Genome Biology | Volume 2 Issue 11

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	Volume 2 Issue 11
	Comment
	Comment Winter, plague and pestilence Gregory A Petsko Genome Biology 2001, 2:comment1013-comment1013.2 (23 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary "From winter, plague and pestilence, good Lord, deliver us."
	Opinion What does a worm want with 20,000 genes? Jonathan Hodgkin Genome Biology 2001, 2:comment2008-comment2008.4 (17 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The number of genes predicted for the Caenorhabditis elegans genome is remarkably high: approximately 20,000, if both protein-coding and RNA-coding genes are counted. This article discusses possible explanations for such a high value.
	Opinion What use is the human genome for understanding the mouse? Paul Denny, Rachael Bate, Ann-Marie Mallon Genome Biology 2001, 2:comment2009-comment2009.5 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Having a working draft of the human genome sequence is proving invaluable to mouse genetic and genomic studies, providing a useful stepping-stone towards the finished sequence of the mouse genome.
	Review
	Protein family review The syntaxins Felicia Yu Hsuan Teng, Ya Wang, Bor Luen Tang Genome Biology 2001, 2:reviews3012-reviews3012.7 (24 October 2001) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Syntaxins are SNAP receptors (SNAREs) that mediate and provide specificity to vesicle fusion processes in the exocytic and endocytic pathways. There are 15 syntaxins in the human genome, and syntaxin-like genes are found in all eukaryotes.
	Minireview HIV: master of the host cell Christopher W Arendt, Dan R Littman Genome Biology 2001, 2:reviews1030-reviews1030.4 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses to HIV.
	Minireview Intraepithelial gamma delta T cells exposed by functional genomics Richard Boismenu, Wendy L Havran Genome Biology 2001, 2:reviews1031-reviews1031.4 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Whole-genome gene-expression analysis provides a new way to study the signals required for the activation of γδ T cells, their mode of action and relationships among cells of the mucosal immune system.
	Report
	Web report Prostate gene expression Steven G Gray Genome Biology 2001, 2:reports2015 (25 October 2001) Abstract \| Full text
	Web report Human-fly homologies Steven G Gray Genome Biology 2001, 2:reports2016 (25 October 2001) Abstract \| Full text \| Editor’s summary HOMOPHILA is a searchable database of human disease genes, obtained from the Online Mendelian Inheritance in Man database, that have significant homology at the protein level to genes contained in FlyBase, the current Drosophila sequence database.
	Web report Asthma genetics Steven G Gray Genome Biology 2001, 2:reports2017 (25 October 2001) Abstract \| Full text \| Editor’s summary The broad-ranging Asthma and Allergy Gene Database covers many aspects of asthma and allergy genetics, including linkage data, gene expression data and gene therapy trials.
	Paper report Centenarian genes Norman A Johnson Genome Biology 2001, 2:reports0039 (23 October 2001) Abstract \| Full text
	Paper report Possible target for male contraception John C Rockett Genome Biology 2001, 2:reports0040 (26 October 2001) Abstract \| Full text \| Editor’s summary A human sperm-specific protein has been isolated that may prove useful in the development of a contraceptive vaccine.
	Paper report New bugs in the human genome draft Reiner Veitia Genome Biology 2001, 2:reports0041 (26 October 2001) Abstract \| Full text
	Paper report Virtual restriction analysis Agnieszka M Lichanska Genome Biology 2001, 2:reports0042 (26 October 2001) Abstract \| Full text \| Editor’s summary A new computational method for whole-genome analysis by in silico restriction mapping has been developed and has been evaluated by comparison with experimental restriction analysis of tumor DNA.
	Paper report Cell biology in orbit Agnieszka M Lichanska Genome Biology 2001, 2:reports0043 (26 October 2001) Abstract \| Full text
	Meeting report Evolution enters the genomic era David A Liberles Genome Biology 2001, 2:reports4026-reports4026.5 (12 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 18th Congress of the European Society for Evolutionary Biology (ESEB), Aarhus, Denmark, 20-25 August, 2001.
