Genome Biology | Volume 4 Issue 11

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	Volume 4 Issue 11
	Comment
	Comment Sleeping dogs Gregory A Petsko Genome Biology 2003, 4:120 (23 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The dog genome sequence represents a landmark in the genomics era for a number of reasons.
	Review
	Protein family review The septins Makoto Kinoshita Genome Biology 2003, 4:236 (27 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The septins are guanine-nucleotide binding proteins that mostly form filaments. They are important in cytokinesis and also have roles in sporulation in yeasts and embryonic development and in the nervous system in animals.
	Minireview Multi-level response of the yeast genome to glucose Ruud Geladé, Sam Van de Velde, Patrick Van Dijck, Johan M Thevelein Genome Biology 2003, 4:233 (15 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent microarray analysis has revealed multiple levels of genomic sensitivity to glucose and highlighted the power of genome-wide analysis to detect cellular responses to minute environmental changes in the yeast Saccharomyces cerevisiae.
	Minireview Asthma investigators begin to reap the fruits of genomics David J Erle, Yee Yang Genome Biology 2003, 4:232 (27 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In the near future, genomics may have a profound impact on the way we think about the common and complex disease asthma.
	Minireview Detergent-resistant membranes and the protein composition of lipid rafts Anthony I Magee, Ingela Parmryd Genome Biology 2003, 4:234 (27 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Several recent proteomic studies have addressed the composition of lipid rafts in the plasma membrane, but the different definitions used for lipid rafts need scrutinizing before results can be evaluated.
	Minireview Extending knowledge of Escherichia coli metabolism by modeling and experiment Eberhard O Voit, Monica Riley Genome Biology 2003, 4:235 (28 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two recent studies integrate data from many different sources for Escherichia coli, using mathematical modeling and a combination of gene expression and protein levels to predict new gene functions and metabolic behaviors.
	Report
	Paper report Articles selected by Faculty of 1000: chemical modification analysis of siRNAs; allele-specific variation in gene expression; gut parasite comparative genomics; functional promoter variants; microRNA finction in leaf development Genome Biology 2003, 4:348 (9 October 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering a chemical modification analysis of siRNAs; allele-specific variation in gene expression in the human genome; gut parasite comparative genomics; functional promoter variants; microRNA finction in leaf development.
	Paper report Articles selected by Faculty of 1000: identifying pol III-dependent genes; entomopathogen genome; microbial genome dynamics; profiling ES cells; gene expression regulation by small RNAs Genome Biology 2003, 4:349 (17 October 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the identification of pol III-dependent genes, the genome sequence of Photorhabdus luminescens, microbial genome dynamics, profiling ES cells and gene expression regulation by small RNAs.
	Meeting report Developments in developmental genomics Holly A Field, Kevin P White Genome Biology 2003, 4:345 (15 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 62nd Annual Meeting for the Society for Developmental Biology (SDB), Boston, USA, 30 July to 3 August 2003.
	Meeting report Making and breaking the message David A Mangus, Ambro van Hoof Genome Biology 2003, 4:346 (21 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Cold Spring Harbor Laboratory meeting 'Eukaryotic mRNA Processing', Cold Spring Harbor, USA, 20-24 August 2003.
	Meeting report A golden age for microbial genomics Tom Coenye Genome Biology 2003, 4:347 (21 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the main symposium 'Exploiting genomes: from bases to megabases in 50 years' at the 153rd Meeting of the Society for General Microbiology (SGM), Manchester, UK, 8-9 September 2003.
	Deposited research article MicroRNA Targets in Drosophila Anton Enright, Bino John, Ulrike Gaul, Thomas Tuschl, Chris Sander, Debora Marks Genome Biology 2003, 4:P8 (14 October 2003) Abstract \| Full text \| PDF \| Editor’s summary We present a novel three-step method for whole-genome prediction of miRNA target genes, validated using known examples. We apply the method to discover hundreds of potential target genes in D. melanogaster.
	Research news Mixed views on Wilkie censure Anna Fazackerley Genome Biology 2003, 4:spotlight-20031104-01 (4 November 2003) Abstract \| Full text \| Editor’s summary There have been widely varying reactions to the suspension of an Oxford academic who rejected an Israeli student
	Research news Nervous atlas Cathy Holding Genome Biology 2003, 4:spotlight-20031104-02 (4 November 2003) Abstract \| Full text \| Editor’s summary A CNS gene expression atlas provides an invaluable resource for neurological disorder research
	Research news Germany's genome boost Jane Burgermeister Genome Biology 2003, 4:spotlight-20031105-01 (5 November 2003) Abstract \| Full text \| Editor’s summary The National Genome Research Network gets a cash influx, but some feel it isn't delivering the goods
	Research news Antiterror ethics code urged Anna Fazackerley Genome Biology 2003, 4:spotlight-20031106-01 (6 November 2003) Abstract \| Full text \| Editor’s summary Science needs stronger self-regulation to prevent misuse by terrorists, UK politicians say
	Research news Diphtheria exposed during comeback Cathy Holding Genome Biology 2003, 4:spotlight-20031107-01 (7 November 2003) Abstract \| Full text \| Editor’s summary Corynebacterium genome sequence identifies novel therapeutic targets and medical intervention routes
	Research news Fly screen Cathy Holding Genome Biology 2003, 4:spotlight-20031107-02 (7 November 2003) Abstract \| Full text \| Editor’s summary A genome-scale protein interaction map provides novel targets for therapeutics
	Research news Worm reanimation checkpoint David Secko Genome Biology 2003, 4:spotlight-20031107-03 (7 November 2003) Abstract \| Full text \| Editor’s summary Anoxia-induced suspended animation in C. elegans requires spindle checkpoint components
