Genome Biology | Volume 2 Issue 6

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	Volume 2 Issue 6
	Comment
	Comment Location, location, location Gregory A Petsko Genome Biology 2001, 2:comment1008-comment1008.2 (6 June 2001) Full text \| PDF \| PubMed \| Editor’s summary There is no such thing as a freely floating protein in a eukaryotic cell, and changes in targeting are used to alter protein function at the cellular level.
	Review
	Review Evolution of mammalian genome organization inferred from comparative gene mapping William J Murphy, Roscoe Stanyon, Stephen J O'Brien Genome Biology 2001, 2:reviews0005-reviews0005.8 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative genome analyses, including chromosome painting in over 40 diverse mammalian species, ordered gene maps from several representatives of different mammalian and vertebrate orders, and large-scale sequencing of the human and mouse genomes are beginning to provide insight into the rates and patterns of chromosomal evolution on a whole-genome scale, as well as into the forces that have sculpted the genomes of extant mammalian species.
	Protein family review Importin-beta-like nuclear transport receptors Anne-Christine Ström, Karsten Weis Genome Biology 2001, 2:reviews3008-reviews3008.9 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The importin-β-like family of nuclear transport receptors mediates the transport of a large number of substrates between the cytoplasm and the nucleus. The family is made up of importins and exportins which shuttle between the nucleus and the cytoplasm and are regulated by the small GTPase Ran.
	Minireview Endogenous retroviruses in the human genome sequence David J Griffiths Genome Biology 2001, 2:reviews1017-reviews1017.5 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The human genome contains many endogenous retroviral sequences, and these have been suggested to play important roles in a number of physiological and pathological processes. Can the draft human genome sequences help us to define the role of these elements more closely?
	Minireview The origin and early evolution of mitochondria Michael W Gray, Gertraud Burger, B Franz Lang Genome Biology 2001, 2:reviews1018-reviews1018.5 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Complete sequences of numerous mitochondrial, many prokaryotic, and several nuclear genomes are now available. These data confirm that the mitochondrial genome originated from a eubacterial (specifically a-proteobacterial) ancestor but raise questions about the evolutionary antecedents of the mitochondrial proteome.
	Opinion Chemical genomics: what will it take and who gets to play? Gavin MacBeath Genome Biology 2001, 2:comment2005-comment2005.6 (6 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chemical genomics requires continued advances in combinatorial chemistry, protein biochemistry, miniaturization, automation, and global profiling technology, and will require large, well-funded centers to integrate these components and freely distribute data and reagents.
	Report
	Paper report Searching sequence space for ATP-binding proteins Rachel Brem Genome Biology 2001, 2:reports0015 (22 May 2001) Abstract \| Full text \| Editor’s summary A library of random protein sequences has yielded novel, ATP-binding proteins not found in any organism.
	Meeting report The many uses of a genome sequence Anna Sharman Genome Biology 2001, 2:reports4013-reports4013.4 (30 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Keystone Symposium on 'Human Genetics and Genomics', Breckenridge, Colorado, USA, 31 March to 6 April, 2001.
	Meeting report Where are they going? Directed cell movement in morphogenesis Frank Zimmermann Genome Biology 2001, 2:reports4014-reports4014.3 (30 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 'Cell and Tissue Morphogenesis' Spring Meeting of the British Societies for Cell and Developmental Biology, University of Sussex, Brighton, UK, 3-6 April, 2001.
	Tutorial Bases and spaces: resources on the web for accessing the draft human genome - II - After publication of the draft Colin AM Semple Genome Biology 2001, 2:reviews2001-reviews2001.6 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The volume of human genome sequence and the variety of web-based tools to access it continue to grow at an impressive rate, but a working knowledge of certain key resources can be sufficient to get the most from your genome. This article provides an update to Genome Biology 2000, 1(4):reviews2001.1-2001.5.
	Deposited research article The functional genomic response of developing embryonic submandibular glands to NFκB inhibition Michael Melnick, Haiming Chen, Yan Min Zhou, Tina Jaskoll Genome Biology 2001, 2:preprint0005-preprint0005.44 (4 May 2001) Abstract \| Full text \| PDF \| Editor’s summary Following inhibition of NFκB nuclear translocation, morphological and functional genomic analyses indicate that NFκB-mediated transcription is critical to embryonic submandibular gland development.
