Genome Biology | Volume 4 Issue 6

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	Volume 4 Issue 6
	Comment
	Comment Ira Gregory A Petsko Genome Biology 2003, 4:112 (19 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary For a quarter of a century in genetics if you said Ira the chances were you meant Ira Herskowitz. When he died, on April 28 this year, it left a hole in the fields of genetics and genomics the size of the Grand Canyon.
	Review
	Review Matrix metalloproteinases: old dogs with new tricks Robert PT Somerville, Samantha A Oblander, Suneel S Apte Genome Biology 2003, 4:216 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary It was previously thought that the matrix metalloproteinase family acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates.
	Minireview The genomics and proteomics of biofilm formation Karin Sauer Genome Biology 2003, 4:219 (27 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during bacterial biofilm formation, revealing the complexity of this developmental process.
	Minireview The Neurospora crassa genome opens up the world of filamentous fungi Michael J Hynes Genome Biology 2003, 4:217 (28 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The draft genome sequence of Neurospora crassa has revealed several unusual features which suggest that its evolution has been greatly influenced by several unique genome-defense mechanisms.
	Minireview What makes a mitochondrion? Joshua L Heazlewood, A Millar, David A Day, James Whelan Genome Biology 2003, 4:218 (28 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Experimental analyses of the proteins found in the mitochondria of yeast, humans and Arabidopsis have confirmed some expectations but given some surprises and some insights into the evolutionary origins of mitochondrial proteins.
	Report
	Paper report Articles selected by Faculty of 1000: sugar arrays; C. elegans ORFeome v1.1; identifying tRNA genes; method to analyze human serum proteome; rates of molecular divergence Genome Biology 2003, 4:325 (9 May 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the synthesis of sugar arrays, C. elegans ORFeome v1.1, a novel method for identifying tRNA genes, a step towards analysis of the human serum proteome and rates of molecular divergence in rearranged chromosomes.
	Paper report Articles selected by Faculty of 1000: Neurospora crassa genome sequence; human c-Myc target genes; prokaryote genome annotation database; diversity of marine eukaryotes; transcriptional regulation by a pseudogene Genome Biology 2003, 4:326 (15 May 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the complete genome sequence of Neurospora crassa, a genome-wide screen for human c-Myc target genes, a prokaryote genome annoation database, an analysis of marine eukaryote diversity and regulation of transcription by a pseudogene.
	Meeting report Assembling a jigsaw puzzle with 20,000 parts Edward M Marcotte Genome Biology 2003, 4:323 (23 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Keystone Symposium 'Proteomics: Technologies and Applications', Keystone, USA, 25-30 March 2003.
	Meeting report Translating genome sequences into biological understanding Vishwanath R Iyer Genome Biology 2003, 4:324 (23 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Genomics, Proteomics and Bioinformatics Thematic Meeting during the 2003 American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, San Diego, USA, 11-15 April 2003.
	Deposited research article Identifying biological themes within lists of genes with EASE Douglas A Hosack, Glynn Dennis, Brad T Sherman, H Lane, Richard A Lempicki Genome Biology 2003, 4:P4 (25 April 2003) Abstract \| Full text \| PDF \| Editor’s summary EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE, and other high-throughput genomic data.
	Deposited research article Reverse engineering of gene regulatory networks: a finite state linear model Alvis Brazma, Thomas Schlitt Genome Biology 2003, 4:P5 (29 April 2003) Abstract \| Full text \| PDF \| Editor’s summary A new model is proposed for describing gene regulatory networks that can capture discrete (Boolean) and continuous (differential) aspects of gene regulation.