	Research news Whole genome knockout library Cathy Holding Genome Biology 2003, 4:spotlight-20031111-01 (11 November 2003) Abstract \| Full text \| Editor’s summary High-throughput gene disruption of Pseudomonas aeruginosa suggests novel therapeutic targets
	Research news US DOE presents priorities Eugene Russo Genome Biology 2003, 4:spotlight-20031112-01 (12 November 2003) Abstract \| Full text \| Editor’s summary Protein and molecular machines projects are among a list of 28 initiatives for the next 20 years
	Research news Digital biology: challenges remain Eugene Russo Genome Biology 2003, 4:spotlight-20031112-02 (12 November 2003) Abstract \| Full text \| Editor’s summary NIH symposium tackles difficult networking and reliability issues in computational research
	Research news Giant leaps, not small steps Cathy Holding Genome Biology 2003, 4:spotlight-20031113-01 (13 November 2003) Abstract \| Full text \| Editor’s summary Adaptive change occurs by a single major mutation in plant species
	Research news Ancient 'GM' corn C L Bishop Genome Biology 2003, 4:spotlight-20031114-01 (14 November 2003) Abstract \| Full text \| Editor’s summary Allelic selection established in ancient crops is maintained in modern-day maize
	Research news Shortening LINEs Cathy Holding Genome Biology 2003, 4:spotlight-20031117-01 (17 November 2003) Abstract \| Full text \| Editor’s summary Internal polyadenylation signals in mobile genetic elements limits their mobility
	Research news How many genomes are enough? Tabitha M Powledge Genome Biology 2003, 4:spotlight-20031118-01 (18 November 2003) Abstract \| Full text \| Editor’s summary The more, the merrier, researchers declare. Is the sky the limit?
	Research news Caenorhabditis comparative genomics Cathy Holding Genome Biology 2003, 4:spotlight-20031118-08 (18 November 2003) Abstract \| Full text \| Editor’s summary The C. briggsae draft genome strengthens the case for sequencing additional worm species
	Research news Genome complexity Cathy Holding Genome Biology 2003, 4:spotlight-20031124-01 (24 November 2003) Abstract \| Full text \| Editor’s summary Did complex genomes evolve by chance?
	Research news Germany goes interdisciplinary Jane Burgermeister Genome Biology 2003, 4:spotlight-20031127-01 (27 November 2003) Abstract \| Full text \| Editor’s summary An ambitious project allocates millions to long, complicated biomedical research
	Research news Cross-species transfer is last straw Cathy Holding Genome Biology 2003, 4:spotlight-20031128-01 (28 November 2003) Abstract \| Full text \| Editor’s summary Staphylococcus-acquired vancomycin resistance from enterococcal co-isolate
	Research
	Research Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels Janet M Young, Benjamin M Shykind, Robert P Lane, Lori Tonnes-Priddy, Joseph A Ross, Megan Walker, Eleanor M Williams, Barbara J Trask Genome Biology 2003, 4:R71 (7 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Previous computational analyses have identified approximately 1,500 mouse olfactory receptors, but experimental evidence confirming olfactory function is available for very few receptors. A mouse olfactory epithelium cDNA library was screened to obtain olfactory receptor expressed sequence tags, providing evidence of olfactory function for many additional olfactory receptors, as well as identifying gene structure and putative promoter regions.
	Research The non-LTR retrotransposons in Ciona intestinalis: new insights into the evolution of chordate genomes Jon Permanyer, Roser Gonzàlez-Duarte, Ricard Albalat Genome Biology 2003, 4:R73 (21 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In silico and experimental approaches have been used to identify the non-long terminal repeat retrotransposons of the urochordate Ciona intestinalis providing valuable data for understanding the evolution of early chordate genomes.
	Research Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates Kazuhiko Ohshima, Masahira Hattori, Tetsusi Yada, Takashi Gojobori, Yoshiyuki Sakaki, Norihiro Okada Genome Biology 2003, 4:R74 (28 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first comprehensive analysis of human processed pseudogenes (PPs) using all known human genes as queries is presented. The data suggest a nearly simultaneous burst of PP and Alu formation in the genomes of ancestral primates.
	Research The amino-acid mutational spectrum of human genetic disease Dennis Vitkup, Chris Sander, George M Church Genome Biology 2003, 4:R72 (30 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The human disease spectrum is compared to the spectra of mutual amino-acid mutation frequencies, non-disease polymorphisms in human genes, and substitutions fixed between species.
	Method POCUS: mining genomic sequence annotation to predict disease genes Frances S Turner, Daniel R Clutterbuck, Colin Semple Genome Biology 2003, 4:R75 (10 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary POCUS (prioritization of candidate genes using statistics) is a novel computational approach to prioritize candidate disease genes that is based on over-representation of functional annotation between loci for the same disease.
	Method Application of independent component analysis to microarrays Su-In Lee, Serafim Batzoglou Genome Biology 2003, 4:R76 (24 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Linear and nonlinear independent component analysis (ICA) was used to project microarray data into statistically independent components that correspond to putative biological processes, and to cluster genes according to over- or under-expression in each component.
	Software Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl Gertrud Fischer, Saleh M Ibrahim, Gudrun A Brockmann, Jens Pahnke, Ezio Bartocci, Hans-Jürgen Thiesen, Pablo Serrano-Fernández, Steffen Möller Genome Biology 2003, 4:R77 (10 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Expressionview is a software tool for combined visualization of gene-expression data and quantitative trait loci (QTL). The application is implemented as an extension to the Ensembl project and caters for a direct transition from microarray experiments of gene or protein expression levels to the genomic context of individual genes and QTL.