	Research news ssDNA Tools Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010601-02 (1 June 2001) Abstract \| Full text \| Editor’s summary Single-stranded oligonucleotides may provide a new tool for homologous recombination and genome modification.
	Research news Error-prone polymerases make efficient immunity Tudor Toma Genome Biology 2001, 2:spotlight-20010601-01 (1 June 2001) Abstract \| Full text \| Editor’s summary Multiple error-prone DNA polymerases contribute to immunoglobulin somatic hypermutation - the process behind increasing antibody affinities after multiple exposures to the same antigen.
	Research news Apoptosis and disease in plants Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010604-01 (4 June 2001) Abstract \| Full text \| Editor’s summary Animal anti-apoptotic genes can defend transgenic plants against pathogen attack.
	Research news Schizophrenic NOTCH? Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010605-01 (5 June 2001) Abstract \| Full text \| Editor’s summary Large-scale studies of British schizophrenics fail to detect an association with the NOTCH4 locus.
	Research news A single amino acid in HLA can alter AIDS progression Tudor Toma Genome Biology 2001, 2:spotlight-20010606-01 (6 June 2001) Abstract \| Full text \| Editor’s summary A single amino acid change in HLA molecules can have a substantial effect on the rate of progression to AIDS in patients infected with HIV-1.
	Research news Snip-SNPs in the worm genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010606-02 (6 June 2001) Abstract \| Full text \| Editor’s summary A snip-SNP map facilitates rapid mapping of genes and mutations in the Caenorhabditis elegans genome.
	Research news One potato, two potato Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010607-01 (7 June 2001) Abstract \| Full text \| Editor’s summary PCR analysis sheds light on the history of the pathogen that caused the Irish potato famine.
	Research news In silico pathogenesis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010608-01 (8 June 2001) Abstract \| Full text \| Editor’s summary A computational approach is being used to identify disease-related regions in the mouse genome.
	Research news Genes modulated by Ginkgo biloba revealed by DNA microarrays Dan Ferber Genome Biology 2001, 2:spotlight-20010611-01 (11 June 2001) Abstract \| Full text \| Editor’s summary Millions of people take herbal remedies for conditions such as the common cold and Alzheimer's. Microarray studies may help to explain how these compounds work in the body.
	Research news Gene trap Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010611-02 (11 June 2001) Abstract \| Full text \| Editor’s summary A promoterless vector encoding a green fluorescent protein-nitroreductase fusion protein offers a versatile approach to trapping genes.
	Research news Sexual isolation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010612-01 (12 June 2001) Abstract \| Full text \| Editor’s summary Genetic analysis identifies a locus in Drosophila that may affect mate discrimination and sexual isolation.
	Research news Ongoing study examines links between genes and environment Jacqui Wise Genome Biology 2001, 2:spotlight-20010613-01 (13 June 2001) Abstract \| Full text \| Editor’s summary The world's largest study of the interaction between genes and environment and their effects on children's health reviewed achievements so far at its tenth anniversary this month.
	Research news RNomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010613-02 (13 June 2001) Abstract \| Full text \| Editor’s summary A screen for small RNA molecules has identified over 200 new small non-messenger RNAs.
	Research news Gum disease genome on line Tudor Toma Genome Biology 2001, 2:spotlight-20010614-02 (14 June 2001) Abstract \| Full text \| Editor’s summary The Porphyromonas gingivalis genome of 2.3 million base pairs is the first of the bacteroides group of Gram-negative anaerobes to be sequenced.
	Research news Finger arrays Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010614-01 (14 June 2001) Abstract \| Full text \| Editor’s summary DNA microarrays have been used to characterize sequence-specific DNA recognition by zinc-finger proteins.
	Research news Fast forward to a sensitive test for prion diseases Tudor Toma Genome Biology 2001, 2:spotlight-20010615-01 (15 June 2001) Abstract \| Full text \| Editor’s summary In vitro acceleration of the protein conversion process induced by pathological prions can be used as a simple blood test to diagnose variant Creutzfeldt-Jakob disease.
	Research news Events at the ends Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010615-02 (15 June 2001) Abstract \| Full text \| Editor’s summary Telomere position effects in human cells may account for gene expression changes as cells grow older.
	Research news The dangers of vitamin C Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010618-01 (18 June 2001) Abstract \| Full text \| Editor’s summary Experiments in vitro show that vitamin C induces the formation of genotoxins, explaining why it has proved ineffective as a cancer therapeutic agent.
