Genome Biology | Volume 2 Issue 5

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	Volume 2 Issue 5
	Comment
	Comment After the (draft) sequence Sydney Brenner Genome Biology 2001, 2:comment1006-comment1006.2 (17 April 2001) Full text \| PDF \| PubMed \| Editor’s summary We now have two reports on the human genome sequence that provide a first look at a first draft.
	Comment The Rosetta Stone Gregory A Petsko Genome Biology 2001, 2:comment1007-comment1007.2 (1 May 2001) Full text \| PDF \| PubMed \| Editor’s summary Few things can cause so much trouble, especially in scientific discourse, as metaphor. Various metaphors have been used for the human genome project: the sequence would represent a blueprint for building a human being or would be like an encyclopedia. I think the best metaphor is the Rosetta Stone.
	Review
	Review Characterizing glycosylation pathways Kevin J Yarema, Carolyn R Bertozzi Genome Biology 2001, 2:reviews0004-reviews0004.10 (1 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Numerous factors that influence cell-surface carbohydrate composition remain to be elucidated. The combination of novel biochemical and metabolism-based approaches with emerging genomic methods promises to accelerate efforts to understand glycosylation.
	Protein family review The Rab GTPase family Harald Stenmark, Vesa M Olkkonen Genome Biology 2001, 2:reviews3007-reviews3007.7 (27 April 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Rab family of small GTPases are central regulators of vesicle budding, motility and fusion. The GTP-bound forms of the proteins interact with a range of specific effector proteins, which play central roles in different stages of vesicular transport events.
	Minireview Homologous recombination: from model organisms to human disease Mauro Modesti, Roland Kanaar Genome Biology 2001, 2:reviews1014-reviews1014.5 (26 April 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.
	Minireview Morpholino antisense oligonucleotides: tools for investigating vertebrate development David R Corey, John M Abrams Genome Biology 2001, 2:reviews1015-reviews1015.3 (26 April 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential.
	Minireview Towards a complete sequence of the human Y chromosome Doris Bachtrog, Brian Charlesworth Genome Biology 2001, 2:reviews1016-reviews1016.5 (26 April 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A few dozen genes are known on the human Y chromosome. The completion of the human genome sequence will allow identification of the remaining loci, which should shed further light on the function and evolution of this peculiar chromosome.
	Report
	Web report Exploring protein family relationships David Chambers Genome Biology 2001, 2:reports2003 (4 May 2001) Abstract \| Full text
	Paper report Two's twice as useful Jonathan B Weitzman Genome Biology 2001, 2:reports0013 (10 May 2001) Abstract \| Full text
	Paper report BRCA1 linked with Fanconi anemia Cathy Holding Genome Biology 2001, 2:reports0014 (10 May 2001) Abstract \| Full text
	Paper report Knowing your head from your tail Cathy Holding Genome Biology 2001, 2:reports0012 (18 May 2001) Abstract \| Full text
	Meeting report Microarray gene expression database: progress towards an international repository of gene expression data Paul Kellam Genome Biology 2001, 2:reports4011-reports4011.3 (2 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the third Microarray Gene Expression Database group meeting (MGED3), Stanford University, Palo Alto, California, USA, 29-31 March, 2001.
	Meeting report Macromolecular technologies: applications and improvements Susan Hardin Genome Biology 2001, 2:reports4012-reports4012.3 (2 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Association of Biomolecular Resource Facilities (ABRF) meeting, San Diego, USA, 24-27 February, 2001.
	Deposited research article Conserved protein domains are maintained in an average ratio to proteome size Joel A Malek, Daniel H Haft Genome Biology 2001, 2:preprint0004-preprint0004.16 (9 April 2001) Abstract \| Full text \| PDF \| Editor’s summary Average occurrences of conserved domains have been calculated in each of five eukaryote genomes using two databases of conserved domains. Ratios between two genomes of genes containing a conserved domain, on average, reflected the ratio of the predicted total number of genes in the two genomes.
