Genome Biology | Volume 1 Issue 3

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	Volume 1 Issue 3
	Comment
	Comment The dark side Gregory A Petsko Genome Biology 2000, 1:comment1003-comment1003.2 (15 September 2000) Full text \| PDF \| PubMed \| Editor’s summary We will all face the dark side before long, as the emphasis in genomics shifts from identifying and sequencing genes to the problem of determining what their products do.
	Review
	Review A comparison of programmed cell death between species Jan N Tittel, Hermann Steller Genome Biology 2000, 1:reviews0003-reviews0003.6 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Key components of the programmed cell death pathway are conserved between Caenorhabditis elegans, Drosophila melanogaster and humans. The search for additional homologs has been facilitated by the availability of the entire genomic sequence for each of these organisms.
	Minireview The complete genome sequence of Vibrio cholerae: a tale of two chromosomes and of two lifestyles Gary K Schoolnik, Fitnat H Yildiz Genome Biology 2000, 1:reviews1016-reviews1016.3 (1 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vibrio cholerae O1 has figured prominently in the history of infectious diseases as a cause of periodic global epidemics, an affliction of refugees in areas of social strife and as the disease first subjected to modern epidemiological analysis during the classic investigations of John Snow in mid-19th century London [1]. Thus, publication of the entire genome sequence of V. cholerae O1 (biotype El Tor) in Nature [2] by a consortium of investigators from The Institute for Genomic Research, the University of Maryland and Harvard Medical School is properly regarded as an historic event that will trigger a paradigm shift in the study of this organism.
	Minireview The function and regulation of vasa-like genes in germ-cell development Erez Raz Genome Biology 2000, 1:reviews1017-reviews1017.6 (1 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The vasa gene, essential for germ-cell development, was originally identified in Drosophila, and has since been found in other invertebrates and vertebrates. Analysis of these vasa homologs has revealed a highly conserved role for Vasa protein among different organisms, as well as some important differences in its regulation.
	Minireview A conserved mechanism for post-transcriptional gene silencing? Eleanor M Maine Genome Biology 2000, 1:reviews1018-reviews1018.4 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Proteins with homology to RNA-directed RNA polymerases function in post-transcriptional gene silencing: in quelling in the fungus Neurospora crassa, RNAi in the nematode Caenorhabditis elegans, and co-suppression in the mustard plant Arabidopsis thaliana. These findings are consistent with a conserved mechanism operating in these diverse species.
	Minireview From rags to riches: insights from the first genomic sequence of a plant pathogenic bacterium Noel T Keen, C Korsi Dumenyo, Ching-Hong Yang, Donald A Cooksey Genome Biology 2000, 1:reviews1019-reviews1019.4 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The recently published genomic sequence of Xylella fastidiosa is the first for a free-living plant pathogen and provides clues to mechanisms of pathogenesis and survival in insect vectors. The sequence data should lead to improved control of this pathogen.
	Minireview Where does DNA replication start in archaea? Amit Vas, Janet Leatherwood Genome Biology 2000, 1:reviews1020-reviews1020.4 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome-wide measures of DNA strand composition have been used to find archaeal DNA replication origins. Archaea seem to replicate using a single origin (as do eubacteria) even though archaeal replication factors are more like those of eukaryotes.
	Minireview Does massively parallel transcriptome analysis signify the end of cancer histopathology as we know it? Samuel AJR Aparicio, Carlos Caldas, Bruce Ponder Genome Biology 2000, 1:reviews1021-reviews1021.3 (15 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transcriptional analysis of all the genes expressed by breast tumors has provided the first steps towards defining a molecular signature for the disease, and might ultimately make conventional diagnostic techniques obsolete.
	Minireview The fork'ed path to mitosis Paul Jorgensen, Mike Tyers Genome Biology 2000, 1:reviews1022-reviews1022.4 (15 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A concurrence of genomic, reverse genetic and biochemical approaches has cracked the decade-long enigma concerning the identity of the transcription factors that control gene expression at the G2/M transition in the budding yeast cell cycle.
