Genome Biology | Volume 1 Issue 5

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	Volume 1 Issue 5
	Comment
	Comment Seek and ye shall maybe find Gregory A Petsko Genome Biology 2000, 1:comment1005-comment1005.2 (10 November 2000) Full text \| PDF \| PubMed \| Editor’s summary Many of the literature databases limit their coverage in ways that are not obvious to the casual user. The scientific community needs to pressure database curators to be as inclusive as possible.
	Review
	Review Can sequence determine function? John A Gerlt, Patricia C Babbitt Genome Biology 2000, 1:reviews0005-reviews0005.10 (8 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism.
	Protein family review The F-box protein family Edward T Kipreos, Michele Pagano Genome Biology 2000, 1:reviews3002-reviews3002.7 (10 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary F-box proteins were first described as components of ubiquitin ligase complexes, but have more recently been found to be involved in a variety of cellular functions, including in the kinetochore and in translational elongation.
	Minireview Beyond the Hox complex Nipam H Patel, Victoria E Prince Genome Biology 2000, 1:reviews1027-reviews1027.4 (8 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Hox complex is an example of a gene cluster created by tandem duplications. Recent findings suggest the Hox complex may be just part of a larger chromosomal assemblage of homeobox-containing genes that existed in the ancestor to all vertebrates.
	Minireview Imprinting: silently crossing the boundary Jo Peters Genome Biology 2000, 1:reviews1028-reviews1028.4 (10 November 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent studies have identified silencers as control elements that may interact with enhancers to regulate the expression of imprinted genes.
	Opinion Human genomic variation Todd R Disotell Genome Biology 2000, 1:comment2004-comment2004.2 (10 November 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The recent completion and assembly of the first draft of the human genome, which combines samples from several ethnically diverse males and females, provides preliminary data on the extent of human genetic variation.
	Report
	Paper report Membrane fusion specificity Jason B Bock Genome Biology 2000, 1:reports0071 (25 October 2000) Abstract \| Full text \| Editor’s summary Isolated SNARE proteins have been shown to confer only partial specificity on the fusion of artificial liposomes that mimic cellular membranes, modifying the SNARE hypothesis of membrane fusion.
	Paper report New technology for protein microarrays Rachel Brem Genome Biology 2000, 1:reports0072 (25 October 2000) Abstract \| Full text \| Editor’s summary Nanodroplets of active, solvated protein can be printed onto treated glass slides for protein microarray experiments.
	Paper report Probing the worm germline Barry Lubarsky Genome Biology 2000, 1:reports0073 (25 October 2000) Abstract \| Full text \| Editor’s summary Genes expressed during C. elegans germline development have been identified using DNA microarrays.
	Paper report A second gene for color blindness Gargi Talukder Genome Biology 2000, 1:reports0074 (25 October 2000) Abstract \| Full text \| Editor’s summary Analysis of families suffering from total color blindness has revealed one potential cause of the condition - mutations in a gene encoding a α subunit of the retinal cone cGMP-gated ion channel.
	Paper report Neuronal pathfinding Joe Hao Genome Biology 2000, 1:reports0075 (25 October 2000) Abstract \| Full text
	Meeting report Big science meets small embryos Carol Irving, Anna Sharman Genome Biology 2000, 1:reports4019-reports4019.3 (6 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A meeting report from the Santa Cruz Developmental Biology Meeting, University of California at Santa Cruz, USA, July 21-25, 2000.
	Meeting report Dynamic chromosomes Sally G Pasion, Eliana B Gómez, Susan L Forsburg Genome Biology 2000, 1:reports4020-reports4020.3 (6 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the sixth biannual FASEB conference on Yeast Chromosome Structure, Replication and Segregation held in Snowmass, Colorado, 19-24 August, 2000.
	Meeting report The disease business Robin C May Genome Biology 2000, 1:reports4021-reports4021.2 (6 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'Host-Pathogen Interactions' minisymposium at the first meeting of the European Life Scientist Organization (ELSO), Geneva, Switzerland, September 2-6, 2000.
