Genome Biology | Volume 4 Issue 5

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	Volume 4 Issue 5
	Comment
	Comment War and peace Gregory A Petsko Genome Biology 2003, 4:110 (28 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary If the fiftieth anniversary of the double helix teaches us anything it ought to be that great scientific discoveries are almost never made in time of war or directly for the purpose of war.
	Review
	Minireview Discovering human history from stomach bacteria Todd R Disotell Genome Biology 2003, 4:213 (28 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent analyses of human pathogens have revealed that their evolutionary histories are congruent with the hypothesized pattern of ancient and modern human population migrations.
	Minireview The role of DNA sequence in centromere formation Jonathan C Lamb, James A Birchler Genome Biology 2003, 4:214 (29 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Recent analyses of centromeric sequences in human, Drosophila and Arabidopsis, have provided new insights into the importance of DNA sequence for centromere function.
	Minireview Expression profiling of plant development Giovanni Mele, Sarah Hake Genome Biology 2003, 4:215 (29 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Microarrays studies of the response of plants to many signals give an overall view of the global response to each signal and can reveal new links between different signaling pathways.
	Opinion Genomic analysis of the eukaryotic protein kinase superfamily: a perspective Steven K Hanks Genome Biology 2003, 4:111 (29 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Efforts to identify and classify all the members of the eukaryotic protein kinase superfamily have recently culminated in the mining of essentially complete human genome data.
	Report
	Paper report Articles selected by Faculty of 1000: estimating linkage disequilibrium; nematode-induced gene expression in Arabidopsis; vertebrate microRNA genes; human antisense transcription; protein arrays from PCR DNA Genome Biology 2003, 4:321 (7 April 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the extent of linkage disequilibrium in the human genome, nematode-induced gene expression in Arabidopsis, identification of microRNA genes in human, mouse and pufferfish genomes, antisense transcription in the human genome and generation of protein arrays from PCR DNA.
	Paper report Articles selected by Faculty of 1000: arraying fly eye development; genome-wide analysis of phosphatidylinositol pathway; temperature-induced B. burgdorferi expression profiles; candidate genes for Parkinson's disease; Arabidopsis GST database Genome Biology 2003, 4:322 (17 April 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering microarray analysis of eye development in Drosophila, profiling the phosphatidylinositol metabolic pathway, temperature-induced gene-expression changes in Borrelia burgdorferi, bioinformatic identification of candidate genes for Parkinson's disease and an Arabidopsis GST database.
	Meeting report The modular era of functional genomics Eran Segal, Stuart K Kim Genome Biology 2003, 4:317 (14 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A report on the Keystone Symposium 'Functional Genomics: Global Analysis of Complex Biological Systems', Santa Fe, USA, 20-24 February 2003.
	Meeting report Cancer and programmed cell death Ben Croker, Adam Hart Genome Biology 2003, 4:318 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 15th Lorne Cancer Conference, Lorne, Australia, 13-16 February 2003.
	Meeting report How is the Drosophila research community making use of the genome sequence? Stephen Richards Genome Biology 2003, 4:319 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 44th Annual Drosophila Research Conference, Chicago, USA, 5-9 March, 2003.
	Meeting report Unscrambling the genome Merlin Crossley Genome Biology 2003, 4:320 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 24th Annual Lorne Conference on the Organization and Expression of the Genome, Lorne, Victoria, Australia, 16-20 February 2003.
	Deposited research article DAVID: Database for Annotation, Visualization, and Integrated Discovery Glynn Dennis, Brad T Sherman, Douglas A Hosack, Jun Yang, Wei Gao, H Clifford Lane, Richard A Lempicki Genome Biology 2003, 4:P3 (3 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. Database for Annotation, Visualization, and Integrated Discovery (DAVID) provides querybased access to an integrated database that disseminates biologically rich information across large datasets and displays graphic summaries of functional information.
