Genome Biology | Volume 1 Issue 4

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	Volume 1 Issue 4
	Comment
	Editorial Editor's note Genome Biology 2000, 1:comment0002-comment0002.2 (13 October 2000) Full text \| Editor’s summary The fourth issue of GenomeBiology sees the launch of two new article types, the protein family review and the tutorial.
	Comment Perpetual motion of the worst kind Gregory A Petsko Genome Biology 2000, 1:comment1004-comment1004.2 (13 October 2000) Full text \| PDF \| PubMed \| Editor’s summary A plea for less 'busyness' and more time for scientific pursuits.
	Review
	Review An overview of the potassium channel family Christopher Miller Genome Biology 2000, 1:reviews0004-reviews0004.5 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K⁺ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K⁺ channel genes each. The structure of a bacterial K⁺ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.
	Protein family review Higher plant cellulose synthases Todd Richmond Genome Biology 2000, 1:reviews3001-reviews3001.6 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The sole function of cellulose synthases, which are found in plants bacteria, fungi, and animals, is to produce the biopolymer cellulose. Although no crystal structure has yet been solved, a considerable amount is known about their structure, function and evolution.
	Minireview From biological clock to biological rhythms Paul E Hardin Genome Biology 2000, 1:reviews1023-reviews1023.5 (10 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genetic and molecular analysis of circadian timekeeping mechanisms has accelerated as a result of the increasing volume of genomic markers and nucleotide sequence information. Completion of whole genome sequences and the use of differential gene expression technology will hasten the discovery of the clock output pathways that control diverse rhythmic phenomena.
	Minireview Expression profiling in reference bacteria: dreams and reality Antoine Danchin, Agnieszka Sekowska Genome Biology 2000, 1:reviews1024-reviews1024.5 (10 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Profiling of gene expression in bacteria is now being used to uncover unknown genes expressed in particular genetic backgrounds or environmental conditions. Obtaining the best possible information from the expected avalanche of such experiments will require standardization of both experimental approach and statistical analysis. The first such experiments reveal challenges, pitfalls and reasonable solutions.
	Minireview Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation Nancy Maizels Genome Biology 2000, 1:reviews1025-reviews1025.3 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.
	Minireview Mergers and acquisitions: malaria and the great chloroplast heist Geoffrey I McFadden Genome Biology 2000, 1:reviews1026-reviews1026.4 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.
	Report
	Web report Information about cancer-associated genes Igor E Brodsky Genome Biology 2000, 1:reports2055 (25 October 2000) Abstract \| Full text
	Paper report Fish eye development Karen Liu Genome Biology 2000, 1:reports0070 (25 October 2000) Abstract \| Full text \| Editor’s summary The importance of the lens in eye development has been demonstrated using reciprocal transplantations between an eyed surface-dwelling fish and an eyeless cave fish of the same species.
	Meeting report Model legumes in the limelight Murali Dhandaydham Genome Biology 2000, 1:reports4016-reports4016.3 (10 October 2000) Abstract \| Full text \| PDF \| Editor’s summary A report of the Molecular Genetics of Model Legumes meeting, John Innes Centre, Norwich, 24-28 June, 2000.
	Meeting report Order out of chaos in the nucleus Peter WH Holland Genome Biology 2000, 1:reports4017-reports4017.2 (10 October 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'Nuclear architecture and control of gene expression' minisymposium at the first meeting of the European Life Scientists Organisation (ELSO), Geneva, Switzerland, September 2-6, 2000.
	Meeting report Aging in the post-genomic era: simple or complex? Trudy FC Mackay Genome Biology 2000, 1:reports4018-reports4018.6 (16 October 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the Third Genetic Effects on Aging Meeting, The Jackson Laboratory, Bar Harbor, Maine, August 4-8, 2000.
	Tutorial Bases and spaces: resources on the web for accessing the draft human genome Colin Semple Genome Biology 2000, 1:reviews2001-reviews2001.5 (16 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Much is expected of the draft human genome sequence, and yet there is no central resource to host the plethora of sequence and mapping information available. Consequently, finding the most useful and reliable human genome data and resources currently available on the web can be challenging, but is not impossible.
