Genome Biology | Volume 1 Issue 6

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	Volume 1 Issue 6
	Comment
	Comment Count me out Gregory A Petsko Genome Biology 2000, 1:comment1006-comment1006.2 (8 December 2000) Full text \| PDF \| PubMed \| Editor’s summary A transcript of testimony before the Supreme Court of the State of Florida, where Eugene Finder, lawyer on behalf of the Human Genome Organization, is urging the justices not to certify a count of the number of genes in the human genome
	Review
	Review Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes Diarmaid Hughes Genome Biology 2000, 1:reviews0006-reviews0006.8 (8 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Inversions and transpositions distinguish the genomes of closely related bacterial species, but most of these rearrangements preserve the relationship between the rearranged fragments and the axis of chromosome replication. Within species, such rearrangements are found less frequently, except in the case of clinical isolates of human pathogens, where rearrangements are very frequent
	Protein family review Cytochromes P450: a success story Danièle Werck-Reichhart, René Feyereisen Genome Biology 2000, 1:reviews3003-reviews3003.9 (8 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cytochrome P450 proteins are enzymes that function in diverse pathways, from carbon source assimilation to hormone biosynthesis. In all P450s, heme is bound in a structurally conserved protein core, allowing them to catalyze regioselective and stereoselective oxidation of hydrocarbons.
	Minireview Extreme genomes Edward F DeLong Genome Biology 2000, 1:reviews1029-reviews1029.3 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The complete genome sequence of Thermoplasma acidophilum, an acid- and heat-loving archaeon, has recently been reported. Comparative genomic analysis of this 'extremophile' is providing new insights into the metabolic machinery, ecology and evolution of thermophilic archaea.
	Minireview Multiple RNA-protein interactions in Drosophila dosage compensation Hubert Amrein Genome Biology 2000, 1:reviews1030-reviews1030.5 (6 December 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.
	Minireview Metabolic control analysis: biological applications and insights Mary C Wildermuth Genome Biology 2000, 1:reviews1031-reviews1031.5 (8 December 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolic control analysis provides a robust mathematical and theoretical framework for describing metabolic and signaling pathways and networks, and for quantifying the controls over these processes. Its application has already shed light on some of the principles underlying the regulation of metabolic pathways, and it is well suited to the analysis of the types of data emerging from genomic studies.
	Report
	Web report The definitive source for protein structures Melanie Nelson Genome Biology 2000, 1:reports2056 (28 November 2000) Abstract \| Full text
	Paper report Oldest archaea? James Cotton Genome Biology 2000, 1:reports0076 (26 November 2000) Abstract \| Full text
	Paper report Bacterial virulence determinants William Deakin Genome Biology 2000, 1:reports0077 (26 November 2000) Abstract \| Full text \| Editor’s summary A third type III secretion system involved in virulence in Yersinia enterocolitica has been identified.
	Paper report New clustering method for expression array data Rachel Brem Genome Biology 2000, 1:reports0078 (26 November 2000) Abstract \| Full text
	Paper report The sea urchin joins the genome era Barry Lubarsky Genome Biology 2000, 1:reports0081 (26 November 2000) Abstract \| Full text
	Paper report Vaccinia tricks Toll Rachel Allan Genome Biology 2000, 1:reports0079 (4 December 2000) Abstract \| Full text \| Editor’s summary The first evidence that viruses may subvert signaling pathways from Toll-like receptors within their mammalian hosts has been found.
	Paper report DAP12 and dendritic cells Rachel Allan Genome Biology 2000, 1:reports0080 (4 December 2000) Abstract \| Full text \| Editor’s summary Characterization of immune system abnormalities in mice deficient for the transmembrane adaptor protein DAP12 is described.
	Meeting report Communal weeding Murray Grant, Steve Smith Genome Biology 2000, 1:reports4024-reports4024.3 (6 December 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the first annual Genomic Arabidopsis Resource Network (GARNet) meeting, York, UK, 2-3 October, 2000.
