17 March 2000) Abstract \| Full text \| Editor’s summary This integrated immunogenetics database specializes in immunoglobulins, T-cell receptors and major histocompatibility complex (MHC) molecules.
	Web report A database of MHC-peptide interactions Christopher J Thorpe Genome Biology 2000, 1:reports203 (17 March 2000) Abstract \| Full text \| Editor’s summary SYFPEITHI, a database of interactions between proteins of the major histocompatibility complex (MHC) and antigenic peptides, contains information on MHC-associated peptide sequences, anchor positions, MHC molecule specificities and references to the published literature.
	Web report Jobs and grants for junior researchers Bryony Wiseman Genome Biology 2000, 1:reports204 (17 March 2000) Abstract \| Full text \| Editor’s summary A new, free-access part of Science's main website, devoted to career advice for junior scientists.
	Web report Emerging online forum for life scientists Bryony Wiseman Genome Biology 2000, 1:reports205 (17 March 2000) Abstract \| Full text
	Web report Mammary glands explained Bryony Wiseman Genome Biology 2000, 1:reports206 (17 March 2000) Abstract \| Full text
	Web report Online reference book for biological topics Ines Chyla Genome Biology 2000, 1:reports207 (17 March 2000) Abstract \| Full text
	Web report Ribozymes as tools for the analysis of gene function Ines Chyla Genome Biology 2000, 1:reports208 (17 March 2000) Abstract \| Full text
	Web report How to design experiments logically Ines Chyla Genome Biology 2000, 1:reports209 (17 March 2000) Abstract \| Full text
	Web report Fugu: the small genome of a puffed-up fish Aengus Stewart Genome Biology 2000, 1:reports210 (17 March 2000) Abstract \| Full text \| Editor’s summary The puffer fish Fugu rubripes is perhaps better known as a Japanese delicacy, but its gene-rich, relatively small genome makes the puffer fish a suitable vertebrate for comparative mapping.
	Web report Xenopus: from tadpole to model organism Aengus Stewart Genome Biology 2000, 1:reports211 (17 March 2000) Abstract \| Full text \| Editor’s summary Developmental biology, primarily work with the embryos of Xenopus species X. laevis and X. tropicalis, is the focus of this site.
	Web report Fish development in black and white, and color too Aengus Stewart Genome Biology 2000, 1:reports212 (17 March 2000) Abstract \| Full text
	Web report An introduction to genetic diseases Basil Safwat Genome Biology 2000, 1:reports213 (17 March 2000) Abstract \| Full text
	Web report The implications of genetic research Basil Safwat Genome Biology 2000, 1:reports214 (17 March 2000) Abstract \| Full text
	Web report The human genome project explained Basil Safwat Genome Biology 2000, 1:reports215 (17 March 2000) Abstract \| Full text
	Web report The official repository for human genome mapping data Matthew Betts Genome Biology 2000, 1:reports216 (17 March 2000) Abstract \| Full text
	Web report Database of publicly available nucleotide sequences Matthew Betts Genome Biology 2000, 1:reports217 (17 March 2000) Abstract \| Full text
	Web report Biological and genetic information about the laboratory mouse Matthew Betts Genome Biology 2000, 1:reports218 (17 March 2000) Abstract \| Full text
	Web report Linked graphical maps of major signal transduction pathways Iain Gilfillan Genome Biology 2000, 1:reports219 (17 March 2000) Abstract \| Full text
	Web report A database of proteins that are known to interact Iain Gilfillan Genome Biology 2000, 1:reports220 (17 March 2000) Abstract \| Full text
	Web report Signaling molecules put into context Iain Gilfillan Genome Biology 2000, 1:reports221 (17 March 2000) Abstract \| Full text \| Editor’s summary Data are collected from Nature, Science, Cell, and Nature Cell Biology to form a database and resource for the signaling pathways of human cells.
	Web report Identification of complete gene structures in genomic DNA Todd Richmond Genome Biology 2000, 1:reports222 (17 March 2000) Abstract \| Full text
	Web report Prediction of intron splice sites Todd Richmond Genome Biology 2000, 1:reports223 (17 March 2000) Abstract \| Full text \| Editor’s summary The NetGene2 server uses a neural network combined with a rule-based system to predict intron splice sites in Arabidopsis thaliana, Caenorhabditis elegans and humans.