	Research news Bcl-3 gene is involved in T cell survival Tudor Toma Genome Biology 2001, 2:spotlight-20010501-01 (1 May 2001) Abstract \| Full text \| Editor’s summary Immunological adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene.
	Research news Cloned stem cells Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010501-02 (1 May 2001) Abstract \| Full text \| Editor’s summary Nuclear transfer cloning technology has been used to generate cloned pluripotent stem cells.
	Research news Genetic susceptibility to infertility Tudor Toma Genome Biology 2001, 2:spotlight-20010502-01 (2 May 2001) Abstract \| Full text \| Editor’s summary Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.
	Research news A pathway for cardiomyopathy Tudor Toma Genome Biology 2001, 2:spotlight-20010502-02 (2 May 2001) Abstract \| Full text \| Editor’s summary Disruption of the a-actinin-associated LIM gene destabilizes actin anchorage sites in cardiac muscle.
	Research news Yeasts: the basis for new vaccines Tudor Toma Genome Biology 2001, 2:spotlight-20010503-01 (3 May 2001) Abstract \| Full text \| Editor’s summary Saccharomyces cerevisiae engineered to express tumor or HIV-1 antigens can elicit a cytotoxic T lymphocyte-mediated response and protective immunity in mice.
	Research news Amplicon analysis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010503-02 (3 May 2001) Abstract \| Full text \| Editor’s summary Genomic and microarray analysis identifies highly expressed genes within the 17q23 region that is amplified in some cancers.
	Research news Anorexia susceptibility gene variant SPIS MedWire Genome Biology 2001, 2:spotlight-20010504-01 (4 May 2001) Abstract \| Full text \| Editor’s summary A variant of the agouti-related protein (AGRP) - involved in controlling appetite - has been found more frequently in patients with anorexia nervosa than in controls.
	Research news Nephrogenesis profiling Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010504-02 (4 May 2001) Abstract \| Full text \| Editor’s summary Microarray analysis defines five distinct patterns of gene expression during kidney development.
	Research news Integrating genomics and proteomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010508-01 (8 May 2001) Abstract \| Full text \| Editor’s summary Global analysis of mRNA and protein changes can be integrated to obtain new insights into the regulation of metabolic networks.
	Research news New genetic vaccines using self-replicative RNA Tudor Toma Genome Biology 2001, 2:spotlight-20010510-01 (10 May 2001) Abstract \| Full text \| Editor’s summary Self-replicative RNA vaccines are capable of protecting mice against influenza A, respiratory syncytial virus (RSV), and a tick-borne encephalitis virus.
	Research news Mouse control Pete Moore Genome Biology 2001, 2:spotlight-20010510-03 (10 May 2001) Abstract \| Full text \| Editor’s summary Eleven days after Celera revealed its mouse sequence, the publicly-funded consortium claims to be there as well.
	Research news Carcinogen selection Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010510-02 (10 May 2001) Abstract \| Full text \| Editor’s summary Specific carcinogens can select for cancer cells with different forms of genetic instability.
	Research news Death by MAO Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010511-01 (11 May 2001) Abstract \| Full text \| Editor’s summary A search for genes involved in neuronal cell death identifies monoamine oxidase (MAO) as a pro-apoptotic gene.
	Research news Linkage disequilibrium Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010514-01 (14 May 2001) Abstract \| Full text \| Editor’s summary Analysis of SNPs in the human genome suggests that linkage disequilibrium may extend as much as 60 kilobases from common alleles.
	Research news Mutation in Cd36 gene protects from malaria Tudor Toma Genome Biology 2001, 2:spotlight-20010515-01 (15 May 2001) Abstract \| Full text \| Editor’s summary A mutation from T to G in the Cd36 gene is associated with protection from severe falciparium malaria.
	Research news Twelve thousand Asian men Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010515-02 (15 May 2001) Abstract \| Full text \| Editor’s summary Analysis of over 12,000 Y chromosomes from Asian men suggests a common African origin.
