Genome Biology | Volume 3 Issue 2

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	Volume 3 Issue 2
	Comment
	Comment If you can't take any more of this, please press two Gregory A Petsko Genome Biology 2002, 3:comment1002-comment1002.2 (28 January 2002) Full text \| PDF \| PubMed
	Comment Life sentences: Hunters and gatherers Sydney Brenner Genome Biology 2002, 3:comment1003-comment1003.2 (5 February 2002) Full text \| PDF \| PubMed
	Review
	Review The evolutionary history of effectors downstream of Cdc42 and Rac Sophie Cotteret, Jonathan Chernoff Genome Biology 2002, 3:reviews0002-reviews0002.8 (14 January 2002) Abstract \| Full text \| PDF \| PubMed
	Review Exploring prokaryotic diversity in the genomic era Philip Hugenholtz Genome Biology 2002, 3:reviews0003-reviews0003.8 (29 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Protein family review Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases Susan H Harvey, Michael JE Krien, Matthew J O'Connell Genome Biology 2002, 3:reviews3003-reviews3003.5 (30 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The structural maintenance of chromosomes (SMC) proteins are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. They function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression.
	Minireview Epigenetic reprogramming in the mammalian embryo: struggle of the clones Mellissa RW Mann, Marisa S Bartolomei Genome Biology 2002, 3:reviews1003-reviews1003.4 (29 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Minireview Pollen recognition during the self-incompatibility response in plants Simon J Hiscock Genome Biology 2002, 3:reviews1004-reviews1004.6 (30 January 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent work has identified the elusive male (pollen) determinant that underlies self-incompatibility in Brassica (cabbage). The key pollen factor, recognized by the stigma of an incompatible plant, is a small cysteine-rich protein that interacts directly with the receptor domain of a stigma receptor serine-threonine kinase to initiate haplotype-specific pollen recognition and rejection.
	Opinion The past, present and future of genome-wide re-annotation Christos A Ouzounis, Peter D Karp Genome Biology 2002, 3:comment2001-comment2001.6 (31 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Web report Finding the needle in the haystack Alessandro Guffanti Genome Biology 2002, 3:reports2008 (21 January 2002) Abstract \| Full text
	Web report Linking out to functional genomics Pancy Oi Sin Tam Genome Biology 2002, 3:reports2009 (1 February 2002) Abstract \| Full text \| Editor’s summary Y.F. Leung's Functional Genomics website is a portal of up-to-date annotated links to databases, software, analysis materials and protocols for functional genomics, microarrays, bioinformatics, proteomics and complex-disease trait mapping
	Web report All you need to know about p53 Eliezer Kopf Genome Biology 2002, 3:reports2010 (1 February 2002) Abstract \| Full text \| 1 comment \| Editor’s summary For researchers interested in tumor suppressors, and in particular the p53 protein, this is a useful website; it includes a p53 database, an APC database and a p53 mutation-analysis database
	Paper report Ras signaling in Drosophila oogenesis Chris Berrie Genome Biology 2002, 3:reports0008 (24 January 2002) Abstract \| Full text \| Editor’s summary Dorsoventral patterning in Drosophila oogenesis reveals new links between Ras1 and genes involved in signaling and cytoskeletal organization
	Paper report Getting Cre protein into cells Negar Jamshidi Genome Biology 2002, 3:reports0009 (24 January 2002) Abstract \| Full text \| Editor’s summary A novel protein-based approach has been developed to import a cell-permeable form of the site-specific recombinase Cre into undifferentiated and terminally differentiated mammalian cells
	Paper report More neuropeptides in C. elegans Nektarios Tavernarakis Genome Biology 2002, 3:reports0010 (24 January 2002) Abstract \| Full text \| Editor’s summary A genome-wide scan has revealed multiple conserved groups of neuropeptide genes in the nematode Caenorhabditis elegans
	Paper report Bacterial drug transporters Wim D'Haeze Genome Biology 2002, 3:reports0011 (1 February 2002) Abstract \| Full text \| Editor’s summary An expression study of prospective bacterial drug-transporter genes has extended the range of substrates known to be transported and has identified an ABC-family drug transporter in Gram-negative bacteria
	Meeting report Structural genomics: a new era for pharmaceutical research Yang Liu, Nicholas M Luscombe, Vadim Alexandrov, Paul Bertone, Paul Harrison, Zhaolei Zhang, Mark Gerstein Genome Biology 2002, 3:reports4004-reports4004.3 (14 January 2002) Abstract \| Full text \| PDF \| PubMed
	Meeting report 2001: a mouse genome odyssey David R Beier, Bruce J Herron Genome Biology 2002, 3:reports4005-reports4005.4 (31 January 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 15th International Mouse Genome Conference, Edinburgh, UK, 21-24 October 2001.
	Research news BLAST off Christopher Thorpe Genome Biology 2002, 3:spotlight-20020201-01 (1 February 2002) Abstract \| Full text \| Editor’s summary A G4 Macintosh computer can run an Apple-optimized version of BLAST up to five-fold faster than previous processors
	Research news Breast cancer prognosis Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020204-01 (4 February 2002) Abstract \| Full text \| Editor’s summary Microarray experiments have identified a gene-expression signature that can accurately predict prognosis in breast cancer patients.
	Research news The riddle of the pharynx Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020205-01 (5 February 2002) Abstract \| Full text \| Editor’s summary Microarray analysis of worms identifies a genetic programme involved in organogenesis of the pharynx.
	Research news Mammalian gene 'knock-down' Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020206-01 (6 February 2002) Abstract \| Full text \| Editor’s summary Long double-stranded RNA can drive stable gene silencing in mammalian embryonic cell lines.
	Research news The death of Max Perutz Kate Hooper Genome Biology 2002, 3:spotlight-20020207-01 (7 February 2002) Abstract \| Full text \| Editor’s summary The Nobel prizewinner and eminent biologist Max Perutz has died.
	Research news Eukaryotic origins Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020207-02 (7 February 2002) Abstract \| Full text \| Editor’s summary Comparison of eukaryotic and prokaryotic genomes gives insights into the origins of the eukaryotic cell and its nucleus.