	Web report Topology prediction of membrane proteins Todd Richmond Genome Biology 2000, 1:reports224 (17 March 2000) Abstract \| Full text
	Web report Analysis of protein sequences Mar Albà Genome Biology 2000, 1:reports225 (17 March 2000) Abstract \| Full text \| Editor’s summary Several programs to predict sequence and structural features of a protein can be run simultaneously on the PredictProtein server.
	Web report Analysis of microarray expression data Paul Kellam Genome Biology 2000, 1:reports226 (17 March 2000) Abstract \| Full text
	Web report Chick pre-B cell encyclopedia Julie Curran Genome Biology 2000, 1:reports227 (17 March 2000) Abstract \| Full text
	Web report A 'handy' site for calcium-binding proteins Julie Curran Genome Biology 2000, 1:reports228 (17 March 2000) Abstract \| Full text
	Web report All you need to know about genetic mapping Julie Curran Genome Biology 2000, 1:reports229 (17 March 2000) Abstract \| Full text
	Web report Transcript mining Colin Semple Genome Biology 2000, 1:reports230 (17 March 2000) Abstract \| Full text
	Web report The structure of genomes Shuba Gopal Genome Biology 2000, 1:reports231 (17 March 2000) Abstract \| Full text
	Web report A database of restriction endonuclease buffers Todd Richmond Genome Biology 2000, 1:reports232 (17 March 2000) Abstract \| Full text
	Web report Gene recognition via spliced alignment Todd Richmond Genome Biology 2000, 1:reports233 (17 March 2000) Abstract \| Full text
	Web report A simple modular architecture research tool for the identification of signaling domains Todd Richmond Genome Biology 2000, 1:reports234 (17 March 2000) Abstract \| Full text
	Web report Links to molecular biology databases Mar Albà Genome Biology 2000, 1:reports235 (27 April 2000) Abstract \| Full text \| Editor’s summary Finding the relevant database is not always easy, and for some years Nucleic Acids Research has dedicated its first issue of the year to information about the most important existing databases.
	Web report Clustering of protein families Mar Albà Genome Biology 2000, 1:reports236 (27 April 2000) Abstract \| Full text \| Editor’s summary The Protomap program classifies proteins into clusters according to sequence similarity.
	Web report Expressed sequence tag (EST) clustering database Paul Kellam Genome Biology 2000, 1:reports237 (27 April 2000) Abstract \| Full text
	Web report Integrated chromosomal maps Kathryn Evans Genome Biology 2000, 1:reports238 (27 April 2000) Abstract \| Full text
	Web report Phylogenetic classification of proteins encoded in complete genomes Todd Richmond Genome Biology 2000, 1:reports239 (27 April 2000) Abstract \| Full text
	Web report Designing degenerate PCR primers Todd Richmond Genome Biology 2000, 1:reports240 (27 April 2000) Abstract \| Full text \| Editor’s summary The purpose of CODEHOP is to help in the design of degenerate PCR primers from protein sequence.
	Web report Precompiled codon-usage tables Todd Richmond Genome Biology 2000, 1:reports241 (27 April 2000) Abstract \| Full text
	Web report Identification of homology in human and mouse genomes Kathryn Evans Genome Biology 2000, 1:reports242 (27 April 2000) Abstract \| Full text
	Web report Variations on a gene Colin Semple Genome Biology 2000, 1:reports243 (27 April 2000) Abstract \| Full text
	Paper report Yersinia perturbs host cell signaling Jonathan B Weitzman Genome Biology 2000, 1:reports001 (17 March 2000) Abstract \| Full text \| Editor’s summary YopJ, a virulence factor of Yersinia pseudotuberculosis, can bind to several key intracellular signaling proteins, members of the MAPKK family, preventing their activation and protecting the pathogen from host defense mechanisms.
	Paper report Gadd45a knockout mice resemble p53 knockouts Jonathan B Weitzman Genome Biology 2000, 1:reports002 (17 March 2000) Abstract \| Full text \| Editor’s summary Mice with a disrupted Gadd45a gene share several phenotypic characteristics with p53 knockout mice, including genomic instability, increased carcinogenesis and exencephaly.
