Genome Biology | Volume 4 Issue 3

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	Volume 4 Issue 3
	Comment
	Comment Still no flying cars Gregory A Petsko Genome Biology 2003, 4:106 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Why, after less than two centuries of almost incomprehensible technological progress has progress in so many areas seemed to slow almost to a halt.
	Review
	Review Overview of the voltage-gated sodium channel family Frank H Yu, William A Catterall Genome Biology 2003, 4:207 (24 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Different sodium channels have remarkably similar functional properties, but small changes in sodium-channel function are biologically relevant, as underscored by mutations that cause several human diseases of hyperexcitability.
	Minireview Seeing chordate evolution through the Ciona genome sequence Cristian Cañestro, Susan Bassham, John H Postlethwait Genome Biology 2003, 4:208 (3 March 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A draft sequence of the compact genome of the sea squirt Ciona intestinalis illuminates how chordates originated and how vertebrate developmental innovations evolved.
	Minireview Genomics and chloroplast evolution: what did cyanobacteria do for plants? John A Raven, John F Allen Genome Biology 2003, 4:209 (3 March 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Plant chloroplast originated, through endosymbiosis, from a cyanobacterium, but the genomic legacy of cyanobacterial ancestry extends far beyond the chloroplast itself, and persists in organisms that have lost chloroplasts completely.
	Opinion Beenomes to Bombyx: future directions in applied insect genomics Jay D Evans, Dawn Gundersen-Rindal Genome Biology 2003, 4:107 (26 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Various traits in insect species make them important candidates for genomics projects, and several recent workshops have aimed to unite researchers working with insect species to efficiently address problems in medicine, biotechnology, and agriculture.
	Report
	Paper report Articles selected by Faculty of 1000: Fat regulation in C. elegans; disease gene identification; comparision of mouse and human genomes; C. elegans early embryonic transcriptome; functional genomics in C. elegans Genome Biology 2003, 4:311 (14 February 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering several post-genomic studies in C. elegans, the use of 'integrative genomics' in disease gene identification and a comparison of mouse and human genomes.
	Paper report Articles selected by Faculty of 1000: p53 gene silencing; duplications in the Arabidopsis genome; RNA interference and disease protection; arraying environmental gene diversity; predicting RNA folding patterns. Genome Biology 2003, 4:312 (26 February 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering p53 gene silencing, Arabidopsis genome duplications, RNA interference and disease protection, environmental gene diversity and predicting RNA folding patterns.
	Meeting report The epigenetics of the cell Michael A Goldman Genome Biology 2003, 4:309 (24 February 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 42nd Annual Meeting of the American Society for Cell Biology, San Francisco, 14-18 December 2002.
	Meeting report From linear genome sequence to three-dimensional organization of the cell nucleus Joan Politz, Roel van Driel, Markus Sauer, Ana Pombo Genome Biology 2003, 4:310 (28 February 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Jackson Laboratory 'Advances in nanostructural genomics II' meeting, Bar Harbor, USA, 3-6 October 2002.
	Research news Mediator of damage checkpoint Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030303-01 (3 March 2003) Abstract \| Full text \| Editor’s summary The MDC1 protein is involved in regulating the DNA-damage repair pathways in mammalian cells.
	Research news Shadows provide illumination Richard Robinson Genome Biology 2003, 4:spotlight-20030304-01 (4 March 2003) Abstract \| Full text \| Editor’s summary Primate sequence comparisons reveal data not detected in mouse-human analyses.
	Research news Heart failure mutation Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030305-01 (5 March 2003) Abstract \| Full text \| Editor’s summary A mutation in the phospholamban protein affects calcium handling and causes heart failure in mice and man.
	Research news Post-genome project launches Leslie Pray Genome Biology 2003, 4:spotlight-20030306-01 (6 March 2003) Abstract \| Full text \| Editor’s summary NIH begins pilot program to create encyclopedia of functional elements.
	Research news Reverse evolution Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030306-02 (6 March 2003) Abstract \| Full text \| Editor’s summary Experiments in yeast demonstrate that genomic collinearity is important in speciation.