	Research news Phototrophs at sea Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020208-01 (8 February 2002) Abstract \| Full text \| Editor’s summary Genomic analysis reveals the richness and diversity of marine ecosystems.
	Research news Radiation risks Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020211-01 (11 February 2002) Abstract \| Full text \| Editor’s summary People living near nuclear test sites have an almost two-fold increase in germline mutation rates.
	Research news Doing the genome shuffle Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020212-01 (12 February 2002) Abstract \| Full text \| Editor’s summary Shuffling bacterial genomes can generate improved strains by accelerating evolution.
	Research news Proteomic early detection of ovarian cancer Tudor Toma Genome Biology 2002, 3:spotlight-20020213-01 (13 February 2002) Abstract \| Full text \| Editor’s summary Computer-assisted detection of proteomic patterns identifies types of ovarian cancer and could help screen high-risk populations.
	Research news Vasculature mapping Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020213-02 (13 February 2002) Abstract \| Full text \| Editor’s summary High-throughput phage display in patients identifies peptides that target specific tissues.
	Research news Premature death Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020214-01 (14 February 2002) Abstract \| Full text \| Editor’s summary Mice born after somatic cloning die prematurely from hepatic and immune defects.
	Research news Viruses on the brain Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020215-01 (15 February 2002) Abstract \| Full text \| Editor’s summary Viral delivery of Cre recombinase can result in genetic engineering in the nervous system of adult mice.
	Research news Chromosome conformation Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020218-02 (18 February 2002) Abstract \| Full text \| Editor’s summary A new high-throughput technique allows analysis of the spatial organization of individual chromosomes.
	Research news Diagnosing cancer with artificial neural networks Tudor Toma Genome Biology 2002, 3:spotlight-20020218-01 (18 February 2002) Abstract \| Full text \| Editor’s summary Artificial neural networks can efficiently distinguish human subtypes of neoplastic colorectal lesions.
	Research news Stress-induced recombination Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020219-01 (19 February 2002) Abstract \| Full text \| Editor’s summary The stress of pathogenic attack can stimulate somatic recombination in plants.
	Research news Shaping gene expression Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020220-01 (20 February 2002) Abstract \| Full text \| Editor’s summary Changes in cell and nuclear shape drive the expression of genes characteristic of differentiation.
	Research news The other yeast genome Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020221-01 (21 February 2002) Abstract \| Full text \| Editor’s summary The sequencing of the sixth model eukaryotic genome, that of Schizosaccharomyces pombe, has been completed.
	Research news Copy cat Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020222-01 (22 February 2002) Abstract \| Full text \| Editor’s summary Our feline friends join the list of animal species cloned by nuclear transfer.
	Research news Histone modification in heterochromatin Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020225-01 (25 February 2002) Abstract \| Full text \| Editor’s summary The spatial organization of pericentric chromatin is established by histone acetylation and methylation, and involves an RNA component.
	Research news Mouse mutagenesis Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020226-01 (26 February 2002) Abstract \| Full text \| Editor’s summary Archives of DNA and sperm allow the rapid identification of mouse mutants.
	Research news Extracellular DNA Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020227-01 (27 February 2002) Abstract \| Full text \| Editor’s summary DNA secreted by bacteria is important for the formation and maintenance of biofilms.
	Research
	Research Evaluation of differential gene expression during behavioral development in the honeybee using microarrays and northern blots Robert Kucharski, Ryszard Maleszka Genome Biology 2002, 3:research0007-research0007.9 (14 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary DNA arrays have been used to explore the dynamics of gene expression in honeybees during distinct behavioral stages of adult development and during drug-induced behavioral modifications.
	Research Selection in the evolution of gene duplications Fyodor A Kondrashov, Igor B Rogozin, Yuri I Wolf, Eugene V Koonin Genome Biology 2002, 3:research0008-research0008.9 (14 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of bacterial, archael and eukaryotic genomes indicate that recently duplicated paralogs evolve faster than orthologs with the same level of divergence and similar functions, but apparently do not experience a phase of neutral evolution.
	Research A database for the provisional identification of species using only genotypes: web-based genome profiling Takehiro Watanabe, Ayumu Saito, Yusuke Takeuchi, Mohammed Naimuddin, Koichi Nishigaki Genome Biology 2002, 3:research0010-research0010.8 (28 January 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An approach that will allow rapid and accurate phylogenetic comparison of any unknown microbial strain to all known type strains has been developed, enabling tentative assignments of strains to species. The approach is based on two main technologies: genome profiling and Internet-based databases.
	Research Model-based cluster analysis of microarray gene-expression data Wei Pan, Jizhen Lin, Chap T Le Genome Biology 2002, 3:research0009-research0009.8 (29 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Clustering techniques have been widely applied in analyzing microarray data, but normal mixture model-based cluster analysis has not been widely used. Here, the method is applied to a data set containing expression levels of 1,176 genes of rats with and without pneumococcal middle-ear infection.
	Correspondence
	Correspondence Rosetta Stone proteins: "chance and necessity"? Reiner A Veitia Genome Biology 2002, 3:interactions1001-interactions1001.3 (8 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A response to Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions by AJ Enright, CA Ouzounis. Genome Biology 2000, 2:research0034.1-0034.7