	Research news Evolutionary ESTs Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010619-01 (19 June 2001) Abstract \| Full text \| Editor’s summary Comparative analysis of expressed sequence tags (ESTs) identifies rapidly evolving proteins in the reproductive glands of male flies.
	Research news Viral protein K5 modulates T-cell costimulation Tudor Toma Genome Biology 2001, 2:spotlight-20010620-01 (20 June 2001) Abstract \| Full text \| Editor’s summary The expression of the herpesvirus gene K5 in B cells dramatically reduces ICAM-1 and B7-2 surface expression, impairing B cell induction of T cell activation.
	Research news Wigglesworthia genomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010620-02 (20 June 2001) Abstract \| Full text \| Editor’s summary Escherichia coli microarrays can be used to study related bacteria for which complete genome sequences are not available.
	Research news Step-by-step account of HIV-1 infection Tudor Toma Genome Biology 2001, 2:spotlight-20010620-03 (20 June 2001) Abstract \| Full text \| Editor’s summary In response to HIV-1 infection immune cells decrease mRNA synthesis, suppress DNA repair gene transcripts and increase expression of apoptosis inducing genes.
	Research news No horitzontal transfer Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010621-01 (21 June 2001) Abstract \| Full text \| Editor’s summary Phylogenetic analysis refutes previous suggestions that there was extensive horizontal gene transfer from bacteria to vertebrates.
	Research news A new class of nodule-forming bacteria David Bruce Genome Biology 2001, 2:spotlight-20010622-01 (22 June 2001) Abstract \| Full text \| Editor’s summary A second class of Proteobacteria can form rhizobia, suggesting this ability is more widespread than previously thought.
	Research news Stress alarm Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010622-02 (22 June 2001) Abstract \| Full text \| Editor’s summary Phosphorylation of the human checkpoint protein hRad17 signals DNA damage.
	Research news Profiling and policing Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010625-01 (25 June 2001) Abstract \| Full text \| Editor’s summary Simple DNA profiling techniques can authenticate laboratory cell lines and eliminate scientific misrepresentation.
	Research news Cancer drug resistance Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010626-01 (26 June 2001) Abstract \| Full text \| Editor’s summary Leukemia patients who become resistant to anti-cancer drugs acquire mutations or amplifications of the initiating oncogene.
	Research news A thousand northerns Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010627-01 (27 June 2001) Abstract \| Full text \| Editor’s summary High-throughput northern hybridizations have generated a 'Rosetta Stone' of standardized reference data for yeast.
	Research news Crenarchaeon genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010628-01 (28 June 2001) Abstract \| Full text \| Editor’s summary Unique features of crenarchaea are revealed by the genome sequence of Sulfolobus solfataricus P2.
	Research news Id and aging Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010629-01 (29 June 2001) Abstract \| Full text \| Editor’s summary The Id1 protein inhibits cell senescence by repressing cell-cycle genes.
	Research
	Research The human olfactory receptor repertoire Sergey Zozulya, Fernando Echeverri, Trieu Nguyen Genome Biology 2001, 2:research0018-research0018.12 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The identification and cloning of 347 putative human full-length odorant receptor genes is an important initial step in understanding receptor-ligand specificity and combinatorial encoding of odorant stimuli in human olfaction.
	Research Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in Bacillus subtilis Agnieszka Sekowska, Stephane Robin, Jean-Jacques Daudin, Alain Henaut, Antoine Danchin Genome Biology 2001, 2:research0019-research0019.12 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Using variance analysis it is possible to distinguish between systematic biases and relevant gene-expression variation in transcriptome experiments. Co-variation of metabolic gene expression pathways was thus uncovered linking nitrogen and sulfur metabolism in B. subtilis.
	Research Evolution of gene order conservation in prokaryotes Javier Tamames Genome Biology 2001, 2:research0020-research0020.11 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Gene order conservation is a genomic measure that can be useful for studying relationships between prokaryotes and the evolutionary forces shaping their genomes. Gene organization is extensively conserved in some genomic regions.
	Research Survey of human mitochondrial diseases using new genomic/proteomic tools Thomas N Plasterer, Temple F Smith, Scott C Mohr Genome Biology 2001, 2:research0021-research0021.16 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bayesian prior-based, amino-acid sequence profiles have been constructed for the complete yeast mitochondrial proteome and used to develop methods for identifying and characterizing the context of protein mutations that give rise to human mitochondrial diseases.

