Genome Biology | Volume 13 Issue 2

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	Volume 13 Issue 2
	Comment
	Editorial The Research Works Act: a comment Naomi Attar, GB Editorial Team Genome Biology 2012, 13:416 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A bill before Congress aims to skew the market and bar those paying for research (taxpayers) from access to its benefits
	Comment A case of the flu Gregory A Petsko Genome Biology 2012, 13:146 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The public perception of science is a crucial factor in whether the availability of recent work on constructing a virulent strain of influenza should be restricted
	Research highlight Extensive regulation of NAGNAG alternative splicing: new tricks for the spliceosome? Anke Busch, Klemens J Hertel Genome Biology 2012, 13:143 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Anke Busch and Klemens Hertel highlight a recent RNA-seq study demonstrating that alternative tandem acceptor splicing is tissue-specifically regulated
	Research highlight Old soldiers never die .... Jacobus J Boomsma, Sanne Nygaard Genome Biology 2012, 13:144 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A Research Highlight by Boomsma and Nygaard on the evolutionary persistence of "supersoldier" development pathway potential in supersoldier-less ant lineages
	Research highlight Maternal-to-zygotic transition: soma versus germline Martine Simonelig Genome Biology 2012, 13:145 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Martine Simonelig highlights our Research article on differences between the Drosophila maternal-to-zygotic transition in primordial germ cells and soma
	Review
	Review The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks Tatiana V Morozova, David Goldman, Trudy FC Mackay, Robert RH Anholt Genome Biology 2012, 13:239 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Robert Anholt and colleagues describe the genetics underlying alcohol-related phenotypes emerging from GWAS and work on genetically tractable model organisms
	Review Synthetic biology: advancing biological frontiers by building synthetic systems Yvonne Y Chen, Kate E Galloway, Christina D Smolke Genome Biology 2012, 13:240 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Christina Smolke and colleagues review an emerging science, whose frontiers include biomanufacturing, radical therapeutic approaches, and insights into natural biological systems
	Report
	Meeting report Epigenomics and chromatin dynamics Veronika Akopian, Michelle M Chan, Kendell Clement, Christina Galonska, Casey A Gifford, Elizabeth Lehtola, Jing Liao, Payman Samavarchi-Tehrani, Camille Sindhu, Zachary D Smith, Alexander M Tsankov, Jamie Webster, Yingying Zhang, Michael J Ziller, Alexander Meissner Genome Biology 2012, 13:313 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Joint Keystone Symposium on Epigenomics and Chromatin Dynamics, Keystone, Colorado, 17-22 January 2012
	Research
	Research Population-specificity of human DNA methylation Hunter B Fraser, Lucia L Lam, Sarah M Neumann, Michael S Kobor Genome Biology 2012, 13:R8 (9 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Measurement of TSS-proximal DNA methylation in CEU and YRI genomes reveals significant population specificity
	Research Autosomal monoallelic expression in the mouse Lillian M Zwemer, Alexander Zak, Benjamin R Thompson, Andrew Kirby, Mark J Daly, Andrew Chess, Alexander A Gimelbrant Genome Biology 2012, 13:R10 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comprehensive genome-wide analysis of random monoallelic expression in mouse, and a detailed comparison with human
	Research Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells Najeeb U Siddiqui, Xiao Li, Hua Luo, Angelo Karaiskakis, Huayun Hou, Thomas Kislinger, J Timothy Westwood, Quaid Morris, Howard D Lipshitz Genome Biology 2012, 13:R11 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Maternal-to-zygotic transition in Drosophila primordial germ cells is delayed relative to the soma and requires the RNA-binding protein Smaug
	Research Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase Radek Szklarczyk, Bas FJ Wanschers, Thomas D Cuypers, John J Esseling, Moniek Riemersma, Mariël AM van den Brand, Jolein Gloerich, Edwin Lasonder, Lambert P van den Heuvel, Leo G Nijtmans, Martijn A Huynen Genome Biology 2012, 13:R12 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An iterative orthology prediction method identifies previously uncharacterized human orthologs of yeast mitochondrial proteins that are robust to multiple validation approaches
	Research Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence Julie MJ Lepesant, Céline Cosseau, Jérome Boissier, Michael Freitag, Julien Portela, Déborah Climent, Cécile Perrin, Adhemar Zerlotini, Christoph Grunau Genome Biology 2012, 13:R14 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sex chromosome-specific sequences are identified in the blood fluke genome, shedding light on sex chromosome evolution
	Research Characterizing linkage disequilibrium and evaluating imputation power of human genomic insertion-deletion polymorphisms James T Lu, Yi Wang, Richard A Gibbs, Fuli Yu Genome Biology 2012, 13:R15 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of 1000 Genomes phase 3 data reveals that indels are in tight linkage disequilibrium with SNPs
	Method Predicting the effects of frameshifting indels Jing Hu, Pauline C Ng Genome Biology 2012, 13:R9 (9 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SIFT Indel is a method for predicting the effects of frameshifting indels in coding regions
	Method All Your Base: a fast and accurate probabilistic approach to base calling Tim Massingham, Nick Goldman Genome Biology 2012, 13:R13 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A fast and accurate base calling method enables improved genotyping and assembly compared to existing tools