	Meeting report Genomics and embryology in amphibians Curtis R Altmann, Esther Bell, Ali H Brivanlou Genome Biology 2000, 1:reports4022-reports4022.3 (8 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the Eighth Biannual Xenopus Conference, Estes Park, Colorado, August 16-20, 2000.
	Meeting report Genome regulation in the (so-called) post-genomic era Mikhail S Gelfand Genome Biology 2000, 1:reports4023-reports4023.3 (10 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the Second International Conference on Bioinformatics of Genome Regulation and Structure, Novosibirsk, 7-11 August, 2000.
	Research news Timing development William Wells Genome Biology 2000, 1:spotlight-20001102-02 (2 November 2000) Abstract \| Full text \| Editor’s summary A 21-nucleotide RNA that controls worm development is found in a wide range of bilaterian animals.
	Research news Fishy mutations Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001102-01 (2 November 2000) Abstract \| Full text \| Editor’s summary Transgenic fish carrying a bacteriophage lambdacII detection gene can be used to monitor mutagenesis rates.
	Research news Life after ESTs William Wells Genome Biology 2000, 1:spotlight-20001107-01 (7 November 2000) Abstract \| Full text \| Editor’s summary Microarray experiments suggest that the human genome project will uncover many genes not previously discovered by EST sequencing.
	Research news Architectural role for BCL6 Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001107-02 (7 November 2000) Abstract \| Full text \| Editor’s summary Ultrastructural analysis of nuclear subdomains reveals a role for the BCL6 protein in organizing chromatin architecture and orchestrating replication.
	Research news Creating kingdoms William Wells Genome Biology 2000, 1:spotlight-20001107-03 (7 November 2000) Abstract \| Full text \| Editor’s summary Analysis of four conserved proteins allows a better prediction of eukaryotic phylogeny.
	Research news Reeling in DNA William Wells Genome Biology 2000, 1:spotlight-20001108-01 (8 November 2000) Abstract \| Full text \| Editor’s summary A bacterial protein pumps DNA into a pre-spore by tracking along the DNA.
	Research news Neurogenomics Emma Veitch Genome Biology 2000, 1:spotlight-20001108-02 (8 November 2000) Abstract \| Full text \| Editor’s summary Microarrays and SAGE are being used to identify genes involved in the development and function of the nervous system (from the Annual Society for Neuroscience Meeting).
	Research news Metabolite profiling William Wells Genome Biology 2000, 1:spotlight-20001108-03 (8 November 2000) Abstract \| Full text \| Editor’s summary The relative levels of over 300 small compounds from a plant leaf extract can be assayed simultaneously.
	Research news Identifying the Black Plague William Wells Genome Biology 2000, 1:spotlight-20001109-01 (9 November 2000) Abstract \| Full text \| Editor’s summary 'Suicide' PCR of DNA remnants from tooth pulp has confirmed that medieval Black Death was caused by Yersinia pestis.
	Research news Downsizing the Paramecium genome Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001109-02 (9 November 2000) Abstract \| Full text \| Editor’s summary An in vivo excision assay demonstrates that regulatory sequences are necessary for eliminating DNA during the genomic rearrangements of ciliated protozoa.
	Research news Senior scientists promise to boycott journals Andrew McLaughlin Genome Biology 2000, 1:spotlight-20001113-02 (13 November 2000) Abstract \| Full text \| Editor’s summary Leading scientists will refuse to publish, edit or subscribe to journals that do not make research articles available free of charge.
	Research news Mitochondrial proteomics Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001113-01 (13 November 2000) Abstract \| Full text \| Editor’s summary A proteomics strategy identifies new classes of mammalian mitochondrial small-subunit ribosomal proteins.
	Research news Duplicate and die William Wells Genome Biology 2000, 1:spotlight-20001113-03 (13 November 2000) Abstract \| Full text \| Editor’s summary Most duplicated genes are quickly inactivated by mutation, but variation in this process may drive some speciation events.
	Research news Europe had ten Adams William Wells Genome Biology 2000, 1:spotlight-20001115-01 (15 November 2000) Abstract \| Full text \| Editor’s summary Haplotypes from the non-recombining portion of the Y chromosome indicate that ten lineages can account for 95% of European Y chromosomes.
