Genome Biology | Volume 2 Issue 7

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	Volume 2 Issue 7
	Comment
	Comment Model behavior Gregory A Petsko Genome Biology 2001, 2:comment1009-comment1009.2 (4 July 2001) Full text \| PDF \| PubMed \| Editor’s summary Scientists are prone to believing that two and two can, sometimes, with the aid of the right technology, make five. As the euphoria over all things genomic continues, we would all do well to remind ourselves that two plus two still equals four, and always will.
	Review
	Review Histone variants: are they functionally heterogeneous? David T Brown Genome Biology 2001, 2:reviews0006-reviews0006.6 (5 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In most eukaryotes, histones, which are the major structural components of chromatin, are expressed as a family of sequence variants encoded by multiple genes. Because different histone variants can contribute to a distinct or unique nucleosomal architecture, this heterogeneity can be exploited to regulate a wide range of nuclear functions, and evidence is accumulating that histone variants do indeed have distinct functions.
	Protein family review Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs Anne M Verhagen, Elizabeth J Coulson, David L Vaux Genome Biology 2001, 2:reviews3009-reviews3009.10 (5 July 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The inhibitor of apoptosis (IAP) proteins prevent cell death by binding to and inhibiting caspases. They share the BIR domain with a second group of proteins that regulate cytokinesis and chromosomal segregation.
	Minireview Mining mouse microarray data Dennis A Wigle, Janet Rossant, Igor Jurisica Genome Biology 2001, 2:reviews1019-reviews1019.4 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Microarrays of mouse genes are now available from several sources, and they have so far given new insights into gene expression in embryonic development, regions of the brain and during apoptosis. Microarray data posted on the internet can be reanalyzed to study a range of questions.
	Minireview Anatomy of a bacterial cell cycle Jean D Amick, Yves V Brun Genome Biology 2001, 2:reviews1020-reviews1020.4 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two recent reports describe mRNA and protein expression patterns in the bacterium Caulobacter crescentus. The combined use of DNA microarray and proteomic analyses provides a powerful new perspective for unraveling the global regulatory networks of this complex bacterium.
	Opinion Genome cartography through domain annotation Chris P Ponting, Nicholas J Dickens Genome Biology 2001, 2:comment2006-comment2006.6 (3 July 2001) Abstract \| Full text \| PDF \| Editor’s summary The evolutionary history of eukaryotic proteins involves rapid sequence divergence, addition and deletion of domains, and fusion and fission of genes. Although the protein repertoires of distantly related species differ greatly, their domain repertoires do not. To account for the great diversity of domain contexts and an unexpected paucity of ortholog conservation, we must categorize the coding regions of completely sequenced genomes into domain families, as well as protein families.
	Report
	Web report All you need for proteomics David Chambers Genome Biology 2001, 2:reports2004 (28 June 2001) Abstract \| Full text
	Paper report A new profusion of planktonic eukaryotes James Cotton Genome Biology 2001, 2:reports0016 (13 June 2001) Abstract \| Full text \| Editor’s summary Techniques commonly applied to the discovery of unknown prokaryotes have now been used to identify new eukaryotic lineages within picoplankton.
	Paper report A new histone variant: macroH2A2 Cathy Holding Genome Biology 2001, 2:reports0017 (27 June 2001) Abstract \| Full text
	Paper report SRY is a target of WT1 Cathy Holding Genome Biology 2001, 2:reports0018 (27 June 2001) Abstract \| Full text \| Editor’s summary The SRY gene has been shown to be a direct transcriptional target of the WT1 transcription factor.
	Paper report SIFTing the effects of SNPs Reiner Veitia Genome Biology 2001, 2:reports0019 (27 June 2001) Abstract \| Full text \| Editor’s summary An in silico approach has been used to sort the effects on protein structure or function of amino-acid substitutions at conserved compared to non-conserved sites.
	Paper report Amino-acid substitution and protein function Reiner Veitia Genome Biology 2001, 2:reports0020 (27 June 2001) Abstract \| Full text \| Editor’s summary A novel in silico method based on comparative and physicochemical considerations can help to predict the impact of amino-acid replacement on protein structure and function.