	Meeting report Structure and dynamics of the post-transcriptional mRNA-processing machinery Elisa Izaurralde Genome Biology 2000, 1:reports4025-reports4025.3 (6 December 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'RNA processsing' and 'Nuclear Import and Export' minisymposia at the first meeting of the European Life Scientist Organization (ELSO), Geneva, 2-6 September, 2000.
	Meeting report Changing diagnostics and therapeutics forever with cDNA arrays Matthew A Roberts Genome Biology 2000, 1:reports4026-reports4026.2 (6 December 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'cDNA arrays/DNA diagnostics' session at the first meeting of the European Life Scientist Organization (ELSO), Geneva, Switzerland, 2-6 September, 2000.
	Deposited research article Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions Brain B Haab, Maitreya J Dunham, Patrick O Brown Genome Biology 2000, 1:preprint0001-preprint0001.22 (17 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A method is described for printing protein microarrays and using them in a comparative fluorescence assay to measure the abundance of specific proteins in complex solutions. Antigens or antibodies were spotted onto the arrays, and accurate measurements of their cognate ligands were made at concentrations of 1.6 υg/ml or below. Some antibody-antigen pairs allowed detection of the cognate ligands at absolute concentrations below 1 ng/ml and partial concentrations of less than 1 part in 10⁶, sensitivities sufficient for measurement of many clinically important proteins in patient blood samples.
	Research news Everything binds everything William Wells Genome Biology 2000, 1:spotlight-20001204-01 (4 December 2000) Abstract \| Full text \| Editor’s summary An analysis of two-hybrid results in yeast reveals a single large network of 2,358 interactions among 1,548 proteins.
	Research news Protecting plants William Wells Genome Biology 2000, 1:spotlight-20001204-02 (4 December 2000) Abstract \| Full text \| Editor’s summary Microarray analysis and promoter gazing help define how plants regulate their response to pathogens.
	Research news Old flies oxidize William Wells Genome Biology 2000, 1:spotlight-20001205-01 (5 December 2000) Abstract \| Full text \| Editor’s summary Only some of the processes of aging in the fly can be explained by increased oxidative stress.
	Research news Probing E. coli William Wells Genome Biology 2000, 1:spotlight-20001205-02 (5 December 2000) Abstract \| Full text \| Editor’s summary An E. coli oligonucleotide array with 30-base-pair resolution allows the detection of antisense transcripts, and transcription starts and stops.
	Research news Gypsy at the periphery Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001207-01 (7 December 2000) Abstract \| Full text \| Editor’s summary An elegant series of experiments suggests that the Drosophila gypsy insulator element functions by imposing chromosomal organisation at the nuclear periphery.
	Research news Tracking human origins William Wells Genome Biology 2000, 1:spotlight-20001207-02 (7 December 2000) Abstract \| Full text \| Editor’s summary Complete mitochondrial DNA sequences give a clearer picture of human origins.
	Research news Sequence-specific drugs Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001208-01 (8 December 2000) Abstract \| Full text \| Editor’s summary Polyamide drugs that bind specific DNA repeats can be used to probe the mechanisms of position effect variation and epigenetic phenomena.
	Research news Signaling for survival William Wells Genome Biology 2000, 1:spotlight-20001208-02 (8 December 2000) Abstract \| Full text \| Editor’s summary Rhodopsin ensures photoreceptor survival by organizing actin and directing the cell's morphogenesis.
	Research news Slimy catenins William Wells Genome Biology 2000, 1:spotlight-20001211-01 (11 December 2000) Abstract \| Full text \| Editor’s summary A slime mold, like metazoans, has a beta-catenin involved both in signaling and in forming adherens junctions.
	Research news DNA repair within nucleosomes Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001211-02 (11 December 2000) Abstract \| Full text \| Editor’s summary In vitro reconstitution experiments show that organizing DNA into nucleosomes inhibits DNA repair.