	Research news A variant histone controls transcription William Wells Genome Biology 2000, 1:spotlight-20001115-02 (15 November 2000) Abstract \| Full text \| Editor’s summary Modulation of chromatin structure by inclusion of H2A.Z, a highly variant, highly conserved histone, can regulate transcription.
	Research news The ESTs from Brazil William Wells Genome Biology 2000, 1:spotlight-20001115-03 (15 November 2000) Abstract \| Full text \| Editor’s summary A quarter of a million ESTs from Brazil prove that the only way to identify all eukaryotic genes is to sequence their transcripts.
	Research news Rearranging kinetochores William Wells Genome Biology 2000, 1:spotlight-20001116-01 (16 November 2000) Abstract \| Full text \| Editor’s summary A chromatin-remodeling complex required for passage through mitosis has been localized to kinetochores.
	Research news Skim before you fly William Wells Genome Biology 2000, 1:spotlight-20001116-03 (16 November 2000) Abstract \| Full text \| Editor’s summary For stoneflys, surface skimming seems to be an early state from which flying evolved, rather than resulting from a later loss of flying ability.
	Research news Mice without rings Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001116-02 (16 November 2000) Abstract \| Full text \| Editor’s summary Ring1A functions as a true mammalian Polycomb group gene.
	Research news Killing me softly with his sperm William Wells Genome Biology 2000, 1:spotlight-20001120-01 (20 November 2000) Abstract \| Full text \| Editor’s summary The more toxic that a male fly's sperm is to his mate, the more it ensures that a competitor's sperm doesn't get a look in.
	Research news Interfering with worms William Wells Genome Biology 2000, 1:spotlight-20001120-02 (20 November 2000) Abstract \| Full text \| Editor’s summary Two systematic RNAi screens in worms provide the first large-scale reverse genetic analyses of a multicellular organism.
	Research news Zebrafish on drugs William Wells Genome Biology 2000, 1:spotlight-20001122-02 (22 November 2000) Abstract \| Full text \| Editor’s summary A screen yields chemicals that can be used to interfere with, and time, developmental events in zebrafish.
	Research news FLiP-ing insulators Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001122-01 (22 November 2000) Abstract \| Full text \| Editor’s summary An ingenious use of the FLP recombinase reveals distinct properties of genomic insulator elements in Drosophila.
	Research news Curing diabetes William Wells Genome Biology 2000, 1:spotlight-20001123-01 (23 November 2000) Abstract \| Full text \| Editor’s summary A truncated insulin gene, a promoter responsive to glucose levels, and adeno-associated virus have been combined to cure diabetes in mice.
	Research news Coiled interactions William Wells Genome Biology 2000, 1:spotlight-20001123-02 (23 November 2000) Abstract \| Full text \| Editor’s summary A computational screen for coiled-coil domains, followed by directed two-hybrid experiments, yields a vast array of protein interaction information.
	Research news Two for the price of one Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001124-01 (24 November 2000) Abstract \| Full text \| Editor’s summary The plant RNA polymerase RpoT;2 is targeted to both mitochondria and chloroplasts, suggesting that it can regulate genes in two different genomes.
	Research news Zebrafish genome to be sequenced Gail Vines Genome Biology 2000, 1:spotlight-20001124-03 (24 November 2000) Abstract \| Full text \| Editor’s summary The genome of the zebrafish is to be sequenced at the Wellcome Trust's Sanger Centre near Cambridge, UK.
	Research news Green is go, red is stop William Wells Genome Biology 2000, 1:spotlight-20001124-02 (24 November 2000) Abstract \| Full text \| Editor’s summary A mutant fluorescent protein that changes from green to red over time can indicate when transcription is turned on and off.
	Research news History matters William Wells Genome Biology 2000, 1:spotlight-20001128-02 (28 November 2000) Abstract \| Full text \| Editor’s summary A return to ancestral conditions can result in evolutionary reversal, but it is not inevitable.
