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Volume 13 Issue 5
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Comment |
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Goodbye, Columbus
Gregory A Petsko Genome Biology 2012, 13:155 (18 May 2012)
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Editor’s summary
Guaranteeing experimental outcomes and findings: funding then and now
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Layer cake: the first bite at gene expression diversity in the human brain
Philipp Khaitovich Genome Biology 2012, 13:157 (22 May 2012)
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Editor’s summary
Philipp Khaitovich highlights research by Allan Jones and colleagues that assesses regional gene expression in the human brain neocortex
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Enhancer dysfunction: how the main regulators of gene expression contribute to cancer
Siavash K Kurdistani Genome Biology 2012, 13:156 (23 May 2012)
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Editor’s summary
A Research Highlight on the role of variant epigenetics in establishing an enhancer element-mediated oncogenic transcriptional program
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Review |
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High-throughput sequencing to decipher the genetic heterogeneity of deafness
Zippora Brownstein, Yoni Bhonker, Karen B Avraham Genome Biology 2012, 13:245 (29 May 2012)
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Editor’s summary
High-throughput sequencing approaches have accelerated the discovery of genes related to hearing loss, and may reshape clinical diagnosis of deafness
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Power to the people: a wiki-governance model for biobanks
Edward S Dove, Yann Joly, Bartha M Knoppers Genome Biology 2012, 13:158 (29 May 2012)
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Editor’s summary
Edward Dove and colleagues propose a wiki-governance model for biobanks that gives citizens the ability to collaborate in biobank governance and policymaking.
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Report |
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A Keystone for ncRNA
Ezgi Hacisuleyman, Moran N Cabili, John L Rinn Genome Biology 2012, 13:315 (25 May 2012)
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Editor’s summary
John Rinn and colleagues give a report on the Keystone symposium 'Non-coding RNAs' held at Snowbird, Utah, USA, 31 March to 5 April 2012.
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Research |
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Mammalian tissues defective in nonsense-mediated mRNA decay display highly aberrant splicing patterns
Joachim Weischenfeldt, Johannes Waage, Geng Tian, Jing Zhao, Inge Damgaard, Janus Jakobsen, Karsten Kristiansen, Anders Krogh, Jun Wang, Bo T Porse Genome Biology 2012, 13:R35 (24 May 2012)
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Editor’s summary
An extensive in vivo analysis of how nonsense mediated mRNA decay regulates alternative splicing in two mouse tissues
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A systematic screen reveals new elements acting at the G2/M cell cycle control
Francisco J Navarro, Paul Nurse Genome Biology 2012, 13:R36 (24 May 2012)
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Editor’s summary
A screen for regulators of the G2/M transition in fission yeast reveals novel regulators of cell cycle control
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Comparative multi-omics systems analysis of Escherichia coli strains B and K-12
Sung Yoon, Mee-Jung Han, Haeyoung Jeong, Choong Lee, Xiao-Xia Xia, Dae-Hee Lee, Ji Shim, Sang Lee, Tae Oh, Jihyun F Kim Genome Biology 2012, 13:R37 (25 May 2012)
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Editor’s summary
An analysis of multi-omics data and the generation of a genome-scale metabolic network to determine the phenotypic characteristics of E. coli
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Genomic diversity of the human intestinal parasite Entamoeba histolytica
Gareth D Weedall, C Graham Clark, Pia Koldkjaer, Suzanne Kay, Iris Bruchhaus, Egbert Tannich, Steve Paterson, Neil Hall Genome Biology 2012, 13:R38 (25 May 2012)
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Editor’s summary
Ten strains of Entamoeba histolytica are sequenced. Low levels of genetic diversity are found, and evidence for sexual reproduction is uncovered
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The genome of the polar eukaryotic microalga Coccomyxa subellipsoidea reveals traits of cold adaptation
Guillaume Blanc, Irina Agarkova, Jane Grimwood, Alan Kuo, Andrew Brueggeman, David D Dunigan, James Gurnon, Istvan Ladunga, Erika Lindquist, Susan Lucas, Jasmyn Pangilinan, Thomas Pröschold, Asaf Salamov, Jeremy Schmutz, Donald Weeks, Takashi Yamada, Alexandre Lomsadze, Mark Borodovsky, Jean-Michel Claverie, Igor V Grigoriev, James L Van Etten Genome Biology 2012, 13:R39 (25 May 2012)
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Editor’s summary
The first genome of a polar eukaryotic microorganism, an alga called Coccomyxa subellipsoidea C-169, reveals universal strategies for cold adaptation
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A new approach for detecting low-level mutations in next-generation sequence data
Mingkun Li, Mark Stoneking Genome Biology 2012, 13:R34 (23 May 2012)
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Editor’s summary
A method is presented for differentiating mutations present at low level in a sample from sequencing errors
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A high-throughput approach to identify genomic variants of bacterial metabolite producers at the single-cell level
Stephan Binder, Georg Schendzielorz, Norma Stäbler, Karin Krumbach, Kristina Hoffmann, Michael Bott, Lothar Eggeling Genome Biology 2012, 13:R40 (28 May 2012)
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Editor’s summary
A novel high-throughput method that uses in vivo metabolite sensors to identify bacterial metabolite producers
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Correspondence |
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A quantitative literature-curated gold standard for kinase-substrate pairs
Sara Sharifpoor, Alex N Nguyen Ba, Ji-Young Youn, Dewald van Dyk, Helena Friesen, Alison C Douglas, Christoph F Kurat, Yolanda T Chong, Karen Founk, Alan M Moses, Brenda J Andrews Genome Biology 2012, 13:417 (10 May 2012)
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