	Volume 3 Issue 2
	Comment
	Comment If you can't take any more of this, please press two Gregory A Petsko Genome Biology 2002, 3:comment1002-comment1002.2 (28 January 2002) Full text \| PDF \| PubMed
	Comment Life sentences: Hunters and gatherers Sydney Brenner Genome Biology 2002, 3:comment1003-comment1003.2 (5 February 2002) Full text \| PDF \| PubMed
	Review
	Review The evolutionary history of effectors downstream of Cdc42 and Rac Sophie Cotteret, Jonathan Chernoff Genome Biology 2002, 3:reviews0002-reviews0002.8 (14 January 2002) Abstract \| Full text \| PDF \| PubMed
	Review Exploring prokaryotic diversity in the genomic era Philip Hugenholtz Genome Biology 2002, 3:reviews0003-reviews0003.8 (29 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Protein family review Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases Susan H Harvey, Michael JE Krien, Matthew J O'Connell Genome Biology 2002, 3:reviews3003-reviews3003.5 (30 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The structural maintenance of chromosomes (SMC) proteins are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. They function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair and epigenetic silencing of gene expression.
	Minireview Epigenetic reprogramming in the mammalian embryo: struggle of the clones Mellissa RW Mann, Marisa S Bartolomei Genome Biology 2002, 3:reviews1003-reviews1003.4 (29 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Minireview Pollen recognition during the self-incompatibility response in plants Simon J Hiscock Genome Biology 2002, 3:reviews1004-reviews1004.6 (30 January 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent work has identified the elusive male (pollen) determinant that underlies self-incompatibility in Brassica (cabbage). The key pollen factor, recognized by the stigma of an incompatible plant, is a small cysteine-rich protein that interacts directly with the receptor domain of a stigma receptor serine-threonine kinase to initiate haplotype-specific pollen recognition and rejection.
	Opinion The past, present and future of genome-wide re-annotation Christos A Ouzounis, Peter D Karp Genome Biology 2002, 3:comment2001-comment2001.6 (31 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central
	Report
	Web report Finding the needle in the haystack Alessandro Guffanti Genome Biology 2002, 3:reports2008 (21 January 2002) Abstract \| Full text
	Web report Linking out to functional genomics Pancy Oi Sin Tam Genome Biology 2002, 3:reports2009 (1 February 2002) Abstract \| Full text \| Editor’s summary Y.F. Leung's Functional Genomics website is a portal of up-to-date annotated links to databases, software, analysis materials and protocols for functional genomics, microarrays, bioinformatics, proteomics and complex-disease trait mapping
	Web report All you need to know about p53 Eliezer Kopf Genome Biology 2002, 3:reports2010 (1 February 2002) Abstract \| Full text \| 1 comment \| Editor’s summary For researchers interested in tumor suppressors, and in particular the p53 protein, this is a useful website; it includes a p53 database, an APC database and a p53 mutation-analysis database
	Paper report Ras signaling in Drosophila oogenesis Chris Berrie Genome Biology 2002, 3:reports0008 (24 January 2002) Abstract \| Full text \| Editor’s summary Dorsoventral patterning in Drosophila oogenesis reveals new links between Ras1 and genes involved in signaling and cytoskeletal organization
	Paper report Getting Cre protein into cells Negar Jamshidi Genome Biology 2002, 3:reports0009 (24 January 2002) Abstract \| Full text \| Editor’s summary A novel protein-based approach has been developed to import a cell-permeable form of the site-specific recombinase Cre into undifferentiated and terminally differentiated mammalian cells
	Paper report More neuropeptides in C. elegans Nektarios Tavernarakis Genome Biology 2002, 3:reports0010 (24 January 2002) Abstract \| Full text \| Editor’s summary A genome-wide scan has revealed multiple conserved groups of neuropeptide genes in the nematode Caenorhabditis elegans
	Paper report Bacterial drug transporters Wim D'Haeze Genome Biology 2002, 3:reports0011 (1 February 2002) Abstract \| Full text \| Editor’s summary An expression study of prospective bacterial drug-transporter genes has extended the range of substrates known to be transported and has identified an ABC-family drug transporter in Gram-negative bacteria
