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Volume 13 Issue 1
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Comment |
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The dog particle
Gregory A Petsko Genome Biology 2012, 13:142 (30 January 2012)
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Editor’s summary
In a big announcement suspiciously soon before their funding is renewed, canine researchers have news about the Briggs Noson
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DNA-protein interactions in high definition
Eric M Mendenhall, Bradley E Bernstein Genome Biology 2012, 13:139 (27 January 2012)
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Editor’s summary
Mendenhall and Bernstein highlight ChIP-exo, which is an elegant, genome-wide approach to define the precise DNA sequences bound by transcription factors
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Whack-an-E. coli with the morbidostat
Ofer Fridman, Amir Goldberg, Nathalie Q Balaban Genome Biology 2012, 13:140 (27 January 2012)
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Editor’s summary
Nathalie Balaban and colleagues highlight a landmark study of antibiotic resistance evolutionary trajectories, which is centered on a morbidostat
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Co-survival of the fittest few: mosaic amplification of receptor tyrosine kinases in glioblastoma
Feng Chen, Li Ding Genome Biology 2012, 13:141 (30 January 2012)
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Editor’s summary
Li Ding highlights recent findings suggesting that tumor cells with different driver mutations may coevolve rather than compete during clonal evolution
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Review |
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Transcriptional enhancers in development and disease
Noboru Sakabe, Daniel Savic, Marcelo A Nobrega Genome Biology 2012, 13:238 (23 January 2012)
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Editor’s summary
Distal enhancers are important in development and disease, and genome-wide analyses are now giving greater insights into their function
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What is complex about complex disorders?
Kevin J Mitchell Genome Biology 2012, 13:237 (23 January 2012)
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Editor’s summary
Complex disorders such as diabetes and schizophrenia are really groups of many distinct genetic disorders caused by rare, recent deleterious mutations
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Report |
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Low-cost sequencing opens new insights into diverse plant genomes
Kenneth D Birnbaum Genome Biology 2012, 13:311 (30 January 2012)
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Editor’s summary
A report on the 2011 ?Plant Genomes and Biotechnology: From Genes to Networks? meeting, held at Cold Spring Harbor Laboratory.
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Dynamic systems
Chris Bakal Genome Biology 2012, 13:312 (30 January 2012)
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Editor’s summary
A report of the Wellcome Trust Functional Genomics and Systems Biology Conference, Hinxton, UK, 29 November to 1 December 2011.
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Research |
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Genetic adaptation to high altitude in the Ethiopian highlands
Laura B Scheinfeldt, Sameer Soi, Simon Thompson, Alessia Ranciaro, Dawit Woldemeskel, William Beggs, Charla Lambert, Joseph P Jarvis, Dawit Abate, Gurja Belay, Sarah A Tishkoff Genome Biology 2012, 13:R1 (20 January 2012)
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Editor’s summary
The genetics of hypoxia selection in an Ethiopian high-altitude population are distinct from Andean and Tibetan genotypes, suggestive of convergent evolution
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Implications for health and disease in the genetic signature of the Ashkenazi Jewish population
Saurav Guha, Jeffrey A Rosenfeld, Anil K Malhotra, Annette T Lee, Peter K Gregersen, John M Kane, Itsik Pe'er, Ariel Darvasi, Todd Lencz Genome Biology 2012, 13:R2 (25 January 2012)
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Editor’s summary
A population-specific genetic signature, derived from a large genotyping study, helps explain why some diseases are overrepresented in the Ashkenazi population
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A genome triplication associated with early diversification of the core eudicots
Yuannian Jiao, Jim Leebens-Mack, Saravanaraj Ayyampalayam, John E Bowers, Michael R McKain, Joel McNeal, Megan Rolf, Daniel R Ruzicka, Eric Wafula, Norman J Wickett, Xiaolei Wu, Yong Zhang, Jun Wang, Yeting Zhang, Eric J Carpenter, Michael K Deyholos, Toni M Kutchan, Andre S Chanderbali, Pamela S Soltis, Dennis W Stevenson, Richard McCombie, J Pires, Gane Wong, Douglas E Soltis, Claude W dePamphilis Genome Biology 2012, 13:R3 (26 January 2012)
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Editor’s summary
An investigation of when the gamma polyploidization event occurred in relation to speciation events in angiosperm history
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Dissecting the regulatory architecture of gene expression QTLs
Daniel J Gaffney, Jean-Baptiste Veyrieras, Jacob F Degner, Roger Pique-Regi, Athma A Pai, Gregory E Crawford, Matthew Stephens, Yoav Gilad, Jonathan K Pritchard Genome Biology 2012, 13:R7 (31 January 2012)
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Editor’s summary
An analysis of eQTLs located in regulatory elements in the human genome
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SpliceGrapher: detecting patterns of alternative splicing from RNA-Seq data in the context of gene models and EST data
Mark F Rogers, Julie Thomas, Anireddy SN Reddy, Asa Ben-Hur Genome Biology 2012, 13:R4 (31 January 2012)
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Editor’s summary
A tool that uses a priori information to optimize alternative splicing prediction from RNA-seq data
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Uberon, an integrative multi-species anatomy ontology
Christopher J Mungall, Carlo Torniai, Georgios V Gkoutos, Suzanna E Lewis, Melissa A Haendel Genome Biology 2012, 13:R5 (31 January 2012)
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Editor’s summary
A description of the Uberon ontology tool that allows comparisons of genomic information across multiple animal phyla
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MetaMerge: scaling up genome-scale metabolic reconstructions with application to Mycobacterium tuberculosis
Leonid Chindelevitch, Sarah Stanley, Deborah Hung, Aviv Regev, Bonnie Berger Genome Biology 2012, 13:r6 (31 January 2012)
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Editor’s summary
An algorithm that reconciles metabolic network reconstructions into a single model
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Correspondence |
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Sequencing three crocodilian genomes to illuminate the evolution of archosaurs and amniotes
John A St John, Edward L Braun, Sally R Isberg, Lee G Miles, Amanda Y Chong, Jaime Gongora, Pauline Dalzell, Christopher Moran, Bertrand Bed'Hom, Arkhat Abzhanov, Shane C Burgess, Amanda M Cooksey, Todd A Castoe, Nicholas G Crawford, Llewellyn D Densmore, Jennifer C Drew, Scott V Edwards, Brant C Faircloth, Matthew K Fujita, Matthew J Greenwold, Federico G Hoffmann, Jonathan M Howard, Taisen Iguchi, Daniel E Janes, Shahid Khan, Satomi Kohno, AP Jason de Koning, Stacey L Lance, Fiona M McCarthy, John E McCormack et al.
Genome Biology 2012, 13:415 (31 January 2012)
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Editor’s summary
An Open Letter describing the project to sequence the genomes of the saltwater crocodile, the American alligator and the Indian gharial
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