	Paper report Secretion by bacterial flagella William Deakin Genome Biology 2000, 1:reports003 (17 March 2000) Abstract \| Full text
	Paper report All the motifs in all known proteins Rachel Brem Genome Biology 2000, 1:reports004 (17 March 2000) Abstract \| Full text
	Paper report How aminoacyl-tRNA synthetase recognizes tRNA Rachel Brem Genome Biology 2000, 1:reports005 (17 March 2000) Abstract \| Full text \| Editor’s summary Can the selection by aminoacyl-tRNA synthetases for the correct tRNA substrate happen during binding? The results of equilibrium experiments suggest that it can.
	Paper report Axon guidance gene screen Alan Shirras Genome Biology 2000, 1:reports006 (17 March 2000) Abstract \| Full text
	Paper report A lectin receptor for rhizobial nodulation William Deakin Genome Biology 2000, 1:reports007 (17 March 2000) Abstract \| Full text \| Editor’s summary The isolation of a putative receptor protein for rhizobial nod factors that is located on the surface of legume roots and also has nucleotide hydrolytic properties is described.
	Paper report Classifying tumors by gene expression profiling Jonathan B Weitzman Genome Biology 2000, 1:reports008 (17 March 2000) Abstract \| Full text
	Paper report Predicting protein interactions from sequence Paul Kellam Genome Biology 2000, 1:reports009 (17 March 2000) Abstract \| Full text
	Paper report Perturbing gene expression with baculovirus Alan Shirras Genome Biology 2000, 1:reports012 (17 March 2000) Abstract \| Full text \| Editor’s summary A novel baculovirus misexpression system is shown to be functional in insect and vertebrate embryos.
	Paper report Plants recognize bacterial flagella William Deakin Genome Biology 2000, 1:reports013 (17 March 2000) Abstract \| Full text \| Editor’s summary Plant defense responses are induced by recognition of a conserved epitope of the major protein of the bacterial flagellum. This could represent a general perception mechanism for plants to detect infection by eubacteria.
	Paper report Polymorphisms suggest mitochondrial recombination Gilean McVean Genome Biology 2000, 1:reports014 (17 March 2000) Abstract \| Full text
	Paper report How many genes does it take to make a fly? Gilean McVean Genome Biology 2000, 1:reports015 (17 March 2000) Abstract \| Full text \| Editor’s summary The largest contiguous stretch of DNA yet sequenced in Drosophila suggests that fruit-flies have only half as many genes as Caenorhabditis elegans.
	Paper report Dispatched protein releases Hedgehog from cells Alan Shirras Genome Biology 2000, 1:reports017 (17 March 2000) Abstract \| Full text \| Editor’s summary A novel Drosophila segment polarity gene is identified and shown to be required for release of Hedgehog protein from secreting cells.
	Paper report Generation of Arabidopsis transposon lines Farhah Assaad Genome Biology 2000, 1:reports018 (17 March 2000) Abstract \| Full text \| Editor’s summary Positive and negative selection for unlinked transposition has been used to generate a large collection of Arabidopsis transposon lines.
	Paper report Unraveling chromosome 22 Jonathan B Weitzman Genome Biology 2000, 1:reports019 (17 March 2000) Abstract \| Full text
	Paper report Using gene chips to count DNA copy numbers Aude Fahrer Genome Biology 2000, 1:reports011 (17 April 2000) Abstract \| Full text
	Paper report Global gene expression patterns in rice Philippe Reymond Genome Biology 2000, 1:reports010 (27 April 2000) Abstract \| Full text
	Paper report Genome-wide analysis of bacterial metabolic pathways Mary Wildermuth Genome Biology 2000, 1:reports016 (27 April 2000) Abstract \| Full text \| Editor’s summary Systems analysis of the complete genome sequence combined with biochemical information on metabolic pathways has been used to define and elucidate the relationship between genotype and phenotype for Haemophilus influenzae Rd.