	Research news Anthrax genome sequenced Cathy Holding Genome Biology 2003, 4:spotlight-20030501-02 (1 May 2003) Abstract \| Full text \| Editor’s summary Two Bacillus genomes reveal the pathogenicity, virulence, and ancestry of the anthrax causative agent.
	Research news NAS Awards Brendan A Maher Genome Biology 2003, 4:spotlight-20030501-01 (1 May 2003) Abstract \| Full text \| Editor’s summary A ceremony honoring scientists and educators acknowledges history and looks to the future.
	Research news Oocytes direct from embryonic stem cells Cathy Holding Genome Biology 2003, 4:spotlight-20030502-01 (2 May 2003) Abstract \| Full text \| Editor’s summary A new cloning technique potentially side-steps problems associated using adult nuclei.
	Research news Ira Herskowitz dies Brendan Maher Genome Biology 2003, 4:spotlight-20030506-01 (6 May 2003) Abstract \| Full text \| Editor’s summary The geneticist whose discoveries in yeast profoundly influenced cell science has died at 56.
	Research news SARS death rate up to 43% Robert Walgate Genome Biology 2003, 4:spotlight-20030507-01 (7 May 2003) Abstract \| Full text \| Editor’s summary Epidemiological study published today gives more accurate picture than previous WHO figures.
	Research news Malaria mosquito resistance revealed Cathy Holding Genome Biology 2003, 4:spotlight-20030508-01 (8 May 2003) Abstract \| Full text \| Editor’s summary A G119S substitution in the acetylcholinesterase-1 gene confers insecticide resistance.
	Research news Longevity gene identified Cathy Holding Genome Biology 2003, 4:spotlight-20030509-01 (9 May 2003) Abstract \| Full text \| Editor’s summary PNC1 is necessary and sufficient for increasing lifespan in calorie-restricted yeasts.
	Research news Preemptive SARS patents Peg Brickley Genome Biology 2003, 4:spotlight-20030512-01 (12 May 2003) Abstract \| Full text \| Editor’s summary U.S. and Canadian agencies say patents will preserve access
	Research news Navigating the doldrums Ted Agres Genome Biology 2003, 4:spotlight-20030512-01 (13 May 2003) Abstract \| Full text \| Editor’s summary New report finds European biotech stalled in 2002 but predicts bright future
	Research news New faces at the National Academy Emma Hitt Genome Biology 2003, 4:spotlight-20030512-02 (13 May 2003) Abstract \| Full text \| Editor’s summary Record induction of women was unintentional, but neglected groups will be a future focus
	Research news New MRC head named Pat Hagan Genome Biology 2003, 4:spotlight-20030514-02 (14 May 2003) Abstract \| Full text \| Editor’s summary Distinguished neuroscientist named as new head of UK's Medical Research Council
	Research news Ariad licenses prized pathway Peg Brickley Genome Biology 2003, 4:spotlight-20030514-01 (14 May 2003) Abstract \| Full text \| Editor’s summary Noncommercial researchers still free to explore NF-κB for disease cures
	Research news Many yeasts win the vote Cathy Holding Genome Biology 2003, 4:spotlight-20030515-01 (15 May 2003) Abstract \| Full text \| Editor’s summary Comparative genomics with two or more related species reveal limitations of single genome analysis
	Research news 2003 Royal Society fellows David Bruce Genome Biology 2003, 4:spotlight-20030519-01 (19 May 2003) Abstract \| Full text \| Editor’s summary UK's Royal Society elects record number of women
	Research news SARS unanswered questions Catherine Zandonella Genome Biology 2003, 4:spotlight-20030520-01 (20 May 2003) Abstract \| Full text \| Editor’s summary New York meeting explores remaining mysteries and clues about the new virus
	Research news Of mice and mitochondria Cathy Holding Genome Biology 2003, 4:spotlight-20030522-01 (22 May 2003) Abstract \| Full text \| Editor’s summary A murine mitochondrial haplotype in Chicago has all but disappeared in the past century
	Research news Leading or lagging - it makes no difference Cathy Holding Genome Biology 2003, 4:spotlight-20030523-01 (23 May 2003) Abstract \| Full text \| Editor’s summary A mutation in one DNA strand does not affect the synthesis of the other strand