	Deposited research article Ancient origin and evolution of the Indian wolf: evidence from mitochondrial DNA typing of wolves from Trans-Himalayan region and Pennisular India Ramesh K Aggarwal, J Ramadevi, Lalji Singh Genome Biology 2003, 4:P6 (29 April 2003) Abstract \| Full text \| PDF \| Editor’s summary A study of mitochondrial DNA diversity across three different taxonomically informative domains (cytochrome-B gene, 16S rDNA and hypervariable d-loop control region) revealed that the Himalayan wolf and the Indian Gray wolf are genetically distinct from each other as well as from all other wolves of the world
	Research news NIH says scientists should share Peg Brickley Genome Biology 2003, 4:spotlight-20030604-01 (4 June 2003) Abstract \| Full text \| Editor’s summary Agency leans on researchers to be generous with laboratory mouse strains
	Research news NIH names computational boss Willie Schatz Genome Biology 2003, 4:spotlight-20030605-01 (5 June 2003) Abstract \| Full text \| Editor’s summary Eric Jakobsson becomes first director of the Center for Bioinformatics and Computational Biology
	Research news NIMR closure on hold Pat Hagan Genome Biology 2003, 4:spotlight-20030605-02 (5 June 2003) Abstract \| Full text \| Editor’s summary UK's Medical Research Council reconsiders plans after revolt by scientists
	Research news New head for European Science Foundation Helen Gavaghan Genome Biology 2003, 4:spotlight-20030610-01 (10 June 2003) Abstract \| Full text \| Editor’s summary The new head of the ESF will push for greater financial influence and more funding for basic research
	Research news Gene therapy by mRNA stabilization? Tudor P Toma Genome Biology 2003, 4:spotlight-20030610-02 (10 June 2003) Abstract \| Full text \| Editor’s summary Selective stabilization of mRNA in tumor cells can control gene expression from viral vectors
	Research news Max Planck announces cuts Martina Habeck Genome Biology 2003, 4:spotlight-20030611-01 (11 June 2003) Abstract \| Full text \| Editor’s summary Germany's Max Planck Society is to close 12 research departments and one institute
	Research news NIH censured for Taxol deal Peg Brickley Genome Biology 2003, 4:spotlight-20030611-02 (11 June 2003) Abstract \| Full text \| Editor’s summary US auditors criticize NIH for its poor deal over Taxol royalties, while the patent row continues in Canada
	Research news US genetic policy panel forms Peg Brickley Genome Biology 2003, 4:spotlight-20030612-01 (12 June 2003) Abstract \| Full text \| Editor’s summary The composition of the new US genetic policy panel draws criticism for its conservative stance on embryonic stem-cell research
	Research news Sex drives evolution Cathy Holding Genome Biology 2003, 4:spotlight-20030613-01 (13 June 2003) Abstract \| Full text \| Editor’s summary Microarray analysis of expression of genes throughout the Drosophila genome reveals that sex-dependent selection is an evolutionary driving force
	Research news UC to launch open-access journals Catherine Zandonella Genome Biology 2003, 4:spotlight-20030616-02 (16 June 2003) Abstract \| Full text \| Editor’s summary University of California is to use its electronic superarchive as platform for launching journals
	Research news Gut response Cathy Holding Genome Biology 2003, 4:spotlight-20030616-01 (16 June 2003) Abstract \| Full text \| Editor’s summary A bio-containable genetically modified organism promises hope for sufferers of inflammatory bowel disease
	Research news China claims SARS under control Robert Walgate Genome Biology 2003, 4:spotlight-20030618-01 (17 June 2003) Abstract \| Full text \| Editor’s summary At the first global meeting of SARS scientists, China claims its outbreak is under control
	Research news First global SARS meeting Robert Walgate Genome Biology 2003, 4:spotlight-20030618-02 (17 June 2003) Abstract \| Full text \| Editor’s summary The world's first SARS conference assembles to set research and surveillance objectives
	Research news Y: waving, not drowning Cathy Holding Genome Biology 2003, 4:spotlight-20030618-03 (18 June 2003) Abstract \| Full text \| Editor’s summary Analysis of the Y chromosome suggests how it is saving itself from evolving to extinction
	Research news Tall, skinny, RNAi decaf, to go Tudor Toma Genome Biology 2003, 4:spotlight-20030620-03 (20 June 2003) Abstract \| Full text \| Editor’s summary RNA interference technology can produce decaffeinated coffee plants
	Research news Cancer Research UK names new head Pat Hagan Genome Biology 2003, 4:spotlight-20030620-02 (20 June 2003) Abstract \| Full text \| Editor’s summary Geneticist Alex Markham is to be chief executive of the leading UK cancer charity