	Paper report How is the human signal peptide recognized? Rachel Brem Genome Biology 2000, 1:reports020 (27 April 2000) Abstract \| Full text \| Editor’s summary The crystal structure of human SRP54M from the signal recognition particle (SRP) reveals a homodimer interaction, which may be a model for the way signal sequences on nascent proteins recognize and activate the SRP.
	Paper report Sequence of the major histocompatibility complex Jonathan B Weitzman Genome Biology 2000, 1:reports021 (27 April 2000) Abstract \| Full text
	Paper report Predicting protein phosphorylation sites Rachel Brem Genome Biology 2000, 1:reports022 (27 April 2000) Abstract \| Full text
	Paper report Predicting global protein-protein interactions Rachel Brem Genome Biology 2000, 1:reports023 (27 April 2000) Abstract \| Full text
	Paper report Calcium dynamics in single plant cells Kath Carr, Alistair Hetherington Genome Biology 2000, 1:reports024 (27 April 2000) Abstract \| Full text \| Editor’s summary A new noninvasive technique has been developed that successfully measures calcium dynamics in single Arabidopsis guard cells.
	Paper report Mutagenesis of a large MYB gene family in Arabidopsis Seung Yon Rhee Genome Biology 2000, 1:reports025 (27 April 2000) Abstract \| Full text \| Editor’s summary PCR screening five collections of mutagenized Arabidopsis lines to find those that have T-DNA or transposon insertions in 73 members of the R2R3 MYB gene family has identified 47 insertions into 36 genes.
	Paper report A census of E. coli sequence repeats Rachel Brem Genome Biology 2000, 1:reports026 (27 April 2000) Abstract \| Full text \| Editor’s summary A statistical analysis of simple repeat motifs in DNA across the Escherichia coli genome is described.
	Paper report Mouse chromosomal deletions Paul Denny Genome Biology 2000, 1:reports027 (27 April 2000) Abstract \| Full text
	Paper report More efficient transposon mutagenesis in Arabidopsis? Leonore Reiser Genome Biology 2000, 1:reports028 (27 April 2000) Abstract \| Full text \| Editor’s summary A maize transposable element has been used to generate a tool for identifying gene function in Arabidopsis thaliana.
	Paper report Arabidopsis chromosome 2 sequence Todd Richmond Genome Biology 2000, 1:reports029 (27 April 2000) Abstract \| Full text \| Editor’s summary Members of the Arabidopsis Genome Initiative, primarily from The Institute for Genomic Research, have completed sequencing one of the first two plant chromosomes.
	Paper report Arabidopsis chromosome 4 sequence Todd Richmond Genome Biology 2000, 1:reports030 (27 April 2000) Abstract \| Full text \| Editor’s summary Members of the Arabidopsis Genome Initiative, including the European Union Arabidopsis Genome Sequencing Consortium and The Cold Spring Harbor, Washington University in St Louis and PE Biosystems Arabidopsis Sequencing Consortium, have completed sequencing one of the first two plant chromosomes.
	Paper report What transcripts are found in a human cell? Hamish Scott Genome Biology 2000, 1:reports031 (27 April 2000) Abstract \| Full text
	Paper report Improved oligonucleotides for microarrays Elaine Mardis Genome Biology 2000, 1:reports032 (27 April 2000) Abstract \| Full text \| Editor’s summary A novel method for the synthesis of 5'-attached oligonucleotides that eliminates truncated sequences may improve microarray construction.
	Paper report Predicting genes associated with prostate cancer Zach Perlman Genome Biology 2000, 1:reports033 (27 April 2000) Abstract \| Full text \| Editor’s summary A sensitive coexpression algorithm detects new genes associated with markers of prostate cancer.
	Paper report Profiling the flavonoid pathway Leonore Reiser Genome Biology 2000, 1:reports034 (27 April 2000) Abstract \| Full text
	Paper report Mapping replication origins Shuba Gopal Genome Biology 2000, 1:reports035 (11 May 2000) Abstract \| Full text
	Paper report Cholera virulence gene expression William Deakin Genome Biology 2000, 1:reports036 (11 May 2000) Abstract \| Full text \| Editor’s summary Expression patterns of Vibrio cholerae virulence genes determined during an infection differ dramatically from those observed in conventional in vitro analyses.