	Research news Gene acquisition in eukaryotes C L Bishop Genome Biology 2003, 4:spotlight-20030528-01 (28 May 2003) Abstract \| Full text \| Editor’s summary A marine protist has acquired genes from several sources through lateral gene transfer
	Research news Resistant sheep get BSE Tudor P Toma Genome Biology 2003, 4:spotlight-20030530-01 (30 May 2003) Abstract \| Full text \| Editor’s summary Even sheep with the PrP genotype associated with most resistance are susceptible to BSE
	Research news A third generation genomics group forms Doug Payne Genome Biology 2004, 4:spotlight-20040506-01 (6 May 2004) Abstract \| Full text \| Editor’s summary Researchers from half a dozen countries launch a project to be based in Ottawa
	Research news Finding promise in white rot Cathy Holding Genome Biology 2004, 4:spotlight-20040606-02 (6 May 2004) Abstract \| Full text \| Editor’s summary A fungus sequence shows potential for biotechnological and environmental applications
	Research news Genetic secrets of good wine Xavier Bosch Genome Biology 2004, 4:spotlight-20040507-01 (7 May 2004) Abstract \| Full text \| Editor’s summary Spain and Canada work together to identify the genomic determinants of what makes quality wine
	Research news Mitochondrial DNA recombines Cathy Holding Genome Biology 2004, 4:spotlight-20040514-01 (14 May 2004) Abstract \| Full text \| Editor’s summary A finding in the muscle of a patient with myopathy may change the thinking on inheritance, say authors
	Research news Clone telomeres behave normally Cathy Holding Genome Biology 2004, 4:spotlight-20040519-01 (19 May 2004) Abstract \| Full text \| Editor’s summary Early embryo telomerase-dependent length resetting means clones won't have short telomeres
	Research news HHMI to recruit 50 new fellows Edward Winnick Genome Biology 2004, 4:spotlight-20040519-02 (19 May 2004) Abstract \| Full text \| Editor’s summary As endowment rebounds, Howard Hughes launches new general competition
	Research news New gene expression modulator Cathy Holding Genome Biology 2004, 4:spotlight-20040520-01 (20 May 2004) Abstract \| Full text \| Editor’s summary Transposons inhibiting transcription could have had a profound effect on evolution
	Research news How microsporidia evolve Cathy Holding Genome Biology 2004, 4:spotlight-20040526-01 (26 May 2004) Abstract \| Full text \| Editor’s summary Genes evolve rapidly but genomes don't, suggesting that space constraints play a role
	Research
	Research Identifying related L1 retrotransposons by analyzing 3' transduced sequences Suzanne T Szak, Oxana K Pickeral, David Landsman, Jef D Boeke Genome Biology 2003, 4:R30 (16 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Computational methods have been used to characterize the genomic sequences adjacent to L1 retrotransposons, shedding light on the mechanisms of integration and the frequency of L1-mediated transduction.
	Research Duplication and selection in the evolution of primate β-defensin genes Colin AM Semple, Mark Rolfe, Julia R Dorin Genome Biology 2003, 4:R31 (17 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Peptides such as β-defensins are an important component in innate immunity. A combination of laboratory and computational techniques have been used to characterize the main human β-defensin locus on chromosome 8p22-p23. The genomic structures and expression patterns of four novel human β-defensin genes and a related pseudogene reveal prior duplication events and selection.
	Method A novel exploratory method for visual recombination detection Korbinian Strimmer, Kristoffer Forslund, Barbara Holland, Vincent Moulton Genome Biology 2003, 4:R33 (25 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A versatile visual approach for detecting recombination and identifying recombination breakpoints within a sequence alignment is presented.