	Research news Sequence of a single-celled vulture William Wells Genome Biology 2000, 1:spotlight-20001003-02 (3 October 2000) Abstract \| Full text \| Editor’s summary Thermoplasma acidophilum, which lives off the carcasses of organisms that perish in its hot, acidic home, has scavenged genes from its neighbors in order to survive.
	Research news A worm germline parts list William Wells Genome Biology 2000, 1:spotlight-20001003-01 (3 October 2000) Abstract \| Full text \| Editor’s summary Over 11% of genes on an almost-whole-genome worm array are implicated in operation of the worm germline. Now the hard work begins.
	Research news Comparing cows with humans Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001005-04 (5 October 2000) Abstract \| Full text \| Editor’s summary The analysis of RH maps with ESTs and bioinformatic tools reveals similarities between cattle and human genome maps.
	Research news Simplifying genetic disorders David Bradley Genome Biology 2000, 1:spotlight-20001005-02 (5 October 2000) Abstract \| Full text \| Editor’s summary Recent work implicating a single gene in a population with a complex disease, type 2 diabetes mellitus, could represent a shift in the study of genetic diseases.
	Research news De-differentiation in vitro William Wells Genome Biology 2000, 1:spotlight-20001005-03 (5 October 2000) Abstract \| Full text \| Editor’s summary Egg cytoplasm protein ISW1 remodels the chromatin of added somatic nuclei. The same process probably drives the de-differentiation required during cloning.
	Research news Possible solution for obesity - in mice SPIS MedWire Genome Biology 2000, 1:spotlight-20001005-01 (5 October 2000) Abstract \| Full text \| Editor’s summary A gene identified in mice could encourage excess energy to be released as heat rather than converted to fat.
	Research news Intracellular localization gives first clue to protein function Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001006-02 (6 October 2000) Abstract \| Full text \| Editor’s summary A strategy that uses GFP fusion proteins to follow intracellular localization can speed up the path from DNA sequence to understanding protein function.
	Research news SNPing away William Wells Genome Biology 2000, 1:spotlight-20001006-03 (6 October 2000) Abstract \| Full text \| Editor’s summary Aided by new techniques, the SNP consortium is producing hundreds of thousands of SNPs to be used in disease-linkage studies.
	Research news Prion-driven evolution William Wells Genome Biology 2000, 1:spotlight-20001006-01 (6 October 2000) Abstract \| Full text \| Editor’s summary A nonsense-suppressing prion alters a yeast's fitness in different environments. Could the prion be facilitating the evolution of new traits?
	Research news Screening with X-rays William Wells Genome Biology 2000, 1:spotlight-20001010-01 (10 October 2000) Abstract \| Full text \| Editor’s summary Drug or inhibitor leads can be identified by high throughput X-ray crystallography, using changes in the electron density map after binding of a ligand.
	Research news Watch out for the neighbors William Wells Genome Biology 2000, 1:spotlight-20001010-02 (10 October 2000) Abstract \| Full text \| Editor’s summary A radiation-induced rearrangement may be common in thyroid tumors because the two relevant genes are close to each other in thyroid cells.
	Research news Gene expression profiles of mouse brains Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001013-04 (13 October 2000) Abstract \| Full text \| Editor’s summary Highly parallel gene expression profiling reveals that two inbred mouse strains differ in their baseline gene expression patterns in the brain, in their molecular response to seizure and in their brain region-specific expression.
	Research news Evolution and aging flies Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001013-02 (13 October 2000) Abstract \| Full text \| Editor’s summary Polymorphism analysis at the Drosophila methuselah locus reveals patterns of amino acid divergence that imply adaptive evolution of this lifespan-modulating gene.
	Research news Gene therapy with histones William Wells Genome Biology 2000, 1:spotlight-20001013-03 (13 October 2000) Abstract \| Full text \| Editor’s summary Histone H2A increases the efficacy of gene therapy in stimulating tumor immunogenicity.