	Meeting report The meso-genomic era Colin AM Semple, Martin S Taylor, Stephane Ballereau Genome Biology 2001, 2:reports4015-reports4015.5 (28 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report from HGM2001, the sixth annual International Human Genome Meeting organized by The Human Genome Organisation (HUGO), Edinburgh, UK, 19-22 April 2001.
	Meeting report Fish are rising David Bassett Genome Biology 2001, 2:reports4016-reports4016.2 (28 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the second European conference on zebrafish genetics and development. University College, London, 19-22 April 2001.
	Meeting report Eleven years of sexual discovery Andrew Sinclair Genome Biology 2001, 2:reports4017-reports4017.3 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on Novartis Foundation Symposium 244 "The Genetics and Biology of Sex Determination", London, UK, 1-3 May 2001.
	Deposited research article RuNAway Disease: A two cycle model for transmissible spongiform encephalopathies (TSEs) wherein SINE proliferation drives PrP overproduction Toby J Gibson Genome Biology 2001, 2:preprint0006-preprint0006.17 (6 June 2001) Abstract \| Full text \| PDF \| Editor’s summary It is widely believed that modified host prion protein is the transmissible agent in spongiform encephalopathies, but this has not been verified. Here, a new scheme is proposed whereby uncontrolled proliferation of SINE repeat sequences induces overproduction of prion protein, with pathogenic consequences.
	Research news Degrading mutations Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010702-01 (2 July 2001) Abstract \| Full text \| Editor’s summary Mutations in matrix metalloproteases have been detected in inherited osteolytic and arthritic disorder.
	Research news Deadly fusion Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010703-02 (3 July 2001) Abstract \| Full text \| Editor’s summary Translocations in acute megakaryoblastic leukemia result in the fusion of two novel genes.
	Research news Pollen coat protein gene families David Bruce Genome Biology 2001, 2:spotlight-20010703-01 (3 July 2001) Abstract \| Full text \| Editor’s summary Pollen coat proteins have been found to be encoded by genes clustered within Arabidopsis genome.
	Research news Caught by the secretory-trap Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010704-01 (4 July 2001) Abstract \| Full text \| Editor’s summary A modified gene-trap approach has identified a large number of mouse genes encoding secreted and membrane proteins that are involved in development.
	Research news Hippocampus arrays Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010705-01 (5 July 2001) Abstract \| Full text \| Editor’s summary Microarray analysis identifies gene clusters associated with the development of the hippocampus in mice.
	Research news Stem-cell genomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010706-01 (6 July 2001) Abstract \| Full text \| Editor’s summary Analysis of distinct stem-cell populations attempts to define a universal stem-cell gene expression profile.
	Research news Epigenetically unstable Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010709-01 (9 July 2001) Abstract \| Full text \| Editor’s summary Analysis of cloned mice reveals widespread epigenetic instability throughout the genome.
	Research news Death by endonuclease Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010710-03 (10 July 2001) Abstract \| Full text \| Editor’s summary Experiments in nematodes and mice identify a mitochondrial endonuclease that is critical for regulating cell death.
	Research news Glyoxylate cycle as drug target? David Bruce Genome Biology 2001, 2:spotlight-20010710-01 (10 July 2001) Abstract \| Full text \| Editor’s summary Candida albicans cells require the glyoxylate cycle for replication inside macrophages, providing a potentially selective target for the treatment of systemic candidiasis.
	Research news A circadian clock in the cardiovascular system Simon Frantz Genome Biology 2001, 2:spotlight-20010710-02 (10 July 2001) Abstract \| Full text \| Editor’s summary The genetic circuitry underlying circadian rhythms in the cardiovascular system are being unravelled.
	Research news Pin-ning down breast cancer Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010711-01 (11 July 2001) Abstract \| Full text \| Editor’s summary The prolyl isomerase Pin1 regulates the cell cycle and may contribute to tumour growth.
	Research news Circulating DNA fragments involved in vasculitis Tudor Toma Genome Biology 2001, 2:spotlight-20010712-01 (12 July 2001) Abstract \| Full text \| Editor’s summary DNA fragments containing the CpG motif in the sera of patients with systemic lupus erythematosus may be implicated in vasculitis.