	Research news Keeping an eye on glaucoma Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030307-02 (7 March 2003) Abstract \| Full text \| Editor’s summary The tyrosinase/L-dopa pathway modifies glaucoma in a mouse model and suggests novel therapeutic avenues.
	Research news Gut up and go Richard Robinson Genome Biology 2003, 4:spotlight-20030307-01 (7 March 2003) Abstract \| Full text \| Editor’s summary Genetic variations in stomach bacteria are closely aligned with human migrations.
	Research news Counting vertebrate microRNAs Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030310-01 (10 March 2003) Abstract \| Full text \| Editor’s summary MicroRNAs may represent as much as one percent of the genes in the human genome.
	Research news HaploCHIPs Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030311-02 (11 March 2003) Abstract \| Full text \| Editor’s summary A haplotype-specific chromatin immunoprecipitation protocol helps identify common DNA polymorphisms that affect gene regulation in vivo.
	Research news Revisiting Bermuda Tabitha M Powledge Genome Biology 2003, 4:spotlight-20030311-01 (11 March 2003) Abstract \| Full text \| Editor’s summary Proposed revision of data-sharing principles recognizes changing times and technologies.
	Research news Imprinted by Eed Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030312-01 (12 March 2003) Abstract \| Full text \| Editor’s summary The mammalian Polycomb-group gene Eed regulates imprinting of genes at autosomal loci as well as on the inactivated X chromosome.
	Research news Modest, neglected DNA pioneer dies Robert Walgate Genome Biology 2003, 4:spotlight-20030313-01 (13 March 2003) Abstract \| Full text \| Editor’s summary Mathematical physicist Alec Stokes dies, aged 83.
	Research news Shaping a snapdragon Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030314-01 (14 March 2003) Abstract \| Full text \| Editor’s summary Clonal analysis has been used to explore the role of cell growth in petal shape formation.
	Research news ATR mutation Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030317-01 (17 March 2003) Abstract \| Full text \| Editor’s summary A mutation in the ATR gene leads to defective DNA-damage response in patients with Seckel syndrome.
	Research news Silencing and lifespan Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030318-01 (18 March 2003) Abstract \| Full text \| Editor’s summary Phosphorylation of the yeast silencing protein Sir3p leads to shortened lifespan.
	Research news All that antisense Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030319-01 (19 March 2003) Abstract \| Full text \| Editor’s summary A computational analysis predicts over 1,500 human genes that may be regulated by antisense transcripts.
	Research news Quantitative gene expression Richard Robinson Genome Biology 2003, 4:spotlight-20030320-01 (20 March 2003) Abstract \| Full text \| Editor’s summary Revealing the loci that control gene expression levels.
	Research news Six legs good Richard Robinson Genome Biology 2003, 4:spotlight-20030321-01 (21 March 2003) Abstract \| Full text \| Editor’s summary The six-legged arthropods are a result of convergent evolution.
	Research news Cox-2 confusion Peg Brickley Genome Biology 2003, 4:spotlight-20030325-02 (25 March 2003) Abstract \| Full text \| Editor’s summary Disagreement over court ruling's significance for basic science patents.
	Research news Early inklings about SARS Emma Hitt Genome Biology 2003, 4:spotlight-20030325-01 (25 March 2003) Abstract \| Full text \| Editor’s summary An informal infectious disease reporting system shows the value of broad access.
	Research news MRC under attack Pat Hagan Genome Biology 2003, 4:spotlight-20030326-03 (26 March 2003) Abstract \| Full text \| Editor’s summary MPs accuse UK's Medical Research Council of poor financial management.
	Research news Cause of SARS still uncertain Robert Walgate Genome Biology 2003, 4:spotlight-20030326-02 (26 March 2003) Abstract \| Full text \| Editor’s summary WHO moves to clarify conflicting evidence on SARS causative agent
	Research news Cloning patent claim rejected Peg Brickley Genome Biology 2003, 4:spotlight-20030326-01 (26 March 2003) Abstract \| Full text \| Editor’s summary Spat over rights to one technique settled, but many more remain.