	Method Combined histomorphometric and gene-expression profiling applied to toxicology Andres Kriete, Mary K Anderson, Brad Love, John Freund, James J Caffrey, M Brook Young, Timothy J Sendera, Scott R Magnuson, J Mark Braughler Genome Biology 2003, 4:R32 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A unique methodology has been developed for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology.
	Software Clustering gene-expression data with repeated measurements Ka Yeung, Mario Medvedovic, Roger E Bumgarner Genome Biology 2003, 4:R34 (25 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Algorithms that take advantage of repeated measurements yield more accurate and more stable clusters.
	Software GeneHopper: a web-based search engine to link gene-expression platforms through GenBank accession numbers B Anders T Svensson, Arja J Kreeft, Gert-Jan B van Ommen, Johan T den Dunnen, Judith M Boer Genome Biology 2003, 4:R35 (25 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary To compare experiments that are performed on different platforms, array probes and sequence tags need to be linked. A web-based search engine GeneHopper has been developed to link different expression resources based on UniGene clusters and HomoloGene orthologs databases of the National Center for Biotechnology Information (NCBI).
	Correspondence
	Correspondence Beyond 100 genomes Paul Janssen, Benjamin Audit, Ildefonso Cases, Nikos Darzentas, Leon Goldovsky, Victor Kunin, Nuria Lopez-Bigas, José Peregrin-Alvarez, José B Pereira-Leal, Sophia Tsoka, Christos A Ouzounis Genome Biology 2003, 4:402 (28 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary By the end of 2002, we witnessed the landmark submission of the 100th complete genome sequence in the databases. An overview of these genomes reveals certain interesting trends and provides valuable insights into possible future developments.

	Volume 4 Issue 5
	Comment
	Comment War and peace Gregory A Petsko Genome Biology 2003, 4:110 (28 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary If the fiftieth anniversary of the double helix teaches us anything it ought to be that great scientific discoveries are almost never made in time of war or directly for the purpose of war.
	Review
	Minireview Discovering human history from stomach bacteria Todd R Disotell Genome Biology 2003, 4:213 (28 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent analyses of human pathogens have revealed that their evolutionary histories are congruent with the hypothesized pattern of ancient and modern human population migrations.
	Minireview The role of DNA sequence in centromere formation Jonathan C Lamb, James A Birchler Genome Biology 2003, 4:214 (29 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Recent analyses of centromeric sequences in human, Drosophila and Arabidopsis, have provided new insights into the importance of DNA sequence for centromere function.
	Minireview Expression profiling of plant development Giovanni Mele, Sarah Hake Genome Biology 2003, 4:215 (29 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Microarrays studies of the response of plants to many signals give an overall view of the global response to each signal and can reveal new links between different signaling pathways.
	Opinion Genomic analysis of the eukaryotic protein kinase superfamily: a perspective Steven K Hanks Genome Biology 2003, 4:111 (29 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Efforts to identify and classify all the members of the eukaryotic protein kinase superfamily have recently culminated in the mining of essentially complete human genome data.
	Report
	Paper report Articles selected by Faculty of 1000: estimating linkage disequilibrium; nematode-induced gene expression in Arabidopsis; vertebrate microRNA genes; human antisense transcription; protein arrays from PCR DNA Genome Biology 2003, 4:321 (7 April 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the extent of linkage disequilibrium in the human genome, nematode-induced gene expression in Arabidopsis, identification of microRNA genes in human, mouse and pufferfish genomes, antisense transcription in the human genome and generation of protein arrays from PCR DNA.