	Research news Repairing BRCA1 science Peg Brickley Genome Biology 2003, 4:spotlight-20030620-01 (20 June 2003) Abstract \| Full text \| Editor’s summary DNA-repair researchers trying to separate sound science from allegedly false data in retracted papers
	Research news Large-scale science Ted Agres Genome Biology 2003, 4:spotlight-20030623-01 (23 June 2003) Abstract \| Full text \| Editor’s summary Big collaborations require new attitudes about industry-academia ties and professional status
	Research news UK unveils £50 million genetics strategy Pat Hagan Genome Biology 2003, 4:spotlight-20030625-01 (25 June 2003) Abstract \| Full text \| Editor’s summary The UK government says genetic testing and gene therapy will transform healthcare, but critics want safeguards
	Research news Driving man and chimp apart Cathy Holding Genome Biology 2003, 4:spotlight-20030626-01 (26 June 2003) Abstract \| Full text \| Editor’s summary Indels, not single base substitutions, in the MHC region account for differential immune responses
	Research news Open access law introduced Catherine Zandonella Genome Biology 2003, 4:spotlight-20030627-01 (27 June 2003) Abstract \| Full text \| Editor’s summary A US congressman joins the push to promote public access to publicly funded research
	Research news New FASEB president starts term Eugene Russo Genome Biology 2003, 4:spotlight-20030630-01 (30 June 2003) Abstract \| Full text \| Editor’s summary Biochemist Robert D. Wells lays out priorities for the biomedical research advocacy organization
	Research
	Research The mosaic structure of the symbiotic plasmid of Rhizobium etli CFN42 and its relation to other symbiotic genome compartments Víctor González, Patricia Bustos, Miguel A Ramírez-Romero, Arturo Medrano-Soto, Heladia Salgado, Ismael Hernández-González, Juan Hernández-Celis, Verónica Quintero, Gabriel Moreno-Hagelsieb, Lourdes Girard, Oscar Rodríguez, Margarita Flores, Miguel A Cevallos, Julio Collado-Vides, David Romero, Guillermo Dávila Genome Biology 2003, 4:R36 (13 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In rhizobia, essential genes for symbiosis are compartmentalized in symbiotic plasmids or in chromosomal symbiotic islands. The complete sequence of the symbiotic plasmid of Rhizobium etli CFN42, a microsymbiont of beans is reported, along with and a comparison with other symbiotic genome compartments sequences available.
	Research Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor Paul-Martin Holterhus, Olaf Hiort, Janos Demeter, Patrick O Brown, James D Brooks Genome Biology 2003, 4:R37 (15 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Most individuals with androgen insensitivity syndrome (AIS) carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of the AR in vitro, genital skin fibroblasts from normal males and 46,XY females with complete AIS due to known AR mutations were analysed using microarrays to gain insights into the role of the AR in human genital differentiation.
	Research Horizontally transferred genes in plant-parasitic nematodes: a high-throughput genomic approach Elizabeth H Scholl, Jeffrey L Thorne, James P McCarter, David Mck Bird Genome Biology 2003, 4:R39 (19 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A method for a high-throughput genome screening for horizontally acquired genes is presented, and is illustrated using EST data from three species of root-knot nematode, Meloidogyne species.
	Research A phylogenetic study of cytochrome b561 proteins Wim Verelst, Han Asard Genome Biology 2003, 4:R38 (28 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary All cytochromes b561 have probably evolved from a common ancestral protein before the separation of plants and animals. Their phyletic distribution mirrors the use of ascorbate as primary antioxidant, indicating their role in ascorbate homeostasis and antioxidative defense.
	Method Statistical methods for ranking differentially expressed genes Per Broberg Genome Biology 2003, 4:R41 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A method is outlined for finding an optimal test statistic with which to rank genes from microarray data with respect to differential expression.
	Method A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes Paul M Harrison, Mark Gerstein Genome Biology 2003, 4:R40 (30 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel method has been derived to assess compositional biases in biological sequences. It is based on finding the lowest-probability subsequences for a given residue-type set.

	Volume 4 Issue 6
	Comment
	Comment Ira Gregory A Petsko Genome Biology 2003, 4:112 (19 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary For a quarter of a century in genetics if you said Ira the chances were you meant Ira Herskowitz. When he died, on April 28 this year, it left a hole in the fields of genetics and genomics the size of the Grand Canyon.