	Research news Rock, paper, scissors, lizard William Wells Genome Biology 2000, 1:spotlight-20001213-01 (13 December 2000) Abstract \| Full text \| Editor’s summary Three alternative male mating strategies coexist stably, because each strategy has strengths over one other, and weaknesses in the face of the third.
	Research news Go to the end of the Ku Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001213-02 (13 December 2000) Abstract \| Full text \| Editor’s summary A complex between Ku and telomere-binding proteins is critical for telomere capping and preventing the fusion of chromosome ends.
	Research news Rax2 marks the spot William Wells Genome Biology 2000, 1:spotlight-20001213-03 (13 December 2000) Abstract \| Full text \| Editor’s summary The Rax2 protein in yeast appears to mark the cortex so that yeast can bud from their poles.
	Research news Variant of the RANTES cytokine associated with asthma Tudor Toma Genome Biology 2000, 1:spotlight-20001214-01 (14 December 2000) Abstract \| Full text \| Editor’s summary A polymorphism within the promoter region of the RANTES chemokine gene is associated with an increased risk of asthma and atopy.
	Research news Plant sequence completed William Wells Genome Biology 2000, 1:spotlight-20001214-02 (14 December 2000) Abstract \| Full text \| Editor’s summary The complete sequence of Arabidopsis thaliana gives us an idea of how plants function.
	Research news Plant transcription: it's different William Wells Genome Biology 2000, 1:spotlight-20001215-01 (15 December 2000) Abstract \| Full text \| Editor’s summary New motifs, shuffled motifs, and old motifs put to new uses make plant transcriptional regulation very different from that found in other eukaryotes.
	Research news The plant clock William Wells Genome Biology 2000, 1:spotlight-20001215-02 (15 December 2000) Abstract \| Full text \| Editor’s summary Array analysis yields a large number of genes regulated by the plant circadian clock.
	Research news Plant duplications William Wells Genome Biology 2000, 1:spotlight-20001215-03 (15 December 2000) Abstract \| Full text \| Editor’s summary Four large-scale duplication events, followed by gene loss, have shaped the Arabidopsis genome.
	Research news Celera submits to Science - or is it the other way around? Peter Moore Genome Biology 2000, 1:spotlight-20001218-01 (18 December 2000) Abstract \| Full text \| Editor’s summary Celera will be allowed to publish its research in Science while retaining some control over the intellectual property that it contains. Welcome to the future, says Editor-in-Chief of Science Donald Kennedy.
	Research news Controlling the bacterial cell cycle William Wells Genome Biology 2000, 1:spotlight-20001218-02 (18 December 2000) Abstract \| Full text \| Editor’s summary A full 19% of a bacterial genome is subject to cell-cycle-specific regulation.
	Research news Targeted methylation Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001221-01 (21 December 2000) Abstract \| Full text \| Editor’s summary Introducing methylated DNA at specific genomic loci affects local histone acetylation.
	Research news Hot DNA William Wells Genome Biology 2000, 1:spotlight-20001221-02 (21 December 2000) Abstract \| Full text \| Editor’s summary Thermophiles adapt to the heat by clustering purines and pyrimidines and by making more basic proteins.
	Research news SWI/SNF is a tumour suppressor Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001222-01 (22 December 2000) Abstract \| Full text \| Editor’s summary The SNF5 chromatin-remodeling factor suppresses tumor formation in mice.
	Research news Immunizing against Alzheimer's William Wells Genome Biology 2000, 1:spotlight-20001222-02 (22 December 2000) Abstract \| Full text \| Editor’s summary Immunization with amyloid-beta peptide reduces the learning deficits seen in mouse models of Alzheimer's disease.
	Research news Making way for repair William Wells Genome Biology 2000, 1:spotlight-20001227-01 (27 December 2000) Abstract \| Full text \| Editor’s summary Phosphorylation of histone H2A in response to radiation damage loosens up chromatin to allow the entry of repair proteins.