	Meeting report Learning the language of cell-cell communication through connexin channels Roberto Bruzzone Genome Biology 2001, 2:reports4027-reports4027.5 (15 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Ninth International Gap Junction Conference, Honolulu, USA, 4-9 August 2001.
	Meeting report DNA-damage signaling and apoptosis Noel F Lowndes Genome Biology 2001, 2:reports4028-reports4028.2 (24 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 674th meeting of the Biochemical Society, Dublin, Ireland, 11-12 July 2001.
	Meeting report Human fungal pathogens accelerate into the genomics era Melissa Straffon Genome Biology 2001, 2:reports4029-reports4029.3 (24 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Euroconference on Fungal Virulence Factors and Disease: 'Human Fungal Pathogens', Seefeld, Austria, 8-13 September 2001.
	Research news Autocrine loops Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011101-01 (1 November 2001) Abstract \| Full text \| Editor’s summary Analysis of expression-profiling data identifies ligand-receptor pairs and autocrine signalling loops involved in cancer.
	Research news Hammerhead selection Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011102-01 (2 November 2001) Abstract \| Full text \| Editor’s summary Hammerhead ribozymes appear to be the molecules of choice for self-cleaving RNAs.
	Research news Light-induced apoptosis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011105-01 (5 November 2001) Abstract \| Full text \| Editor’s summary Analysis of light-induced apoptosis in mouse retinas identifies clusters of genes that respond differentially to illumination.
	Research news More genes on the fly Y Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011106-01 (6 November 2001) Abstract \| Full text \| Editor’s summary Screening of the unmapped heterochromatic fragments of the Drosophila genome has identified five new genes from the Y chromosome.
	Research news Sanger Institute looks to the future Susan Aldridge Genome Biology 2001, 2:spotlight-20011106-02 (6 November 2001) Abstract \| Full text \| Editor’s summary Following the completion of the first draft of the Human Genome the Sanger Institute looks to the post-genomic future.
	Research news PTEN profiling Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011107-01 (7 November 2001) Abstract \| Full text \| Editor’s summary Microarray analysis using an inducible expression system identifies genes regulated by the PTEN tumour suppressor.
	Research news Placental profiling Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011108-01 (8 November 2001) Abstract \| Full text \| Editor’s summary A combination of cDNA subtraction and microarray hybridization identifies genes expressed during placental development.
	Research news What is the normal range for gene expression? Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011109-01 (9 November 2001) Abstract \| Full text \| Editor’s summary Microarray analysis attempts to define the range of normal variation in mouse gene expression in vivo.
	Research news Barcode screening Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011112-01 (12 November 2001) Abstract \| Full text \| Editor’s summary A 'barcode' screen of yeast pools has identified genes associated with nonhomologous end joining.
	Research news Ancient introns Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011113-01 (13 November 2001) Abstract \| Full text \| Editor’s summary A computer program, INTRONMAP, investigates the origins and evolution of introns.
	Research news Translation defects Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011114-01 (14 November 2001) Abstract \| Full text \| Editor’s summary Mutations in two different subunits of the translation initiation factor eIF2B are found in patients with a severe neurological disorder.
	Research news Genomic workout in Parkinson disease Tudor Toma Genome Biology 2001, 2:spotlight-20011115-01 (15 November 2001) Abstract \| Full text \| Editor’s summary New work suggests that different genetic factors influence the development of early- and late-onset Parkinson disease.
	Research news Human endogenous retroviruses Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011115-02 (15 November 2001) Abstract \| Full text \| Editor’s summary Analysis of human endogenous retrovirus (HERV) sequences suggests how they might have affected evolution of the human genome.
	Research news Genetics of social behaviour Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011116-01 (16 November 2001) Abstract \| Full text \| Editor’s summary A gene involved in colony social organization of fire ants has been identified.