	Research news Gill-specific glutamine synthetase Andrea Rinaldi Genome Biology 2003, 4:spotlight-20030327-01 (27 March 2003) Abstract \| Full text \| Editor’s summary Evolutionary and metabolic implications of a novel toadfish glutamine synthetase gene.
	Research news Members of the gut community Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030328-01 (28 March 2003) Abstract \| Full text \| Editor’s summary Genomes of bugs from the gut reveal information about host-symbiont relationships.
	Research news Power law governs gene expression Cathy Holding Genome Biology 2004, 4:spotlight-20040304-01 (4 March 2004) Abstract \| Full text \| Editor’s summary Proportional dynamics illustrates commonality of gene expression levels in all organisms
	Research news Venter takes a shot at the sea Cathy Holding Genome Biology 2004, 4:spotlight-20040305-01 (5 March 2004) Abstract \| Full text \| Editor’s summary Shotgun sequencing of the ocean reveals 1.2 million new genes in a single sweep
	Research news Varmus wants tighter NIH rules Ted Agres Genome Biology 2004, 4:spotlight-20040315-01 (15 March 2004) Abstract \| Full text \| Editor’s summary After liberalizing consulting rules in 1995, the former director now favors change
	Research news Lab on a chip Cathy Holding Genome Biology 2004, 4:spotlight-20040316-01 (16 March 2004) Abstract \| Full text \| Editor’s summary A miniaturized microfluidic device analyzes multiple samples in parallel
	Research news Riboswitch ribozyme Cathy Holding Genome Biology 2004, 4:spotlight-20040319-02 (19 March 2004) Abstract \| Full text \| Editor’s summary Gene expression is controlled directly by metabolites binding to RNA
	Research news Cancer data initiative launched Stephen Pincock Genome Biology 2004, 4:spotlight-20040319-01 (19 March 2004) Abstract \| Full text \| Editor’s summary Britain's NCRI begins a project aimed at developing an international informatics system
	Research news Retroviruses reinfect humans Cathy Holding Genome Biology 2004, 4:spotlight-20040324-01 (24 March 2004) Abstract \| Full text \| Editor’s summary Genomic sequences are remnants of repeated reinfections during primate evolution
	Research news Bite makes way for brain Brendan A Maher Genome Biology 2004, 4:spotlight-20040326-01 (26 March 2004) Abstract \| Full text \| Editor’s summary A single mutation may have caused gross anatomical changes that spurred human evolution
	Research news Decoding Cryptosporidium Helen Dell Genome Biology 2004, 4:spotlight-20040329-01 (29 March 2004) Abstract \| Full text \| Editor’s summary A comparatively simple genome reveals why standard antiparasitic drugs have been ineffective
	Research news New genomics lab in Germany Jane Burgermeister Genome Biology 2004, 4:spotlight-20040331-01 (31 March 2004) Abstract \| Full text \| Editor’s summary A functional genomics center at Greifwald University is to work on infectious diseases
	Research
	Research Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer Helen C Pace, Charles Brenner Genome Biology 2003, 4:R18 (17 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In birds females are heterogametic with a ZW karyotype, while males are ZZ homogametes but the molecular basis for sexual differentiation in birds is unknown. Genomic and expression data suggest that Asw may feminize chicks, dominantly interfering with Hint function by heterodimerization.
	Research MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues Seth Blackshaw, Winston P Kuo, Peter J Park, Motokazu Tsujikawa, Jenny M Gunnersen, Hamish S Scott, Wee-Ming Boon, Seong-Seng Tan, Constance L Cepko Genome Biology 2003, 4:R17 (18 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Serial analysis of gene expression using small amounts of starting material (microSAGE) is shown to be highly representative, reproducible and accurate, but pronounced differences in gene expression are seen between tissue samples taken from different individuals.