	Research news Methylation in flies Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001227-02 (27 December 2000) Abstract \| Full text \| Editor’s summary A highly sensitive assay has detected 5-methylcytosine in Drosophila
	Research news Inverted yeast William Wells Genome Biology 2000, 1:spotlight-20001227-03 (27 December 2000) Abstract \| Full text \| Editor’s summary In two yeast species, gene adjacencies have been broken as frequently by small inversions as by translocations or long-distance transpositions.
	Research news This amoeba is a cheater William Wells Genome Biology 2000, 1:spotlight-20001228-01 (28 December 2000) Abstract \| Full text \| Editor’s summary @Dictyostelium# amoebae of different genotypes can combine to form a single fruiting body, but they cheat on each other in a bid to maximize their share of spore cells.
	Research news Spot the protein William Wells Genome Biology 2000, 1:spotlight-20001228-02 (28 December 2000) Abstract \| Full text \| Editor’s summary A new approach to analyzing electron tomograms may make it possible to visualize individual proteins in action in cells.
	Research news Calling all binding sites William Wells Genome Biology 2000, 1:spotlight-20001229-01 (29 December 2000) Abstract \| Full text \| Editor’s summary Chromatin immunoprecipitation combined with DNA microarrays yields all binding sites for transcription activators.
	Research news And the winner is... William Wells Genome Biology 2000, 1:spotlight-20001229-02 (29 December 2000) Abstract \| Full text \| Editor’s summary Science magazine declares that genome sequencing was the top scientific advance of 2000.
	Research
	Research Evidence for symmetric chromosomal inversions around the replication origin in bacteria Jonathan A Eisen, John F Heidelberg, Owen White, Steven L Salzberg Genome Biology 2000, 1:research0011-research0011.9 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary By comparing recently completed bacterial genome sequences to those of closely related species an unusual and previously unobserved feature of bacterial genome structure has been identified. The distance of a particular feature from the replication origin is conserved between closely related pairs of species. This suggests that chromosomal inversions around the replication origin are a common feature of bacterial genome evolution.
	Research A search for reverse transcriptase-coding sequences reveals new non-LTR retrotransposons in the genome of Drosophila melanogaster Eugene Berezikov, Alain Bucheton, Isabelle Busseau Genome Biology 2000, 1:research0012-research0012.15 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A systematic search for sequences matching the characteristic reverse transcriptase domain of non-LTR retrotransposons in the sequenced regions of the Drosophila melanogaster genome has revealed at least ten families of non-site-specific non-LTR retrotransposons representing three distinct clades. Many of these families contain potentially active members.
	Research Interkingdom gene fusions Yuri I Wolf, Alexey S Kondrashov, Eugene V Koonin Genome Biology 2000, 1:research0013-research0013.13 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Complete genomes of fifteen bacteria, four archaea and one eukaryote were searched for interkingdom gene fusions; genes coding for proteins that apparently consist of domains originating from different primary kingdoms. The results of this comparative genome analysis show that interkingdom gene fusion is a real, but relatively rare, evolutionary phenomenon.
	Research Genetic snapshots of the Rhizobium species NGR234 genome Virginie Viprey, André Rosenthal, William J Broughton, Xavier Perret Genome Biology 2000, 1:research0014-research0014.17 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Skimming' the genome of Rhizobium sp. NGR234, a nitrogen-fixing symbiont of many legumes, sheds new light on the fine structure and evolution of its replicons, as well as on the integration of symbiotic functions in the genome of a soil bacterium.