	Research news Reactivating liver genes Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010516-02 (16 May 2001) Abstract \| Full text \| Editor’s summary Experiments in hepatocytes show that the hepatic transcription factor HNF1α functions in the developmental control of methylation and chromatin remodelling.
	Research news Horizontal transfer of tumorigenesis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010517-01 (17 May 2001) Abstract \| Full text \| Editor’s summary Phagocytic uptake of apoptotic bodies leads to the horizontal transfer of tumorigenic oncogenes.
	Research news Bugs in the genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010518-01 (18 May 2001) Abstract \| Full text \| Editor’s summary Comparative proteome analysis identifies just 40 genes that are candidates for lateral transfer from bacteria to vertebrates.
	Research news Mining the mouse Pete Moore Genome Biology 2001, 2:spotlight-20010518-02 (18 May 2001) Abstract \| Full text \| Editor’s summary Despite the announcement of two draft mouse genome sequences, it will be some time before a credible mouse genome sequence is established.
	Research news Lively lipids Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010521-01 (21 May 2001) Abstract \| Full text \| Editor’s summary A genetic screen using fluorescent phospholipid reporters identifies zebrafish genes involved in lipid and cholesterol metabolism.
	Research news Prohibitin SNP as breast cancer indicator Tudor Toma Genome Biology 2001, 2:spotlight-20010522-01 (22 May 2001) Abstract \| Full text \| Editor’s summary Prohibitin genotyping can help in assessing breast cancer risk in women under 50 who have at least one first degree relative with the disease.
	Research news Painting the fourth Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010522-02 (22 May 2001) Abstract \| Full text \| Editor’s summary The Painting of fourth (POF) protein 'paints' the fourth chromosome of Drosophila melanogaster.
	Research news Myc in chicks Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010523-01 (23 May 2001) Abstract \| Full text \| Editor’s summary Microarray analysis identifies genes associated with early stages of myc-induced lymphomagenesis in chickens.
	Research news Gene linked to Crohn's disease SPIS MedWire Genome Biology 2001, 2:spotlight-20010523-02 (23 May 2001) Abstract \| Full text \| Editor’s summary Two independent research teams in Europe and the US have identified a defective gene that increases susceptibility to Crohn's disease.
	Research news Association of viral genomic DNA with heart graft loss Tudor Toma Genome Biology 2001, 2:spotlight-20010524-01 (24 May 2001) Abstract \| Full text \| Editor’s summary Identification of viral DNA in the myocardium of paediatric transplant recipients is predictive of adverse clinical events, including coronary vasculopathy.
	Research news A link between WNT2 and increased susceptibility to autism? SPIS MedWire Genome Biology 2001, 2:spotlight-20010524-02 (24 May 2001) Abstract \| Full text \| Editor’s summary A gene has been identified that could influence susceptibility to autism in humans.
	Research news Breast cancer mouse Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010524-03 (24 May 2001) Abstract \| Full text \| Editor’s summary Mice expressing a truncated Brca1 protein develop various tumors, including breast cancer.
	Research news Mammalian RNAi Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010525-01 (25 May 2001) Abstract \| Full text \| Editor’s summary RNA interference techniques have been used to disrupt gene expression in mammalian cells.
	Research news Prion disease incubation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010525-02 (25 May 2001) Abstract \| Full text \| Editor’s summary Analysis of mouse strain crosses identifies several genetic loci linked to prion disease incubation periods.
	Research news DNase II and erythropoiesis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010529-01 (29 May 2001) Abstract \| Full text \| Editor’s summary Knockout mice demonstrate that deoxyribonuclease II is indispensable for erythropoiesis in fetal liver.
	Research news Meticillin-resistance spread by horizontal gene transfer Tudor Toma Genome Biology 2001, 2:spotlight-20010530-01 (30 May 2001) Abstract \| Full text \| Editor’s summary A paediatric clinical case suggests horizontal gene transfer from Staphylococcus epidermidis can result in the emergence of meticillin-resistant Staphylococcus aureus.
