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Volume 13 Issue 3
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Comment |
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Apocalypse now?
Gregory A Petsko Genome Biology 2012, 13:151 (30 March 2012)
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Editor’s summary
Greg Petsko identifies some signs of the coming end of the world and, in that context, urges readers to pay close attention to the coming US presidential election
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Toward a complete Drosophila deficiency kit
John Roote, Steven Russell Genome Biology 2012, 13:149 (23 March 2012)
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Editor’s summary
Roote and Russell discuss our Research article describing the development of a second-generation Drosophila deficiency kit
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Modifier genetics in neuropsychiatric disease: challenges and opportunities
Elizabeth K Ruzzo, Andrea L Pappas, David B Goldstein Genome Biology 2012, 13:150 (28 March 2012)
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Editor’s summary
David Goldstein and colleagues highlight a recent study that focuses attention on multigenic interactions influencing the risk of autism spectrum disorders
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Review |
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Life at the extreme: lessons from the genome
Dong-Ha Oh, Maheshi Dassanayake, Hans J Bohnert, John M Cheeseman Genome Biology 2012, 13:241 (6 March 2012)
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Editor’s summary
High-throughput studies are providing insights into how extremophile plants adapt to life in places where most plant species cannot survive
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The R-spondin protein family
Wim BM de Lau, Berend Snel, Hans C Clevers Genome Biology 2012, 13:242 (22 March 2012)
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Editor’s summary
Hans Clevers and colleagues review R-spondins, a protein family of potent stem cell proliferation stimulators with potential utility in regenerative medicine
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Women in Science
Genome Biology Genome Biology 2012, 13:148 (8 March 2012)
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Editor’s summary
Four leading scientists answer our questions on how being female can impact upon a scientific career
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Q & A: the Snyderome
Michael Snyder Genome Biology 2012, 13:147 (16 March 2012)
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Editor’s summary
Michael Snyder answers Genome Biology's questions on the human and professional stories underlying his Snyderome integrative omics project
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Report |
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Faster sequencers, larger datasets, new challenges
Christopher E Mason, Olivier Elemento Genome Biology 2012, 13:314 (27 March 2012)
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Editor’s summary
The Advances in Genome Biology and Technology (AGBT) meeting included announcements of some major advances in sequencing technology
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Research |
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The fine-scale architecture of structural variants in 17 mouse genomes
Binnaz Yalcin, Kim Wong, Amarjit Bhomra, Martin Goodson, Thomas M Keane, David J Adams, Jonathan Flint Genome Biology 2012, 13:R18 (20 March 2012)
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Editor’s summary
An extensive characterization of structural variations in the genomes of seventeen inbred mouse strains
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The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes
Minna-Liisa Änkö, Michaela Müller-McNicoll, Holger Brandl, Tomaz Curk, Crtomir Gorup, Ian Henry, Jernej Ule, Karla M Neugebauer Genome Biology 2012, 13:R17 (21 March 2012)
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Editor’s summary
RNA-binding protein SRSF3 is the master regulator of a splicing network, and - together with SRSF4 - mysteriously regulates unsplicable histone transcripts
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Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNA-seq, RNA interference and irradiation approach
Jordi Solana, Damian Kao, Yuliana Mihaylova, Farah Jaber-Hijazi, Sunir Malla, Ray Wilson, Aziz Aboobaker Genome Biology 2012, 13:R19 (22 March 2012)
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Editor’s summary
Planarian stem cells are ablated by RNAi against histone 2B and the neoblast-specific transcriptome is determined
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Genome-wide analysis of plant nat-siRNAs reveals insights into their distribution, biogenesis and function
Xiaoming Zhang, Jing Xia, Yifan E Lii, Blanca E Barrera-Figueroa, Xuefeng Zhou, Shang Gao, Lu Lu, Dongdong Niu, Zheng Chen, Christy Leung, Timothy Wong, Huiming Zhang, Jianhua Guo, Yi Li, Renyi Liu, Wanqi Liang, Jian-Kang Zhu, Weixiong Zhang, Hailing Jin Genome Biology 2012, 13:R20 (22 March 2012)
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Editor’s summary
In Arabidopsis and rice, natural antisense transcripts are processed into siRNAs by DCL1 and DCL3
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The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome
R Kimberley Cook, Stacey J Christensen, Jennifer A Deal, Rachel A Coburn, Megan E Deal, Jill M Gresens, Thomas C Kaufman, Kevin R Cook Genome Biology 2012, 13:R21 (22 March 2012)
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Editor’s summary
A new, large-scale collection of Drosophila deficiency strains from the BDSC, providing increased coverage of the genome
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MAnorm: a robust model for quantitative comparison of ChIP-Seq data sets
Zhen Shao, Yijing Zhang, Guo-Cheng Yuan, Stuart H Orkin, David J Waxman Genome Biology 2012, 13:R16 (16 March 2012)
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Editor’s summary
MAnorm is a method for quantitative comparison of ChIP-seq datasets
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An integrative probabilistic model for identification of structural variation in sequencing data
Suzanne S Sindi, Selim Önal, Luke C Peng, Hsin-Ta Wu, Benjamin J Raphael Genome Biology 2012, 13:R22 (27 March 2012)
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Editor’s summary
GASVpro is a method for structural variant detection that takes in to account both paired read and read depth signals
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Efficient and robust RNA-seq process for cultured bacteria and complex community transcriptomes
Georgia Giannoukos, Dawn M Ciulla, Katherine Huang, Brian J Haas, Jacques Izard, Joshua Z Levin, Jonathan Livny, Ashlee M Earl, Dirk Gevers, Doyle V Ward, Chad Nusbaum, Bruce W Birren, Andreas Gnirke Genome Biology 2012, 13:r23 (28 March 2012)
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Editor’s summary
A method is presented for transcriptome sequencing of complex bacterial mixtures or communities
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The Transcription Factor Encyclopedia
Dimas Yusuf, Stefanie L Butland, Magdalena I Swanson, Eugene Bolotin, Amy Ticoll, Warren A Cheung, Xiao Cindy Zhang, Christopher TD Dickman, Debra L Fulton, Jonathan S Lim, Jake M Schnabl, Oscar HP Ramos, Mireille Vasseur-Cognet, Charles N de Leeuw, Elizabeth M Simpson, Gerhart U Ryffel, Eric W-F Lam, Ralf Kist, Miranda SC Wilson, Raquel Marco-Ferreres, Jan J Brosens, Leonardo L Beccari, Paola Bovolenta, Bérénice A Benayoun, Lara J Monteiro, Helma DC Schwenen, Lars Grontved, Elizabeth Wederell, Susanne Mandrup, Reiner A Veitia et al.
Genome Biology 2012, 13:R24 (29 March 2012)
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Editor’s summary
A high quality compendium of transcription factor data that allows researchers to add new data via a peer-review system
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