	Meeting report Structural genomics: a new era for pharmaceutical research Yang Liu, Nicholas M Luscombe, Vadim Alexandrov, Paul Bertone, Paul Harrison, Zhaolei Zhang, Mark Gerstein Genome Biology 2002, 3:reports4004-reports4004.3 (14 January 2002) Abstract \| Full text \| PDF \| PubMed
	Meeting report 2001: a mouse genome odyssey David R Beier, Bruce J Herron Genome Biology 2002, 3:reports4005-reports4005.4 (31 January 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 15th International Mouse Genome Conference, Edinburgh, UK, 21-24 October 2001.
	Research news BLAST off Christopher Thorpe Genome Biology 2002, 3:spotlight-20020201-01 (1 February 2002) Abstract \| Full text \| Editor’s summary A G4 Macintosh computer can run an Apple-optimized version of BLAST up to five-fold faster than previous processors
	Research news Breast cancer prognosis Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020204-01 (4 February 2002) Abstract \| Full text \| Editor’s summary Microarray experiments have identified a gene-expression signature that can accurately predict prognosis in breast cancer patients.
	Research news The riddle of the pharynx Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020205-01 (5 February 2002) Abstract \| Full text \| Editor’s summary Microarray analysis of worms identifies a genetic programme involved in organogenesis of the pharynx.
	Research news Mammalian gene 'knock-down' Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020206-01 (6 February 2002) Abstract \| Full text \| Editor’s summary Long double-stranded RNA can drive stable gene silencing in mammalian embryonic cell lines.
	Research news The death of Max Perutz Kate Hooper Genome Biology 2002, 3:spotlight-20020207-01 (7 February 2002) Abstract \| Full text \| Editor’s summary The Nobel prizewinner and eminent biologist Max Perutz has died.
	Research news Eukaryotic origins Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020207-02 (7 February 2002) Abstract \| Full text \| Editor’s summary Comparison of eukaryotic and prokaryotic genomes gives insights into the origins of the eukaryotic cell and its nucleus.
	Research news Phototrophs at sea Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020208-01 (8 February 2002) Abstract \| Full text \| Editor’s summary Genomic analysis reveals the richness and diversity of marine ecosystems.
	Research news Radiation risks Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020211-01 (11 February 2002) Abstract \| Full text \| Editor’s summary People living near nuclear test sites have an almost two-fold increase in germline mutation rates.
	Research news Doing the genome shuffle Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020212-01 (12 February 2002) Abstract \| Full text \| Editor’s summary Shuffling bacterial genomes can generate improved strains by accelerating evolution.
	Research news Proteomic early detection of ovarian cancer Tudor Toma Genome Biology 2002, 3:spotlight-20020213-01 (13 February 2002) Abstract \| Full text \| Editor’s summary Computer-assisted detection of proteomic patterns identifies types of ovarian cancer and could help screen high-risk populations.
	Research news Vasculature mapping Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020213-02 (13 February 2002) Abstract \| Full text \| Editor’s summary High-throughput phage display in patients identifies peptides that target specific tissues.
	Research news Premature death Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020214-01 (14 February 2002) Abstract \| Full text \| Editor’s summary Mice born after somatic cloning die prematurely from hepatic and immune defects.
	Research news Viruses on the brain Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020215-01 (15 February 2002) Abstract \| Full text \| Editor’s summary Viral delivery of Cre recombinase can result in genetic engineering in the nervous system of adult mice.
	Research news Chromosome conformation Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020218-02 (18 February 2002) Abstract \| Full text \| Editor’s summary A new high-throughput technique allows analysis of the spatial organization of individual chromosomes.
	Research news Diagnosing cancer with artificial neural networks Tudor Toma Genome Biology 2002, 3:spotlight-20020218-01 (18 February 2002) Abstract \| Full text \| Editor’s summary Artificial neural networks can efficiently distinguish human subtypes of neoplastic colorectal lesions.