	Volume 13 Issue 2
	Comment
	Editorial The Research Works Act: a comment Naomi Attar, GB Editorial Team Genome Biology 2012, 13:416 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A bill before Congress aims to skew the market and bar those paying for research (taxpayers) from access to its benefits
	Comment A case of the flu Gregory A Petsko Genome Biology 2012, 13:146 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The public perception of science is a crucial factor in whether the availability of recent work on constructing a virulent strain of influenza should be restricted
	Research highlight Extensive regulation of NAGNAG alternative splicing: new tricks for the spliceosome? Anke Busch, Klemens J Hertel Genome Biology 2012, 13:143 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Anke Busch and Klemens Hertel highlight a recent RNA-seq study demonstrating that alternative tandem acceptor splicing is tissue-specifically regulated
	Research highlight Old soldiers never die .... Jacobus J Boomsma, Sanne Nygaard Genome Biology 2012, 13:144 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A Research Highlight by Boomsma and Nygaard on the evolutionary persistence of "supersoldier" development pathway potential in supersoldier-less ant lineages
	Research highlight Maternal-to-zygotic transition: soma versus germline Martine Simonelig Genome Biology 2012, 13:145 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Martine Simonelig highlights our Research article on differences between the Drosophila maternal-to-zygotic transition in primordial germ cells and soma
	Review
	Review The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks Tatiana V Morozova, David Goldman, Trudy FC Mackay, Robert RH Anholt Genome Biology 2012, 13:239 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Robert Anholt and colleagues describe the genetics underlying alcohol-related phenotypes emerging from GWAS and work on genetically tractable model organisms
	Review Synthetic biology: advancing biological frontiers by building synthetic systems Yvonne Y Chen, Kate E Galloway, Christina D Smolke Genome Biology 2012, 13:240 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Christina Smolke and colleagues review an emerging science, whose frontiers include biomanufacturing, radical therapeutic approaches, and insights into natural biological systems
	Report
	Meeting report Epigenomics and chromatin dynamics Veronika Akopian, Michelle M Chan, Kendell Clement, Christina Galonska, Casey A Gifford, Elizabeth Lehtola, Jing Liao, Payman Samavarchi-Tehrani, Camille Sindhu, Zachary D Smith, Alexander M Tsankov, Jamie Webster, Yingying Zhang, Michael J Ziller, Alexander Meissner Genome Biology 2012, 13:313 (24 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Joint Keystone Symposium on Epigenomics and Chromatin Dynamics, Keystone, Colorado, 17-22 January 2012
	Research
	Research Population-specificity of human DNA methylation Hunter B Fraser, Lucia L Lam, Sarah M Neumann, Michael S Kobor Genome Biology 2012, 13:R8 (9 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Measurement of TSS-proximal DNA methylation in CEU and YRI genomes reveals significant population specificity
	Research Autosomal monoallelic expression in the mouse Lillian M Zwemer, Alexander Zak, Benjamin R Thompson, Andrew Kirby, Mark J Daly, Andrew Chess, Alexander A Gimelbrant Genome Biology 2012, 13:R10 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comprehensive genome-wide analysis of random monoallelic expression in mouse, and a detailed comparison with human
	Research Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells Najeeb U Siddiqui, Xiao Li, Hua Luo, Angelo Karaiskakis, Huayun Hou, Thomas Kislinger, J Timothy Westwood, Quaid Morris, Howard D Lipshitz Genome Biology 2012, 13:R11 (20 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Maternal-to-zygotic transition in Drosophila primordial germ cells is delayed relative to the soma and requires the RNA-binding protein Smaug
	Research Iterative orthology prediction uncovers new mitochondrial proteins and identifies C12orf62 as the human ortholog of COX14, a protein involved in the assembly of cytochrome c oxidase Radek Szklarczyk, Bas FJ Wanschers, Thomas D Cuypers, John J Esseling, Moniek Riemersma, Mariël AM van den Brand, Jolein Gloerich, Edwin Lasonder, Lambert P van den Heuvel, Leo G Nijtmans, Martijn A Huynen Genome Biology 2012, 13:R12 (22 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An iterative orthology prediction method identifies previously uncharacterized human orthologs of yeast mitochondrial proteins that are robust to multiple validation approaches
	Research Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence Julie MJ Lepesant, Céline Cosseau, Jérome Boissier, Michael Freitag, Julien Portela, Déborah Climent, Cécile Perrin, Adhemar Zerlotini, Christoph Grunau Genome Biology 2012, 13:R14 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sex chromosome-specific sequences are identified in the blood fluke genome, shedding light on sex chromosome evolution
	Research Characterizing linkage disequilibrium and evaluating imputation power of human genomic insertion-deletion polymorphisms James T Lu, Yi Wang, Richard A Gibbs, Fuli Yu Genome Biology 2012, 13:R15 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Analysis of 1000 Genomes phase 3 data reveals that indels are in tight linkage disequilibrium with SNPs
	Method Predicting the effects of frameshifting indels Jing Hu, Pauline C Ng Genome Biology 2012, 13:R9 (9 February 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary SIFT Indel is a method for predicting the effects of frameshifting indels in coding regions
	Method All Your Base: a fast and accurate probabilistic approach to base calling Tim Massingham, Nick Goldman Genome Biology 2012, 13:R13 (29 February 2012) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A fast and accurate base calling method enables improved genotyping and assembly compared to existing tools

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Volume 13 Issue 2

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