	Research news Minos mutagenesis Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001128-01 (28 November 2000) Abstract \| Full text \| Editor’s summary Transposon mobile elements from flies have been used to drive efficient insertional mutagenesis throughout the human genome.
	Research news Caught in the act William Wells Genome Biology 2000, 1:spotlight-20001130-02 (30 November 2000) Abstract \| Full text \| Editor’s summary Altered regulation of the bric-a-brac (bab) gene drove the evolution of sexually dimorphic pigmentation in Drosophila.
	Research news Searching for nuclear localization signals Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001130-01 (30 November 2000) Abstract \| Full text \| Editor’s summary In silico mutagenesis methods are used to predict nuclear localization signals.
	Research
	Research Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs) Darren A Natale, Uma T Shankavaram, Michael Y Galperin, Yuri I Wolf, L Aravind, Eugene V Koonin Genome Biology 2000, 1:research0009-research0009.19 (6 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The database of Clusters of Orthologous Groups of proteins (COGs) was used to reannotate the genomes of Aeropyrum pernix and Pyrococcus abyssi. A differential genome display approach helps in a systematic investigation of common and distinct features of gene repertoires and in some cases reveals unexpected connections that may be indicative of functional similarities between phylogenetically distant organisms and of lateral gene exchange.
	Research Accessing and distributing EMBL data using CORBA (common object request broker architecture) Lichun Wang, Patricia Rodriguez-Tomé, Nicole Redaschi, Phil McNeil, Alan Robinson, Philip Lijnzaad Genome Biology 2000, 1:research0010-research0010.10 (6 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The common object request broker architecture (CORBA) interfaces to the EMBL nucleotide sequence database address some of the problems of traditional flat-file formats and provide an efficient means for accessing and distributing EMBL data. CORBA also provides a flexible environment for users to develop their applications by building clients to our CORBA servers, which can be integrated into existing systems.

	Volume 1 Issue 5
	Comment
	Comment Seek and ye shall maybe find Gregory A Petsko Genome Biology 2000, 1:comment1005-comment1005.2 (10 November 2000) Full text \| PDF \| PubMed \| Editor’s summary Many of the literature databases limit their coverage in ways that are not obvious to the casual user. The scientific community needs to pressure database curators to be as inclusive as possible.
	Review
	Review Can sequence determine function? John A Gerlt, Patricia C Babbitt Genome Biology 2000, 1:reviews0005-reviews0005.10 (8 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The functional annotation of proteins identified in genome sequencing projects is based on similarities to homologs in the databases. As a result of the possible strategies for divergent evolution, homologous enzymes frequently do not catalyze the same reaction, and we conclude that assignment of function from sequence information alone should be viewed with some skepticism.
	Protein family review The F-box protein family Edward T Kipreos, Michele Pagano Genome Biology 2000, 1:reviews3002-reviews3002.7 (10 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary F-box proteins were first described as components of ubiquitin ligase complexes, but have more recently been found to be involved in a variety of cellular functions, including in the kinetochore and in translational elongation.
	Minireview Beyond the Hox complex Nipam H Patel, Victoria E Prince Genome Biology 2000, 1:reviews1027-reviews1027.4 (8 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Hox complex is an example of a gene cluster created by tandem duplications. Recent findings suggest the Hox complex may be just part of a larger chromosomal assemblage of homeobox-containing genes that existed in the ancestor to all vertebrates.
	Minireview Imprinting: silently crossing the boundary Jo Peters Genome Biology 2000, 1:reviews1028-reviews1028.4 (10 November 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent studies have identified silencers as control elements that may interact with enhancers to regulate the expression of imprinted genes.
	Opinion Human genomic variation Todd R Disotell Genome Biology 2000, 1:comment2004-comment2004.2 (10 November 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The recent completion and assembly of the first draft of the human genome, which combines samples from several ethnically diverse males and females, provides preliminary data on the extent of human genetic variation.