	Research news Resistance to vCJD Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011119-01 (19 November 2001) Abstract \| Full text \| Editor’s summary HLA typing may identify groups at risk for variant Creutzfeldt-Jakob disease.
	Research news Hemoglobin and malaria Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011120-01 (20 November 2001) Abstract \| Full text \| Editor’s summary Hemoglobin C alleles are associated with protection from malaria in West Africa.
	Research news Fly SNPs Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011121-01 (21 November 2001) Abstract \| Full text \| Editor’s summary The generation of a SNP map for the Drosophila genome will accelerate the rate of positional cloning in flies.
	Research news Radiation resistance Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011122-01 (22 November 2001) Abstract \| Full text \| Editor’s summary A screen of diploid yeast mutants has identified over a hundred genes involved in the response to ionizing radiation.
	Research news Genetic classification of lung tumors Tudor Toma Genome Biology 2001, 2:spotlight-20011123-01 (23 November 2001) Abstract \| Full text \| Editor’s summary DNA microarray studies of crudely dissected lung tumors can detect tumor subtypes that correlate with biological and clinical phenotypes.
	Research news Genomic systems biology Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011123-02 (23 November 2001) Abstract \| Full text \| Editor’s summary Combining genetic and physiological analysis can identify loci involved in complex disease conditions.
	Research news Limited variation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011126-01 (26 November 2001) Abstract \| Full text \| Editor’s summary Microarray analysis of SNPs on human chromosome 21 has revealed more limited haplotype diversity than expected.
	Research news Parasites bare all David Bruce Genome Biology 2001, 2:spotlight-20011126-02 (26 November 2001) Abstract \| Full text \| Editor’s summary The completion of a microsporidian parasite genome could have important implications for microbial comparative genomics.
	Research news Arsenic and old telomerase Tudor Toma Genome Biology 2001, 2:spotlight-20011127-01 (27 November 2001) Abstract \| Full text \| Editor’s summary Arsenic inhibits the transcription of the reverse transcriptase subunit of the human telomerase gene.
	Research news Predicting promoters Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011128-01 (28 November 2001) Abstract \| Full text \| Editor’s summary A new computer program aims to predict promoters and first exons within genomic sequences.
	Research news Radiation resistance genes discovered Vicki Glaser Genome Biology 2001, 2:spotlight-20011129-01 (29 November 2001) Abstract \| Full text \| Editor’s summary Analysis of gene function in radiation-exposed yeast cells reveals that many more cellular pathways are affected than previously thought.
	Research news Regulating the hypoxia response Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011129-02 (29 November 2001) Abstract \| Full text \| Editor’s summary A novel protein inhibits angiogenesis by regulating hypoxia-induced gene expression.
	Research news Transgene transfer Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011130-01 (30 November 2001) Abstract \| Full text \| Editor’s summary Analysis of native maize plants from remote Mexican locations provides evidence for gene flow from transgenic plants.
	Research
	Research Detection of chromosomes tagged with green fluorescent protein in live Arabidopsis thaliana plants Naohiro Kato, Eric Lam Genome Biology 2001, 2:research0045-research0045.10 (12 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary GFP fused to DNA-binding proteins can be used in conjunction with concatameric binding-site arrays to track genomic loci in living plants, allowing study of the organization and dynamics of chromatin in specific cell types during various times of development.
	Research Prediction of co-regulated genes in Bacillus subtilis on the basis of upstream elements conserved across three closely related species Goro Terai, Toshihisa Takagi, Kenta Nakai Genome Biology 2001, 2:research0048-research0048.12 (15 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Three closely related species of Bacillus were used to identify co-regulated genes in Bacillus subtilis. 1,884 phylogenetically conserved elements from the upstream intergenic regions of 1,568 B. subtilis genes were identified.
	Research Sources of nonlinearity in cDNA microarray expression measurements Latha Ramdas, Kevin R Coombes, Keith Baggerly, Lynne Abruzzo, W Edward Highsmith, Tammy Krogmann, Stanley R Hamilton, Wei Zhang Genome Biology 2001, 2:research0047-research0047.7 (18 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary To test the assumption that quantified signal intensities of microarray data are linearly related to expression levels, the relationship between signal and expression was examinde for two types of microarray.