	Paper report Articles selected by Faculty of 1000: arraying fly eye development; genome-wide analysis of phosphatidylinositol pathway; temperature-induced B. burgdorferi expression profiles; candidate genes for Parkinson's disease; Arabidopsis GST database Genome Biology 2003, 4:322 (17 April 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering microarray analysis of eye development in Drosophila, profiling the phosphatidylinositol metabolic pathway, temperature-induced gene-expression changes in Borrelia burgdorferi, bioinformatic identification of candidate genes for Parkinson's disease and an Arabidopsis GST database.
	Meeting report The modular era of functional genomics Eran Segal, Stuart K Kim Genome Biology 2003, 4:317 (14 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A report on the Keystone Symposium 'Functional Genomics: Global Analysis of Complex Biological Systems', Santa Fe, USA, 20-24 February 2003.
	Meeting report Cancer and programmed cell death Ben Croker, Adam Hart Genome Biology 2003, 4:318 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 15th Lorne Cancer Conference, Lorne, Australia, 13-16 February 2003.
	Meeting report How is the Drosophila research community making use of the genome sequence? Stephen Richards Genome Biology 2003, 4:319 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 44th Annual Drosophila Research Conference, Chicago, USA, 5-9 March, 2003.
	Meeting report Unscrambling the genome Merlin Crossley Genome Biology 2003, 4:320 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 24th Annual Lorne Conference on the Organization and Expression of the Genome, Lorne, Victoria, Australia, 16-20 February 2003.
	Deposited research article DAVID: Database for Annotation, Visualization, and Integrated Discovery Glynn Dennis, Brad T Sherman, Douglas A Hosack, Jun Yang, Wei Gao, H Clifford Lane, Richard A Lempicki Genome Biology 2003, 4:P3 (3 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Functional annotation of differentially expressed genes is a necessary and critical step in the analysis of microarray data. Database for Annotation, Visualization, and Integrated Discovery (DAVID) provides querybased access to an integrated database that disseminates biologically rich information across large datasets and displays graphic summaries of functional information.
	Research news Anthrax genome sequenced Cathy Holding Genome Biology 2003, 4:spotlight-20030501-02 (1 May 2003) Abstract \| Full text \| Editor’s summary Two Bacillus genomes reveal the pathogenicity, virulence, and ancestry of the anthrax causative agent.
	Research news NAS Awards Brendan A Maher Genome Biology 2003, 4:spotlight-20030501-01 (1 May 2003) Abstract \| Full text \| Editor’s summary A ceremony honoring scientists and educators acknowledges history and looks to the future.
	Research news Oocytes direct from embryonic stem cells Cathy Holding Genome Biology 2003, 4:spotlight-20030502-01 (2 May 2003) Abstract \| Full text \| Editor’s summary A new cloning technique potentially side-steps problems associated using adult nuclei.
	Research news Ira Herskowitz dies Brendan Maher Genome Biology 2003, 4:spotlight-20030506-01 (6 May 2003) Abstract \| Full text \| Editor’s summary The geneticist whose discoveries in yeast profoundly influenced cell science has died at 56.
	Research news SARS death rate up to 43% Robert Walgate Genome Biology 2003, 4:spotlight-20030507-01 (7 May 2003) Abstract \| Full text \| Editor’s summary Epidemiological study published today gives more accurate picture than previous WHO figures.
	Research news Malaria mosquito resistance revealed Cathy Holding Genome Biology 2003, 4:spotlight-20030508-01 (8 May 2003) Abstract \| Full text \| Editor’s summary A G119S substitution in the acetylcholinesterase-1 gene confers insecticide resistance.
	Research news Longevity gene identified Cathy Holding Genome Biology 2003, 4:spotlight-20030509-01 (9 May 2003) Abstract \| Full text \| Editor’s summary PNC1 is necessary and sufficient for increasing lifespan in calorie-restricted yeasts.