	Volume 1 Issue 6
	Comment
	Comment Count me out Gregory A Petsko Genome Biology 2000, 1:comment1006-comment1006.2 (8 December 2000) Full text \| PDF \| PubMed \| Editor’s summary A transcript of testimony before the Supreme Court of the State of Florida, where Eugene Finder, lawyer on behalf of the Human Genome Organization, is urging the justices not to certify a count of the number of genes in the human genome
	Review
	Review Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes Diarmaid Hughes Genome Biology 2000, 1:reviews0006-reviews0006.8 (8 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Inversions and transpositions distinguish the genomes of closely related bacterial species, but most of these rearrangements preserve the relationship between the rearranged fragments and the axis of chromosome replication. Within species, such rearrangements are found less frequently, except in the case of clinical isolates of human pathogens, where rearrangements are very frequent
	Protein family review Cytochromes P450: a success story Danièle Werck-Reichhart, René Feyereisen Genome Biology 2000, 1:reviews3003-reviews3003.9 (8 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Cytochrome P450 proteins are enzymes that function in diverse pathways, from carbon source assimilation to hormone biosynthesis. In all P450s, heme is bound in a structurally conserved protein core, allowing them to catalyze regioselective and stereoselective oxidation of hydrocarbons.
	Minireview Extreme genomes Edward F DeLong Genome Biology 2000, 1:reviews1029-reviews1029.3 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The complete genome sequence of Thermoplasma acidophilum, an acid- and heat-loving archaeon, has recently been reported. Comparative genomic analysis of this 'extremophile' is providing new insights into the metabolic machinery, ecology and evolution of thermophilic archaea.
	Minireview Multiple RNA-protein interactions in Drosophila dosage compensation Hubert Amrein Genome Biology 2000, 1:reviews1030-reviews1030.5 (6 December 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary From worms to humans, recognizing and modifying a specific chromosome is essential for dosage compensation, the mechanism by which equal X-linked gene expression in males and females is achieved. Recent molecular genetic and biochemical studies have provided new insights into how regulatory factors in Drosophila are recruited and assembled on the X chromosome, leading to the essential hypertranscription of its genes.
	Minireview Metabolic control analysis: biological applications and insights Mary C Wildermuth Genome Biology 2000, 1:reviews1031-reviews1031.5 (8 December 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Metabolic control analysis provides a robust mathematical and theoretical framework for describing metabolic and signaling pathways and networks, and for quantifying the controls over these processes. Its application has already shed light on some of the principles underlying the regulation of metabolic pathways, and it is well suited to the analysis of the types of data emerging from genomic studies.
	Report
	Web report The definitive source for protein structures Melanie Nelson Genome Biology 2000, 1:reports2056 (28 November 2000) Abstract \| Full text
	Paper report Oldest archaea? James Cotton Genome Biology 2000, 1:reports0076 (26 November 2000) Abstract \| Full text
	Paper report Bacterial virulence determinants William Deakin Genome Biology 2000, 1:reports0077 (26 November 2000) Abstract \| Full text \| Editor’s summary A third type III secretion system involved in virulence in Yersinia enterocolitica has been identified.
	Paper report New clustering method for expression array data Rachel Brem Genome Biology 2000, 1:reports0078 (26 November 2000) Abstract \| Full text
	Paper report The sea urchin joins the genome era Barry Lubarsky Genome Biology 2000, 1:reports0081 (26 November 2000) Abstract \| Full text
	Paper report Vaccinia tricks Toll Rachel Allan Genome Biology 2000, 1:reports0079 (4 December 2000) Abstract \| Full text \| Editor’s summary The first evidence that viruses may subvert signaling pathways from Toll-like receptors within their mammalian hosts has been found.
	Paper report DAP12 and dendritic cells Rachel Allan Genome Biology 2000, 1:reports0080 (4 December 2000) Abstract \| Full text \| Editor’s summary Characterization of immune system abnormalities in mice deficient for the transmembrane adaptor protein DAP12 is described.
	Meeting report Communal weeding Murray Grant, Steve Smith Genome Biology 2000, 1:reports4024-reports4024.3 (6 December 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the first annual Genomic Arabidopsis Resource Network (GARNet) meeting, York, UK, 2-3 October, 2000.