	Research news We are the web William Wells Genome Biology 2000, 1:spotlight-20001013-01 (13 October 2000) Abstract \| Full text \| Editor’s summary Cellular metabolism is not a homogeneous network, but looks more like the internet, in which a few key nodes are highly connected.
	Research news Could selfish DNA create new proteins? William Wells Genome Biology 2000, 1:spotlight-20001017-01 (17 October 2000) Abstract \| Full text \| Editor’s summary Selfish DNA may help to expand protein sequences, based on the discovery of DNA repeats inserted, in-frame, into 19 genes of an intracellular bacterium.
	Research news Many ways to be minimal William Wells Genome Biology 2000, 1:spotlight-20001017-02 (17 October 2000) Abstract \| Full text \| Editor’s summary The genome sequence of a third mycoplasma brings home the message that few genes are essential in all contexts.
	Research news Mapping recombination William Wells Genome Biology 2000, 1:spotlight-20001018-02 (18 October 2000) Abstract \| Full text \| Editor’s summary Hotspots and coldspots of meiotic recombination have been mapped across the whole yeast genome using arrays.
	Research news Defining relevance William Wells Genome Biology 2000, 1:spotlight-20001018-03 (18 October 2000) Abstract \| Full text \| Editor’s summary Relevance networks could provide a better way of analyzing genomic information than phylogenetic trees.
	Research news Daughters keep to themselves William Wells Genome Biology 2000, 1:spotlight-20001018-01 (18 October 2000) Abstract \| Full text \| Editor’s summary Array analysis unveils a transmembrane protein that, combined with a septin barrier, may keep proteins in the daughter cells of budding yeast.
	Research news SNP genotyping with arrays William Wells Genome Biology 2000, 1:spotlight-20001019-01 (19 October 2000) Abstract \| Full text \| Editor’s summary Generic tags and arrays of anti-tags allow parallel genotyping of SNPs.
	Research news Very old bugs William Wells Genome Biology 2000, 1:spotlight-20001019-02 (19 October 2000) Abstract \| Full text \| Editor’s summary A Bacillus bacterium isolated from a salt inclusion has been dated at 250 million years old.
	Research news Linked evolution William Wells Genome Biology 2000, 1:spotlight-20001023-03 (23 October 2000) Abstract \| Full text \| Editor’s summary The proteins of linked genes evolve at similar rates.
	Research news dsRNA can turn off genes Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001023-01 (23 October 2000) Abstract \| Full text \| Editor’s summary Double-stranded RNA can induce transcriptional silencing and methylation of plant gene promoters.
	Research news Mutating mice with oligos William Wells Genome Biology 2000, 1:spotlight-20001023-02 (23 October 2000) Abstract \| Full text \| Editor’s summary Triplex-forming oligonucleotides can induce site-specific mutations in adult mice, although the frequency is extremely low.
	Research news Smoking selects mutants William Wells Genome Biology 2000, 1:spotlight-20001025-01 (25 October 2000) Abstract \| Full text \| Editor’s summary The link between lung cancer and smoking may be caused not by carcinogens inducing more mutations, but by physiological stresses that select for existing mutations.
	Research news Selective remodelling Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001025-02 (25 October 2000) Abstract \| Full text \| Editor’s summary DNA-binding transcription factors can target the SWI/SNF chromatin remodelling complex to specific nucleosome sites.
	Research news Becoming a worm William Wells Genome Biology 2000, 1:spotlight-20001027-02 (27 October 2000) Abstract \| Full text \| Editor’s summary Array analysis shows that worm-specific genes take over from evolutionarily conserved genes as worms age.
	Research news Error-filled embryos William Wells Genome Biology 2000, 1:spotlight-20001027-01 (27 October 2000) Abstract \| Full text \| Editor’s summary Few human pre-implantation embryos have a normal chromosome complement, according to an analysis of all chromosomes in all cells of these embryos.
	Research news Fine-mapping of fearfulness William Wells Genome Biology 2000, 1:spotlight-20001030-02 (30 October 2000) Abstract \| Full text \| Editor’s summary A new method for fine-mapping quantitative trait loci has been tested out by identifying loci controlling fearfulness in mice.