	Review
	Review Matrix metalloproteinases: old dogs with new tricks Robert PT Somerville, Samantha A Oblander, Suneel S Apte Genome Biology 2003, 4:216 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary It was previously thought that the matrix metalloproteinase family acted only to degrade components of the extracellular matrix, but this view has changed with the discovery that non-extracellular-matrix molecules are also substrates.
	Minireview The genomics and proteomics of biofilm formation Karin Sauer Genome Biology 2003, 4:219 (27 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Recent genomic and proteomic studies have identified many of the genes and gene products differentially expressed during bacterial biofilm formation, revealing the complexity of this developmental process.
	Minireview The Neurospora crassa genome opens up the world of filamentous fungi Michael J Hynes Genome Biology 2003, 4:217 (28 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The draft genome sequence of Neurospora crassa has revealed several unusual features which suggest that its evolution has been greatly influenced by several unique genome-defense mechanisms.
	Minireview What makes a mitochondrion? Joshua L Heazlewood, A Millar, David A Day, James Whelan Genome Biology 2003, 4:218 (28 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Experimental analyses of the proteins found in the mitochondria of yeast, humans and Arabidopsis have confirmed some expectations but given some surprises and some insights into the evolutionary origins of mitochondrial proteins.
	Report
	Paper report Articles selected by Faculty of 1000: sugar arrays; C. elegans ORFeome v1.1; identifying tRNA genes; method to analyze human serum proteome; rates of molecular divergence Genome Biology 2003, 4:325 (9 May 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the synthesis of sugar arrays, C. elegans ORFeome v1.1, a novel method for identifying tRNA genes, a step towards analysis of the human serum proteome and rates of molecular divergence in rearranged chromosomes.
	Paper report Articles selected by Faculty of 1000: Neurospora crassa genome sequence; human c-Myc target genes; prokaryote genome annotation database; diversity of marine eukaryotes; transcriptional regulation by a pseudogene Genome Biology 2003, 4:326 (15 May 2003) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the complete genome sequence of Neurospora crassa, a genome-wide screen for human c-Myc target genes, a prokaryote genome annoation database, an analysis of marine eukaryote diversity and regulation of transcription by a pseudogene.
	Meeting report Assembling a jigsaw puzzle with 20,000 parts Edward M Marcotte Genome Biology 2003, 4:323 (23 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Keystone Symposium 'Proteomics: Technologies and Applications', Keystone, USA, 25-30 March 2003.
	Meeting report Translating genome sequences into biological understanding Vishwanath R Iyer Genome Biology 2003, 4:324 (23 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Genomics, Proteomics and Bioinformatics Thematic Meeting during the 2003 American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting, San Diego, USA, 11-15 April 2003.
	Deposited research article Identifying biological themes within lists of genes with EASE Douglas A Hosack, Glynn Dennis, Brad T Sherman, H Lane, Richard A Lempicki Genome Biology 2003, 4:P4 (25 April 2003) Abstract \| Full text \| PDF \| Editor’s summary EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE, and other high-throughput genomic data.
	Deposited research article Reverse engineering of gene regulatory networks: a finite state linear model Alvis Brazma, Thomas Schlitt Genome Biology 2003, 4:P5 (29 April 2003) Abstract \| Full text \| PDF \| Editor’s summary A new model is proposed for describing gene regulatory networks that can capture discrete (Boolean) and continuous (differential) aspects of gene regulation.