	Opinion The impact of open access on biomedical research Harold Varmus, David Lipman, Paul Ginsparg, Barry P Markovitz Genome Biology 2000, 1:comment2003-comment2003.1 (15 September 2000) Abstract \| Full text \| Editor’s summary A series of reports - and extracts of reports - from the Freedom of Information Conference, 6-7 July, 2000, New York Academy of Medicine. The conference was sponsored by BioMed Central, to promote debate about the communication and validation of biomedical research published on the internet. Details of the meeting and all presentations are available in full online at http://biomedcentral.com/info/conference.asp
	Report
	Web report A one-step source for information about human genes Melanie Nelson Genome Biology 2000, 1:reports2049 (18 September 2000) Abstract \| Full text
	Web report The thousand doors to disease Colin Semple Genome Biology 2000, 1:reports2050 (18 September 2000) Abstract \| Full text \| Editor’s summary Online Mendelian Inheritance in Man is a database of human genes and genetic disorders.
	Web report Digital biochemical pathways database Todd Richmond Genome Biology 2000, 1:reports2051 (18 September 2000) Abstract \| Full text
	Web report Finding motifs in protein sequences Todd Richmond Genome Biology 2000, 1:reports2052 (18 September 2000) Abstract \| Full text
	Web report Gene identification software Todd Richmond Genome Biology 2000, 1:reports2053 (18 September 2000) Abstract \| Full text
	Web report Signal peptide cleavage site prediction David W Ussery Genome Biology 2000, 1:reports2054 (18 September 2000) Abstract \| Full text
	Paper report Bacterial two-hybrid screening Rachel Brem Genome Biology 2000, 1:reports0064 (18 September 2000) Abstract \| Full text
	Paper report Genetic analysis of bacterial motility William Deakin Genome Biology 2000, 1:reports0065 (18 September 2000) Abstract \| Full text \| Editor’s summary The genes involved in the assembly and function of the polar flagellum of Vibrio parahaemolyticus have been analyzed systematically by mutagenesis, DNA sequencing and transcriptional studies.
	Paper report Matrix methods for gene expression analysis Rachel Brem Genome Biology 2000, 1:reports0066 (18 September 2000) Abstract \| Full text
	Paper report Mechanisms of melanoma metastasis Jonathan B Weitzman Genome Biology 2000, 1:reports0067 (18 September 2000) Abstract \| Full text \| Editor’s summary Analysis of highly metastatic melanoma cells using oligonucleotide arrays has identified genes regulating tumor invasiveness.
	Paper report Evolution without sex James Cotton Genome Biology 2000, 1:reports0068 (18 September 2000) Abstract \| Full text
	Paper report Mouse placental gene expression Paul Denny Genome Biology 2000, 1:reports0069 (26 September 2000) Abstract \| Full text
	Meeting report Bioinformatics 2000 David W Ussery Genome Biology 2000, 1:reports4014-reports4014.2 (1 September 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Bioinformatics 2000 conference [http://www.cbs.dtu.dk/bioinformatics2000/], held in Elsinore, Denmark, 27-30 April, 2000.
	Meeting report Retroviruses at a glance Cecile Voisset, Mariam Andrawiss Genome Biology 2000, 1:reports4015-reports4015.4 (15 September 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Cold Spring Harbor Laboratory 2000 conference on Retroviruses, Cold Spring Harbor, May 23-28, 2000.
	Research news Sex and asymmetry in yeast Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000901-03 (1 September 2000) Abstract \| Full text \| Editor’s summary DNA density gradient centrifugation has been used to understand the molecular mechanisms that regulate how fission yeast cells change sex.
	Research news Creating protein folds William Wells Genome Biology 2000, 1:spotlight-20000901-02 (1 September 2000) Abstract \| Full text \| Editor’s summary A new protein fold can be constructed from half of an existing fold plus some random genomic segments.
	Research news Sequence of a big bug William Wells Genome Biology 2000, 1:spotlight-20000901-04 (1 September 2000) Abstract \| Full text \| Editor’s summary The 6.3 Mbp sequence of Pseudomonas aeruginosa, the bug responsible for most cystic fibrosis deaths, reveals lots of pumps and lots of regulation.