	Research The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis Robert W Williams, Jing Gu, Shuhua Qi, Lu Lu Genome Biology 2001, 2:research0046-research0046.18 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The density of typed microsatellite markers has been increased 2- to 5-fold in each of several major recombinant inbred sets of mice and consensus RI maps that integrate genotypes of approximately 1600 microsatellite loci assembled.
	Research Optimality of the genetic code with respect to protein stability and amino-acid frequencies Dimitri Gilis, Serge Massar, Nicolas J Cerf, Marianne Rooman Genome Biology 2001, 2:research0049-research0049.12 (24 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Previous studies have attempted to address the fraction of randomly generated genetic codes that do better than the genetic code in respect of overall robustness. This study estimates that around two random codes in 109 are fitter than the natural code.
	Software RESOURCERER: a database for annotating and linking microarray resources within and across species Jennifer Tsai, Razvan Sultana, Yudan Lee, Geo Pertea, Svetlana Karamycheva, Valentin Antonescu, Jennifer Cho, Babak Parvizi, Foo Cheung, John Quackenbush Genome Biology 2001, 2:software0002-software0002.4 (19 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Microarray expression analysis is providing unprecedented data on gene expression in humans and mammalian model systems. Although such studies provide a tremendous resource for understanding human disease states, one of the significant challenges is cross-referencing the data derived from different species, across diverse expression analysis platforms, in order to properly derive inferences regarding gene expression and disease state. To address this problem, we have developed RESOURCERER, a microarray-resource annotation and cross-reference database built using the analysis of expressed sequence tags (ESTs) and gene sequences provided by the TIGR Gene Index (TGI) and TIGR Orthologous Gene Alignment (TOGA) databases [now called Eukaryotic Gene Orthologs (EGO)].

	Volume 2 Issue 11
	Comment
	Comment Winter, plague and pestilence Gregory A Petsko Genome Biology 2001, 2:comment1013-comment1013.2 (23 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary "From winter, plague and pestilence, good Lord, deliver us."
	Opinion What does a worm want with 20,000 genes? Jonathan Hodgkin Genome Biology 2001, 2:comment2008-comment2008.4 (17 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The number of genes predicted for the Caenorhabditis elegans genome is remarkably high: approximately 20,000, if both protein-coding and RNA-coding genes are counted. This article discusses possible explanations for such a high value.
	Opinion What use is the human genome for understanding the mouse? Paul Denny, Rachael Bate, Ann-Marie Mallon Genome Biology 2001, 2:comment2009-comment2009.5 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Having a working draft of the human genome sequence is proving invaluable to mouse genetic and genomic studies, providing a useful stepping-stone towards the finished sequence of the mouse genome.
	Review
	Protein family review The syntaxins Felicia Yu Hsuan Teng, Ya Wang, Bor Luen Tang Genome Biology 2001, 2:reviews3012-reviews3012.7 (24 October 2001) Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Syntaxins are SNAP receptors (SNAREs) that mediate and provide specificity to vesicle fusion processes in the exocytic and endocytic pathways. There are 15 syntaxins in the human genome, and syntaxin-like genes are found in all eukaryotes.
	Minireview HIV: master of the host cell Christopher W Arendt, Dan R Littman Genome Biology 2001, 2:reviews1030-reviews1030.4 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two DNA microarray studies have illustrated a remarkably broad-based perturbation in host transcriptional responses to HIV.
	Minireview Intraepithelial gamma delta T cells exposed by functional genomics Richard Boismenu, Wendy L Havran Genome Biology 2001, 2:reviews1031-reviews1031.4 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Whole-genome gene-expression analysis provides a new way to study the signals required for the activation of γδ T cells, their mode of action and relationships among cells of the mucosal immune system.