	Research Characterizing the stress/defense transcriptome of Arabidopsis Ramamurthy Mahalingam, AnaMaria Gomez-Buitrago, Nancy Eckardt, Nigam Shah, Angel Guevara-Garcia, Philip Day, Ramesh Raina, Nina V Fedoroff Genome Biology 2003, 4:R20 (18 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary PCR-based suppression subtractive hybridization was used to identify Arabidopsis genes that are differentially expressed in response to ozone, pathogens and the signaling molecules salicylic acid and jasmonic acid. A total of 1,058 differentially expressed genes were identified.
	Research Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data Shizuko Muro, Ichiro Takemasa, Shigeyuki Oba, Ryo Matoba, Noriko Ueno, Chiyuri Maruyama, Riu Yamashita, Mitsugu Sekimoto, Hirofumi Yamamoto, Shoji Nakamori, Morito Monden, Shin Ishii, Kikuya Kato Genome Biology 2003, 4:R21 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The malignancy of human colorectal carcinoma is correlated with a unique expression pattern of a specific group of genes, allowing the classification of tumor tissues into two clinically distinct groups.
	Research The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers Eugene V Koonin, Kira S Makarova, Igor B Rogozin, Laetitia Davidovic, Marie-Claude Letellier, Luca Pellegrini Genome Biology 2003, 4:R19 (28 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The near-universal presence of the rhomboid family in bacteria, archaea and eukaryotes appears to suggest that this protein is part of the heritage of the last universal common ancestor, phylogenetic tree analysis indicates a likely bacterial origin with subsequent dissemination by horizontal gene transfer.
	Software Osprey: a network visualization system Bobby-Joe Breitkreutz, Chris Stark, Mike Tyers Genome Biology 2003, 4:R22-0012.6 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A software platform called Osprey has been developed for visualization and manipulation of complex interaction networks.
	Software The GRID: The General Repository for Interaction Datasets Bobby-Joe Breitkreutz, Chris Stark, Mike Tyers Genome Biology 2003, 4:R23 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A relational database, called the General Repository for Interaction Datasets (The GRID) has been developed to archive and display physical, genetic and functional interactions.

	Volume 4 Issue 3
	Comment
	Comment Still no flying cars Gregory A Petsko Genome Biology 2003, 4:106 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Why, after less than two centuries of almost incomprehensible technological progress has progress in so many areas seemed to slow almost to a halt.
	Review
	Review Overview of the voltage-gated sodium channel family Frank H Yu, William A Catterall Genome Biology 2003, 4:207 (24 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Different sodium channels have remarkably similar functional properties, but small changes in sodium-channel function are biologically relevant, as underscored by mutations that cause several human diseases of hyperexcitability.
	Minireview Seeing chordate evolution through the Ciona genome sequence Cristian Cañestro, Susan Bassham, John H Postlethwait Genome Biology 2003, 4:208 (3 March 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A draft sequence of the compact genome of the sea squirt Ciona intestinalis illuminates how chordates originated and how vertebrate developmental innovations evolved.
	Minireview Genomics and chloroplast evolution: what did cyanobacteria do for plants? John A Raven, John F Allen Genome Biology 2003, 4:209 (3 March 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Plant chloroplast originated, through endosymbiosis, from a cyanobacterium, but the genomic legacy of cyanobacterial ancestry extends far beyond the chloroplast itself, and persists in organisms that have lost chloroplasts completely.
	Opinion Beenomes to Bombyx: future directions in applied insect genomics Jay D Evans, Dawn Gundersen-Rindal Genome Biology 2003, 4:107 (26 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Various traits in insect species make them important candidates for genomics projects, and several recent workshops have aimed to unite researchers working with insect species to efficiently address problems in medicine, biotechnology, and agriculture.
	Report
	Paper report Articles selected by Faculty of 1000: Fat regulation in C. elegans; disease gene identification; comparision of mouse and human genomes; C. elegans early embryonic transcriptome; functional genomics in C. elegans Genome Biology 2003, 4:311 (14 February 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering several post-genomic studies in C. elegans, the use of 'integrative genomics' in disease gene identification and a comparison of mouse and human genomes.
