Genome Biology | Volume 10 Issue 8

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	Volume 10 Issue 8
	Comment
	Comment Nation of twits Gregory A Petsko Genome Biology 2009, 10:110 (28 August 2009) Abstract \| Full text \| PDF \| Editor’s summary Gregory Petsko bemoans the rise of the Twittering classes.
	Review
	Protein family review The claudins Madhu Lal-Nag, Patrice J Morin Genome Biology 2009, 10:235 (26 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Claudins are crucial components of tight junctions and are important in regulating permeability and maintaining cell polarity in cell sheets.
	Minireview New levels of sophistication in the transcriptional landscape of bacteria Arnoud HM van Vliet, Brendan W Wren Genome Biology 2009, 10:233 (3 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Previously unanticipated roles of noncoding and antisense RNAs give the regulation of gene expression in bacteria an extra layer of complexity.
	Minireview Virus-mediated mRNA decay by hyperadenylation Kevin J Sokoloski, Emily L Chaskey, Jeffrey Wilusz Genome Biology 2009, 10:234 (11 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Degradation of cellular mRNAs in Kaposi's sarcoma-associated herpesvirus infection is associated with hyperadenylation of transcripts.
	Minireview Reprogramming the epigenome during germline and seed development Mark A Johnson, Judith Bender Genome Biology 2009, 10:232 (24 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Gene silencing by DNA methylation and small RNAs is globally reconfigured during gametogenesis in Arabidopsis.
	Report
	Meeting report Phenotypic variation meets systems biology Teresa M Przytycka Genome Biology 2009, 10:313 (3 August 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the 18th Annual Growth Factor and Signal Transduction Symposium, Ames, USA, 11-14 June 2009.
	Meeting report Malaria genomics meets drug-resistance phenotyping in the field Paul Hunt, Bronwyn MacInnis, Cally Roper Genome Biology 2009, 10:314 (11 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A report of the 2nd Wellcome Trust Conference on Genomic Epidemiology of Malaria, Hinxton, UK, 14-17 June 2009.
	Research
	Research Whole genome sequencing of a single Bos taurus animal for single nucleotide polymorphism discovery Sebastian H Eck, Anna Benet-Pagès, Krzysztof Flisikowski, Thomas Meitinger, Ruedi Fries, Tim M Strom Genome Biology 2009, 10:R82 (6 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The next generation sequencing of a single cow genome with low-to-medium coverage has revealed 2.44 million new SNPs.
	Research Community-wide analysis of microbial genome sequence signatures Gregory J Dick, Anders F Andersson, Brett J Baker, Sheri L Simmons, Brian C Thomas, A Pepper Yelton, Jillian F Banfield Genome Biology 2009, 10:R85 (21 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genome signatures are used to identify and cluster sequences de novo from an acid biofilm microbial community metagenomic dataset, revealing information about the low-abundance community members.
	Research Depletion of T-cell intracellular antigen proteins promotes cell proliferation Raquel Reyes, José Alcalde, José M Izquierdo Genome Biology 2009, 10:R87 (26 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The transcriptome of TIA-1/TIAR-depleted cells indicates roles in inflammation, cell-cell signaling, immune suppression, angiogenesis, metabolism and cell proliferation.
	Method Assisted assembly: how to improve a de novo genome assembly by using related species Sante Gnerre, Eric S Lander, Kerstin Lindblad-Toh, David B Jaffe Genome Biology 2009, 10:R88 (27 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A method is described for improving low sequence coverage genome assemblies
	Software Improved base calling for the Illumina Genome Analyzer using machine learning strategies Martin Kircher, Udo Stenzel, Janet Kelso Genome Biology 2009, 10:R83 (14 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Ibis is an accurate, fast and easy-to-use base caller for the Illumina Genome Analyzer that reduces error rates and increases output of usable reads.
	Software MouseCyc: a curated biochemical pathways database for the laboratory mouse Alexei V Evsikov, Mary E Dolan, Michael P Genrich, Emily Patek, Carol J Bult Genome Biology 2009, 10:R84 (14 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary MouseCyc is a database of curated metabolic pathways for the laboratory mouse.
	Software Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes Xianjun Dong, David Fredman, Boris Lenhard Genome Biology 2009, 10:R86 (21 August 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Synorth is a web resource for exploring and categorizing the syntenic relationships in gene regulatory blocks across multiple genomes.