	Report
	Web report Prostate gene expression Steven G Gray Genome Biology 2001, 2:reports2015 (25 October 2001) Abstract \| Full text
	Web report Human-fly homologies Steven G Gray Genome Biology 2001, 2:reports2016 (25 October 2001) Abstract \| Full text \| Editor’s summary HOMOPHILA is a searchable database of human disease genes, obtained from the Online Mendelian Inheritance in Man database, that have significant homology at the protein level to genes contained in FlyBase, the current Drosophila sequence database.
	Web report Asthma genetics Steven G Gray Genome Biology 2001, 2:reports2017 (25 October 2001) Abstract \| Full text \| Editor’s summary The broad-ranging Asthma and Allergy Gene Database covers many aspects of asthma and allergy genetics, including linkage data, gene expression data and gene therapy trials.
	Paper report Centenarian genes Norman A Johnson Genome Biology 2001, 2:reports0039 (23 October 2001) Abstract \| Full text
	Paper report Possible target for male contraception John C Rockett Genome Biology 2001, 2:reports0040 (26 October 2001) Abstract \| Full text \| Editor’s summary A human sperm-specific protein has been isolated that may prove useful in the development of a contraceptive vaccine.
	Paper report New bugs in the human genome draft Reiner Veitia Genome Biology 2001, 2:reports0041 (26 October 2001) Abstract \| Full text
	Paper report Virtual restriction analysis Agnieszka M Lichanska Genome Biology 2001, 2:reports0042 (26 October 2001) Abstract \| Full text \| Editor’s summary A new computational method for whole-genome analysis by in silico restriction mapping has been developed and has been evaluated by comparison with experimental restriction analysis of tumor DNA.
	Paper report Cell biology in orbit Agnieszka M Lichanska Genome Biology 2001, 2:reports0043 (26 October 2001) Abstract \| Full text
	Meeting report Evolution enters the genomic era David A Liberles Genome Biology 2001, 2:reports4026-reports4026.5 (12 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 18th Congress of the European Society for Evolutionary Biology (ESEB), Aarhus, Denmark, 20-25 August, 2001.
	Meeting report Learning the language of cell-cell communication through connexin channels Roberto Bruzzone Genome Biology 2001, 2:reports4027-reports4027.5 (15 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Ninth International Gap Junction Conference, Honolulu, USA, 4-9 August 2001.
	Meeting report DNA-damage signaling and apoptosis Noel F Lowndes Genome Biology 2001, 2:reports4028-reports4028.2 (24 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 674th meeting of the Biochemical Society, Dublin, Ireland, 11-12 July 2001.
	Meeting report Human fungal pathogens accelerate into the genomics era Melissa Straffon Genome Biology 2001, 2:reports4029-reports4029.3 (24 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Euroconference on Fungal Virulence Factors and Disease: 'Human Fungal Pathogens', Seefeld, Austria, 8-13 September 2001.
	Research news Autocrine loops Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011101-01 (1 November 2001) Abstract \| Full text \| Editor’s summary Analysis of expression-profiling data identifies ligand-receptor pairs and autocrine signalling loops involved in cancer.
	Research news Hammerhead selection Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011102-01 (2 November 2001) Abstract \| Full text \| Editor’s summary Hammerhead ribozymes appear to be the molecules of choice for self-cleaving RNAs.
	Research news Light-induced apoptosis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011105-01 (5 November 2001) Abstract \| Full text \| Editor’s summary Analysis of light-induced apoptosis in mouse retinas identifies clusters of genes that respond differentially to illumination.
	Research news More genes on the fly Y Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011106-01 (6 November 2001) Abstract \| Full text \| Editor’s summary Screening of the unmapped heterochromatic fragments of the Drosophila genome has identified five new genes from the Y chromosome.
	Research news Sanger Institute looks to the future Susan Aldridge Genome Biology 2001, 2:spotlight-20011106-02 (6 November 2001) Abstract \| Full text \| Editor’s summary Following the completion of the first draft of the Human Genome the Sanger Institute looks to the post-genomic future.