	Meeting report Structure and dynamics of the post-transcriptional mRNA-processing machinery Elisa Izaurralde Genome Biology 2000, 1:reports4025-reports4025.3 (6 December 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'RNA processsing' and 'Nuclear Import and Export' minisymposia at the first meeting of the European Life Scientist Organization (ELSO), Geneva, 2-6 September, 2000.
	Meeting report Changing diagnostics and therapeutics forever with cDNA arrays Matthew A Roberts Genome Biology 2000, 1:reports4026-reports4026.2 (6 December 2000) Abstract \| Full text \| PDF \| Editor’s summary A report on the 'cDNA arrays/DNA diagnostics' session at the first meeting of the European Life Scientist Organization (ELSO), Geneva, Switzerland, 2-6 September, 2000.
	Deposited research article Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions Brain B Haab, Maitreya J Dunham, Patrick O Brown Genome Biology 2000, 1:preprint0001-preprint0001.22 (17 November 2000) Abstract \| Full text \| PDF \| Editor’s summary A method is described for printing protein microarrays and using them in a comparative fluorescence assay to measure the abundance of specific proteins in complex solutions. Antigens or antibodies were spotted onto the arrays, and accurate measurements of their cognate ligands were made at concentrations of 1.6 υg/ml or below. Some antibody-antigen pairs allowed detection of the cognate ligands at absolute concentrations below 1 ng/ml and partial concentrations of less than 1 part in 10⁶, sensitivities sufficient for measurement of many clinically important proteins in patient blood samples.
	Research news Everything binds everything William Wells Genome Biology 2000, 1:spotlight-20001204-01 (4 December 2000) Abstract \| Full text \| Editor’s summary An analysis of two-hybrid results in yeast reveals a single large network of 2,358 interactions among 1,548 proteins.
	Research news Protecting plants William Wells Genome Biology 2000, 1:spotlight-20001204-02 (4 December 2000) Abstract \| Full text \| Editor’s summary Microarray analysis and promoter gazing help define how plants regulate their response to pathogens.
	Research news Old flies oxidize William Wells Genome Biology 2000, 1:spotlight-20001205-01 (5 December 2000) Abstract \| Full text \| Editor’s summary Only some of the processes of aging in the fly can be explained by increased oxidative stress.
	Research news Probing E. coli William Wells Genome Biology 2000, 1:spotlight-20001205-02 (5 December 2000) Abstract \| Full text \| Editor’s summary An E. coli oligonucleotide array with 30-base-pair resolution allows the detection of antisense transcripts, and transcription starts and stops.
	Research news Gypsy at the periphery Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001207-01 (7 December 2000) Abstract \| Full text \| Editor’s summary An elegant series of experiments suggests that the Drosophila gypsy insulator element functions by imposing chromosomal organisation at the nuclear periphery.
	Research news Tracking human origins William Wells Genome Biology 2000, 1:spotlight-20001207-02 (7 December 2000) Abstract \| Full text \| Editor’s summary Complete mitochondrial DNA sequences give a clearer picture of human origins.
	Research news Sequence-specific drugs Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001208-01 (8 December 2000) Abstract \| Full text \| Editor’s summary Polyamide drugs that bind specific DNA repeats can be used to probe the mechanisms of position effect variation and epigenetic phenomena.
	Research news Signaling for survival William Wells Genome Biology 2000, 1:spotlight-20001208-02 (8 December 2000) Abstract \| Full text \| Editor’s summary Rhodopsin ensures photoreceptor survival by organizing actin and directing the cell's morphogenesis.
	Research news Slimy catenins William Wells Genome Biology 2000, 1:spotlight-20001211-01 (11 December 2000) Abstract \| Full text \| Editor’s summary A slime mold, like metazoans, has a beta-catenin involved both in signaling and in forming adherens junctions.
