Genome Biology | Volume 11 Issue 1

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	Volume 11 Issue 1
	Comment
	Editorial Ten years of Genome Biology Clare Garvey Genome Biology 2010, 11:101 (29 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Huge advances in the field of genomics along with the continued rise of open access has made the past ten years an exciting time to be a biologist.
	Comment Rising in the East Gregory A Petsko Genome Biology 2010, 11:102 (29 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genome sequence of the giant panda using next- generation sequencing marks a watershed in genome sequencing - in more ways than one.
	Review
	Minireview Targeting viral infection by microRNA inhibition Ashley PE Roberts, Catherine L Jopling Genome Biology 2010, 11:201 (26 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An inhibitor of microRNA-122 reduces viral load in chimpanzees that are chronically infected with hepatitis C virus, suggesting that such an approach might have therapeutic potential in humans.
	Minireview Assembling genomes using short-read sequencing technology Shaun D Jackman, İnanç Birol Genome Biology 2010, 11:202 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short-read sequencing technology can bring gigabase genome assemblies in under a million dollars.
	Minireview Looking for signatures of sex-specific demography and local adaptation on the X chromosome Evelyne Heyer, Laure Segurel Genome Biology 2010, 11:203 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide study of X chromosome genetic diversity in human populations shows the impact of social organization and local adaptation.
	Research
	Research Genomic characterization of the Yersinia genus Peter E Chen, Christopher Cook, Andrew C Stewart, Niranjan Nagarajan, Dan D Sommer, Mihai Pop, Brendan Thomason, Maureen Thomason, Shannon Lentz, Nichole Nolan, Shanmuga Sozhamannan, Alexander Sulakvelidze, Alfred Mateczun, Lei Du, Michael E Zwick, Timothy D Read Genome Biology 2010, 11:R1 (4 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative Yersinia genomics identifies features responsible for the colonization of specific host habitats and the horizontal transfer of virulence determinants.
	Research Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts Ishita S Mehta, Manelle Amira, Amanda J Harvey, Joanna M Bridger Genome Biology 2010, 11:R5 (13 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary Nuclear myosin 1β-dependent repositioning of chromosome territories occurs within 15 minutes of serum starvation in human cells.
	Research Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies Shaolin Wang, Eric Peatman, Jason Abernathy, Geoff Waldbieser, Erika Lindquist, Paul Richardson, Susan Lucas, Mei Wang, Ping Li, Jyothi Thimmapuram, Lei Liu, Deepika Vullaganti, Huseyin Kucuktas, Christopher Murdock, Brian C Small, Melanie Wilson, Hong Liu, Yanliang Jiang, Yoona Lee, Fei Chen, Jianguo Lu, Wenqi Wang, Peng Xu, Benjaporn Somridhivej, Puttharat Baoprasertkul, Jonas Quilang, Zhenxia Sha, Baolong Bao, Yaping Wang, Qun Wang et al. Genome Biology 2010, 11:R8 (22 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twelve cDNA libraries from two species of catfish have been sequenced, resulting in the generation of nearly 500,000 ESTs.
	Research Characterization of X-Linked SNP genotypic variation in globally distributed human populations Amanda M Casto, Jun Z Li, Devin Absher, Richard Myers, Sohini Ramachandran, Marcus W Feldman Genome Biology 2010, 11:R10 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of X-linked genetic variation in human populations provides insights into population structure and demographic patterns.
	Method Integrating phenotype ontologies across multiple species Christopher J Mungall, Georgios V Gkoutos, Cynthia L Smith, Melissa A Haendel, Suzanna E Lewis, Michael Ashburner Genome Biology 2010, 11:R2 (8 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A phenotypic ontology that can be used for the analysis of phenotype-genotype data across multiple species, paving the way for truly cross species translational research.
	Method NetPath: a public resource of curated signal transduction pathways Kumaran Kandasamy, S Sujatha Mohan, Rajesh Raju, Shivakumar Keerthikumar, Ghantasala Kumar, Abhilash K Venugopal, Deepthi Telikicherla, J Daniel Navarro, Suresh Mathivanan, Christian Pecquet, Sashi Gollapudi, Sudhir Tattikota, Shyam Mohan, Hariprasad Padhukasahasram, Yashwanth Subbannayya, Renu Goel, Harrys KC Jacob, Jun Zhong, Raja Sekhar, Vishalakshi Nanjappa, Lavanya Balakrishnan, Roopashree Subbaiah, YL Ramachandra, B Abdul Rahiman, TS Keshava Prasad, Jian-Xin Lin, Jon CD Houtman, Stephen Desiderio, Jean-Christophe Renauld, Stefan N Constantinescu et al. Genome Biology 2010, 11:R3 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data.
	Method Substantial deletion overlap among divergent Arabidopsis genomes revealed by intersection of short reads and tiling arrays Luca Santuari, Sylvain Pradervand, Amelia-Maria Amiguet-Vercher, Jerôme Thomas, Eavan Dorcey, Keith Harshman, Ioannis Xenarios, Thomas E Juenger, Christian S Hardtke Genome Biology 2010, 11:R4 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| f1000 \| Editor’s summary A new approach to detect deletions in divergentgenomes combines short read sequencing and tilling array data. Its utility is demonstrated on Arabidopsis strains.
	Method Genome-wide prediction of transcription factor binding sites using an integrated model Kyoung-Jae Won, Bing Ren, Wei Wang Genome Biology 2010, 11:R7 (22 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new approach for genome-wide transcription factor binding site prediction is presented that integrates sequence and chromatin modification data.
	Method Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data Manuela Marullo, Chiara Zuccato, Caterina Mariotti, Nayana Lahiri, Sarah J Tabrizi, Stefano Di Donato, Elena Cattaneo Genome Biology 2010, 11:R9 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Expressed Alu repeats are a reliable, accurate and universal reference for use in RT-qPCR normalization of human genes
	Software PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes Andreas Ruepp, Andreas Kowarsch, Daniel Schmidl, Felix Buggenthin, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, Fabian J Theis Genome Biology 2010, 11:R6 (20 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary PhenomiR is a comprehensive database of 542 studies reporting deregulation of miRNAs allowing large-scale statistical analysis of miRNA expression changes.