	Volume 4 Issue 11
	Comment
	Comment Sleeping dogs Gregory A Petsko Genome Biology 2003, 4:120 (23 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The dog genome sequence represents a landmark in the genomics era for a number of reasons.
	Review
	Protein family review The septins Makoto Kinoshita Genome Biology 2003, 4:236 (27 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The septins are guanine-nucleotide binding proteins that mostly form filaments. They are important in cytokinesis and also have roles in sporulation in yeasts and embryonic development and in the nervous system in animals.
	Minireview Multi-level response of the yeast genome to glucose Ruud Geladé, Sam Van de Velde, Patrick Van Dijck, Johan M Thevelein Genome Biology 2003, 4:233 (15 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent microarray analysis has revealed multiple levels of genomic sensitivity to glucose and highlighted the power of genome-wide analysis to detect cellular responses to minute environmental changes in the yeast Saccharomyces cerevisiae.
	Minireview Asthma investigators begin to reap the fruits of genomics David J Erle, Yee Yang Genome Biology 2003, 4:232 (27 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary In the near future, genomics may have a profound impact on the way we think about the common and complex disease asthma.
	Minireview Detergent-resistant membranes and the protein composition of lipid rafts Anthony I Magee, Ingela Parmryd Genome Biology 2003, 4:234 (27 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Several recent proteomic studies have addressed the composition of lipid rafts in the plasma membrane, but the different definitions used for lipid rafts need scrutinizing before results can be evaluated.
	Minireview Extending knowledge of Escherichia coli metabolism by modeling and experiment Eberhard O Voit, Monica Riley Genome Biology 2003, 4:235 (28 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two recent studies integrate data from many different sources for Escherichia coli, using mathematical modeling and a combination of gene expression and protein levels to predict new gene functions and metabolic behaviors.
	Report
	Paper report Articles selected by Faculty of 1000: chemical modification analysis of siRNAs; allele-specific variation in gene expression; gut parasite comparative genomics; functional promoter variants; microRNA finction in leaf development Genome Biology 2003, 4:348 (9 October 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering a chemical modification analysis of siRNAs; allele-specific variation in gene expression in the human genome; gut parasite comparative genomics; functional promoter variants; microRNA finction in leaf development.
	Paper report Articles selected by Faculty of 1000: identifying pol III-dependent genes; entomopathogen genome; microbial genome dynamics; profiling ES cells; gene expression regulation by small RNAs Genome Biology 2003, 4:349 (17 October 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the identification of pol III-dependent genes, the genome sequence of Photorhabdus luminescens, microbial genome dynamics, profiling ES cells and gene expression regulation by small RNAs.
	Meeting report Developments in developmental genomics Holly A Field, Kevin P White Genome Biology 2003, 4:345 (15 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 62nd Annual Meeting for the Society for Developmental Biology (SDB), Boston, USA, 30 July to 3 August 2003.
	Meeting report Making and breaking the message David A Mangus, Ambro van Hoof Genome Biology 2003, 4:346 (21 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Cold Spring Harbor Laboratory meeting 'Eukaryotic mRNA Processing', Cold Spring Harbor, USA, 20-24 August 2003.
	Meeting report A golden age for microbial genomics Tom Coenye Genome Biology 2003, 4:347 (21 October 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the main symposium 'Exploiting genomes: from bases to megabases in 50 years' at the 153rd Meeting of the Society for General Microbiology (SGM), Manchester, UK, 8-9 September 2003.
