Genome Biology | Volume 10 Issue 12

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	Volume 10 Issue 12
	Comment
	Comment A harsh climate Gregory A Petsko Genome Biology 2009, 10:115 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We should not be distracted by the debate about whether or not global warming is caused by humans; whatever the answer is, we urgently need to retard or reverse the trend.
	Review
	Protein family review The WUS homeobox-containing (WOX) protein family Eric van der Graaff, Thomas Laux, Stefan A Rensing Genome Biology 2009, 10:248 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The plant-specific WOX family of homeobox proteins have key functions in plant development.
	Protein family review The PIN-FORMED (PIN) protein family of auxin transporters Pavel Křeček, Petr Skůpa, Jiří Libus, Satoshi Naramoto, Ricardo Tejos, Jiří Friml, Eva Zažímalová Genome Biology 2009, 10:249 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A review of the PIN auxin-efflux transporters, which have important roles in plant development.
	Minireview Structural and functional map of a bacterial nucleoid Agustino Martínez-Antonio, Alejandra Medina-Rivera, Julio Collado-Vides Genome Biology 2009, 10:247 (11 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mapping global protein binding in the E. coli genome reveals extended domains of high protein occupancy.
	Report
	Meeting report Unraveling the genomic diversity of small eukaryotes Gilles Fischer, Dawn Thompson, Jennifer Wortman, Cécile Fairhead Genome Biology 2009, 10:318 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the meeting Comparative Genomics of Eukaryotic Microorganisms, 17-22 October 2009, San Feliu de Guixols, Spain.
	Research
	Research Plant polycistronic precursors containing non-homologous microRNAs target transcripts encoding functionally related proteins Francisco Merchan, Adnane Boualem, Martin Crespi, Florian Frugier Genome Biology 2009, 10:R136 (1 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Functional homologous and non-homologous clusters of MIR genes that co-regulate target mRNA transcripts have been identified in plants
	Research Tandem repeats modify the structure of human genes hosted in segmental duplications Anna De Grassi, Francesca D Ciccarelli Genome Biology 2009, 10:R137 (2 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Internal tandem repeats are shown to modify the gene structure of human primate-specific paralogs.
	Research Non-imprinted allele-specific DNA methylation on human autosomes Yingying Zhang, Christian Rohde, Richard Reinhardt, Claudia Voelcker-Rehage, Albert Jeltsch Genome Biology 2009, 10:R138 (3 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Single-nucleotide polymorphisms located within CpG islands are found to cause differences in CpG methylation between alleles, reflecting differences in gene expression.
	Research Characterizing the admixed African ancestry of African Americans Fouad Zakharia, Analabha Basu, Devin Absher, Themistocles L Assimes, Alan S Go, Mark A Hlatky, Carlos Iribarren, Joshua W Knowles, Jun Li, Balasubramanian Narasimhan, Steven Sidney, Audrey Southwick, Richard M Myers, Thomas Quertermous, Neil Risch, Hua Tang Genome Biology 2009, 10:R141 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genome-wide SNP analyses reveal the admixed African genetic ancestry of African Americans.
	Method Towards accurate imputation of quantitative genetic interactions Igor Ulitsky, Nevan J Krogan, Ron Shamir Genome Biology 2009, 10:R140 (10 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new method for calculating quantitative genetic interactions allows for the inference of 190,000 new genetic interactions in Saccharomyces cerevisae.
	Method A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data Desmond S Lun, Ashley Sherrid, Brian Weiner, David R Sherman, James E Galagan Genome Biology 2009, 10:R142 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary CSdeconv is a novel method for determining the location of transcription factor binding from ChIP-seq data that discriminates closely-spaced sites.
	Method Correlating measurements across samples improves accuracy of large-scale expression profile experiments Mariano Alvarez, Pavel Sumazin, Presha Rajbhandari, Andrea Califano Genome Biology 2009, 10:R143 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cleaner is a method for removing uninformative and flawed probes from microarray experiment data, thus improving reproducibility between replicate experiments.
	Software Mining for coexpression across hundreds of datasets using novel rank aggregation and visualization methods Priit Adler, Raivo Kolde, Meelis Kull, Aleksandr Tkachenko, Hedi Peterson, Jüri Reimand, Jaak Vilo Genome Biology 2009, 10:R139 (4 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The MEM web resource allows users to search for co-expressed genes across all microarray datasets in the ArrayExpress database.