	Research news PTEN profiling Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011107-01 (7 November 2001) Abstract \| Full text \| Editor’s summary Microarray analysis using an inducible expression system identifies genes regulated by the PTEN tumour suppressor.
	Research news Placental profiling Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011108-01 (8 November 2001) Abstract \| Full text \| Editor’s summary A combination of cDNA subtraction and microarray hybridization identifies genes expressed during placental development.
	Research news What is the normal range for gene expression? Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011109-01 (9 November 2001) Abstract \| Full text \| Editor’s summary Microarray analysis attempts to define the range of normal variation in mouse gene expression in vivo.
	Research news Barcode screening Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011112-01 (12 November 2001) Abstract \| Full text \| Editor’s summary A 'barcode' screen of yeast pools has identified genes associated with nonhomologous end joining.
	Research news Ancient introns Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011113-01 (13 November 2001) Abstract \| Full text \| Editor’s summary A computer program, INTRONMAP, investigates the origins and evolution of introns.
	Research news Translation defects Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011114-01 (14 November 2001) Abstract \| Full text \| Editor’s summary Mutations in two different subunits of the translation initiation factor eIF2B are found in patients with a severe neurological disorder.
	Research news Genomic workout in Parkinson disease Tudor Toma Genome Biology 2001, 2:spotlight-20011115-01 (15 November 2001) Abstract \| Full text \| Editor’s summary New work suggests that different genetic factors influence the development of early- and late-onset Parkinson disease.
	Research news Human endogenous retroviruses Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011115-02 (15 November 2001) Abstract \| Full text \| Editor’s summary Analysis of human endogenous retrovirus (HERV) sequences suggests how they might have affected evolution of the human genome.
	Research news Genetics of social behaviour Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011116-01 (16 November 2001) Abstract \| Full text \| Editor’s summary A gene involved in colony social organization of fire ants has been identified.
	Research news Resistance to vCJD Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011119-01 (19 November 2001) Abstract \| Full text \| Editor’s summary HLA typing may identify groups at risk for variant Creutzfeldt-Jakob disease.
	Research news Hemoglobin and malaria Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011120-01 (20 November 2001) Abstract \| Full text \| Editor’s summary Hemoglobin C alleles are associated with protection from malaria in West Africa.
	Research news Fly SNPs Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011121-01 (21 November 2001) Abstract \| Full text \| Editor’s summary The generation of a SNP map for the Drosophila genome will accelerate the rate of positional cloning in flies.
	Research news Radiation resistance Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011122-01 (22 November 2001) Abstract \| Full text \| Editor’s summary A screen of diploid yeast mutants has identified over a hundred genes involved in the response to ionizing radiation.
	Research news Genetic classification of lung tumors Tudor Toma Genome Biology 2001, 2:spotlight-20011123-01 (23 November 2001) Abstract \| Full text \| Editor’s summary DNA microarray studies of crudely dissected lung tumors can detect tumor subtypes that correlate with biological and clinical phenotypes.
	Research news Genomic systems biology Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011123-02 (23 November 2001) Abstract \| Full text \| Editor’s summary Combining genetic and physiological analysis can identify loci involved in complex disease conditions.
	Research news Limited variation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011126-01 (26 November 2001) Abstract \| Full text \| Editor’s summary Microarray analysis of SNPs on human chromosome 21 has revealed more limited haplotype diversity than expected.
	Research news Parasites bare all David Bruce Genome Biology 2001, 2:spotlight-20011126-02 (26 November 2001) Abstract \| Full text \| Editor’s summary The completion of a microsporidian parasite genome could have important implications for microbial comparative genomics.
	Research news Arsenic and old telomerase Tudor Toma Genome Biology 2001, 2:spotlight-20011127-01 (27 November 2001) Abstract \| Full text \| Editor’s summary Arsenic inhibits the transcription of the reverse transcriptase subunit of the human telomerase gene.