	Research news Preemptive SARS patents Peg Brickley Genome Biology 2003, 4:spotlight-20030512-01 (12 May 2003) Abstract \| Full text \| Editor’s summary U.S. and Canadian agencies say patents will preserve access
	Research news Navigating the doldrums Ted Agres Genome Biology 2003, 4:spotlight-20030512-01 (13 May 2003) Abstract \| Full text \| Editor’s summary New report finds European biotech stalled in 2002 but predicts bright future
	Research news New faces at the National Academy Emma Hitt Genome Biology 2003, 4:spotlight-20030512-02 (13 May 2003) Abstract \| Full text \| Editor’s summary Record induction of women was unintentional, but neglected groups will be a future focus
	Research news New MRC head named Pat Hagan Genome Biology 2003, 4:spotlight-20030514-02 (14 May 2003) Abstract \| Full text \| Editor’s summary Distinguished neuroscientist named as new head of UK's Medical Research Council
	Research news Ariad licenses prized pathway Peg Brickley Genome Biology 2003, 4:spotlight-20030514-01 (14 May 2003) Abstract \| Full text \| Editor’s summary Noncommercial researchers still free to explore NF-κB for disease cures
	Research news Many yeasts win the vote Cathy Holding Genome Biology 2003, 4:spotlight-20030515-01 (15 May 2003) Abstract \| Full text \| Editor’s summary Comparative genomics with two or more related species reveal limitations of single genome analysis
	Research news 2003 Royal Society fellows David Bruce Genome Biology 2003, 4:spotlight-20030519-01 (19 May 2003) Abstract \| Full text \| Editor’s summary UK's Royal Society elects record number of women
	Research news SARS unanswered questions Catherine Zandonella Genome Biology 2003, 4:spotlight-20030520-01 (20 May 2003) Abstract \| Full text \| Editor’s summary New York meeting explores remaining mysteries and clues about the new virus
	Research news Of mice and mitochondria Cathy Holding Genome Biology 2003, 4:spotlight-20030522-01 (22 May 2003) Abstract \| Full text \| Editor’s summary A murine mitochondrial haplotype in Chicago has all but disappeared in the past century
	Research news Leading or lagging - it makes no difference Cathy Holding Genome Biology 2003, 4:spotlight-20030523-01 (23 May 2003) Abstract \| Full text \| Editor’s summary A mutation in one DNA strand does not affect the synthesis of the other strand
	Research news Gene acquisition in eukaryotes C L Bishop Genome Biology 2003, 4:spotlight-20030528-01 (28 May 2003) Abstract \| Full text \| Editor’s summary A marine protist has acquired genes from several sources through lateral gene transfer
	Research news Resistant sheep get BSE Tudor P Toma Genome Biology 2003, 4:spotlight-20030530-01 (30 May 2003) Abstract \| Full text \| Editor’s summary Even sheep with the PrP genotype associated with most resistance are susceptible to BSE
	Research news A third generation genomics group forms Doug Payne Genome Biology 2004, 4:spotlight-20040506-01 (6 May 2004) Abstract \| Full text \| Editor’s summary Researchers from half a dozen countries launch a project to be based in Ottawa
	Research news Finding promise in white rot Cathy Holding Genome Biology 2004, 4:spotlight-20040606-02 (6 May 2004) Abstract \| Full text \| Editor’s summary A fungus sequence shows potential for biotechnological and environmental applications
	Research news Genetic secrets of good wine Xavier Bosch Genome Biology 2004, 4:spotlight-20040507-01 (7 May 2004) Abstract \| Full text \| Editor’s summary Spain and Canada work together to identify the genomic determinants of what makes quality wine
	Research news Mitochondrial DNA recombines Cathy Holding Genome Biology 2004, 4:spotlight-20040514-01 (14 May 2004) Abstract \| Full text \| Editor’s summary A finding in the muscle of a patient with myopathy may change the thinking on inheritance, say authors
	Research news Clone telomeres behave normally Cathy Holding Genome Biology 2004, 4:spotlight-20040519-01 (19 May 2004) Abstract \| Full text \| Editor’s summary Early embryo telomerase-dependent length resetting means clones won't have short telomeres