	Research news Replication coupled to recombination William Wells Genome Biology 2000, 1:spotlight-20001030-01 (30 October 2000) Abstract \| Full text \| Editor’s summary Recombination in budding yeast is initiated a set length of time after DNA replication.
	Research news Malaria's dangerous neighborhood William Wells Genome Biology 2000, 1:spotlight-20001031-02 (31 October 2000) Abstract \| Full text \| Editor’s summary Genes for malaria's virulence factors undergo frequent recombination because the relevant chromosome regions cluster together.
	Research news Flower power Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001031-01 (31 October 2000) Abstract \| Full text \| Editor’s summary Epigenetic regulation of the FWA homeodomain transcription factor affects the induction of flowering in plants.
	Research
	Research The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates L Aravind, Eugene V Koonin Genome Biology 2000, 1:research0007-research0007.8 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Uracil DNA glycosylases (UDGs) are repair enzymes that protect DNA from certain types of mutational damage. UDGs form a single protein superfamily with a distinct structural fold and a common evolutionary origin. Differences in the catalytic mechanism of the different families cobined with the construction of the catalytic pocket have resulted in extreme sequence divergence of these enzymes.
	Research Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques Christine Bole-Feysot, Eric Perret, Paul Roustan, Brigitte Bouchard, Paul A Kelly Genome Biology 2000, 1:research0008-research0008.15 (16 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Five techniques have been used to determine which genes are differentially expressed in Nb2 lymphoma cells. Comparison with other eukaryotic models of cell-cycle progression has enabled the identification of several new potential signaling molecules that may be involved in Nb2 cell growth.

	Volume 1 Issue 4
	Comment
	Editorial Editor's note Genome Biology 2000, 1:comment0002-comment0002.2 (13 October 2000) Full text \| Editor’s summary The fourth issue of GenomeBiology sees the launch of two new article types, the protein family review and the tutorial.
	Comment Perpetual motion of the worst kind Gregory A Petsko Genome Biology 2000, 1:comment1004-comment1004.2 (13 October 2000) Full text \| PDF \| PubMed \| Editor’s summary A plea for less 'busyness' and more time for scientific pursuits.
	Review
	Review An overview of the potassium channel family Christopher Miller Genome Biology 2000, 1:reviews0004-reviews0004.5 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Potassium channels, tetrameric integral membrane proteins that form aqueous pores through which K⁺ can flow, are found in virtually all organisms; the genomes of humans, Drosophila, and Caenorhabditis elegans contain 30-100 K⁺ channel genes each. The structure of a bacterial K⁺ channel, sequence comparisons with other channels and electrophysiological measurements have enabled conclusions about the mechanism of gating and ion flow to be drawn for many other channels.
	Protein family review Higher plant cellulose synthases Todd Richmond Genome Biology 2000, 1:reviews3001-reviews3001.6 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The sole function of cellulose synthases, which are found in plants bacteria, fungi, and animals, is to produce the biopolymer cellulose. Although no crystal structure has yet been solved, a considerable amount is known about their structure, function and evolution.
	Minireview From biological clock to biological rhythms Paul E Hardin Genome Biology 2000, 1:reviews1023-reviews1023.5 (10 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genetic and molecular analysis of circadian timekeeping mechanisms has accelerated as a result of the increasing volume of genomic markers and nucleotide sequence information. Completion of whole genome sequences and the use of differential gene expression technology will hasten the discovery of the clock output pathways that control diverse rhythmic phenomena.
	Minireview Expression profiling in reference bacteria: dreams and reality Antoine Danchin, Agnieszka Sekowska Genome Biology 2000, 1:reviews1024-reviews1024.5 (10 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Profiling of gene expression in bacteria is now being used to uncover unknown genes expressed in particular genetic backgrounds or environmental conditions. Obtaining the best possible information from the expected avalanche of such experiments will require standardization of both experimental approach and statistical analysis. The first such experiments reveal challenges, pitfalls and reasonable solutions.