	Research news Promiscuity in Trinidad William Wells Genome Biology 2000, 1:spotlight-20000901-01 (1 September 2000) Abstract \| Full text \| Editor’s summary Female Trinidadian guppies often mate with multiple males, because the resultant offspring show substantially increased fitness.
	Research news Antibody arrays William Wells Genome Biology 2000, 1:spotlight-20000906-03 (6 September 2000) Abstract \| Full text \| Editor’s summary Protein-detection arrays can be made by robotic spotting, using bacterial colonies that produce single-chain antibodies.
	Research news Repair polymerases in a double act William Wells Genome Biology 2000, 1:spotlight-20000906-01 (6 September 2000) Abstract \| Full text \| Editor’s summary Two eukaryotic DNA polymerases act sequentially to repair DNA lesions.
	Research news Double-duplication evolution William Wells Genome Biology 2000, 1:spotlight-20000906-02 (6 September 2000) Abstract \| Full text \| Editor’s summary Two biosynthetic enzymes appear to have evolved from gene duplication, followed by fusion, followed by a second gene duplication.
	Research news MODY-fying gene expression in diabetes Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000912-01 (12 September 2000) Abstract \| Full text \| Editor’s summary Identification of genes that are regulated by the transcription factor HNF1alpha may explain its involvement in MODY3 diabetes.
	Research news Better chips through chemistry William Wells Genome Biology 2000, 1:spotlight-20000912-03 (12 September 2000) Abstract \| Full text \| Editor’s summary Some ingenious chemistry yields improved DNA and protein microarrays.
	Research news Bacterium or organelle? William Wells Genome Biology 2000, 1:spotlight-20000912-02 (12 September 2000) Abstract \| Full text \| Editor’s summary The complete sequence of Buchnera, an obligate resident of aphid cells, suggests that this bacterium is on its way to becoming an organelle.
	Research news Origin of AIDS: debate intensifies Robert Walgate Genome Biology 2000, 1:spotlight-20000914-01 (14 September 2000) Abstract \| Full text \| Editor’s summary Claims that AIDS originated from trials of a polio vaccine in the 1950s are repudiated, but just won't go away.
	Research news Cytokine gene regulation by NFAT Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000915-01 (15 September 2000) Abstract \| Full text \| Editor’s summary Point mutations in the transcription factor NFAT define sets of cytokine genes whose regulation is dependent on or independent of cooperation between NFAT and Fos/Jun
	Research news The first photosynthesis was purple William Wells Genome Biology 2000, 1:spotlight-20000915-03 (15 September 2000) Abstract \| Full text \| Editor’s summary Purple bacteria were the first to photosynthesize, according to a phylogenetic analysis of genes for photosynthetic pigment synthesis.
	Research news Recognizing Mom's scent William Wells Genome Biology 2000, 1:spotlight-20000915-02 (15 September 2000) Abstract \| Full text \| Editor’s summary A mother mouse finds her offspring, and vice versa, using MHC odortypes.
	Research news Race relations gone cuckoo William Wells Genome Biology 2000, 1:spotlight-20000918-01 (18 September 2000) Abstract \| Full text \| Editor’s summary Female cuckoos can be divided into 'races', as defined by the identity of the bird that hosts their eggs, but male cuckoos will mate with any race.
	Research news Interfering nonsense William Wells Genome Biology 2000, 1:spotlight-20000918-02 (18 September 2000) Abstract \| Full text \| Editor’s summary Worm proteins required for nonsense-mediated mRNA decay are also required for maintenance of RNA interference.
	Research news Cracking cell signalling by sharing - not publishing Andrew McLaughlin Genome Biology 2000, 1:spotlight-20000921-01 (21 September 2000) Abstract \| Full text \| Editor’s summary A new research programme is encouraging researchers to forgo publishing their results in academic journals and instead post them straight on the web.
	Research news How Hydras get their heads William Wells Genome Biology 2000, 1:spotlight-20000921-04 (21 September 2000) Abstract \| Full text \| Editor’s summary The expression of Wnt signaling proteins in the head organizer of Hydra, a freshwater polyp, suggests that Wnt was central in the evolution of axial differentiation.