	Research news Influencing influenza Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010530-02 (30 May 2001) Abstract \| Full text \| Editor’s summary Serial passaging in mouse lungs selects for virulent variants of influenza A virus that result from several mutations.
	Research news Training microarrays Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010531-01 (31 May 2001) Abstract \| Full text \| Editor’s summary Artificial neural networks can help in applying microarray data to tumour diagnosis.
	Research
	Research Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging Ronny Leemans, Thomas Loop, Boris Egger, Haiqiong He, Lars Kammermeier, Beate Hartmann, Ullrich Certa, Heinrich Reichert, Frank Hirth Genome Biology 2001, 2:research0015-research0015.9 (24 April 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High-density oligonucleotide arrays representing 1,513 Drosophila genes have been used to analyze differential gene expression following overexpression of the homeotic gene labial. A number of novel candidate downstream target genes for Labial are identified.
	Research Identification of conserved C2H2 zinc-finger gene families in the Bilateria Robert D Knight, Sebastian M Shimeld Genome Biology 2001, 2:research0016-research0016.8 (24 April 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analyses of C2H2 zinc-finger genes from the complete Drosophila, Caenorhabditis elegans and human genomes identify 39 families that represent the minimum complement of such genes in the genome of the bilaterian common ancestor.
	Research Genomic structure of the gene for mouse germ-cell nuclear factor (GCNF). II. Comparison with the genomic structure of the human GCNF gene Ute Süsens, Uwe Borgmeyer Genome Biology 2001, 2:research0017-research0017.7 (2 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genomic structure of the mouse and human GCNF genes have been compared and found to be highly conserved. Alternative splicing generates a higher complexity of human GNCF isoforms compared with mouse.

	Volume 2 Issue 5
	Comment
	Comment After the (draft) sequence Sydney Brenner Genome Biology 2001, 2:comment1006-comment1006.2 (17 April 2001) Full text \| PDF \| PubMed \| Editor’s summary We now have two reports on the human genome sequence that provide a first look at a first draft.
	Comment The Rosetta Stone Gregory A Petsko Genome Biology 2001, 2:comment1007-comment1007.2 (1 May 2001) Full text \| PDF \| PubMed \| Editor’s summary Few things can cause so much trouble, especially in scientific discourse, as metaphor. Various metaphors have been used for the human genome project: the sequence would represent a blueprint for building a human being or would be like an encyclopedia. I think the best metaphor is the Rosetta Stone.
	Review
	Review Characterizing glycosylation pathways Kevin J Yarema, Carolyn R Bertozzi Genome Biology 2001, 2:reviews0004-reviews0004.10 (1 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Numerous factors that influence cell-surface carbohydrate composition remain to be elucidated. The combination of novel biochemical and metabolism-based approaches with emerging genomic methods promises to accelerate efforts to understand glycosylation.
	Protein family review The Rab GTPase family Harald Stenmark, Vesa M Olkkonen Genome Biology 2001, 2:reviews3007-reviews3007.7 (27 April 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The Rab family of small GTPases are central regulators of vesicle budding, motility and fusion. The GTP-bound forms of the proteins interact with a range of specific effector proteins, which play central roles in different stages of vesicular transport events.
	Minireview Homologous recombination: from model organisms to human disease Mauro Modesti, Roland Kanaar Genome Biology 2001, 2:reviews1014-reviews1014.5 (26 April 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.
	Minireview Morpholino antisense oligonucleotides: tools for investigating vertebrate development David R Corey, John M Abrams Genome Biology 2001, 2:reviews1015-reviews1015.3 (26 April 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Antisense oligonucleotides provide a promising approach to investigating gene function in vivo, but their ability to offer unambiguous insights into phenotypes has been debated. The recent use of morpholino antisense oligonucleotides in zebrafish embryos may prove a major advance, but rigorous controls are essential.