	Research news Predicting promoters Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011128-01 (28 November 2001) Abstract \| Full text \| Editor’s summary A new computer program aims to predict promoters and first exons within genomic sequences.
	Research news Radiation resistance genes discovered Vicki Glaser Genome Biology 2001, 2:spotlight-20011129-01 (29 November 2001) Abstract \| Full text \| Editor’s summary Analysis of gene function in radiation-exposed yeast cells reveals that many more cellular pathways are affected than previously thought.
	Research news Regulating the hypoxia response Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011129-02 (29 November 2001) Abstract \| Full text \| Editor’s summary A novel protein inhibits angiogenesis by regulating hypoxia-induced gene expression.
	Research news Transgene transfer Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20011130-01 (30 November 2001) Abstract \| Full text \| Editor’s summary Analysis of native maize plants from remote Mexican locations provides evidence for gene flow from transgenic plants.
	Research
	Research Detection of chromosomes tagged with green fluorescent protein in live Arabidopsis thaliana plants Naohiro Kato, Eric Lam Genome Biology 2001, 2:research0045-research0045.10 (12 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary GFP fused to DNA-binding proteins can be used in conjunction with concatameric binding-site arrays to track genomic loci in living plants, allowing study of the organization and dynamics of chromatin in specific cell types during various times of development.
	Research Prediction of co-regulated genes in Bacillus subtilis on the basis of upstream elements conserved across three closely related species Goro Terai, Toshihisa Takagi, Kenta Nakai Genome Biology 2001, 2:research0048-research0048.12 (15 October 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Three closely related species of Bacillus were used to identify co-regulated genes in Bacillus subtilis. 1,884 phylogenetically conserved elements from the upstream intergenic regions of 1,568 B. subtilis genes were identified.
	Research Sources of nonlinearity in cDNA microarray expression measurements Latha Ramdas, Kevin R Coombes, Keith Baggerly, Lynne Abruzzo, W Edward Highsmith, Tammy Krogmann, Stanley R Hamilton, Wei Zhang Genome Biology 2001, 2:research0047-research0047.7 (18 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary To test the assumption that quantified signal intensities of microarray data are linearly related to expression levels, the relationship between signal and expression was examinde for two types of microarray.
	Research The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis Robert W Williams, Jing Gu, Shuhua Qi, Lu Lu Genome Biology 2001, 2:research0046-research0046.18 (22 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The density of typed microsatellite markers has been increased 2- to 5-fold in each of several major recombinant inbred sets of mice and consensus RI maps that integrate genotypes of approximately 1600 microsatellite loci assembled.
	Research Optimality of the genetic code with respect to protein stability and amino-acid frequencies Dimitri Gilis, Serge Massar, Nicolas J Cerf, Marianne Rooman Genome Biology 2001, 2:research0049-research0049.12 (24 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Previous studies have attempted to address the fraction of randomly generated genetic codes that do better than the genetic code in respect of overall robustness. This study estimates that around two random codes in 109 are fitter than the natural code.
	Software RESOURCERER: a database for annotating and linking microarray resources within and across species Jennifer Tsai, Razvan Sultana, Yudan Lee, Geo Pertea, Svetlana Karamycheva, Valentin Antonescu, Jennifer Cho, Babak Parvizi, Foo Cheung, John Quackenbush Genome Biology 2001, 2:software0002-software0002.4 (19 October 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Microarray expression analysis is providing unprecedented data on gene expression in humans and mammalian model systems. Although such studies provide a tremendous resource for understanding human disease states, one of the significant challenges is cross-referencing the data derived from different species, across diverse expression analysis platforms, in order to properly derive inferences regarding gene expression and disease state. To address this problem, we have developed RESOURCERER, a microarray-resource annotation and cross-reference database built using the analysis of expressed sequence tags (ESTs) and gene sequences provided by the TIGR Gene Index (TGI) and TIGR Orthologous Gene Alignment (TOGA) databases [now called Eukaryotic Gene Orthologs (EGO)].

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Volume 2 Issue 11

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