	Research news Lasker Awards presented for work on ubiquitination and hepatitis C William Wells Genome Biology 2000, 1:spotlight-20000921-02 (21 September 2000) Abstract \| Full text \| Editor’s summary The 2000 Albert Lasker Medical Research Awards, announced in New York on September 17, will put further pressure on the Nobel Foundation to grant a Nobel Prize for work related to the cell cycle.
	Research news A map of smells William Wells Genome Biology 2000, 1:spotlight-20000921-03 (21 September 2000) Abstract \| Full text \| Editor’s summary Odorants with different functional groups are detected by different areas of the brain's olfactory bulb.
	Research news FAS-cinating proteomics Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000922-02 (22 September 2000) Abstract \| Full text \| Editor’s summary Comparative proteome analysis using 2D gel electrophoresis reveals diverse effects on about 5% of cytosolic proteins during Fas-induced T-cell apoptosis.
	Research news DNA vaccination against autoimmune disease Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000922-01 (22 September 2000) Abstract \| Full text \| Editor’s summary Studies on rats show that vaccination with naked DNA can provide protective immunity from experimental autoimmune encephalomyelitis.
	Research news SNPs pair up in asthma pharmacogenetics Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000925-02 (25 September 2000) Abstract \| Full text \| Editor’s summary Combinations of SNPs within the beta2-adrenergic receptor gene affect the response to asthma drugs.
	Research news Hungry yeast live longer William Wells Genome Biology 2000, 1:spotlight-20000925-01 (25 September 2000) Abstract \| Full text \| Editor’s summary Caloric restriction extends life-span in yeast thanks to the silencing activity of Sir2 protein.
	Research news Many cloned mice William Wells Genome Biology 2000, 1:spotlight-20000925-03 (25 September 2000) Abstract \| Full text \| Editor’s summary Reiterative cloning of mice over six generations does not lead to premature aging or telomere shortening.
	Research news Silencing splicing Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000927-02 (27 September 2000) Abstract \| Full text \| Editor’s summary Inhibitory elements may help to select the correct splice signals from the multitude of pseudosites present in pre-mRNA.
	Research news Chromodomains bind RNA William Wells Genome Biology 2000, 1:spotlight-20000927-01 (27 September 2000) Abstract \| Full text \| Editor’s summary Two proteins involved in male fly dosage compensation use their chromodomains to bind to an RNA, and thus to male X chromosomes.
	Research news Hedgehogs make both fish and fly eyes William Wells Genome Biology 2000, 1:spotlight-20000929-02 (29 September 2000) Abstract \| Full text \| Editor’s summary Hedgehog proteins drive waves of neuronal differentiation to create both fish and fly eyes, suggesting a common evolutionary origin of the animal eye.
	Research news A protein kinase switch William Wells Genome Biology 2000, 1:spotlight-20000929-01 (29 September 2000) Abstract \| Full text \| Editor’s summary The ATP-binding sites of many kinases can be modified to accommodate a specific inhibitor.
	Research
	Research Gene expression changes during murine postnatal brain development M Clinton, J Manson, D McBride, G Miele Genome Biology 2000, 1:research0005-research0005.11 (1 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In order to identify markers for the development of the central nervous system we have analyzed the expression profiles of approximately 25,000 transcripts. Approximately 1% of the genes examined displayed a developmentally regulated pattern of expression and we provide all the necessary information required to easily obtain molecular markers for a subset of these developmentally regulated transcripts. Of this subset, 61 showed increasing expression during development, 61 showed decreasing expression during development, and 9 exhibited a peak of expression during this period.
	Research Genomic structure of the gene for mouse germ cell nuclear factor (GCNF) Ute Süsens, Uwe Borgmeyer Genome Biology 2000, 1:research0006-research0006.3 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The protein-coding region of the mouse Gcnf gene is contained in 11 exons. Exons 1-4 encode the amino-terminal domain and exon 4 also encodes the core DNA-binding domain. The carboxy-terminal extension is encoded by exon 5, exons 6 and 7 encode the hinge region, and exons 7-11 encode the putative ligand-binding domain. The two zinc-finger motifs in the DNA-binding domain are encoded by separate exons.