	Paper report Mycobacterium drug responses Zachary Perlman Genome Biology 2000, 1:reports037 (11 May 2000) Abstract \| Full text
	Paper report Drosophila genome sequence Alan Shirras Genome Biology 2000, 1:reports038 (11 May 2000) Abstract \| Full text \| Editor’s summary The nucleotide sequence of the 120 megabase euchromatic region of the Drosophila melanogaster genome is reported.
	Paper report Identifying plant centromeres Todd Richmond Genome Biology 2000, 1:reports039 (9 June 2000) Abstract \| Full text \| Editor’s summary Clever use of a mutation that allows tetrad analysis in a higher plant has enabled researchers to map the centromeres of Arabidopsis genetically with high precision.
	Paper report Polymorphic Toll-like receptors Ann-Marie Mallon Genome Biology 2000, 1:reports040 (9 June 2000) Abstract \| Full text
	Meeting report How will knowing genome sequences affect the life of the average cell biologist? Janet Rossant Genome Biology 2000, 1:reports401-reports401.2 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
	Meeting report Regulated secretion Colin Jamora Genome Biology 2000, 1:reports402-reports402.4 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the minisymposium on regulated secretion at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999 Conference website: http://www.faseb.org/ascb/meetings/am99/main99mtg.htm
	Meeting report Chemical approaches to understanding biological mechanisms Jason Swedlow Genome Biology 2000, 1:reports403-reports403.2 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work with small-molecule inhibitors of cellular processes presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
	Meeting report Cell motility and the formation of lamellipodia Louise Cramer Genome Biology 2000, 1:reports404-reports404.1 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work presented at the 39th Annual Meeting of the American Society for Cell Bilogy, Washington DC, December 11-15, 1999
	Meeting report Determining the cellular function of myosin VI Lousie Cramer Genome Biology 2000, 1:reports405-reports405.2 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on work presented at the 39th Annual Meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999
	Meeting report From sequence to consequence Gregory A Petsko Genome Biology 2000, 1:reports406-reports406.1 (27 April 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the "Quantitative challenges in the post-genomic sequence era" workshop and symposium, San Diego, January 11-15, 2000
	Meeting report Dynamics of the nucleus Jason Swedlow Genome Biology 2000, 1:reports407-reports407.3 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report of work on the structure and function of the nuclear envelope and nuclear pores, presented at the 39th annual meeting of the American Society for Cell Biology, Washington DC, December 11-15, 1999.
	Meeting report Complexities of protein kinase C regulation David Stokoe Genome Biology 2000, 1:reports408-reports408.2 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Keystone Protein kinase C: structure, regulation and cellular function meeting, New Mexico, February 5-10, 2000.
	Meeting report Cardiovascular genomics: recent progress, current challenges, future promise Christopher J O'Donnell Genome Biology 2000, 1:reports409-reports409.3 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the second Annual Cardiovascular Genomics Meeting, Sponsored by Cambridge Healthtech, Inc., Miami, January 31-February 1, 2000.
	Meeting report The growing utility of microbial genome sequences Nigel J Saunders, Alex C Jeffries Genome Biology 2000, 1:reports410-reports410.3 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Genome Biology session of the 4^th annual conference on microbial genomes, Virginia, February 12-15, 2000.
	Meeting report Genomics and the renaissance of generalism Andrew JG Simpson Genome Biology 2000, 1:reports411-reports411.2 (9 June 2000) Abstract \| Full text \| PDF \| Editor’s summary A meeting report of the sessions on human, eukaryotic and bacterial genome sequencing at the American Society for Microbiology and Institut Pasteur joint conference: Genomes 2000 International Conference on Microbial and Model Genomes, Paris, April 11-15, 2000
	Research news How now, young cow William Wells Genome Biology 2000, 1:spotlight-20000428-01 (28 April 2000) Abstract \| Full text \| Editor’s summary Calves cloned from senescent cells have a surprising advantage: their cells look younger than cells from normal calves.