	Minireview Secret sharers in the immune system: a novel RNA editing activity links switch recombination and somatic hypermutation Nancy Maizels Genome Biology 2000, 1:reviews1025-reviews1025.3 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.
	Minireview Mergers and acquisitions: malaria and the great chloroplast heist Geoffrey I McFadden Genome Biology 2000, 1:reviews1026-reviews1026.4 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A new mechanism for regulation in the immune system has been identified: a cytidine deaminase is critical for both class switch recombination and somatic hypermutation, revealing an unanticipated link between these two processes.
	Report
	Web report Information about cancer-associated genes Igor E Brodsky Genome Biology 2000, 1:reports2055 (25 October 2000) Abstract \| Full text
	Paper report Fish eye development Karen Liu Genome Biology 2000, 1:reports0070 (25 October 2000) Abstract \| Full text \| Editor’s summary The importance of the lens in eye development has been demonstrated using reciprocal transplantations between an eyed surface-dwelling fish and an eyeless cave fish of the same species.
	Meeting report Model legumes in the limelight Murali Dhandaydham Genome Biology 2000, 1:reports4016-reports4016.3 (10 October 2000) Abstract \| Full text \| PDF \| Editor’s summary A report of the Molecular Genetics of Model Legumes meeting, John Innes Centre, Norwich, 24-28 June, 2000.
	Meeting report Order out of chaos in the nucleus Peter WH Holland Genome Biology 2000, 1:reports4017-reports4017.2 (10 October 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'Nuclear architecture and control of gene expression' minisymposium at the first meeting of the European Life Scientists Organisation (ELSO), Geneva, Switzerland, September 2-6, 2000.
	Meeting report Aging in the post-genomic era: simple or complex? Trudy FC Mackay Genome Biology 2000, 1:reports4018-reports4018.6 (16 October 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the Third Genetic Effects on Aging Meeting, The Jackson Laboratory, Bar Harbor, Maine, August 4-8, 2000.
	Tutorial Bases and spaces: resources on the web for accessing the draft human genome Colin Semple Genome Biology 2000, 1:reviews2001-reviews2001.5 (16 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Much is expected of the draft human genome sequence, and yet there is no central resource to host the plethora of sequence and mapping information available. Consequently, finding the most useful and reliable human genome data and resources currently available on the web can be challenging, but is not impossible.
	Research news Sequence of a single-celled vulture William Wells Genome Biology 2000, 1:spotlight-20001003-02 (3 October 2000) Abstract \| Full text \| Editor’s summary Thermoplasma acidophilum, which lives off the carcasses of organisms that perish in its hot, acidic home, has scavenged genes from its neighbors in order to survive.
	Research news A worm germline parts list William Wells Genome Biology 2000, 1:spotlight-20001003-01 (3 October 2000) Abstract \| Full text \| Editor’s summary Over 11% of genes on an almost-whole-genome worm array are implicated in operation of the worm germline. Now the hard work begins.
	Research news Comparing cows with humans Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001005-04 (5 October 2000) Abstract \| Full text \| Editor’s summary The analysis of RH maps with ESTs and bioinformatic tools reveals similarities between cattle and human genome maps.
	Research news Simplifying genetic disorders David Bradley Genome Biology 2000, 1:spotlight-20001005-02 (5 October 2000) Abstract \| Full text \| Editor’s summary Recent work implicating a single gene in a population with a complex disease, type 2 diabetes mellitus, could represent a shift in the study of genetic diseases.
	Research news De-differentiation in vitro William Wells Genome Biology 2000, 1:spotlight-20001005-03 (5 October 2000) Abstract \| Full text \| Editor’s summary Egg cytoplasm protein ISW1 remodels the chromatin of added somatic nuclei. The same process probably drives the de-differentiation required during cloning.
	Research news Possible solution for obesity - in mice SPIS MedWire Genome Biology 2000, 1:spotlight-20001005-01 (5 October 2000) Abstract \| Full text \| Editor’s summary A gene identified in mice could encourage excess energy to be released as heat rather than converted to fat.