	Volume 1 Issue 3
	Comment
	Comment The dark side Gregory A Petsko Genome Biology 2000, 1:comment1003-comment1003.2 (15 September 2000) Full text \| PDF \| PubMed \| Editor’s summary We will all face the dark side before long, as the emphasis in genomics shifts from identifying and sequencing genes to the problem of determining what their products do.
	Review
	Review A comparison of programmed cell death between species Jan N Tittel, Hermann Steller Genome Biology 2000, 1:reviews0003-reviews0003.6 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Key components of the programmed cell death pathway are conserved between Caenorhabditis elegans, Drosophila melanogaster and humans. The search for additional homologs has been facilitated by the availability of the entire genomic sequence for each of these organisms.
	Minireview The complete genome sequence of Vibrio cholerae: a tale of two chromosomes and of two lifestyles Gary K Schoolnik, Fitnat H Yildiz Genome Biology 2000, 1:reviews1016-reviews1016.3 (1 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Vibrio cholerae O1 has figured prominently in the history of infectious diseases as a cause of periodic global epidemics, an affliction of refugees in areas of social strife and as the disease first subjected to modern epidemiological analysis during the classic investigations of John Snow in mid-19th century London [1]. Thus, publication of the entire genome sequence of V. cholerae O1 (biotype El Tor) in Nature [2] by a consortium of investigators from The Institute for Genomic Research, the University of Maryland and Harvard Medical School is properly regarded as an historic event that will trigger a paradigm shift in the study of this organism.
	Minireview The function and regulation of vasa-like genes in germ-cell development Erez Raz Genome Biology 2000, 1:reviews1017-reviews1017.6 (1 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The vasa gene, essential for germ-cell development, was originally identified in Drosophila, and has since been found in other invertebrates and vertebrates. Analysis of these vasa homologs has revealed a highly conserved role for Vasa protein among different organisms, as well as some important differences in its regulation.
	Minireview A conserved mechanism for post-transcriptional gene silencing? Eleanor M Maine Genome Biology 2000, 1:reviews1018-reviews1018.4 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Proteins with homology to RNA-directed RNA polymerases function in post-transcriptional gene silencing: in quelling in the fungus Neurospora crassa, RNAi in the nematode Caenorhabditis elegans, and co-suppression in the mustard plant Arabidopsis thaliana. These findings are consistent with a conserved mechanism operating in these diverse species.
	Minireview From rags to riches: insights from the first genomic sequence of a plant pathogenic bacterium Noel T Keen, C Korsi Dumenyo, Ching-Hong Yang, Donald A Cooksey Genome Biology 2000, 1:reviews1019-reviews1019.4 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The recently published genomic sequence of Xylella fastidiosa is the first for a free-living plant pathogen and provides clues to mechanisms of pathogenesis and survival in insect vectors. The sequence data should lead to improved control of this pathogen.
	Minireview Where does DNA replication start in archaea? Amit Vas, Janet Leatherwood Genome Biology 2000, 1:reviews1020-reviews1020.4 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Genome-wide measures of DNA strand composition have been used to find archaeal DNA replication origins. Archaea seem to replicate using a single origin (as do eubacteria) even though archaeal replication factors are more like those of eukaryotes.
	Minireview Does massively parallel transcriptome analysis signify the end of cancer histopathology as we know it? Samuel AJR Aparicio, Carlos Caldas, Bruce Ponder Genome Biology 2000, 1:reviews1021-reviews1021.3 (15 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transcriptional analysis of all the genes expressed by breast tumors has provided the first steps towards defining a molecular signature for the disease, and might ultimately make conventional diagnostic techniques obsolete.
	Minireview The fork'ed path to mitosis Paul Jorgensen, Mike Tyers Genome Biology 2000, 1:reviews1022-reviews1022.4 (15 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A concurrence of genomic, reverse genetic and biochemical approaches has cracked the decade-long enigma concerning the identity of the transcription factors that control gene expression at the G2/M transition in the budding yeast cell cycle.