	Minireview Towards a complete sequence of the human Y chromosome Doris Bachtrog, Brian Charlesworth Genome Biology 2001, 2:reviews1016-reviews1016.5 (26 April 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A few dozen genes are known on the human Y chromosome. The completion of the human genome sequence will allow identification of the remaining loci, which should shed further light on the function and evolution of this peculiar chromosome.
	Report
	Web report Exploring protein family relationships David Chambers Genome Biology 2001, 2:reports2003 (4 May 2001) Abstract \| Full text
	Paper report Two's twice as useful Jonathan B Weitzman Genome Biology 2001, 2:reports0013 (10 May 2001) Abstract \| Full text
	Paper report BRCA1 linked with Fanconi anemia Cathy Holding Genome Biology 2001, 2:reports0014 (10 May 2001) Abstract \| Full text
	Paper report Knowing your head from your tail Cathy Holding Genome Biology 2001, 2:reports0012 (18 May 2001) Abstract \| Full text
	Meeting report Microarray gene expression database: progress towards an international repository of gene expression data Paul Kellam Genome Biology 2001, 2:reports4011-reports4011.3 (2 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the third Microarray Gene Expression Database group meeting (MGED3), Stanford University, Palo Alto, California, USA, 29-31 March, 2001.
	Meeting report Macromolecular technologies: applications and improvements Susan Hardin Genome Biology 2001, 2:reports4012-reports4012.3 (2 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Association of Biomolecular Resource Facilities (ABRF) meeting, San Diego, USA, 24-27 February, 2001.
	Deposited research article Conserved protein domains are maintained in an average ratio to proteome size Joel A Malek, Daniel H Haft Genome Biology 2001, 2:preprint0004-preprint0004.16 (9 April 2001) Abstract \| Full text \| PDF \| Editor’s summary Average occurrences of conserved domains have been calculated in each of five eukaryote genomes using two databases of conserved domains. Ratios between two genomes of genes containing a conserved domain, on average, reflected the ratio of the predicted total number of genes in the two genomes.
	Research news Bcl-3 gene is involved in T cell survival Tudor Toma Genome Biology 2001, 2:spotlight-20010501-01 (1 May 2001) Abstract \| Full text \| Editor’s summary Immunological adjuvants may improve survival of activated T cells via induction of the Bcl-3 gene.
	Research news Cloned stem cells Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010501-02 (1 May 2001) Abstract \| Full text \| Editor’s summary Nuclear transfer cloning technology has been used to generate cloned pluripotent stem cells.
	Research news Genetic susceptibility to infertility Tudor Toma Genome Biology 2001, 2:spotlight-20010502-01 (2 May 2001) Abstract \| Full text \| Editor’s summary Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.
	Research news A pathway for cardiomyopathy Tudor Toma Genome Biology 2001, 2:spotlight-20010502-02 (2 May 2001) Abstract \| Full text \| Editor’s summary Disruption of the a-actinin-associated LIM gene destabilizes actin anchorage sites in cardiac muscle.
	Research news Yeasts: the basis for new vaccines Tudor Toma Genome Biology 2001, 2:spotlight-20010503-01 (3 May 2001) Abstract \| Full text \| Editor’s summary Saccharomyces cerevisiae engineered to express tumor or HIV-1 antigens can elicit a cytotoxic T lymphocyte-mediated response and protective immunity in mice.
	Research news Amplicon analysis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010503-02 (3 May 2001) Abstract \| Full text \| Editor’s summary Genomic and microarray analysis identifies highly expressed genes within the 17q23 region that is amplified in some cancers.
	Research news Anorexia susceptibility gene variant SPIS MedWire Genome Biology 2001, 2:spotlight-20010504-01 (4 May 2001) Abstract \| Full text \| Editor’s summary A variant of the agouti-related protein (AGRP) - involved in controlling appetite - has been found more frequently in patients with anorexia nervosa than in controls.
	Research news Nephrogenesis profiling Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010504-02 (4 May 2001) Abstract \| Full text \| Editor’s summary Microarray analysis defines five distinct patterns of gene expression during kidney development.