	Research news STAT mutation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010712-03 (12 July 2001) Abstract \| Full text \| Editor’s summary A mutation in the human STAT1 gene causes susceptibility to mycobacteria without affecting viral immunity.
	Research news Cape flora Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010713-02 (13 July 2001) Abstract \| Full text \| Editor’s summary A molecular phylogenetic study has assigned a date - about 7-8 million years - ago to the rapid species diversification of South African Cape flora.
	Research news Nuclear transfer results in inherently unstable offspring Adam Legge Genome Biology 2001, 2:spotlight-20010713-01 (13 July 2001) Abstract \| Full text \| Editor’s summary Mammalian development seems to be relatively tolerant to epigenetic aberrations of the genome, suggesting that cloning could result in viable offspring, despite widespread gene dysregulation.
	Research news Roving sharks Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010716-02 (16 July 2001) Abstract \| Full text \| Editor’s summary Genetic tracking of great white sharks reveals that males are roving, while females stay at home.
	Research news The molecular basis of allergenicity Tudor Toma Genome Biology 2001, 2:spotlight-20010716-01 (16 July 2001) Abstract \| Full text \| Editor’s summary Comparative analysis of the three-dimensional structures of diverse allergens reveals a common structural motif that could potentially serve as a ligand binding site.
	Research news Modified two-hybrid Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010717-01 (17 July 2001) Abstract \| Full text \| Editor’s summary A variation of the classic yeast two-hydrid protein-interaction assay selects for repression of transactivator proteins.
	Research news BRCA2-repair Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010718-01 (18 July 2001) Abstract \| Full text \| Editor’s summary The breast cancer-related protein BRCA2 regulates homologous recombination to repair damaged DNA.
	Research news Actin checkpoint Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010719-01 (19 July 2001) Abstract \| Full text \| Editor’s summary Experiments in fission yeast have identified a mitotic checkpoint controlled by the actin cytoskeleton and spindle orientation.
	Research news Pneumococcus genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010720-01 (20 July 2001) Abstract \| Full text \| Editor’s summary Complete genome sequence of Streptococcus pneumoniae, the bacterial pathogen that causes pneumonia and meningitis, has been reported.
	Research news Genome Rap Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010723-02 (23 July 2001) Abstract \| Full text \| Editor’s summary The yeast Rap1 protein shows a binding preference for promoter regions of the genome.
	Research news Ras controls herpes virus penetration in cells Tudor Toma Genome Biology 2001, 2:spotlight-20010723-01 (23 July 2001) Abstract \| Full text \| Editor’s summary Oncogenes in Ras signalling pathway are essential in host-cell permissiveness to herpes simplex virus 1.
	Research news Targeted destruction Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010724-01 (24 July 2001) Abstract \| Full text \| Editor’s summary Synthetic chimeric molecules can be used to target proteins for ubiquitin-dependent degradation.
	Research news pRB repression in yeast Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010725-01 (25 July 2001) Abstract \| Full text \| Editor’s summary A yeast model has helped to define the mechanism by which mammalian pRB represses gene transcription.
	Research news Neuroferritinopathy Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010726-01 (26 July 2001) Abstract \| Full text \| Editor’s summary A new dominantly inherited genetic disease is caused by mutations in the ferritin light polypeptide gene.
	Research news Proteome chips Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010727-01 (27 July 2001) Abstract \| Full text \| Editor’s summary Screening of a yeast proteome microarray identifies new calmodulin- and phospholipid-interacting proteins.
	Research news Imprinted inactivation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010730-01 (30 July 2001) Abstract \| Full text \| Editor’s summary The mouse eed gene is required for inactivation of the paternal X chromosome in extra-embryonic tissues.
	Research news CpG receptors Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010731-01 (31 July 2001) Abstract \| Full text \| Editor’s summary Human and mouse Toll-like receptors each recognize distinct CpG-DNA motifs.
	Research
	Research Distinct gene expression profiles of human type 1 and type 2 T helper cells Heli Hamalainen, Hua Zhou, William Chou, Hideki Hashizume, Renu Heller, Riitta Lahesmaa Genome Biology 2001, 2:research0022-research0022.11 (21 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An oligonucleotide microarray has been used to screen helper T cell subsets for inflammation-related candidate genes. Subtle changes in the expression of genes that represent growth factors, receptors and other signaling molecules were found.