	Research news Plant interference William Wells Genome Biology 2000, 1:spotlight-20000428-03 (28 April 2000) Abstract \| Full text \| Editor’s summary A simple method for generating loss-of-function plant mutants
	Research news Microarrays for secreted proteins William Wells Genome Biology 2000, 1:spotlight-20000428-02 (28 April 2000) Abstract \| Full text \| Editor’s summary Secreted and membrane-associated proteins
	Research news Introns everywhere William Wells Genome Biology 2000, 1:spotlight-20000504-01 (4 May 2000) Abstract \| Full text \| Editor’s summary Self-splicing group II introns can home to the correct place in their host gene by reverse splicing into DNA.
	Research news GASPing for genes William Wells Genome Biology 2000, 1:spotlight-20000504-02 (4 May 2000) Abstract \| Full text \| Editor’s summary In the Genome Annotation Assessment Project (GASP), 12 groups tested their ability to identify genes in 3 million base pairs of Drosophila DNA.
	Research news Cell memory William Wells Genome Biology 2000, 1:spotlight-20000508-01 (8 May 2000) Abstract \| Full text \| Editor’s summary Binding of an extra dose of the chromatin protein Swi6 can shut down kilobases of DNA - and the alteration is heritable.
	Research news Double-promoting transcription William Wells Genome Biology 2000, 1:spotlight-20000508-02 (8 May 2000) Abstract \| Full text \| Editor’s summary Tandem promoters in a fly gene allow for regulation by both a TATA-binding protein (TBP) and a TBP-related protein.
	Research news Eat the dead William Wells Genome Biology 2000, 1:spotlight-20000508-03 (8 May 2000) Abstract \| Full text \| Editor’s summary Apoptosis eliminates the asymmetry of plasma membrane phospholipids and exposes phosphatidylserine on the outside of cells.
	Research news Sequence of human chromosome 21 William Wells Genome Biology 2000, 1:spotlight-20000509-01 (9 May 2000) Abstract \| Full text \| Editor’s summary The completed sequence of chromosome 21 reveals a paucity of genes - perhaps explaining why children with Down's syndrome survive.
	Research news E. coli: the computer William Wells Genome Biology 2000, 1:spotlight-20000509-03 (9 May 2000) Abstract \| Full text \| Editor’s summary A computer-encoded set of E. coli metabolic enzymes, linked up in the correct configuration and with a few absolute constraints, can qualitatively predict the growth potential of most mutant strains.
	Research news Sequencing on chips William Wells Genome Biology 2000, 1:spotlight-20000509-02 (9 May 2000) Abstract \| Full text \| Editor’s summary Sixteen channels, sixteen minutes, and a wafer 10 cm in diameter yield up to 500 base-pairs of 99% accurate DNA sequence per channel.
	Research news A classy RNA switch William Wells Genome Biology 2000, 1:spotlight-20000516-01 (16 May 2000) Abstract \| Full text \| Editor’s summary An RNA-DNA hybrid is essential for switching from one antibody class to another.
	Research news Big DNA, small channels William Wells Genome Biology 2000, 1:spotlight-20000516-02 (16 May 2000) Abstract \| Full text \| Editor’s summary Long DNA molecules can be separated, rapidly and without gel matrices, using channels made by lithography.
	Research news Down with diversity William Wells Genome Biology 2000, 1:spotlight-20000518-01 (18 May 2000) Abstract \| Full text \| Editor’s summary United by their genetic homogeneity, invading Argentinian ants are dominating their genetically diverse but infighting Californian counterparts.
	Research news Methylated but noisy William Wells Genome Biology 2000, 1:spotlight-20000518-02 (18 May 2000) Abstract \| Full text \| Editor’s summary Mutation of a plant gene relieves gene silencing but leaves methylation intact.
	Research news Guesses, anyone? William Wells Genome Biology 2000, 1:spotlight-20000523-01 (23 May 2000) Abstract \| Full text \| Editor’s summary How many genes are there in the human genome? The latest estimates still range from 30,000 to 120,000.
	Research news Transfecting with antibodies William Wells Genome Biology 2000, 1:spotlight-20000523-02 (23 May 2000) Abstract \| Full text \| Editor’s summary Antibody-coated beads that rip holes in cell membranes allow DNA transfection into specific subsets of cells.
	Research news Forty million years of solitude William Wells Genome Biology 2000, 1:spotlight-20000526-01 (26 May 2000) Abstract \| Full text \| Editor’s summary A bizarre pattern of sequence divergence shows that the bdelloids really have survived without sex.