	Research news DNA repair within nucleosomes Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001211-02 (11 December 2000) Abstract \| Full text \| Editor’s summary In vitro reconstitution experiments show that organizing DNA into nucleosomes inhibits DNA repair.
	Research news Rock, paper, scissors, lizard William Wells Genome Biology 2000, 1:spotlight-20001213-01 (13 December 2000) Abstract \| Full text \| Editor’s summary Three alternative male mating strategies coexist stably, because each strategy has strengths over one other, and weaknesses in the face of the third.
	Research news Go to the end of the Ku Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001213-02 (13 December 2000) Abstract \| Full text \| Editor’s summary A complex between Ku and telomere-binding proteins is critical for telomere capping and preventing the fusion of chromosome ends.
	Research news Rax2 marks the spot William Wells Genome Biology 2000, 1:spotlight-20001213-03 (13 December 2000) Abstract \| Full text \| Editor’s summary The Rax2 protein in yeast appears to mark the cortex so that yeast can bud from their poles.
	Research news Variant of the RANTES cytokine associated with asthma Tudor Toma Genome Biology 2000, 1:spotlight-20001214-01 (14 December 2000) Abstract \| Full text \| Editor’s summary A polymorphism within the promoter region of the RANTES chemokine gene is associated with an increased risk of asthma and atopy.
	Research news Plant sequence completed William Wells Genome Biology 2000, 1:spotlight-20001214-02 (14 December 2000) Abstract \| Full text \| Editor’s summary The complete sequence of Arabidopsis thaliana gives us an idea of how plants function.
	Research news Plant transcription: it's different William Wells Genome Biology 2000, 1:spotlight-20001215-01 (15 December 2000) Abstract \| Full text \| Editor’s summary New motifs, shuffled motifs, and old motifs put to new uses make plant transcriptional regulation very different from that found in other eukaryotes.
	Research news The plant clock William Wells Genome Biology 2000, 1:spotlight-20001215-02 (15 December 2000) Abstract \| Full text \| Editor’s summary Array analysis yields a large number of genes regulated by the plant circadian clock.
	Research news Plant duplications William Wells Genome Biology 2000, 1:spotlight-20001215-03 (15 December 2000) Abstract \| Full text \| Editor’s summary Four large-scale duplication events, followed by gene loss, have shaped the Arabidopsis genome.
	Research news Celera submits to Science - or is it the other way around? Peter Moore Genome Biology 2000, 1:spotlight-20001218-01 (18 December 2000) Abstract \| Full text \| Editor’s summary Celera will be allowed to publish its research in Science while retaining some control over the intellectual property that it contains. Welcome to the future, says Editor-in-Chief of Science Donald Kennedy.
	Research news Controlling the bacterial cell cycle William Wells Genome Biology 2000, 1:spotlight-20001218-02 (18 December 2000) Abstract \| Full text \| Editor’s summary A full 19% of a bacterial genome is subject to cell-cycle-specific regulation.
	Research news Targeted methylation Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001221-01 (21 December 2000) Abstract \| Full text \| Editor’s summary Introducing methylated DNA at specific genomic loci affects local histone acetylation.
	Research news Hot DNA William Wells Genome Biology 2000, 1:spotlight-20001221-02 (21 December 2000) Abstract \| Full text \| Editor’s summary Thermophiles adapt to the heat by clustering purines and pyrimidines and by making more basic proteins.
	Research news SWI/SNF is a tumour suppressor Jonathan Weitzman Genome Biology 2000, 1:spotlight-20001222-01 (22 December 2000) Abstract \| Full text \| Editor’s summary The SNF5 chromatin-remodeling factor suppresses tumor formation in mice.
	Research news Immunizing against Alzheimer's William Wells Genome Biology 2000, 1:spotlight-20001222-02 (22 December 2000) Abstract \| Full text \| Editor’s summary Immunization with amyloid-beta peptide reduces the learning deficits seen in mouse models of Alzheimer's disease.