	Deposited research article MicroRNA Targets in Drosophila Anton Enright, Bino John, Ulrike Gaul, Thomas Tuschl, Chris Sander, Debora Marks Genome Biology 2003, 4:P8 (14 October 2003) Abstract \| Full text \| PDF \| Editor’s summary We present a novel three-step method for whole-genome prediction of miRNA target genes, validated using known examples. We apply the method to discover hundreds of potential target genes in D. melanogaster.
	Research news Mixed views on Wilkie censure Anna Fazackerley Genome Biology 2003, 4:spotlight-20031104-01 (4 November 2003) Abstract \| Full text \| Editor’s summary There have been widely varying reactions to the suspension of an Oxford academic who rejected an Israeli student
	Research news Nervous atlas Cathy Holding Genome Biology 2003, 4:spotlight-20031104-02 (4 November 2003) Abstract \| Full text \| Editor’s summary A CNS gene expression atlas provides an invaluable resource for neurological disorder research
	Research news Germany's genome boost Jane Burgermeister Genome Biology 2003, 4:spotlight-20031105-01 (5 November 2003) Abstract \| Full text \| Editor’s summary The National Genome Research Network gets a cash influx, but some feel it isn't delivering the goods
	Research news Antiterror ethics code urged Anna Fazackerley Genome Biology 2003, 4:spotlight-20031106-01 (6 November 2003) Abstract \| Full text \| Editor’s summary Science needs stronger self-regulation to prevent misuse by terrorists, UK politicians say
	Research news Diphtheria exposed during comeback Cathy Holding Genome Biology 2003, 4:spotlight-20031107-01 (7 November 2003) Abstract \| Full text \| Editor’s summary Corynebacterium genome sequence identifies novel therapeutic targets and medical intervention routes
	Research news Fly screen Cathy Holding Genome Biology 2003, 4:spotlight-20031107-02 (7 November 2003) Abstract \| Full text \| Editor’s summary A genome-scale protein interaction map provides novel targets for therapeutics
	Research news Worm reanimation checkpoint David Secko Genome Biology 2003, 4:spotlight-20031107-03 (7 November 2003) Abstract \| Full text \| Editor’s summary Anoxia-induced suspended animation in C. elegans requires spindle checkpoint components
	Research news Whole genome knockout library Cathy Holding Genome Biology 2003, 4:spotlight-20031111-01 (11 November 2003) Abstract \| Full text \| Editor’s summary High-throughput gene disruption of Pseudomonas aeruginosa suggests novel therapeutic targets
	Research news US DOE presents priorities Eugene Russo Genome Biology 2003, 4:spotlight-20031112-01 (12 November 2003) Abstract \| Full text \| Editor’s summary Protein and molecular machines projects are among a list of 28 initiatives for the next 20 years
	Research news Digital biology: challenges remain Eugene Russo Genome Biology 2003, 4:spotlight-20031112-02 (12 November 2003) Abstract \| Full text \| Editor’s summary NIH symposium tackles difficult networking and reliability issues in computational research
	Research news Giant leaps, not small steps Cathy Holding Genome Biology 2003, 4:spotlight-20031113-01 (13 November 2003) Abstract \| Full text \| Editor’s summary Adaptive change occurs by a single major mutation in plant species
	Research news Ancient 'GM' corn C L Bishop Genome Biology 2003, 4:spotlight-20031114-01 (14 November 2003) Abstract \| Full text \| Editor’s summary Allelic selection established in ancient crops is maintained in modern-day maize
	Research news Shortening LINEs Cathy Holding Genome Biology 2003, 4:spotlight-20031117-01 (17 November 2003) Abstract \| Full text \| Editor’s summary Internal polyadenylation signals in mobile genetic elements limits their mobility
	Research news How many genomes are enough? Tabitha M Powledge Genome Biology 2003, 4:spotlight-20031118-01 (18 November 2003) Abstract \| Full text \| Editor’s summary The more, the merrier, researchers declare. Is the sky the limit?
	Research news Caenorhabditis comparative genomics Cathy Holding Genome Biology 2003, 4:spotlight-20031118-08 (18 November 2003) Abstract \| Full text \| Editor’s summary The C. briggsae draft genome strengthens the case for sequencing additional worm species
	Research news Genome complexity Cathy Holding Genome Biology 2003, 4:spotlight-20031124-01 (24 November 2003) Abstract \| Full text \| Editor’s summary Did complex genomes evolve by chance?