	Research Gene trapping identifies transiently induced survival genes during programmed cell death Frank Wempe, Ji-Yeon Yang, Joanna Hammann, Harald von Melchner Genome Biology 2001, 2:research0023-research0023.10 (27 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To identify transcriptional mechanisms that interfere with cell death and survival, gene-trap mutagenesis has been combined with site-specific recombination to isolate genes from cells undergoing apoptosis by growth factor deprivation. Most of the known genes recovered in this analysis encoded proteins with survival functions.
	Research Isolation, in silico characterization and chromosomal localization of a group of cDNAs from ciliated epithelial cells after in vitro ciliogenesis Amit K Maiti, Mark Jorissen, Patrice Bouvagnet Genome Biology 2001, 2:research0026-research0026.9 (27 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To understand ciliary assembly and motility in human, total RNA was isolated from cultured ciliated nasal epithelial cells after in vitro ciliogenesis and expressed sequenced tags (ESTs) were generated. The functions and locations of 63 of these ESTs were derived by BLAST from two public databases.
	Research Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence Anireddy SN Reddy, Irene S Day Genome Biology 2001, 2:research0024-research0024.17 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Using the motor domain of an Arabidopsis myosin, 17 myosin sequences have been identified in the Arabidopsis genome. Phylogenetic analysis reveals that plant myosins fall into two groups and are unlike myosins from any other organisms except algae.
	Research A draft annotation and overview of the human genome Fred A Wright, William J Lemon, Wei D Zhao, Russell Sears, Degen Zhuo, Jian-Ping Wang, Hee-Yung Yang, Troy Baer, Don Stredney, Joe Spitzner, Al Stutz, Ralf Krahe, Bo Yuan Genome Biology 2001, 2:research0025-research0025.18 (4 July 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A functionally annotated human gene index is reported, placed directly on the genome, based on the integration of public transcript, protein, and mapping information, supplemented with computational prediction. The genome is estimated to contain 65,000-75,000 transcriptional units, with exonic sequences comprising 4%.

	Volume 2 Issue 7
	Comment
	Comment Model behavior Gregory A Petsko Genome Biology 2001, 2:comment1009-comment1009.2 (4 July 2001) Full text \| PDF \| PubMed \| Editor’s summary Scientists are prone to believing that two and two can, sometimes, with the aid of the right technology, make five. As the euphoria over all things genomic continues, we would all do well to remind ourselves that two plus two still equals four, and always will.
	Review
	Review Histone variants: are they functionally heterogeneous? David T Brown Genome Biology 2001, 2:reviews0006-reviews0006.6 (5 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In most eukaryotes, histones, which are the major structural components of chromatin, are expressed as a family of sequence variants encoded by multiple genes. Because different histone variants can contribute to a distinct or unique nucleosomal architecture, this heterogeneity can be exploited to regulate a wide range of nuclear functions, and evidence is accumulating that histone variants do indeed have distinct functions.
	Protein family review Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs Anne M Verhagen, Elizabeth J Coulson, David L Vaux Genome Biology 2001, 2:reviews3009-reviews3009.10 (5 July 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The inhibitor of apoptosis (IAP) proteins prevent cell death by binding to and inhibiting caspases. They share the BIR domain with a second group of proteins that regulate cytokinesis and chromosomal segregation.
	Minireview Mining mouse microarray data Dennis A Wigle, Janet Rossant, Igor Jurisica Genome Biology 2001, 2:reviews1019-reviews1019.4 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Microarrays of mouse genes are now available from several sources, and they have so far given new insights into gene expression in embryonic development, regions of the brain and during apoptosis. Microarray data posted on the internet can be reanalyzed to study a range of questions.
	Minireview Anatomy of a bacterial cell cycle Jean D Amick, Yves V Brun Genome Biology 2001, 2:reviews1020-reviews1020.4 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two recent reports describe mRNA and protein expression patterns in the bacterium Caulobacter crescentus. The combined use of DNA microarray and proteomic analyses provides a powerful new perspective for unraveling the global regulatory networks of this complex bacterium.