	Deposited research article Ancient origin and evolution of the Indian wolf: evidence from mitochondrial DNA typing of wolves from Trans-Himalayan region and Pennisular India Ramesh K Aggarwal, J Ramadevi, Lalji Singh Genome Biology 2003, 4:P6 (29 April 2003) Abstract \| Full text \| PDF \| Editor’s summary A study of mitochondrial DNA diversity across three different taxonomically informative domains (cytochrome-B gene, 16S rDNA and hypervariable d-loop control region) revealed that the Himalayan wolf and the Indian Gray wolf are genetically distinct from each other as well as from all other wolves of the world
	Research news NIH says scientists should share Peg Brickley Genome Biology 2003, 4:spotlight-20030604-01 (4 June 2003) Abstract \| Full text \| Editor’s summary Agency leans on researchers to be generous with laboratory mouse strains
	Research news NIH names computational boss Willie Schatz Genome Biology 2003, 4:spotlight-20030605-01 (5 June 2003) Abstract \| Full text \| Editor’s summary Eric Jakobsson becomes first director of the Center for Bioinformatics and Computational Biology
	Research news NIMR closure on hold Pat Hagan Genome Biology 2003, 4:spotlight-20030605-02 (5 June 2003) Abstract \| Full text \| Editor’s summary UK's Medical Research Council reconsiders plans after revolt by scientists
	Research news New head for European Science Foundation Helen Gavaghan Genome Biology 2003, 4:spotlight-20030610-01 (10 June 2003) Abstract \| Full text \| Editor’s summary The new head of the ESF will push for greater financial influence and more funding for basic research
	Research news Gene therapy by mRNA stabilization? Tudor P Toma Genome Biology 2003, 4:spotlight-20030610-02 (10 June 2003) Abstract \| Full text \| Editor’s summary Selective stabilization of mRNA in tumor cells can control gene expression from viral vectors
	Research news Max Planck announces cuts Martina Habeck Genome Biology 2003, 4:spotlight-20030611-01 (11 June 2003) Abstract \| Full text \| Editor’s summary Germany's Max Planck Society is to close 12 research departments and one institute
	Research news NIH censured for Taxol deal Peg Brickley Genome Biology 2003, 4:spotlight-20030611-02 (11 June 2003) Abstract \| Full text \| Editor’s summary US auditors criticize NIH for its poor deal over Taxol royalties, while the patent row continues in Canada
	Research news US genetic policy panel forms Peg Brickley Genome Biology 2003, 4:spotlight-20030612-01 (12 June 2003) Abstract \| Full text \| Editor’s summary The composition of the new US genetic policy panel draws criticism for its conservative stance on embryonic stem-cell research
	Research news Sex drives evolution Cathy Holding Genome Biology 2003, 4:spotlight-20030613-01 (13 June 2003) Abstract \| Full text \| Editor’s summary Microarray analysis of expression of genes throughout the Drosophila genome reveals that sex-dependent selection is an evolutionary driving force
	Research news UC to launch open-access journals Catherine Zandonella Genome Biology 2003, 4:spotlight-20030616-02 (16 June 2003) Abstract \| Full text \| Editor’s summary University of California is to use its electronic superarchive as platform for launching journals
	Research news Gut response Cathy Holding Genome Biology 2003, 4:spotlight-20030616-01 (16 June 2003) Abstract \| Full text \| Editor’s summary A bio-containable genetically modified organism promises hope for sufferers of inflammatory bowel disease
	Research news China claims SARS under control Robert Walgate Genome Biology 2003, 4:spotlight-20030618-01 (17 June 2003) Abstract \| Full text \| Editor’s summary At the first global meeting of SARS scientists, China claims its outbreak is under control
	Research news First global SARS meeting Robert Walgate Genome Biology 2003, 4:spotlight-20030618-02 (17 June 2003) Abstract \| Full text \| Editor’s summary The world's first SARS conference assembles to set research and surveillance objectives
	Research news Y: waving, not drowning Cathy Holding Genome Biology 2003, 4:spotlight-20030618-03 (18 June 2003) Abstract \| Full text \| Editor’s summary Analysis of the Y chromosome suggests how it is saving itself from evolving to extinction
	Research news Tall, skinny, RNAi decaf, to go Tudor Toma Genome Biology 2003, 4:spotlight-20030620-03 (20 June 2003) Abstract \| Full text \| Editor’s summary RNA interference technology can produce decaffeinated coffee plants
	Research news Cancer Research UK names new head Pat Hagan Genome Biology 2003, 4:spotlight-20030620-02 (20 June 2003) Abstract \| Full text \| Editor’s summary Geneticist Alex Markham is to be chief executive of the leading UK cancer charity