	Report
	Paper report Membrane fusion specificity Jason B Bock Genome Biology 2000, 1:reports0071 (25 October 2000) Abstract \| Full text \| Editor’s summary Isolated SNARE proteins have been shown to confer only partial specificity on the fusion of artificial liposomes that mimic cellular membranes, modifying the SNARE hypothesis of membrane fusion.
	Paper report New technology for protein microarrays Rachel Brem Genome Biology 2000, 1:reports0072 (25 October 2000) Abstract \| Full text \| Editor’s summary Nanodroplets of active, solvated protein can be printed onto treated glass slides for protein microarray experiments.
	Paper report Probing the worm germline Barry Lubarsky Genome Biology 2000, 1:reports0073 (25 October 2000) Abstract \| Full text \| Editor’s summary Genes expressed during C. elegans germline development have been identified using DNA microarrays.
	Paper report A second gene for color blindness Gargi Talukder Genome Biology 2000, 1:reports0074 (25 October 2000) Abstract \| Full text \| Editor’s summary Analysis of families suffering from total color blindness has revealed one potential cause of the condition - mutations in a gene encoding a α subunit of the retinal cone cGMP-gated ion channel.
	Paper report Neuronal pathfinding Joe Hao Genome Biology 2000, 1:reports0075 (25 October 2000) Abstract \| Full text
	Meeting report Big science meets small embryos Carol Irving, Anna Sharman Genome Biology 2000, 1:reports4019-reports4019.3 (6 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A meeting report from the Santa Cruz Developmental Biology Meeting, University of California at Santa Cruz, USA, July 21-25, 2000.
	Meeting report Dynamic chromosomes Sally G Pasion, Eliana B Gómez, Susan L Forsburg Genome Biology 2000, 1:reports4020-reports4020.3 (6 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the sixth biannual FASEB conference on Yeast Chromosome Structure, Replication and Segregation held in Snowmass, Colorado, 19-24 August, 2000.
	Meeting report The disease business Robin C May Genome Biology 2000, 1:reports4021-reports4021.2 (6 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'Host-Pathogen Interactions' minisymposium at the first meeting of the European Life Scientist Organization (ELSO), Geneva, Switzerland, September 2-6, 2000.
	Meeting report Genomics and embryology in amphibians Curtis R Altmann, Esther Bell, Ali H Brivanlou Genome Biology 2000, 1:reports4022-reports4022.3 (8 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the Eighth Biannual Xenopus Conference, Estes Park, Colorado, August 16-20, 2000.
	Meeting report Genome regulation in the (so-called) post-genomic era Mikhail S Gelfand Genome Biology 2000, 1:reports4023-reports4023.3 (10 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the Second International Conference on Bioinformatics of Genome Regulation and Structure, Novosibirsk, 7-11 August, 2000.
	Research news Timing development William Wells Genome Biology 2000, 1:spotlight-20001102-02 (2 November 2000) Abstract \| Full text \| Editor’s summary A 21-nucleotide RNA that controls worm development is found in a wide range of bilaterian animals.
	Research news Fishy mutations Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001102-01 (2 November 2000) Abstract \| Full text \| Editor’s summary Transgenic fish carrying a bacteriophage lambdacII detection gene can be used to monitor mutagenesis rates.
	Research news Life after ESTs William Wells Genome Biology 2000, 1:spotlight-20001107-01 (7 November 2000) Abstract \| Full text \| Editor’s summary Microarray experiments suggest that the human genome project will uncover many genes not previously discovered by EST sequencing.
	Research news Architectural role for BCL6 Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001107-02 (7 November 2000) Abstract \| Full text \| Editor’s summary Ultrastructural analysis of nuclear subdomains reveals a role for the BCL6 protein in organizing chromatin architecture and orchestrating replication.
	Research news Creating kingdoms William Wells Genome Biology 2000, 1:spotlight-20001107-03 (7 November 2000) Abstract \| Full text \| Editor’s summary Analysis of four conserved proteins allows a better prediction of eukaryotic phylogeny.
	Research news Reeling in DNA William Wells Genome Biology 2000, 1:spotlight-20001108-01 (8 November 2000) Abstract \| Full text \| Editor’s summary A bacterial protein pumps DNA into a pre-spore by tracking along the DNA.