	Opinion The impact of open access on biomedical research Harold Varmus, David Lipman, Paul Ginsparg, Barry P Markovitz Genome Biology 2000, 1:comment2003-comment2003.1 (15 September 2000) Abstract \| Full text \| Editor’s summary A series of reports - and extracts of reports - from the Freedom of Information Conference, 6-7 July, 2000, New York Academy of Medicine. The conference was sponsored by BioMed Central, to promote debate about the communication and validation of biomedical research published on the internet. Details of the meeting and all presentations are available in full online at http://biomedcentral.com/info/conference.asp
	Report
	Web report A one-step source for information about human genes Melanie Nelson Genome Biology 2000, 1:reports2049 (18 September 2000) Abstract \| Full text
	Web report The thousand doors to disease Colin Semple Genome Biology 2000, 1:reports2050 (18 September 2000) Abstract \| Full text \| Editor’s summary Online Mendelian Inheritance in Man is a database of human genes and genetic disorders.
	Web report Digital biochemical pathways database Todd Richmond Genome Biology 2000, 1:reports2051 (18 September 2000) Abstract \| Full text
	Web report Finding motifs in protein sequences Todd Richmond Genome Biology 2000, 1:reports2052 (18 September 2000) Abstract \| Full text
	Web report Gene identification software Todd Richmond Genome Biology 2000, 1:reports2053 (18 September 2000) Abstract \| Full text
	Web report Signal peptide cleavage site prediction David W Ussery Genome Biology 2000, 1:reports2054 (18 September 2000) Abstract \| Full text
	Paper report Bacterial two-hybrid screening Rachel Brem Genome Biology 2000, 1:reports0064 (18 September 2000) Abstract \| Full text
	Paper report Genetic analysis of bacterial motility William Deakin Genome Biology 2000, 1:reports0065 (18 September 2000) Abstract \| Full text \| Editor’s summary The genes involved in the assembly and function of the polar flagellum of Vibrio parahaemolyticus have been analyzed systematically by mutagenesis, DNA sequencing and transcriptional studies.
	Paper report Matrix methods for gene expression analysis Rachel Brem Genome Biology 2000, 1:reports0066 (18 September 2000) Abstract \| Full text
	Paper report Mechanisms of melanoma metastasis Jonathan B Weitzman Genome Biology 2000, 1:reports0067 (18 September 2000) Abstract \| Full text \| Editor’s summary Analysis of highly metastatic melanoma cells using oligonucleotide arrays has identified genes regulating tumor invasiveness.
	Paper report Evolution without sex James Cotton Genome Biology 2000, 1:reports0068 (18 September 2000) Abstract \| Full text
	Paper report Mouse placental gene expression Paul Denny Genome Biology 2000, 1:reports0069 (26 September 2000) Abstract \| Full text
	Meeting report Bioinformatics 2000 David W Ussery Genome Biology 2000, 1:reports4014-reports4014.2 (1 September 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Bioinformatics 2000 conference [http://www.cbs.dtu.dk/bioinformatics2000/], held in Elsinore, Denmark, 27-30 April, 2000.
	Meeting report Retroviruses at a glance Cecile Voisset, Mariam Andrawiss Genome Biology 2000, 1:reports4015-reports4015.4 (15 September 2000) Abstract \| Full text \| PDF \| Editor’s summary A report from the Cold Spring Harbor Laboratory 2000 conference on Retroviruses, Cold Spring Harbor, May 23-28, 2000.
	Research news Sex and asymmetry in yeast Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000901-03 (1 September 2000) Abstract \| Full text \| Editor’s summary DNA density gradient centrifugation has been used to understand the molecular mechanisms that regulate how fission yeast cells change sex.
	Research news Creating protein folds William Wells Genome Biology 2000, 1:spotlight-20000901-02 (1 September 2000) Abstract \| Full text \| Editor’s summary A new protein fold can be constructed from half of an existing fold plus some random genomic segments.
	Research news Sequence of a big bug William Wells Genome Biology 2000, 1:spotlight-20000901-04 (1 September 2000) Abstract \| Full text \| Editor’s summary The 6.3 Mbp sequence of Pseudomonas aeruginosa, the bug responsible for most cystic fibrosis deaths, reveals lots of pumps and lots of regulation.