	Research news An inchworm unwinds William Wells Genome Biology 2000, 1:spotlight-20000526-02 (26 May 2000) Abstract \| Full text \| Editor’s summary The RecBC DNA helicase has a binding domain that leaps ahead in 23-nucleotide bounds, and a DNA-unwinding domain that slithers up behind it.
	Research news For B cells, less is more William Wells Genome Biology 2000, 1:spotlight-20000531-01 (31 May 2000) Abstract \| Full text \| Editor’s summary The transcription factor PU.1 is needed for the formation of both macrophages and B cells. High PU.1 makes macrophages, whereas low PU.1 makes B cells.
	Research news Imprinting with insulation William Wells Genome Biology 2000, 1:spotlight-20000531-02 (31 May 2000) Abstract \| Full text \| Editor’s summary Methylation can dismantle a chromatin boundary, thus awakening the paternal copy of the Igf2 gene.
	Research news Don't blame the translocations William Wells Genome Biology 2000, 1:spotlight-20000602-01 (2 June 2000) Abstract \| Full text \| Editor’s summary A survey of translocations in related yeast strains shows that translocations aren't a requisite element of speciation.
	Research news Microbead expression arrays William Wells Genome Biology 2000, 1:spotlight-20000606-01 (6 June 2000) Abstract \| Full text \| Editor’s summary Massively parallel decoding of cDNAs immobilized in microbead arrays allows for fast and accurate expression profiling.
	Research news A lot of bloody genes William Wells Genome Biology 2000, 1:spotlight-20000607-01 (7 June 2000) Abstract \| Full text \| Editor’s summary Global transcription analysis reveals the substantial redundancy between two major transcription complexes in yeast.
	Research news Gene, regulate thyself William Wells Genome Biology 2000, 1:spotlight-20000607-03 (7 June 2000) Abstract \| Full text \| Editor’s summary Negative feedback can decrease the inherent variability of gene expression more than threefold.
	Research news Stem cells branch out William Wells Genome Biology 2000, 1:spotlight-20000607-02 (7 June 2000) Abstract \| Full text \| Editor’s summary Global transcription analysis reveals the substantial redundancy between two major transcription complexes in yeast.
	Research news Genome evolution goes local William Wells Genome Biology 2000, 1:spotlight-20000609-01 (9 June 2000) Abstract \| Full text \| Editor’s summary The variation in retrotransposon number and genome size in barley, which correlates with local microclimates, may serve an adaptive purpose.
	Research news No iron in Lyme William Wells Genome Biology 2000, 1:spotlight-20000609-02 (9 June 2000) Abstract \| Full text \| Editor’s summary The Lyme disease pathogen has no need for iron, and thus is not affected by host efforts to sequester it.
	Research news The birth of AIDS William Wells Genome Biology 2000, 1:spotlight-20000613-01 (13 June 2000) Abstract \| Full text \| Editor’s summary According to a new phylogenetic analysis, the subtype of HIV that causes the majority of AIDS cases started diverging around 1931.
	Research news Sharing transcription duties William Wells Genome Biology 2000, 1:spotlight-20000613-02 (13 June 2000) Abstract \| Full text \| Editor’s summary Global transcription analysis reveals the substantial redundancy between two major transcription complexes in yeast.
	Research news Diversity in axon guidance William Wells Genome Biology 2000, 1:spotlight-20000616-01 (16 June 2000) Abstract \| Full text \| Editor’s summary Thousands of alternatively spliced forms of an axon guidance receptor may contribute to the specificity of neuronal connections.
	Research news Two breaks make a translocation William Wells Genome Biology 2000, 1:spotlight-20000616-02 (16 June 2000) Abstract \| Full text \| Editor’s summary DNA with a single double-stranded break (DSB) is repaired, but two DSBs can result in a translocation.
	Research news Knockout flies William Wells Genome Biology 2000, 1:spotlight-20000621-01 (21 June 2000) Abstract \| Full text \| Editor’s summary Hope for mutation-on-demand in flies comes from a system that combines a recombinase and an endonuclease.