	Research news Neurogenomics Emma Veitch Genome Biology 2000, 1:spotlight-20001108-02 (8 November 2000) Abstract \| Full text \| Editor’s summary Microarrays and SAGE are being used to identify genes involved in the development and function of the nervous system (from the Annual Society for Neuroscience Meeting).
	Research news Metabolite profiling William Wells Genome Biology 2000, 1:spotlight-20001108-03 (8 November 2000) Abstract \| Full text \| Editor’s summary The relative levels of over 300 small compounds from a plant leaf extract can be assayed simultaneously.
	Research news Identifying the Black Plague William Wells Genome Biology 2000, 1:spotlight-20001109-01 (9 November 2000) Abstract \| Full text \| Editor’s summary 'Suicide' PCR of DNA remnants from tooth pulp has confirmed that medieval Black Death was caused by Yersinia pestis.
	Research news Downsizing the Paramecium genome Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001109-02 (9 November 2000) Abstract \| Full text \| Editor’s summary An in vivo excision assay demonstrates that regulatory sequences are necessary for eliminating DNA during the genomic rearrangements of ciliated protozoa.
	Research news Senior scientists promise to boycott journals Andrew McLaughlin Genome Biology 2000, 1:spotlight-20001113-02 (13 November 2000) Abstract \| Full text \| Editor’s summary Leading scientists will refuse to publish, edit or subscribe to journals that do not make research articles available free of charge.
	Research news Mitochondrial proteomics Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001113-01 (13 November 2000) Abstract \| Full text \| Editor’s summary A proteomics strategy identifies new classes of mammalian mitochondrial small-subunit ribosomal proteins.
	Research news Duplicate and die William Wells Genome Biology 2000, 1:spotlight-20001113-03 (13 November 2000) Abstract \| Full text \| Editor’s summary Most duplicated genes are quickly inactivated by mutation, but variation in this process may drive some speciation events.
	Research news Europe had ten Adams William Wells Genome Biology 2000, 1:spotlight-20001115-01 (15 November 2000) Abstract \| Full text \| Editor’s summary Haplotypes from the non-recombining portion of the Y chromosome indicate that ten lineages can account for 95% of European Y chromosomes.
	Research news A variant histone controls transcription William Wells Genome Biology 2000, 1:spotlight-20001115-02 (15 November 2000) Abstract \| Full text \| Editor’s summary Modulation of chromatin structure by inclusion of H2A.Z, a highly variant, highly conserved histone, can regulate transcription.
	Research news The ESTs from Brazil William Wells Genome Biology 2000, 1:spotlight-20001115-03 (15 November 2000) Abstract \| Full text \| Editor’s summary A quarter of a million ESTs from Brazil prove that the only way to identify all eukaryotic genes is to sequence their transcripts.
	Research news Rearranging kinetochores William Wells Genome Biology 2000, 1:spotlight-20001116-01 (16 November 2000) Abstract \| Full text \| Editor’s summary A chromatin-remodeling complex required for passage through mitosis has been localized to kinetochores.
	Research news Skim before you fly William Wells Genome Biology 2000, 1:spotlight-20001116-03 (16 November 2000) Abstract \| Full text \| Editor’s summary For stoneflys, surface skimming seems to be an early state from which flying evolved, rather than resulting from a later loss of flying ability.
	Research news Mice without rings Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001116-02 (16 November 2000) Abstract \| Full text \| Editor’s summary Ring1A functions as a true mammalian Polycomb group gene.
	Research news Killing me softly with his sperm William Wells Genome Biology 2000, 1:spotlight-20001120-01 (20 November 2000) Abstract \| Full text \| Editor’s summary The more toxic that a male fly's sperm is to his mate, the more it ensures that a competitor's sperm doesn't get a look in.
	Research news Interfering with worms William Wells Genome Biology 2000, 1:spotlight-20001120-02 (20 November 2000) Abstract \| Full text \| Editor’s summary Two systematic RNAi screens in worms provide the first large-scale reverse genetic analyses of a multicellular organism.