	Research news Stress-induced recombination Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020219-01 (19 February 2002) Abstract \| Full text \| Editor’s summary The stress of pathogenic attack can stimulate somatic recombination in plants.
	Research news Shaping gene expression Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020220-01 (20 February 2002) Abstract \| Full text \| Editor’s summary Changes in cell and nuclear shape drive the expression of genes characteristic of differentiation.
	Research news The other yeast genome Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020221-01 (21 February 2002) Abstract \| Full text \| Editor’s summary The sequencing of the sixth model eukaryotic genome, that of Schizosaccharomyces pombe, has been completed.
	Research news Copy cat Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020222-01 (22 February 2002) Abstract \| Full text \| Editor’s summary Our feline friends join the list of animal species cloned by nuclear transfer.
	Research news Histone modification in heterochromatin Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020225-01 (25 February 2002) Abstract \| Full text \| Editor’s summary The spatial organization of pericentric chromatin is established by histone acetylation and methylation, and involves an RNA component.
	Research news Mouse mutagenesis Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020226-01 (26 February 2002) Abstract \| Full text \| Editor’s summary Archives of DNA and sperm allow the rapid identification of mouse mutants.
	Research news Extracellular DNA Jonathan B Weitzman Genome Biology 2002, 3:spotlight-20020227-01 (27 February 2002) Abstract \| Full text \| Editor’s summary DNA secreted by bacteria is important for the formation and maintenance of biofilms.
	Research
	Research Evaluation of differential gene expression during behavioral development in the honeybee using microarrays and northern blots Robert Kucharski, Ryszard Maleszka Genome Biology 2002, 3:research0007-research0007.9 (14 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary DNA arrays have been used to explore the dynamics of gene expression in honeybees during distinct behavioral stages of adult development and during drug-induced behavioral modifications.
	Research Selection in the evolution of gene duplications Fyodor A Kondrashov, Igor B Rogozin, Yuri I Wolf, Eugene V Koonin Genome Biology 2002, 3:research0008-research0008.9 (14 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Analysis of bacterial, archael and eukaryotic genomes indicate that recently duplicated paralogs evolve faster than orthologs with the same level of divergence and similar functions, but apparently do not experience a phase of neutral evolution.
	Research A database for the provisional identification of species using only genotypes: web-based genome profiling Takehiro Watanabe, Ayumu Saito, Yusuke Takeuchi, Mohammed Naimuddin, Koichi Nishigaki Genome Biology 2002, 3:research0010-research0010.8 (28 January 2002) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An approach that will allow rapid and accurate phylogenetic comparison of any unknown microbial strain to all known type strains has been developed, enabling tentative assignments of strains to species. The approach is based on two main technologies: genome profiling and Internet-based databases.
	Research Model-based cluster analysis of microarray gene-expression data Wei Pan, Jizhen Lin, Chap T Le Genome Biology 2002, 3:research0009-research0009.8 (29 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Clustering techniques have been widely applied in analyzing microarray data, but normal mixture model-based cluster analysis has not been widely used. Here, the method is applied to a data set containing expression levels of 1,176 genes of rats with and without pneumococcal middle-ear infection.
	Correspondence
	Correspondence Rosetta Stone proteins: "chance and necessity"? Reiner A Veitia Genome Biology 2002, 3:interactions1001-interactions1001.3 (8 January 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A response to Functional associations of proteins in entire genomes by means of exhaustive detection of gene fusions by AJ Enright, CA Ouzounis. Genome Biology 2000, 2:research0034.1-0034.7

Explore Genome Biology

Articles

Volume 3 Issue 2

Comment

Review

Report

Research

Correspondence