	Research news Integrating genomics and proteomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010508-01 (8 May 2001) Abstract \| Full text \| Editor’s summary Global analysis of mRNA and protein changes can be integrated to obtain new insights into the regulation of metabolic networks.
	Research news New genetic vaccines using self-replicative RNA Tudor Toma Genome Biology 2001, 2:spotlight-20010510-01 (10 May 2001) Abstract \| Full text \| Editor’s summary Self-replicative RNA vaccines are capable of protecting mice against influenza A, respiratory syncytial virus (RSV), and a tick-borne encephalitis virus.
	Research news Mouse control Pete Moore Genome Biology 2001, 2:spotlight-20010510-03 (10 May 2001) Abstract \| Full text \| Editor’s summary Eleven days after Celera revealed its mouse sequence, the publicly-funded consortium claims to be there as well.
	Research news Carcinogen selection Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010510-02 (10 May 2001) Abstract \| Full text \| Editor’s summary Specific carcinogens can select for cancer cells with different forms of genetic instability.
	Research news Death by MAO Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010511-01 (11 May 2001) Abstract \| Full text \| Editor’s summary A search for genes involved in neuronal cell death identifies monoamine oxidase (MAO) as a pro-apoptotic gene.
	Research news Linkage disequilibrium Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010514-01 (14 May 2001) Abstract \| Full text \| Editor’s summary Analysis of SNPs in the human genome suggests that linkage disequilibrium may extend as much as 60 kilobases from common alleles.
	Research news Mutation in Cd36 gene protects from malaria Tudor Toma Genome Biology 2001, 2:spotlight-20010515-01 (15 May 2001) Abstract \| Full text \| Editor’s summary A mutation from T to G in the Cd36 gene is associated with protection from severe falciparium malaria.
	Research news Twelve thousand Asian men Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010515-02 (15 May 2001) Abstract \| Full text \| Editor’s summary Analysis of over 12,000 Y chromosomes from Asian men suggests a common African origin.
	Research news Reactivating liver genes Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010516-02 (16 May 2001) Abstract \| Full text \| Editor’s summary Experiments in hepatocytes show that the hepatic transcription factor HNF1α functions in the developmental control of methylation and chromatin remodelling.
	Research news Horizontal transfer of tumorigenesis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010517-01 (17 May 2001) Abstract \| Full text \| Editor’s summary Phagocytic uptake of apoptotic bodies leads to the horizontal transfer of tumorigenic oncogenes.
	Research news Bugs in the genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010518-01 (18 May 2001) Abstract \| Full text \| Editor’s summary Comparative proteome analysis identifies just 40 genes that are candidates for lateral transfer from bacteria to vertebrates.
	Research news Mining the mouse Pete Moore Genome Biology 2001, 2:spotlight-20010518-02 (18 May 2001) Abstract \| Full text \| Editor’s summary Despite the announcement of two draft mouse genome sequences, it will be some time before a credible mouse genome sequence is established.
	Research news Lively lipids Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010521-01 (21 May 2001) Abstract \| Full text \| Editor’s summary A genetic screen using fluorescent phospholipid reporters identifies zebrafish genes involved in lipid and cholesterol metabolism.
	Research news Prohibitin SNP as breast cancer indicator Tudor Toma Genome Biology 2001, 2:spotlight-20010522-01 (22 May 2001) Abstract \| Full text \| Editor’s summary Prohibitin genotyping can help in assessing breast cancer risk in women under 50 who have at least one first degree relative with the disease.
	Research news Painting the fourth Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010522-02 (22 May 2001) Abstract \| Full text \| Editor’s summary The Painting of fourth (POF) protein 'paints' the fourth chromosome of Drosophila melanogaster.
	Research news Myc in chicks Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010523-01 (23 May 2001) Abstract \| Full text \| Editor’s summary Microarray analysis identifies genes associated with early stages of myc-induced lymphomagenesis in chickens.