	Opinion Genome cartography through domain annotation Chris P Ponting, Nicholas J Dickens Genome Biology 2001, 2:comment2006-comment2006.6 (3 July 2001) Abstract \| Full text \| PDF \| Editor’s summary The evolutionary history of eukaryotic proteins involves rapid sequence divergence, addition and deletion of domains, and fusion and fission of genes. Although the protein repertoires of distantly related species differ greatly, their domain repertoires do not. To account for the great diversity of domain contexts and an unexpected paucity of ortholog conservation, we must categorize the coding regions of completely sequenced genomes into domain families, as well as protein families.
	Report
	Web report All you need for proteomics David Chambers Genome Biology 2001, 2:reports2004 (28 June 2001) Abstract \| Full text
	Paper report A new profusion of planktonic eukaryotes James Cotton Genome Biology 2001, 2:reports0016 (13 June 2001) Abstract \| Full text \| Editor’s summary Techniques commonly applied to the discovery of unknown prokaryotes have now been used to identify new eukaryotic lineages within picoplankton.
	Paper report A new histone variant: macroH2A2 Cathy Holding Genome Biology 2001, 2:reports0017 (27 June 2001) Abstract \| Full text
	Paper report SRY is a target of WT1 Cathy Holding Genome Biology 2001, 2:reports0018 (27 June 2001) Abstract \| Full text \| Editor’s summary The SRY gene has been shown to be a direct transcriptional target of the WT1 transcription factor.
	Paper report SIFTing the effects of SNPs Reiner Veitia Genome Biology 2001, 2:reports0019 (27 June 2001) Abstract \| Full text \| Editor’s summary An in silico approach has been used to sort the effects on protein structure or function of amino-acid substitutions at conserved compared to non-conserved sites.
	Paper report Amino-acid substitution and protein function Reiner Veitia Genome Biology 2001, 2:reports0020 (27 June 2001) Abstract \| Full text \| Editor’s summary A novel in silico method based on comparative and physicochemical considerations can help to predict the impact of amino-acid replacement on protein structure and function.
	Meeting report The meso-genomic era Colin AM Semple, Martin S Taylor, Stephane Ballereau Genome Biology 2001, 2:reports4015-reports4015.5 (28 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report from HGM2001, the sixth annual International Human Genome Meeting organized by The Human Genome Organisation (HUGO), Edinburgh, UK, 19-22 April 2001.
	Meeting report Fish are rising David Bassett Genome Biology 2001, 2:reports4016-reports4016.2 (28 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the second European conference on zebrafish genetics and development. University College, London, 19-22 April 2001.
	Meeting report Eleven years of sexual discovery Andrew Sinclair Genome Biology 2001, 2:reports4017-reports4017.3 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on Novartis Foundation Symposium 244 "The Genetics and Biology of Sex Determination", London, UK, 1-3 May 2001.
	Deposited research article RuNAway Disease: A two cycle model for transmissible spongiform encephalopathies (TSEs) wherein SINE proliferation drives PrP overproduction Toby J Gibson Genome Biology 2001, 2:preprint0006-preprint0006.17 (6 June 2001) Abstract \| Full text \| PDF \| Editor’s summary It is widely believed that modified host prion protein is the transmissible agent in spongiform encephalopathies, but this has not been verified. Here, a new scheme is proposed whereby uncontrolled proliferation of SINE repeat sequences induces overproduction of prion protein, with pathogenic consequences.
	Research news Degrading mutations Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010702-01 (2 July 2001) Abstract \| Full text \| Editor’s summary Mutations in matrix metalloproteases have been detected in inherited osteolytic and arthritic disorder.
	Research news Deadly fusion Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010703-02 (3 July 2001) Abstract \| Full text \| Editor’s summary Translocations in acute megakaryoblastic leukemia result in the fusion of two novel genes.
	Research news Pollen coat protein gene families David Bruce Genome Biology 2001, 2:spotlight-20010703-01 (3 July 2001) Abstract \| Full text \| Editor’s summary Pollen coat proteins have been found to be encoded by genes clustered within Arabidopsis genome.
	Research news Caught by the secretory-trap Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010704-01 (4 July 2001) Abstract \| Full text \| Editor’s summary A modified gene-trap approach has identified a large number of mouse genes encoding secreted and membrane proteins that are involved in development.