	Research news Promiscuity in Trinidad William Wells Genome Biology 2000, 1:spotlight-20000901-01 (1 September 2000) Abstract \| Full text \| Editor’s summary Female Trinidadian guppies often mate with multiple males, because the resultant offspring show substantially increased fitness.
	Research news Antibody arrays William Wells Genome Biology 2000, 1:spotlight-20000906-03 (6 September 2000) Abstract \| Full text \| Editor’s summary Protein-detection arrays can be made by robotic spotting, using bacterial colonies that produce single-chain antibodies.
	Research news Repair polymerases in a double act William Wells Genome Biology 2000, 1:spotlight-20000906-01 (6 September 2000) Abstract \| Full text \| Editor’s summary Two eukaryotic DNA polymerases act sequentially to repair DNA lesions.
	Research news Double-duplication evolution William Wells Genome Biology 2000, 1:spotlight-20000906-02 (6 September 2000) Abstract \| Full text \| Editor’s summary Two biosynthetic enzymes appear to have evolved from gene duplication, followed by fusion, followed by a second gene duplication.
	Research news MODY-fying gene expression in diabetes Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000912-01 (12 September 2000) Abstract \| Full text \| Editor’s summary Identification of genes that are regulated by the transcription factor HNF1alpha may explain its involvement in MODY3 diabetes.
	Research news Better chips through chemistry William Wells Genome Biology 2000, 1:spotlight-20000912-03 (12 September 2000) Abstract \| Full text \| Editor’s summary Some ingenious chemistry yields improved DNA and protein microarrays.
	Research news Bacterium or organelle? William Wells Genome Biology 2000, 1:spotlight-20000912-02 (12 September 2000) Abstract \| Full text \| Editor’s summary The complete sequence of Buchnera, an obligate resident of aphid cells, suggests that this bacterium is on its way to becoming an organelle.
	Research news Origin of AIDS: debate intensifies Robert Walgate Genome Biology 2000, 1:spotlight-20000914-01 (14 September 2000) Abstract \| Full text \| Editor’s summary Claims that AIDS originated from trials of a polio vaccine in the 1950s are repudiated, but just won't go away.
	Research news Cytokine gene regulation by NFAT Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000915-01 (15 September 2000) Abstract \| Full text \| Editor’s summary Point mutations in the transcription factor NFAT define sets of cytokine genes whose regulation is dependent on or independent of cooperation between NFAT and Fos/Jun
	Research news The first photosynthesis was purple William Wells Genome Biology 2000, 1:spotlight-20000915-03 (15 September 2000) Abstract \| Full text \| Editor’s summary Purple bacteria were the first to photosynthesize, according to a phylogenetic analysis of genes for photosynthetic pigment synthesis.
	Research news Recognizing Mom's scent William Wells Genome Biology 2000, 1:spotlight-20000915-02 (15 September 2000) Abstract \| Full text \| Editor’s summary A mother mouse finds her offspring, and vice versa, using MHC odortypes.
	Research news Race relations gone cuckoo William Wells Genome Biology 2000, 1:spotlight-20000918-01 (18 September 2000) Abstract \| Full text \| Editor’s summary Female cuckoos can be divided into 'races', as defined by the identity of the bird that hosts their eggs, but male cuckoos will mate with any race.
	Research news Interfering nonsense William Wells Genome Biology 2000, 1:spotlight-20000918-02 (18 September 2000) Abstract \| Full text \| Editor’s summary Worm proteins required for nonsense-mediated mRNA decay are also required for maintenance of RNA interference.
	Research news Cracking cell signalling by sharing - not publishing Andrew McLaughlin Genome Biology 2000, 1:spotlight-20000921-01 (21 September 2000) Abstract \| Full text \| Editor’s summary A new research programme is encouraging researchers to forgo publishing their results in academic journals and instead post them straight on the web.
	Research news How Hydras get their heads William Wells Genome Biology 2000, 1:spotlight-20000921-04 (21 September 2000) Abstract \| Full text \| Editor’s summary The expression of Wnt signaling proteins in the head organizer of Hydra, a freshwater polyp, suggests that Wnt was central in the evolution of axial differentiation.