	Research news HHMI to recruit 50 new fellows Edward Winnick Genome Biology 2004, 4:spotlight-20040519-02 (19 May 2004) Abstract \| Full text \| Editor’s summary As endowment rebounds, Howard Hughes launches new general competition
	Research news New gene expression modulator Cathy Holding Genome Biology 2004, 4:spotlight-20040520-01 (20 May 2004) Abstract \| Full text \| Editor’s summary Transposons inhibiting transcription could have had a profound effect on evolution
	Research news How microsporidia evolve Cathy Holding Genome Biology 2004, 4:spotlight-20040526-01 (26 May 2004) Abstract \| Full text \| Editor’s summary Genes evolve rapidly but genomes don't, suggesting that space constraints play a role
	Research
	Research Identifying related L1 retrotransposons by analyzing 3' transduced sequences Suzanne T Szak, Oxana K Pickeral, David Landsman, Jef D Boeke Genome Biology 2003, 4:R30 (16 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Computational methods have been used to characterize the genomic sequences adjacent to L1 retrotransposons, shedding light on the mechanisms of integration and the frequency of L1-mediated transduction.
	Research Duplication and selection in the evolution of primate β-defensin genes Colin AM Semple, Mark Rolfe, Julia R Dorin Genome Biology 2003, 4:R31 (17 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Peptides such as β-defensins are an important component in innate immunity. A combination of laboratory and computational techniques have been used to characterize the main human β-defensin locus on chromosome 8p22-p23. The genomic structures and expression patterns of four novel human β-defensin genes and a related pseudogene reveal prior duplication events and selection.
	Method A novel exploratory method for visual recombination detection Korbinian Strimmer, Kristoffer Forslund, Barbara Holland, Vincent Moulton Genome Biology 2003, 4:R33 (25 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A versatile visual approach for detecting recombination and identifying recombination breakpoints within a sequence alignment is presented.
	Method Combined histomorphometric and gene-expression profiling applied to toxicology Andres Kriete, Mary K Anderson, Brad Love, John Freund, James J Caffrey, M Brook Young, Timothy J Sendera, Scott R Magnuson, J Mark Braughler Genome Biology 2003, 4:R32 (30 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A unique methodology has been developed for the combined analysis of histomorphometric and gene-expression profiles amenable to intensive data mining and multisample comparison for a comprehensive approach to toxicology.
	Software Clustering gene-expression data with repeated measurements Ka Yeung, Mario Medvedovic, Roger E Bumgarner Genome Biology 2003, 4:R34 (25 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Algorithms that take advantage of repeated measurements yield more accurate and more stable clusters.
	Software GeneHopper: a web-based search engine to link gene-expression platforms through GenBank accession numbers B Anders T Svensson, Arja J Kreeft, Gert-Jan B van Ommen, Johan T den Dunnen, Judith M Boer Genome Biology 2003, 4:R35 (25 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary To compare experiments that are performed on different platforms, array probes and sequence tags need to be linked. A web-based search engine GeneHopper has been developed to link different expression resources based on UniGene clusters and HomoloGene orthologs databases of the National Center for Biotechnology Information (NCBI).
	Correspondence
	Correspondence Beyond 100 genomes Paul Janssen, Benjamin Audit, Ildefonso Cases, Nikos Darzentas, Leon Goldovsky, Victor Kunin, Nuria Lopez-Bigas, José Peregrin-Alvarez, José B Pereira-Leal, Sophia Tsoka, Christos A Ouzounis Genome Biology 2003, 4:402 (28 April 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary By the end of 2002, we witnessed the landmark submission of the 100th complete genome sequence in the databases. An overview of these genomes reveals certain interesting trends and provides valuable insights into possible future developments.

Explore Genome Biology

Articles

Volume 4 Issue 5

Comment

Review

Report

Research

Correspondence