	Research news Repairing BRCA1 science Peg Brickley Genome Biology 2003, 4:spotlight-20030620-01 (20 June 2003) Abstract \| Full text \| Editor’s summary DNA-repair researchers trying to separate sound science from allegedly false data in retracted papers
	Research news Large-scale science Ted Agres Genome Biology 2003, 4:spotlight-20030623-01 (23 June 2003) Abstract \| Full text \| Editor’s summary Big collaborations require new attitudes about industry-academia ties and professional status
	Research news UK unveils £50 million genetics strategy Pat Hagan Genome Biology 2003, 4:spotlight-20030625-01 (25 June 2003) Abstract \| Full text \| Editor’s summary The UK government says genetic testing and gene therapy will transform healthcare, but critics want safeguards
	Research news Driving man and chimp apart Cathy Holding Genome Biology 2003, 4:spotlight-20030626-01 (26 June 2003) Abstract \| Full text \| Editor’s summary Indels, not single base substitutions, in the MHC region account for differential immune responses
	Research news Open access law introduced Catherine Zandonella Genome Biology 2003, 4:spotlight-20030627-01 (27 June 2003) Abstract \| Full text \| Editor’s summary A US congressman joins the push to promote public access to publicly funded research
	Research news New FASEB president starts term Eugene Russo Genome Biology 2003, 4:spotlight-20030630-01 (30 June 2003) Abstract \| Full text \| Editor’s summary Biochemist Robert D. Wells lays out priorities for the biomedical research advocacy organization
	Research
	Research The mosaic structure of the symbiotic plasmid of Rhizobium etli CFN42 and its relation to other symbiotic genome compartments Víctor González, Patricia Bustos, Miguel A Ramírez-Romero, Arturo Medrano-Soto, Heladia Salgado, Ismael Hernández-González, Juan Hernández-Celis, Verónica Quintero, Gabriel Moreno-Hagelsieb, Lourdes Girard, Oscar Rodríguez, Margarita Flores, Miguel A Cevallos, Julio Collado-Vides, David Romero, Guillermo Dávila Genome Biology 2003, 4:R36 (13 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary In rhizobia, essential genes for symbiosis are compartmentalized in symbiotic plasmids or in chromosomal symbiotic islands. The complete sequence of the symbiotic plasmid of Rhizobium etli CFN42, a microsymbiont of beans is reported, along with and a comparison with other symbiotic genome compartments sequences available.
	Research Differential gene-expression patterns in genital fibroblasts of normal males and 46,XY females with androgen insensitivity syndrome: evidence for early programming involving the androgen receptor Paul-Martin Holterhus, Olaf Hiort, Janos Demeter, Patrick O Brown, James D Brooks Genome Biology 2003, 4:R37 (15 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Most individuals with androgen insensitivity syndrome (AIS) carry germline mutations of the androgen receptor (AR) that interfere with or ablate its function. As genital fibroblasts retain expression of the AR in vitro, genital skin fibroblasts from normal males and 46,XY females with complete AIS due to known AR mutations were analysed using microarrays to gain insights into the role of the AR in human genital differentiation.
	Research Horizontally transferred genes in plant-parasitic nematodes: a high-throughput genomic approach Elizabeth H Scholl, Jeffrey L Thorne, James P McCarter, David Mck Bird Genome Biology 2003, 4:R39 (19 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A method for a high-throughput genome screening for horizontally acquired genes is presented, and is illustrated using EST data from three species of root-knot nematode, Meloidogyne species.
	Research A phylogenetic study of cytochrome b561 proteins Wim Verelst, Han Asard Genome Biology 2003, 4:R38 (28 May 2003) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary All cytochromes b561 have probably evolved from a common ancestral protein before the separation of plants and animals. Their phyletic distribution mirrors the use of ascorbate as primary antioxidant, indicating their role in ascorbate homeostasis and antioxidative defense.
	Method Statistical methods for ranking differentially expressed genes Per Broberg Genome Biology 2003, 4:R41 (29 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A method is outlined for finding an optimal test statistic with which to rank genes from microarray data with respect to differential expression.
	Method A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes Paul M Harrison, Mark Gerstein Genome Biology 2003, 4:R40 (30 May 2003) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel method has been derived to assess compositional biases in biological sequences. It is based on finding the lowest-probability subsequences for a given residue-type set.

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Volume 4 Issue 6

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