	Research news Gene linked to Crohn's disease SPIS MedWire Genome Biology 2001, 2:spotlight-20010523-02 (23 May 2001) Abstract \| Full text \| Editor’s summary Two independent research teams in Europe and the US have identified a defective gene that increases susceptibility to Crohn's disease.
	Research news Association of viral genomic DNA with heart graft loss Tudor Toma Genome Biology 2001, 2:spotlight-20010524-01 (24 May 2001) Abstract \| Full text \| Editor’s summary Identification of viral DNA in the myocardium of paediatric transplant recipients is predictive of adverse clinical events, including coronary vasculopathy.
	Research news A link between WNT2 and increased susceptibility to autism? SPIS MedWire Genome Biology 2001, 2:spotlight-20010524-02 (24 May 2001) Abstract \| Full text \| Editor’s summary A gene has been identified that could influence susceptibility to autism in humans.
	Research news Breast cancer mouse Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010524-03 (24 May 2001) Abstract \| Full text \| Editor’s summary Mice expressing a truncated Brca1 protein develop various tumors, including breast cancer.
	Research news Mammalian RNAi Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010525-01 (25 May 2001) Abstract \| Full text \| Editor’s summary RNA interference techniques have been used to disrupt gene expression in mammalian cells.
	Research news Prion disease incubation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010525-02 (25 May 2001) Abstract \| Full text \| Editor’s summary Analysis of mouse strain crosses identifies several genetic loci linked to prion disease incubation periods.
	Research news DNase II and erythropoiesis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010529-01 (29 May 2001) Abstract \| Full text \| Editor’s summary Knockout mice demonstrate that deoxyribonuclease II is indispensable for erythropoiesis in fetal liver.
	Research news Meticillin-resistance spread by horizontal gene transfer Tudor Toma Genome Biology 2001, 2:spotlight-20010530-01 (30 May 2001) Abstract \| Full text \| Editor’s summary A paediatric clinical case suggests horizontal gene transfer from Staphylococcus epidermidis can result in the emergence of meticillin-resistant Staphylococcus aureus.
	Research news Influencing influenza Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010530-02 (30 May 2001) Abstract \| Full text \| Editor’s summary Serial passaging in mouse lungs selects for virulent variants of influenza A virus that result from several mutations.
	Research news Training microarrays Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010531-01 (31 May 2001) Abstract \| Full text \| Editor’s summary Artificial neural networks can help in applying microarray data to tumour diagnosis.
	Research
	Research Identification of candidate downstream genes for the homeodomain transcription factor Labial in Drosophila through oligonucleotide-array transcript imaging Ronny Leemans, Thomas Loop, Boris Egger, Haiqiong He, Lars Kammermeier, Beate Hartmann, Ullrich Certa, Heinrich Reichert, Frank Hirth Genome Biology 2001, 2:research0015-research0015.9 (24 April 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary High-density oligonucleotide arrays representing 1,513 Drosophila genes have been used to analyze differential gene expression following overexpression of the homeotic gene labial. A number of novel candidate downstream target genes for Labial are identified.
	Research Identification of conserved C2H2 zinc-finger gene families in the Bilateria Robert D Knight, Sebastian M Shimeld Genome Biology 2001, 2:research0016-research0016.8 (24 April 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analyses of C2H2 zinc-finger genes from the complete Drosophila, Caenorhabditis elegans and human genomes identify 39 families that represent the minimum complement of such genes in the genome of the bilaterian common ancestor.
	Research Genomic structure of the gene for mouse germ-cell nuclear factor (GCNF). II. Comparison with the genomic structure of the human GCNF gene Ute Süsens, Uwe Borgmeyer Genome Biology 2001, 2:research0017-research0017.7 (2 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genomic structure of the mouse and human GCNF genes have been compared and found to be highly conserved. Alternative splicing generates a higher complexity of human GNCF isoforms compared with mouse.

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Volume 2 Issue 5

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