	Paper report Articles selected by Faculty of 1000: p53 gene silencing; duplications in the Arabidopsis genome; RNA interference and disease protection; arraying environmental gene diversity; predicting RNA folding patterns. Genome Biology 2003, 4:312 (26 February 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering p53 gene silencing, Arabidopsis genome duplications, RNA interference and disease protection, environmental gene diversity and predicting RNA folding patterns.
	Meeting report The epigenetics of the cell Michael A Goldman Genome Biology 2003, 4:309 (24 February 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 42nd Annual Meeting of the American Society for Cell Biology, San Francisco, 14-18 December 2002.
	Meeting report From linear genome sequence to three-dimensional organization of the cell nucleus Joan Politz, Roel van Driel, Markus Sauer, Ana Pombo Genome Biology 2003, 4:310 (28 February 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Jackson Laboratory 'Advances in nanostructural genomics II' meeting, Bar Harbor, USA, 3-6 October 2002.
	Research news Mediator of damage checkpoint Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030303-01 (3 March 2003) Abstract \| Full text \| Editor’s summary The MDC1 protein is involved in regulating the DNA-damage repair pathways in mammalian cells.
	Research news Shadows provide illumination Richard Robinson Genome Biology 2003, 4:spotlight-20030304-01 (4 March 2003) Abstract \| Full text \| Editor’s summary Primate sequence comparisons reveal data not detected in mouse-human analyses.
	Research news Heart failure mutation Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030305-01 (5 March 2003) Abstract \| Full text \| Editor’s summary A mutation in the phospholamban protein affects calcium handling and causes heart failure in mice and man.
	Research news Post-genome project launches Leslie Pray Genome Biology 2003, 4:spotlight-20030306-01 (6 March 2003) Abstract \| Full text \| Editor’s summary NIH begins pilot program to create encyclopedia of functional elements.
	Research news Reverse evolution Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030306-02 (6 March 2003) Abstract \| Full text \| Editor’s summary Experiments in yeast demonstrate that genomic collinearity is important in speciation.
	Research news Keeping an eye on glaucoma Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030307-02 (7 March 2003) Abstract \| Full text \| Editor’s summary The tyrosinase/L-dopa pathway modifies glaucoma in a mouse model and suggests novel therapeutic avenues.
	Research news Gut up and go Richard Robinson Genome Biology 2003, 4:spotlight-20030307-01 (7 March 2003) Abstract \| Full text \| Editor’s summary Genetic variations in stomach bacteria are closely aligned with human migrations.
	Research news Counting vertebrate microRNAs Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030310-01 (10 March 2003) Abstract \| Full text \| Editor’s summary MicroRNAs may represent as much as one percent of the genes in the human genome.
	Research news HaploCHIPs Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030311-02 (11 March 2003) Abstract \| Full text \| Editor’s summary A haplotype-specific chromatin immunoprecipitation protocol helps identify common DNA polymorphisms that affect gene regulation in vivo.
	Research news Revisiting Bermuda Tabitha M Powledge Genome Biology 2003, 4:spotlight-20030311-01 (11 March 2003) Abstract \| Full text \| Editor’s summary Proposed revision of data-sharing principles recognizes changing times and technologies.
	Research news Imprinted by Eed Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030312-01 (12 March 2003) Abstract \| Full text \| Editor’s summary The mammalian Polycomb-group gene Eed regulates imprinting of genes at autosomal loci as well as on the inactivated X chromosome.
	Research news Modest, neglected DNA pioneer dies Robert Walgate Genome Biology 2003, 4:spotlight-20030313-01 (13 March 2003) Abstract \| Full text \| Editor’s summary Mathematical physicist Alec Stokes dies, aged 83.
	Research news Shaping a snapdragon Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030314-01 (14 March 2003) Abstract \| Full text \| Editor’s summary Clonal analysis has been used to explore the role of cell growth in petal shape formation.
	Research news ATR mutation Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030317-01 (17 March 2003) Abstract \| Full text \| Editor’s summary A mutation in the ATR gene leads to defective DNA-damage response in patients with Seckel syndrome.
	Research news Silencing and lifespan Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030318-01 (18 March 2003) Abstract \| Full text \| Editor’s summary Phosphorylation of the yeast silencing protein Sir3p leads to shortened lifespan.