	Volume 2 Issue 6
	Comment
	Comment Location, location, location Gregory A Petsko Genome Biology 2001, 2:comment1008-comment1008.2 (6 June 2001) Full text \| PDF \| PubMed \| Editor’s summary There is no such thing as a freely floating protein in a eukaryotic cell, and changes in targeting are used to alter protein function at the cellular level.
	Review
	Review Evolution of mammalian genome organization inferred from comparative gene mapping William J Murphy, Roscoe Stanyon, Stephen J O'Brien Genome Biology 2001, 2:reviews0005-reviews0005.8 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative genome analyses, including chromosome painting in over 40 diverse mammalian species, ordered gene maps from several representatives of different mammalian and vertebrate orders, and large-scale sequencing of the human and mouse genomes are beginning to provide insight into the rates and patterns of chromosomal evolution on a whole-genome scale, as well as into the forces that have sculpted the genomes of extant mammalian species.
	Protein family review Importin-beta-like nuclear transport receptors Anne-Christine Ström, Karsten Weis Genome Biology 2001, 2:reviews3008-reviews3008.9 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The importin-β-like family of nuclear transport receptors mediates the transport of a large number of substrates between the cytoplasm and the nucleus. The family is made up of importins and exportins which shuttle between the nucleus and the cytoplasm and are regulated by the small GTPase Ran.
	Minireview Endogenous retroviruses in the human genome sequence David J Griffiths Genome Biology 2001, 2:reviews1017-reviews1017.5 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The human genome contains many endogenous retroviral sequences, and these have been suggested to play important roles in a number of physiological and pathological processes. Can the draft human genome sequences help us to define the role of these elements more closely?
	Minireview The origin and early evolution of mitochondria Michael W Gray, Gertraud Burger, B Franz Lang Genome Biology 2001, 2:reviews1018-reviews1018.5 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Complete sequences of numerous mitochondrial, many prokaryotic, and several nuclear genomes are now available. These data confirm that the mitochondrial genome originated from a eubacterial (specifically a-proteobacterial) ancestor but raise questions about the evolutionary antecedents of the mitochondrial proteome.
	Opinion Chemical genomics: what will it take and who gets to play? Gavin MacBeath Genome Biology 2001, 2:comment2005-comment2005.6 (6 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Chemical genomics requires continued advances in combinatorial chemistry, protein biochemistry, miniaturization, automation, and global profiling technology, and will require large, well-funded centers to integrate these components and freely distribute data and reagents.
	Report
	Paper report Searching sequence space for ATP-binding proteins Rachel Brem Genome Biology 2001, 2:reports0015 (22 May 2001) Abstract \| Full text \| Editor’s summary A library of random protein sequences has yielded novel, ATP-binding proteins not found in any organism.
	Meeting report The many uses of a genome sequence Anna Sharman Genome Biology 2001, 2:reports4013-reports4013.4 (30 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Keystone Symposium on 'Human Genetics and Genomics', Breckenridge, Colorado, USA, 31 March to 6 April, 2001.
	Meeting report Where are they going? Directed cell movement in morphogenesis Frank Zimmermann Genome Biology 2001, 2:reports4014-reports4014.3 (30 May 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 'Cell and Tissue Morphogenesis' Spring Meeting of the British Societies for Cell and Developmental Biology, University of Sussex, Brighton, UK, 3-6 April, 2001.
	Tutorial Bases and spaces: resources on the web for accessing the draft human genome - II - After publication of the draft Colin AM Semple Genome Biology 2001, 2:reviews2001-reviews2001.6 (5 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The volume of human genome sequence and the variety of web-based tools to access it continue to grow at an impressive rate, but a working knowledge of certain key resources can be sufficient to get the most from your genome. This article provides an update to Genome Biology 2000, 1(4):reviews2001.1-2001.5.
	Deposited research article The functional genomic response of developing embryonic submandibular glands to NFκB inhibition Michael Melnick, Haiming Chen, Yan Min Zhou, Tina Jaskoll Genome Biology 2001, 2:preprint0005-preprint0005.44 (4 May 2001) Abstract \| Full text \| PDF \| Editor’s summary Following inhibition of NFκB nuclear translocation, morphological and functional genomic analyses indicate that NFκB-mediated transcription is critical to embryonic submandibular gland development.
	Research news ssDNA Tools Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010601-02 (1 June 2001) Abstract \| Full text \| Editor’s summary Single-stranded oligonucleotides may provide a new tool for homologous recombination and genome modification.