	Research news Germany goes interdisciplinary Jane Burgermeister Genome Biology 2003, 4:spotlight-20031127-01 (27 November 2003) Abstract \| Full text \| Editor’s summary An ambitious project allocates millions to long, complicated biomedical research
	Research news Cross-species transfer is last straw Cathy Holding Genome Biology 2003, 4:spotlight-20031128-01 (28 November 2003) Abstract \| Full text \| Editor’s summary Staphylococcus-acquired vancomycin resistance from enterococcal co-isolate
	Research
	Research Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels Janet M Young, Benjamin M Shykind, Robert P Lane, Lori Tonnes-Priddy, Joseph A Ross, Megan Walker, Eleanor M Williams, Barbara J Trask Genome Biology 2003, 4:R71 (7 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Previous computational analyses have identified approximately 1,500 mouse olfactory receptors, but experimental evidence confirming olfactory function is available for very few receptors. A mouse olfactory epithelium cDNA library was screened to obtain olfactory receptor expressed sequence tags, providing evidence of olfactory function for many additional olfactory receptors, as well as identifying gene structure and putative promoter regions.
	Research The non-LTR retrotransposons in Ciona intestinalis: new insights into the evolution of chordate genomes Jon Permanyer, Roser Gonzàlez-Duarte, Ricard Albalat Genome Biology 2003, 4:R73 (21 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In silico and experimental approaches have been used to identify the non-long terminal repeat retrotransposons of the urochordate Ciona intestinalis providing valuable data for understanding the evolution of early chordate genomes.
	Research Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates Kazuhiko Ohshima, Masahira Hattori, Tetsusi Yada, Takashi Gojobori, Yoshiyuki Sakaki, Norihiro Okada Genome Biology 2003, 4:R74 (28 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The first comprehensive analysis of human processed pseudogenes (PPs) using all known human genes as queries is presented. The data suggest a nearly simultaneous burst of PP and Alu formation in the genomes of ancestral primates.
	Research The amino-acid mutational spectrum of human genetic disease Dennis Vitkup, Chris Sander, George M Church Genome Biology 2003, 4:R72 (30 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The human disease spectrum is compared to the spectra of mutual amino-acid mutation frequencies, non-disease polymorphisms in human genes, and substitutions fixed between species.
	Method POCUS: mining genomic sequence annotation to predict disease genes Frances S Turner, Daniel R Clutterbuck, Colin Semple Genome Biology 2003, 4:R75 (10 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary POCUS (prioritization of candidate genes using statistics) is a novel computational approach to prioritize candidate disease genes that is based on over-representation of functional annotation between loci for the same disease.
	Method Application of independent component analysis to microarrays Su-In Lee, Serafim Batzoglou Genome Biology 2003, 4:R76 (24 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Linear and nonlinear independent component analysis (ICA) was used to project microarray data into statistically independent components that correspond to putative biological processes, and to cluster genes according to over- or under-expression in each component.
	Software Expressionview: visualization of quantitative trait loci and gene-expression data in Ensembl Gertrud Fischer, Saleh M Ibrahim, Gudrun A Brockmann, Jens Pahnke, Ezio Bartocci, Hans-Jürgen Thiesen, Pablo Serrano-Fernández, Steffen Möller Genome Biology 2003, 4:R77 (10 October 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Expressionview is a software tool for combined visualization of gene-expression data and quantitative trait loci (QTL). The application is implemented as an extension to the Ensembl project and caters for a direct transition from microarray experiments of gene or protein expression levels to the genomic context of individual genes and QTL.

Explore Genome Biology

Articles

Volume 4 Issue 11

Comment

Review

Report

Research