	Research news All that antisense Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030319-01 (19 March 2003) Abstract \| Full text \| Editor’s summary A computational analysis predicts over 1,500 human genes that may be regulated by antisense transcripts.
	Research news Quantitative gene expression Richard Robinson Genome Biology 2003, 4:spotlight-20030320-01 (20 March 2003) Abstract \| Full text \| Editor’s summary Revealing the loci that control gene expression levels.
	Research news Six legs good Richard Robinson Genome Biology 2003, 4:spotlight-20030321-01 (21 March 2003) Abstract \| Full text \| Editor’s summary The six-legged arthropods are a result of convergent evolution.
	Research news Cox-2 confusion Peg Brickley Genome Biology 2003, 4:spotlight-20030325-02 (25 March 2003) Abstract \| Full text \| Editor’s summary Disagreement over court ruling's significance for basic science patents.
	Research news Early inklings about SARS Emma Hitt Genome Biology 2003, 4:spotlight-20030325-01 (25 March 2003) Abstract \| Full text \| Editor’s summary An informal infectious disease reporting system shows the value of broad access.
	Research news MRC under attack Pat Hagan Genome Biology 2003, 4:spotlight-20030326-03 (26 March 2003) Abstract \| Full text \| Editor’s summary MPs accuse UK's Medical Research Council of poor financial management.
	Research news Cause of SARS still uncertain Robert Walgate Genome Biology 2003, 4:spotlight-20030326-02 (26 March 2003) Abstract \| Full text \| Editor’s summary WHO moves to clarify conflicting evidence on SARS causative agent
	Research news Cloning patent claim rejected Peg Brickley Genome Biology 2003, 4:spotlight-20030326-01 (26 March 2003) Abstract \| Full text \| Editor’s summary Spat over rights to one technique settled, but many more remain.
	Research news Gill-specific glutamine synthetase Andrea Rinaldi Genome Biology 2003, 4:spotlight-20030327-01 (27 March 2003) Abstract \| Full text \| Editor’s summary Evolutionary and metabolic implications of a novel toadfish glutamine synthetase gene.
	Research news Members of the gut community Jonathan B Weitzman Genome Biology 2003, 4:spotlight-20030328-01 (28 March 2003) Abstract \| Full text \| Editor’s summary Genomes of bugs from the gut reveal information about host-symbiont relationships.
	Research news Power law governs gene expression Cathy Holding Genome Biology 2004, 4:spotlight-20040304-01 (4 March 2004) Abstract \| Full text \| Editor’s summary Proportional dynamics illustrates commonality of gene expression levels in all organisms
	Research news Venter takes a shot at the sea Cathy Holding Genome Biology 2004, 4:spotlight-20040305-01 (5 March 2004) Abstract \| Full text \| Editor’s summary Shotgun sequencing of the ocean reveals 1.2 million new genes in a single sweep
	Research news Varmus wants tighter NIH rules Ted Agres Genome Biology 2004, 4:spotlight-20040315-01 (15 March 2004) Abstract \| Full text \| Editor’s summary After liberalizing consulting rules in 1995, the former director now favors change
	Research news Lab on a chip Cathy Holding Genome Biology 2004, 4:spotlight-20040316-01 (16 March 2004) Abstract \| Full text \| Editor’s summary A miniaturized microfluidic device analyzes multiple samples in parallel
	Research news Riboswitch ribozyme Cathy Holding Genome Biology 2004, 4:spotlight-20040319-02 (19 March 2004) Abstract \| Full text \| Editor’s summary Gene expression is controlled directly by metabolites binding to RNA
	Research news Cancer data initiative launched Stephen Pincock Genome Biology 2004, 4:spotlight-20040319-01 (19 March 2004) Abstract \| Full text \| Editor’s summary Britain's NCRI begins a project aimed at developing an international informatics system
	Research news Retroviruses reinfect humans Cathy Holding Genome Biology 2004, 4:spotlight-20040324-01 (24 March 2004) Abstract \| Full text \| Editor’s summary Genomic sequences are remnants of repeated reinfections during primate evolution
	Research news Bite makes way for brain Brendan A Maher Genome Biology 2004, 4:spotlight-20040326-01 (26 March 2004) Abstract \| Full text \| Editor’s summary A single mutation may have caused gross anatomical changes that spurred human evolution