	Research news Intracellular localization gives first clue to protein function Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001006-02 (6 October 2000) Abstract \| Full text \| Editor’s summary A strategy that uses GFP fusion proteins to follow intracellular localization can speed up the path from DNA sequence to understanding protein function.
	Research news SNPing away William Wells Genome Biology 2000, 1:spotlight-20001006-03 (6 October 2000) Abstract \| Full text \| Editor’s summary Aided by new techniques, the SNP consortium is producing hundreds of thousands of SNPs to be used in disease-linkage studies.
	Research news Prion-driven evolution William Wells Genome Biology 2000, 1:spotlight-20001006-01 (6 October 2000) Abstract \| Full text \| Editor’s summary A nonsense-suppressing prion alters a yeast's fitness in different environments. Could the prion be facilitating the evolution of new traits?
	Research news Screening with X-rays William Wells Genome Biology 2000, 1:spotlight-20001010-01 (10 October 2000) Abstract \| Full text \| Editor’s summary Drug or inhibitor leads can be identified by high throughput X-ray crystallography, using changes in the electron density map after binding of a ligand.
	Research news Watch out for the neighbors William Wells Genome Biology 2000, 1:spotlight-20001010-02 (10 October 2000) Abstract \| Full text \| Editor’s summary A radiation-induced rearrangement may be common in thyroid tumors because the two relevant genes are close to each other in thyroid cells.
	Research news Gene expression profiles of mouse brains Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001013-04 (13 October 2000) Abstract \| Full text \| Editor’s summary Highly parallel gene expression profiling reveals that two inbred mouse strains differ in their baseline gene expression patterns in the brain, in their molecular response to seizure and in their brain region-specific expression.
	Research news Evolution and aging flies Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001013-02 (13 October 2000) Abstract \| Full text \| Editor’s summary Polymorphism analysis at the Drosophila methuselah locus reveals patterns of amino acid divergence that imply adaptive evolution of this lifespan-modulating gene.
	Research news Gene therapy with histones William Wells Genome Biology 2000, 1:spotlight-20001013-03 (13 October 2000) Abstract \| Full text \| Editor’s summary Histone H2A increases the efficacy of gene therapy in stimulating tumor immunogenicity.
	Research news We are the web William Wells Genome Biology 2000, 1:spotlight-20001013-01 (13 October 2000) Abstract \| Full text \| Editor’s summary Cellular metabolism is not a homogeneous network, but looks more like the internet, in which a few key nodes are highly connected.
	Research news Could selfish DNA create new proteins? William Wells Genome Biology 2000, 1:spotlight-20001017-01 (17 October 2000) Abstract \| Full text \| Editor’s summary Selfish DNA may help to expand protein sequences, based on the discovery of DNA repeats inserted, in-frame, into 19 genes of an intracellular bacterium.
	Research news Many ways to be minimal William Wells Genome Biology 2000, 1:spotlight-20001017-02 (17 October 2000) Abstract \| Full text \| Editor’s summary The genome sequence of a third mycoplasma brings home the message that few genes are essential in all contexts.
	Research news Mapping recombination William Wells Genome Biology 2000, 1:spotlight-20001018-02 (18 October 2000) Abstract \| Full text \| Editor’s summary Hotspots and coldspots of meiotic recombination have been mapped across the whole yeast genome using arrays.
	Research news Defining relevance William Wells Genome Biology 2000, 1:spotlight-20001018-03 (18 October 2000) Abstract \| Full text \| Editor’s summary Relevance networks could provide a better way of analyzing genomic information than phylogenetic trees.
	Research news Daughters keep to themselves William Wells Genome Biology 2000, 1:spotlight-20001018-01 (18 October 2000) Abstract \| Full text \| Editor’s summary Array analysis unveils a transmembrane protein that, combined with a septin barrier, may keep proteins in the daughter cells of budding yeast.