	Research news Zebrafish on drugs William Wells Genome Biology 2000, 1:spotlight-20001122-02 (22 November 2000) Abstract \| Full text \| Editor’s summary A screen yields chemicals that can be used to interfere with, and time, developmental events in zebrafish.
	Research news FLiP-ing insulators Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001122-01 (22 November 2000) Abstract \| Full text \| Editor’s summary An ingenious use of the FLP recombinase reveals distinct properties of genomic insulator elements in Drosophila.
	Research news Curing diabetes William Wells Genome Biology 2000, 1:spotlight-20001123-01 (23 November 2000) Abstract \| Full text \| Editor’s summary A truncated insulin gene, a promoter responsive to glucose levels, and adeno-associated virus have been combined to cure diabetes in mice.
	Research news Coiled interactions William Wells Genome Biology 2000, 1:spotlight-20001123-02 (23 November 2000) Abstract \| Full text \| Editor’s summary A computational screen for coiled-coil domains, followed by directed two-hybrid experiments, yields a vast array of protein interaction information.
	Research news Two for the price of one Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001124-01 (24 November 2000) Abstract \| Full text \| Editor’s summary The plant RNA polymerase RpoT;2 is targeted to both mitochondria and chloroplasts, suggesting that it can regulate genes in two different genomes.
	Research news Zebrafish genome to be sequenced Gail Vines Genome Biology 2000, 1:spotlight-20001124-03 (24 November 2000) Abstract \| Full text \| Editor’s summary The genome of the zebrafish is to be sequenced at the Wellcome Trust's Sanger Centre near Cambridge, UK.
	Research news Green is go, red is stop William Wells Genome Biology 2000, 1:spotlight-20001124-02 (24 November 2000) Abstract \| Full text \| Editor’s summary A mutant fluorescent protein that changes from green to red over time can indicate when transcription is turned on and off.
	Research news History matters William Wells Genome Biology 2000, 1:spotlight-20001128-02 (28 November 2000) Abstract \| Full text \| Editor’s summary A return to ancestral conditions can result in evolutionary reversal, but it is not inevitable.
	Research news Minos mutagenesis Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001128-01 (28 November 2000) Abstract \| Full text \| Editor’s summary Transposon mobile elements from flies have been used to drive efficient insertional mutagenesis throughout the human genome.
	Research news Caught in the act William Wells Genome Biology 2000, 1:spotlight-20001130-02 (30 November 2000) Abstract \| Full text \| Editor’s summary Altered regulation of the bric-a-brac (bab) gene drove the evolution of sexually dimorphic pigmentation in Drosophila.
	Research news Searching for nuclear localization signals Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001130-01 (30 November 2000) Abstract \| Full text \| Editor’s summary In silico mutagenesis methods are used to predict nuclear localization signals.
	Research
	Research Towards understanding the first genome sequence of a crenarchaeon by genome annotation using clusters of orthologous groups of proteins (COGs) Darren A Natale, Uma T Shankavaram, Michael Y Galperin, Yuri I Wolf, L Aravind, Eugene V Koonin Genome Biology 2000, 1:research0009-research0009.19 (6 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The database of Clusters of Orthologous Groups of proteins (COGs) was used to reannotate the genomes of Aeropyrum pernix and Pyrococcus abyssi. A differential genome display approach helps in a systematic investigation of common and distinct features of gene repertoires and in some cases reveals unexpected connections that may be indicative of functional similarities between phylogenetically distant organisms and of lateral gene exchange.
	Research Accessing and distributing EMBL data using CORBA (common object request broker architecture) Lichun Wang, Patricia Rodriguez-Tomé, Nicole Redaschi, Phil McNeil, Alan Robinson, Philip Lijnzaad Genome Biology 2000, 1:research0010-research0010.10 (6 November 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The common object request broker architecture (CORBA) interfaces to the EMBL nucleotide sequence database address some of the problems of traditional flat-file formats and provide an efficient means for accessing and distributing EMBL data. CORBA also provides a flexible environment for users to develop their applications by building clients to our CORBA servers, which can be integrated into existing systems.

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