	Research news Decoding Cryptosporidium Helen Dell Genome Biology 2004, 4:spotlight-20040329-01 (29 March 2004) Abstract \| Full text \| Editor’s summary A comparatively simple genome reveals why standard antiparasitic drugs have been ineffective
	Research news New genomics lab in Germany Jane Burgermeister Genome Biology 2004, 4:spotlight-20040331-01 (31 March 2004) Abstract \| Full text \| Editor’s summary A functional genomics center at Greifwald University is to work on infectious diseases
	Research
	Research Feminizing chicks: a model for avian sex determination based on titration of Hint enzyme activity and the predicted structure of an Asw-Hint heterodimer Helen C Pace, Charles Brenner Genome Biology 2003, 4:R18 (17 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In birds females are heterogametic with a ZW karyotype, while males are ZZ homogametes but the molecular basis for sexual differentiation in birds is unknown. Genomic and expression data suggest that Asw may feminize chicks, dominantly interfering with Hint function by heterodimerization.
	Research MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues Seth Blackshaw, Winston P Kuo, Peter J Park, Motokazu Tsujikawa, Jenny M Gunnersen, Hamish S Scott, Wee-Ming Boon, Seong-Seng Tan, Constance L Cepko Genome Biology 2003, 4:R17 (18 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Serial analysis of gene expression using small amounts of starting material (microSAGE) is shown to be highly representative, reproducible and accurate, but pronounced differences in gene expression are seen between tissue samples taken from different individuals.
	Research Characterizing the stress/defense transcriptome of Arabidopsis Ramamurthy Mahalingam, AnaMaria Gomez-Buitrago, Nancy Eckardt, Nigam Shah, Angel Guevara-Garcia, Philip Day, Ramesh Raina, Nina V Fedoroff Genome Biology 2003, 4:R20 (18 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary PCR-based suppression subtractive hybridization was used to identify Arabidopsis genes that are differentially expressed in response to ozone, pathogens and the signaling molecules salicylic acid and jasmonic acid. A total of 1,058 differentially expressed genes were identified.
	Research Identification of expressed genes linked to malignancy of human colorectal carcinoma by parametric clustering of quantitative expression data Shizuko Muro, Ichiro Takemasa, Shigeyuki Oba, Ryo Matoba, Noriko Ueno, Chiyuri Maruyama, Riu Yamashita, Mitsugu Sekimoto, Hirofumi Yamamoto, Shoji Nakamori, Morito Monden, Shin Ishii, Kikuya Kato Genome Biology 2003, 4:R21 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The malignancy of human colorectal carcinoma is correlated with a unique expression pattern of a specific group of genes, allowing the classification of tumor tissues into two clinically distinct groups.
	Research The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers Eugene V Koonin, Kira S Makarova, Igor B Rogozin, Laetitia Davidovic, Marie-Claude Letellier, Luca Pellegrini Genome Biology 2003, 4:R19 (28 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The near-universal presence of the rhomboid family in bacteria, archaea and eukaryotes appears to suggest that this protein is part of the heritage of the last universal common ancestor, phylogenetic tree analysis indicates a likely bacterial origin with subsequent dissemination by horizontal gene transfer.
	Software Osprey: a network visualization system Bobby-Joe Breitkreutz, Chris Stark, Mike Tyers Genome Biology 2003, 4:R22-0012.6 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A software platform called Osprey has been developed for visualization and manipulation of complex interaction networks.
	Software The GRID: The General Repository for Interaction Datasets Bobby-Joe Breitkreutz, Chris Stark, Mike Tyers Genome Biology 2003, 4:R23 (27 February 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A relational database, called the General Repository for Interaction Datasets (The GRID) has been developed to archive and display physical, genetic and functional interactions.

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