	Research news Hippocampus arrays Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010705-01 (5 July 2001) Abstract \| Full text \| Editor’s summary Microarray analysis identifies gene clusters associated with the development of the hippocampus in mice.
	Research news Stem-cell genomics Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010706-01 (6 July 2001) Abstract \| Full text \| Editor’s summary Analysis of distinct stem-cell populations attempts to define a universal stem-cell gene expression profile.
	Research news Epigenetically unstable Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010709-01 (9 July 2001) Abstract \| Full text \| Editor’s summary Analysis of cloned mice reveals widespread epigenetic instability throughout the genome.
	Research news Death by endonuclease Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010710-03 (10 July 2001) Abstract \| Full text \| Editor’s summary Experiments in nematodes and mice identify a mitochondrial endonuclease that is critical for regulating cell death.
	Research news Glyoxylate cycle as drug target? David Bruce Genome Biology 2001, 2:spotlight-20010710-01 (10 July 2001) Abstract \| Full text \| Editor’s summary Candida albicans cells require the glyoxylate cycle for replication inside macrophages, providing a potentially selective target for the treatment of systemic candidiasis.
	Research news A circadian clock in the cardiovascular system Simon Frantz Genome Biology 2001, 2:spotlight-20010710-02 (10 July 2001) Abstract \| Full text \| Editor’s summary The genetic circuitry underlying circadian rhythms in the cardiovascular system are being unravelled.
	Research news Pin-ning down breast cancer Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010711-01 (11 July 2001) Abstract \| Full text \| Editor’s summary The prolyl isomerase Pin1 regulates the cell cycle and may contribute to tumour growth.
	Research news Circulating DNA fragments involved in vasculitis Tudor Toma Genome Biology 2001, 2:spotlight-20010712-01 (12 July 2001) Abstract \| Full text \| Editor’s summary DNA fragments containing the CpG motif in the sera of patients with systemic lupus erythematosus may be implicated in vasculitis.
	Research news STAT mutation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010712-03 (12 July 2001) Abstract \| Full text \| Editor’s summary A mutation in the human STAT1 gene causes susceptibility to mycobacteria without affecting viral immunity.
	Research news Cape flora Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010713-02 (13 July 2001) Abstract \| Full text \| Editor’s summary A molecular phylogenetic study has assigned a date - about 7-8 million years - ago to the rapid species diversification of South African Cape flora.
	Research news Nuclear transfer results in inherently unstable offspring Adam Legge Genome Biology 2001, 2:spotlight-20010713-01 (13 July 2001) Abstract \| Full text \| Editor’s summary Mammalian development seems to be relatively tolerant to epigenetic aberrations of the genome, suggesting that cloning could result in viable offspring, despite widespread gene dysregulation.
	Research news Roving sharks Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010716-02 (16 July 2001) Abstract \| Full text \| Editor’s summary Genetic tracking of great white sharks reveals that males are roving, while females stay at home.
	Research news The molecular basis of allergenicity Tudor Toma Genome Biology 2001, 2:spotlight-20010716-01 (16 July 2001) Abstract \| Full text \| Editor’s summary Comparative analysis of the three-dimensional structures of diverse allergens reveals a common structural motif that could potentially serve as a ligand binding site.
	Research news Modified two-hybrid Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010717-01 (17 July 2001) Abstract \| Full text \| Editor’s summary A variation of the classic yeast two-hydrid protein-interaction assay selects for repression of transactivator proteins.
	Research news BRCA2-repair Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010718-01 (18 July 2001) Abstract \| Full text \| Editor’s summary The breast cancer-related protein BRCA2 regulates homologous recombination to repair damaged DNA.
	Research news Actin checkpoint Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010719-01 (19 July 2001) Abstract \| Full text \| Editor’s summary Experiments in fission yeast have identified a mitotic checkpoint controlled by the actin cytoskeleton and spindle orientation.
	Research news Pneumococcus genome Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010720-01 (20 July 2001) Abstract \| Full text \| Editor’s summary Complete genome sequence of Streptococcus pneumoniae, the bacterial pathogen that causes pneumonia and meningitis, has been reported.
	Research news Genome Rap Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010723-02 (23 July 2001) Abstract \| Full text \| Editor’s summary The yeast Rap1 protein shows a binding preference for promoter regions of the genome.