	Research news Error-prone polymerases make efficient immunity Tudor Toma Genome Biology 2001, 2:spotlight-20010601-01 (1 June 2001) Abstract \| Full text \| Editor’s summary Multiple error-prone DNA polymerases contribute to immunoglobulin somatic hypermutation - the process behind increasing antibody affinities after multiple exposures to the same antigen.
	Research news Apoptosis and disease in plants Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010604-01 (4 June 2001) Abstract \| Full text \| Editor’s summary Animal anti-apoptotic genes can defend transgenic plants against pathogen attack.
	Research news Schizophrenic NOTCH? Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010605-01 (5 June 2001) Abstract \| Full text \| Editor’s summary Large-scale studies of British schizophrenics fail to detect an association with the NOTCH4 locus.
	Research news A single amino acid in HLA can alter AIDS progression Tudor Toma Genome Biology 2001, 2:spotlight-20010606-01 (6 June 2001) Abstract \| Full text \| Editor’s summary A single amino acid change in HLA molecules can have a substantial effect on the rate of progression to AIDS in patients infected with HIV-1.
	Research news Snip-SNPs in the worm genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010606-02 (6 June 2001) Abstract \| Full text \| Editor’s summary A snip-SNP map facilitates rapid mapping of genes and mutations in the Caenorhabditis elegans genome.
	Research news One potato, two potato Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010607-01 (7 June 2001) Abstract \| Full text \| Editor’s summary PCR analysis sheds light on the history of the pathogen that caused the Irish potato famine.
	Research news In silico pathogenesis Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010608-01 (8 June 2001) Abstract \| Full text \| Editor’s summary A computational approach is being used to identify disease-related regions in the mouse genome.
	Research news Genes modulated by Ginkgo biloba revealed by DNA microarrays Dan Ferber Genome Biology 2001, 2:spotlight-20010611-01 (11 June 2001) Abstract \| Full text \| Editor’s summary Millions of people take herbal remedies for conditions such as the common cold and Alzheimer's. Microarray studies may help to explain how these compounds work in the body.
	Research news Gene trap Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010611-02 (11 June 2001) Abstract \| Full text \| Editor’s summary A promoterless vector encoding a green fluorescent protein-nitroreductase fusion protein offers a versatile approach to trapping genes.
	Research news Sexual isolation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010612-01 (12 June 2001) Abstract \| Full text \| Editor’s summary Genetic analysis identifies a locus in Drosophila that may affect mate discrimination and sexual isolation.
	Research news Ongoing study examines links between genes and environment Jacqui Wise Genome Biology 2001, 2:spotlight-20010613-01 (13 June 2001) Abstract \| Full text \| Editor’s summary The world's largest study of the interaction between genes and environment and their effects on children's health reviewed achievements so far at its tenth anniversary this month.
	Research news RNomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010613-02 (13 June 2001) Abstract \| Full text \| Editor’s summary A screen for small RNA molecules has identified over 200 new small non-messenger RNAs.
	Research news Gum disease genome on line Tudor Toma Genome Biology 2001, 2:spotlight-20010614-02 (14 June 2001) Abstract \| Full text \| Editor’s summary The Porphyromonas gingivalis genome of 2.3 million base pairs is the first of the bacteroides group of Gram-negative anaerobes to be sequenced.
	Research news Finger arrays Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010614-01 (14 June 2001) Abstract \| Full text \| Editor’s summary DNA microarrays have been used to characterize sequence-specific DNA recognition by zinc-finger proteins.
	Research news Fast forward to a sensitive test for prion diseases Tudor Toma Genome Biology 2001, 2:spotlight-20010615-01 (15 June 2001) Abstract \| Full text \| Editor’s summary In vitro acceleration of the protein conversion process induced by pathological prions can be used as a simple blood test to diagnose variant Creutzfeldt-Jakob disease.
	Research news Events at the ends Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010615-02 (15 June 2001) Abstract \| Full text \| Editor’s summary Telomere position effects in human cells may account for gene expression changes as cells grow older.
	Research news The dangers of vitamin C Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010618-01 (18 June 2001) Abstract \| Full text \| Editor’s summary Experiments in vitro show that vitamin C induces the formation of genotoxins, explaining why it has proved ineffective as a cancer therapeutic agent.
	Research news Evolutionary ESTs Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010619-01 (19 June 2001) Abstract \| Full text \| Editor’s summary Comparative analysis of expressed sequence tags (ESTs) identifies rapidly evolving proteins in the reproductive glands of male flies.