	Research news Lasker Awards presented for work on ubiquitination and hepatitis C William Wells Genome Biology 2000, 1:spotlight-20000921-02 (21 September 2000) Abstract \| Full text \| Editor’s summary The 2000 Albert Lasker Medical Research Awards, announced in New York on September 17, will put further pressure on the Nobel Foundation to grant a Nobel Prize for work related to the cell cycle.
	Research news A map of smells William Wells Genome Biology 2000, 1:spotlight-20000921-03 (21 September 2000) Abstract \| Full text \| Editor’s summary Odorants with different functional groups are detected by different areas of the brain's olfactory bulb.
	Research news FAS-cinating proteomics Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000922-02 (22 September 2000) Abstract \| Full text \| Editor’s summary Comparative proteome analysis using 2D gel electrophoresis reveals diverse effects on about 5% of cytosolic proteins during Fas-induced T-cell apoptosis.
	Research news DNA vaccination against autoimmune disease Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000922-01 (22 September 2000) Abstract \| Full text \| Editor’s summary Studies on rats show that vaccination with naked DNA can provide protective immunity from experimental autoimmune encephalomyelitis.
	Research news SNPs pair up in asthma pharmacogenetics Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000925-02 (25 September 2000) Abstract \| Full text \| Editor’s summary Combinations of SNPs within the beta2-adrenergic receptor gene affect the response to asthma drugs.
	Research news Hungry yeast live longer William Wells Genome Biology 2000, 1:spotlight-20000925-01 (25 September 2000) Abstract \| Full text \| Editor’s summary Caloric restriction extends life-span in yeast thanks to the silencing activity of Sir2 protein.
	Research news Many cloned mice William Wells Genome Biology 2000, 1:spotlight-20000925-03 (25 September 2000) Abstract \| Full text \| Editor’s summary Reiterative cloning of mice over six generations does not lead to premature aging or telomere shortening.
	Research news Silencing splicing Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20000927-02 (27 September 2000) Abstract \| Full text \| Editor’s summary Inhibitory elements may help to select the correct splice signals from the multitude of pseudosites present in pre-mRNA.
	Research news Chromodomains bind RNA William Wells Genome Biology 2000, 1:spotlight-20000927-01 (27 September 2000) Abstract \| Full text \| Editor’s summary Two proteins involved in male fly dosage compensation use their chromodomains to bind to an RNA, and thus to male X chromosomes.
	Research news Hedgehogs make both fish and fly eyes William Wells Genome Biology 2000, 1:spotlight-20000929-02 (29 September 2000) Abstract \| Full text \| Editor’s summary Hedgehog proteins drive waves of neuronal differentiation to create both fish and fly eyes, suggesting a common evolutionary origin of the animal eye.
	Research news A protein kinase switch William Wells Genome Biology 2000, 1:spotlight-20000929-01 (29 September 2000) Abstract \| Full text \| Editor’s summary The ATP-binding sites of many kinases can be modified to accommodate a specific inhibitor.
	Research
	Research Gene expression changes during murine postnatal brain development M Clinton, J Manson, D McBride, G Miele Genome Biology 2000, 1:research0005-research0005.11 (1 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In order to identify markers for the development of the central nervous system we have analyzed the expression profiles of approximately 25,000 transcripts. Approximately 1% of the genes examined displayed a developmentally regulated pattern of expression and we provide all the necessary information required to easily obtain molecular markers for a subset of these developmentally regulated transcripts. Of this subset, 61 showed increasing expression during development, 61 showed decreasing expression during development, and 9 exhibited a peak of expression during this period.
	Research Genomic structure of the gene for mouse germ cell nuclear factor (GCNF) Ute Süsens, Uwe Borgmeyer Genome Biology 2000, 1:research0006-research0006.3 (13 September 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The protein-coding region of the mouse Gcnf gene is contained in 11 exons. Exons 1-4 encode the amino-terminal domain and exon 4 also encodes the core DNA-binding domain. The carboxy-terminal extension is encoded by exon 5, exons 6 and 7 encode the hinge region, and exons 7-11 encode the putative ligand-binding domain. The two zinc-finger motifs in the DNA-binding domain are encoded by separate exons.

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