	Research news Ras controls herpes virus penetration in cells Tudor Toma Genome Biology 2001, 2:spotlight-20010723-01 (23 July 2001) Abstract \| Full text \| Editor’s summary Oncogenes in Ras signalling pathway are essential in host-cell permissiveness to herpes simplex virus 1.
	Research news Targeted destruction Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010724-01 (24 July 2001) Abstract \| Full text \| Editor’s summary Synthetic chimeric molecules can be used to target proteins for ubiquitin-dependent degradation.
	Research news pRB repression in yeast Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010725-01 (25 July 2001) Abstract \| Full text \| Editor’s summary A yeast model has helped to define the mechanism by which mammalian pRB represses gene transcription.
	Research news Neuroferritinopathy Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010726-01 (26 July 2001) Abstract \| Full text \| Editor’s summary A new dominantly inherited genetic disease is caused by mutations in the ferritin light polypeptide gene.
	Research news Proteome chips Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010727-01 (27 July 2001) Abstract \| Full text \| Editor’s summary Screening of a yeast proteome microarray identifies new calmodulin- and phospholipid-interacting proteins.
	Research news Imprinted inactivation Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010730-01 (30 July 2001) Abstract \| Full text \| Editor’s summary The mouse eed gene is required for inactivation of the paternal X chromosome in extra-embryonic tissues.
	Research news CpG receptors Jonathan B Weitzman Genome Biology 2001, 2:spotlight-20010731-01 (31 July 2001) Abstract \| Full text \| Editor’s summary Human and mouse Toll-like receptors each recognize distinct CpG-DNA motifs.
	Research
	Research Distinct gene expression profiles of human type 1 and type 2 T helper cells Heli Hamalainen, Hua Zhou, William Chou, Hideki Hashizume, Renu Heller, Riitta Lahesmaa Genome Biology 2001, 2:research0022-research0022.11 (21 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An oligonucleotide microarray has been used to screen helper T cell subsets for inflammation-related candidate genes. Subtle changes in the expression of genes that represent growth factors, receptors and other signaling molecules were found.
	Research Gene trapping identifies transiently induced survival genes during programmed cell death Frank Wempe, Ji-Yeon Yang, Joanna Hammann, Harald von Melchner Genome Biology 2001, 2:research0023-research0023.10 (27 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To identify transcriptional mechanisms that interfere with cell death and survival, gene-trap mutagenesis has been combined with site-specific recombination to isolate genes from cells undergoing apoptosis by growth factor deprivation. Most of the known genes recovered in this analysis encoded proteins with survival functions.
	Research Isolation, in silico characterization and chromosomal localization of a group of cDNAs from ciliated epithelial cells after in vitro ciliogenesis Amit K Maiti, Mark Jorissen, Patrice Bouvagnet Genome Biology 2001, 2:research0026-research0026.9 (27 June 2001) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary To understand ciliary assembly and motility in human, total RNA was isolated from cultured ciliated nasal epithelial cells after in vitro ciliogenesis and expressed sequenced tags (ESTs) were generated. The functions and locations of 63 of these ESTs were derived by BLAST from two public databases.
	Research Analysis of the myosins encoded in the recently completed Arabidopsis thaliana genome sequence Anireddy SN Reddy, Irene S Day Genome Biology 2001, 2:research0024-research0024.17 (3 July 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Using the motor domain of an Arabidopsis myosin, 17 myosin sequences have been identified in the Arabidopsis genome. Phylogenetic analysis reveals that plant myosins fall into two groups and are unlike myosins from any other organisms except algae.
	Research A draft annotation and overview of the human genome Fred A Wright, William J Lemon, Wei D Zhao, Russell Sears, Degen Zhuo, Jian-Ping Wang, Hee-Yung Yang, Troy Baer, Don Stredney, Joe Spitzner, Al Stutz, Ralf Krahe, Bo Yuan Genome Biology 2001, 2:research0025-research0025.18 (4 July 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A functionally annotated human gene index is reported, placed directly on the genome, based on the integration of public transcript, protein, and mapping information, supplemented with computational prediction. The genome is estimated to contain 65,000-75,000 transcriptional units, with exonic sequences comprising 4%.

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