	Research news Viral protein K5 modulates T-cell costimulation Tudor Toma Genome Biology 2001, 2:spotlight-20010620-01 (20 June 2001) Abstract \| Full text \| Editor’s summary The expression of the herpesvirus gene K5 in B cells dramatically reduces ICAM-1 and B7-2 surface expression, impairing B cell induction of T cell activation.
	Research news Wigglesworthia genomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010620-02 (20 June 2001) Abstract \| Full text \| Editor’s summary Escherichia coli microarrays can be used to study related bacteria for which complete genome sequences are not available.
	Research news Step-by-step account of HIV-1 infection Tudor Toma Genome Biology 2001, 2:spotlight-20010620-03 (20 June 2001) Abstract \| Full text \| Editor’s summary In response to HIV-1 infection immune cells decrease mRNA synthesis, suppress DNA repair gene transcripts and increase expression of apoptosis inducing genes.
	Research news No horitzontal transfer Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010621-01 (21 June 2001) Abstract \| Full text \| Editor’s summary Phylogenetic analysis refutes previous suggestions that there was extensive horizontal gene transfer from bacteria to vertebrates.
	Research news A new class of nodule-forming bacteria David Bruce Genome Biology 2001, 2:spotlight-20010622-01 (22 June 2001) Abstract \| Full text \| Editor’s summary A second class of Proteobacteria can form rhizobia, suggesting this ability is more widespread than previously thought.
	Research news Stress alarm Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010622-02 (22 June 2001) Abstract \| Full text \| Editor’s summary Phosphorylation of the human checkpoint protein hRad17 signals DNA damage.
	Research news Profiling and policing Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010625-01 (25 June 2001) Abstract \| Full text \| Editor’s summary Simple DNA profiling techniques can authenticate laboratory cell lines and eliminate scientific misrepresentation.
	Research news Cancer drug resistance Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010626-01 (26 June 2001) Abstract \| Full text \| Editor’s summary Leukemia patients who become resistant to anti-cancer drugs acquire mutations or amplifications of the initiating oncogene.
	Research news A thousand northerns Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010627-01 (27 June 2001) Abstract \| Full text \| Editor’s summary High-throughput northern hybridizations have generated a 'Rosetta Stone' of standardized reference data for yeast.
	Research news Crenarchaeon genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010628-01 (28 June 2001) Abstract \| Full text \| Editor’s summary Unique features of crenarchaea are revealed by the genome sequence of Sulfolobus solfataricus P2.
	Research news Id and aging Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010629-01 (29 June 2001) Abstract \| Full text \| Editor’s summary The Id1 protein inhibits cell senescence by repressing cell-cycle genes.
	Research
	Research The human olfactory receptor repertoire Sergey Zozulya, Fernando Echeverri, Trieu Nguyen Genome Biology 2001, 2:research0018-research0018.12 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The identification and cloning of 347 putative human full-length odorant receptor genes is an important initial step in understanding receptor-ligand specificity and combinatorial encoding of odorant stimuli in human olfaction.
	Research Extracting biological information from DNA arrays: an unexpected link between arginine and methionine metabolism in Bacillus subtilis Agnieszka Sekowska, Stephane Robin, Jean-Jacques Daudin, Alain Henaut, Antoine Danchin Genome Biology 2001, 2:research0019-research0019.12 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Using variance analysis it is possible to distinguish between systematic biases and relevant gene-expression variation in transcriptome experiments. Co-variation of metabolic gene expression pathways was thus uncovered linking nitrogen and sulfur metabolism in B. subtilis.
	Research Evolution of gene order conservation in prokaryotes Javier Tamames Genome Biology 2001, 2:research0020-research0020.11 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Gene order conservation is a genomic measure that can be useful for studying relationships between prokaryotes and the evolutionary forces shaping their genomes. Gene organization is extensively conserved in some genomic regions.
	Research Survey of human mitochondrial diseases using new genomic/proteomic tools Thomas N Plasterer, Temple F Smith, Scott C Mohr Genome Biology 2001, 2:research0021-research0021.16 (1 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Bayesian prior-based, amino-acid sequence profiles have been constructed for the complete yeast mitochondrial proteome and used to develop methods for identifying and characterizing the context of protein mutations that give rise to human mitochondrial diseases.

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Volume 2 Issue 6

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