	Research news SNP genotyping with arrays William Wells Genome Biology 2000, 1:spotlight-20001019-01 (19 October 2000) Abstract \| Full text \| Editor’s summary Generic tags and arrays of anti-tags allow parallel genotyping of SNPs.
	Research news Very old bugs William Wells Genome Biology 2000, 1:spotlight-20001019-02 (19 October 2000) Abstract \| Full text \| Editor’s summary A Bacillus bacterium isolated from a salt inclusion has been dated at 250 million years old.
	Research news Linked evolution William Wells Genome Biology 2000, 1:spotlight-20001023-03 (23 October 2000) Abstract \| Full text \| Editor’s summary The proteins of linked genes evolve at similar rates.
	Research news dsRNA can turn off genes Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001023-01 (23 October 2000) Abstract \| Full text \| Editor’s summary Double-stranded RNA can induce transcriptional silencing and methylation of plant gene promoters.
	Research news Mutating mice with oligos William Wells Genome Biology 2000, 1:spotlight-20001023-02 (23 October 2000) Abstract \| Full text \| Editor’s summary Triplex-forming oligonucleotides can induce site-specific mutations in adult mice, although the frequency is extremely low.
	Research news Smoking selects mutants William Wells Genome Biology 2000, 1:spotlight-20001025-01 (25 October 2000) Abstract \| Full text \| Editor’s summary The link between lung cancer and smoking may be caused not by carcinogens inducing more mutations, but by physiological stresses that select for existing mutations.
	Research news Selective remodelling Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001025-02 (25 October 2000) Abstract \| Full text \| Editor’s summary DNA-binding transcription factors can target the SWI/SNF chromatin remodelling complex to specific nucleosome sites.
	Research news Becoming a worm William Wells Genome Biology 2000, 1:spotlight-20001027-02 (27 October 2000) Abstract \| Full text \| Editor’s summary Array analysis shows that worm-specific genes take over from evolutionarily conserved genes as worms age.
	Research news Error-filled embryos William Wells Genome Biology 2000, 1:spotlight-20001027-01 (27 October 2000) Abstract \| Full text \| Editor’s summary Few human pre-implantation embryos have a normal chromosome complement, according to an analysis of all chromosomes in all cells of these embryos.
	Research news Fine-mapping of fearfulness William Wells Genome Biology 2000, 1:spotlight-20001030-02 (30 October 2000) Abstract \| Full text \| Editor’s summary A new method for fine-mapping quantitative trait loci has been tested out by identifying loci controlling fearfulness in mice.
	Research news Replication coupled to recombination William Wells Genome Biology 2000, 1:spotlight-20001030-01 (30 October 2000) Abstract \| Full text \| Editor’s summary Recombination in budding yeast is initiated a set length of time after DNA replication.
	Research news Malaria's dangerous neighborhood William Wells Genome Biology 2000, 1:spotlight-20001031-02 (31 October 2000) Abstract \| Full text \| Editor’s summary Genes for malaria's virulence factors undergo frequent recombination because the relevant chromosome regions cluster together.
	Research news Flower power Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001031-01 (31 October 2000) Abstract \| Full text \| Editor’s summary Epigenetic regulation of the FWA homeodomain transcription factor affects the induction of flowering in plants.
	Research
	Research The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates L Aravind, Eugene V Koonin Genome Biology 2000, 1:research0007-research0007.8 (13 October 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Uracil DNA glycosylases (UDGs) are repair enzymes that protect DNA from certain types of mutational damage. UDGs form a single protein superfamily with a distinct structural fold and a common evolutionary origin. Differences in the catalytic mechanism of the different families cobined with the construction of the catalytic pocket have resulted in extreme sequence divergence of these enzymes.
	Research Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques Christine Bole-Feysot, Eric Perret, Paul Roustan, Brigitte Bouchard, Paul A Kelly Genome Biology 2000, 1:research0008-research0008.15 (16 October 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Five techniques have been used to determine which genes are differentially expressed in Nb2 lymphoma cells. Comparison with other eukaryotic models of cell-cycle progression has enabled the identification of several new potential signaling molecules that may be involved in Nb2 cell growth.

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