	Research news Sticky switches William Wells Genome Biology 2000, 1:spotlight-20000621-02 (21 June 2000) Abstract \| Full text \| Editor’s summary Put a hole in each of two proteins that bind each other, fill the combined hole with a chemical, and you have a switch for protein-protein interactions.
	Research news Choosing a smell William Wells Genome Biology 2000, 1:spotlight-20000622-01 (22 June 2000) Abstract \| Full text \| Editor’s summary The selection of a single odorant receptor gene is controlled locally within the genome.
	Research news Lymphocytes in lampreys? William Wells Genome Biology 2000, 1:spotlight-20000622-02 (22 June 2000) Abstract \| Full text \| Editor’s summary The presence of a lymphoid transcription factor in lampreys suggests that jawless vertebrates may have started constructing an immune system.
	Research news The day of the genome William Wells Genome Biology 2000, 1:spotlight-20000622-03 (22 June 2000) Abstract \| Full text \| Editor’s summary A semblance of peace is being restored to the human genome sequencing race as a joint announcement is planned for the coming week.
	Research news Who said what? Robert Walgate Genome Biology 2000, 1:spotlight-20000627-01 (27 June 2000) Abstract \| Full text \| Editor’s summary Read a few of the key points made by the pundits at the release of the draft human genome, 26 June, which took place via two separate press conferences.
	Research news Who has finished what? Robert Walgate Genome Biology 2000, 1:spotlight-20000627-02 (27 June 2000) Abstract \| Full text \| Editor’s summary The 'first draft' of the human genome sequence has been 'finished', but discussions continue about what is meant by finished, and who can patent what portions of the genome sequence and its annotation.
	Research news We're finished! William Wells Genome Biology 2000, 1:spotlight-20000627-03 (27 June 2000) Abstract \| Full text \| Editor’s summary Celera and the Human Genome Project have jointly announced the completion of a draft human genome sequence.
	Research news Gene targeting in sheep William Wells Genome Biology 2000, 1:spotlight-20000629-00 (29 June 2000) Abstract \| Full text \| Editor’s summary Making transgenic sheep need no longer be a hit-and-miss affair in terms of gene targeting, although cloning them remains an inefficient process.
	Research news Watch out for aneuploidy William Wells Genome Biology 2000, 1:spotlight-20000629-01 (29 June 2000) Abstract \| Full text \| Editor’s summary An analysis of both new and old microarray data reveals that results are frequently skewed by aneuploidy.
	Research news Replicating both ways William Wells Genome Biology 2000, 1:spotlight-20000629-02 (29 June 2000) Abstract \| Full text \| Editor’s summary An archeon uses homologs of eukaryotic DNA replication proteins to drive a bacterial mode of replication.
	Research news Transforming mosquitoes William Wells Genome Biology 2000, 1:spotlight-20000629-03 (29 June 2000) Abstract \| Full text \| Editor’s summary A method for introducing DNA into mosquitoes may lead to a mosquito that is incapable of transmitting the malaria parasite.
	Research
	Research Are plant formins integral membrane proteins? Fatima Cvrcková Genome Biology 2000, 1:research001-research001.7 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Formins are implicated in cellular morphogenesis and in communication between the actin cytoskeleton and the cell surface. Eight putative formin-coding genes have been found in the Arabidopsis genome sequence. Some lack parts of the conserved formin-homology 2 (FH2) domain and most have signal sequences and putative transmembrane segments that are not found in yeast or animals formins, placing plant formins in a distinct subfamily
	Research Phylogenetic variation and polymorphism at the Toll-like receptor 4 locus (TLR4) Irina Smirnova, Alexander Poltorak, Edward KL Chan, Colleen McBride, Bruce Beutler Genome Biology 2000, 1:research002-research002.10 (27 April 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Toll-like receptor 4 gene (Tlr4) is thought to bind lipopolysaccharide and mediate lipopolysaccharide signal transduction in immune system cells. The Tlr4 genes of humans and mice have been sequenced, as well as the coding region and splice junctions of Tlr4 from 35 mouse strains, the chimpanzee and the baboon, revealing highly variable domains that may reflect differences in evolutionary selection and may underlie the magnitude of the response to lipopolysaccharide within a species.

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