	Research news Making way for repair William Wells Genome Biology 2000, 1:spotlight-20001227-01 (27 December 2000) Abstract \| Full text \| Editor’s summary Phosphorylation of histone H2A in response to radiation damage loosens up chromatin to allow the entry of repair proteins.
	Research news Methylation in flies Jonathan B Weitzman Genome Biology 2000, 1:spotlight-20001227-02 (27 December 2000) Abstract \| Full text \| Editor’s summary A highly sensitive assay has detected 5-methylcytosine in Drosophila
	Research news Inverted yeast William Wells Genome Biology 2000, 1:spotlight-20001227-03 (27 December 2000) Abstract \| Full text \| Editor’s summary In two yeast species, gene adjacencies have been broken as frequently by small inversions as by translocations or long-distance transpositions.
	Research news This amoeba is a cheater William Wells Genome Biology 2000, 1:spotlight-20001228-01 (28 December 2000) Abstract \| Full text \| Editor’s summary @Dictyostelium# amoebae of different genotypes can combine to form a single fruiting body, but they cheat on each other in a bid to maximize their share of spore cells.
	Research news Spot the protein William Wells Genome Biology 2000, 1:spotlight-20001228-02 (28 December 2000) Abstract \| Full text \| Editor’s summary A new approach to analyzing electron tomograms may make it possible to visualize individual proteins in action in cells.
	Research news Calling all binding sites William Wells Genome Biology 2000, 1:spotlight-20001229-01 (29 December 2000) Abstract \| Full text \| Editor’s summary Chromatin immunoprecipitation combined with DNA microarrays yields all binding sites for transcription activators.
	Research news And the winner is... William Wells Genome Biology 2000, 1:spotlight-20001229-02 (29 December 2000) Abstract \| Full text \| Editor’s summary Science magazine declares that genome sequencing was the top scientific advance of 2000.
	Research
	Research Evidence for symmetric chromosomal inversions around the replication origin in bacteria Jonathan A Eisen, John F Heidelberg, Owen White, Steven L Salzberg Genome Biology 2000, 1:research0011-research0011.9 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary By comparing recently completed bacterial genome sequences to those of closely related species an unusual and previously unobserved feature of bacterial genome structure has been identified. The distance of a particular feature from the replication origin is conserved between closely related pairs of species. This suggests that chromosomal inversions around the replication origin are a common feature of bacterial genome evolution.
	Research A search for reverse transcriptase-coding sequences reveals new non-LTR retrotransposons in the genome of Drosophila melanogaster Eugene Berezikov, Alain Bucheton, Isabelle Busseau Genome Biology 2000, 1:research0012-research0012.15 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A systematic search for sequences matching the characteristic reverse transcriptase domain of non-LTR retrotransposons in the sequenced regions of the Drosophila melanogaster genome has revealed at least ten families of non-site-specific non-LTR retrotransposons representing three distinct clades. Many of these families contain potentially active members.
	Research Interkingdom gene fusions Yuri I Wolf, Alexey S Kondrashov, Eugene V Koonin Genome Biology 2000, 1:research0013-research0013.13 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Complete genomes of fifteen bacteria, four archaea and one eukaryote were searched for interkingdom gene fusions; genes coding for proteins that apparently consist of domains originating from different primary kingdoms. The results of this comparative genome analysis show that interkingdom gene fusion is a real, but relatively rare, evolutionary phenomenon.
	Research Genetic snapshots of the Rhizobium species NGR234 genome Virginie Viprey, André Rosenthal, William J Broughton, Xavier Perret Genome Biology 2000, 1:research0014-research0014.17 (4 December 2000) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Skimming' the genome of Rhizobium sp. NGR234, a nitrogen-fixing symbiont of many legumes, sheds new light on the fine structure and evolution of its replicons, as well as on the integration of symbiotic functions in the genome of a soil bacterium.

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Volume 1 Issue 6

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