Genome Biology | Volume 5 Issue 8

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	Volume 5 Issue 8
	Comment
	Comment A drop in the bucket Gregory A Petsko Genome Biology 2004, 5:112 (22 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With $151 billion, all world-wide AIDS programs could be fully funded for the next 12 years.
	Review
	Minireview The imbalanced supertree of flowering-plant phylogeny Sean W Graham, Quentin CB Cronk Genome Biology 2004, 5:236 (15 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study has produced the most complete phylogeny yet of flowering plant families.
	Minireview What makes us human? Tarjei S Mikkelsen Genome Biology 2004, 5:238 (27 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The sequence of chimpanzee chromosome 22 is starting to help us to define the set of genetic attributes that are unique to humans, but interpreting the biological consequences of these remains a major challenge.
	Minireview Chipping away at 'stemness' April D Pyle, Peter J Donovan, Leslie F Lock Genome Biology 2004, 5:235 (29 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gene-expression analyses of human embryonic stem cells identify new candidate regulators of stem-cell growth but the expression pattern of genes that is common to all stem cells remains unclear.
	Minireview Success for gene therapy: render unto Caesar that which is Caesar's Jian Qiao, Rosa Diaz, Richard G Vile Genome Biology 2004, 5:237 (29 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two reports now take away some of the mystery as to why two young children developed leukemia after being treated for immunodeficiency with their own retrovirally modified bone-marrow cell and allay fears for the safety of gene therapy.
	Opinion Molecular tumor profiling: translating genomic insights into clinical advances Alison H Trainer Genome Biology 2004, 5:113 (15 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Molecular profiling of the transcripts or proteins within an individual tumor may in future provide important prognostic and therapeutic information, but for the time being traditional genetics and pathology retain their place in the clinic.
	Report
	Paper report Articles selected by Faculty of 1000: proteomics of sumoylation; single-molecule sequencing; membrane glycoproteomics; MHC haplotype sequencing; transcriptome evolution Genome Biology 2004, 5:340 (9 July 2004) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the proteomics of sumoylation; sequencing single-molecules; membrane glycoproteomics; MHC haplotype sequencing; transcriptome evolution.
	Paper report Articles selected by Faculty of 1000: Arabidopsis transcription factors; aminoglycoside microarrays; plant microRNAs; the serum interactome; haplotype tagging methods Genome Biology 2004, 5:341 (19 July 2004) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering Arabidopsis transcription factors; aminoglycoside microarrays; plant microRNAs; the serum interactome; haplotype tagging methods.
	Meeting report Addressing the age-old question of old age Joshua J McElwee Genome Biology 2004, 5:337 (14 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Second International Conference on Functional Genomics of Ageing, Hersonissos, Greece, 28 April-1 May 2004.
	Meeting report Bacterial comparative genomics Michael B Prentice Genome Biology 2004, 5:338 (28 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on 'Genomes 2004: International Conference on the Analysis of Microbial and Other Genomes', Hinxton, UK, 14-17 April 2004.
	Meeting report Recent advances in Drosophila genomics Melissa B Davis, Kevin P White Genome Biology 2004, 5:339 (28 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 45th annual Drosophila Research Conference, Washington DC, USA, 23-28 March 2004.
	Deposited research article The influence of RNA integrity, purity and cDNA labelling on glass slide cDNA microarray image quality Dachuan Guo, Belinda Cutri, Daniel R Catchpoole Genome Biology 2004, 5:P13 (16 July 2004) Abstract \| Full text \| PDF \| Editor’s summary This study provides insight into the source of variation in microarray image analysis introduced during sample preparation and may assist in the standardisation of cDNA glass slide microarray protocols.
	Research news MicroRNA microarray disarray? Cathy Holding Genome Biology 2004, 5:spotlight-20040502-02 (2 August 2004) Abstract \| Full text \| Editor’s summary A paper in Proceedings of the National Academy of Sciences USA claims a prognostic use for microarray in CLLs, but others doubt findings
	Research news NIH research to be open access Paula Park Genome Biology 2004, 5:spotlight-20040802-01 (2 August 2004) Abstract \| Full text \| Editor’s summary Publishers and editors meet - Zerhouni plans for publicly available papers with exasperation
	Research news Mexico to open genome center Xavier Bosch Genome Biology 2004, 5:spotlight-20040505-02 (5 August 2004) Abstract \| Full text \| Editor’s summary A 2.4-billion peso center will focus on the health problems of the Mexican population
	Research news Paul Silverman dies Maria W Anderson Genome Biology 2004, 5:spotlight-20040505-01 (5 August 2004) Abstract \| Full text \| Editor’s summary U-C Irvine scientist, administrator founded first human genome research center in Berkeley
	Research news Single-cell enzyme monitoring? Charles Q Choi Genome Biology 2004, 5:spotlight-20040510-01 (10 August 2004) Abstract \| Full text \| Editor’s summary A SERRS-based technique is sensitive enough to measure reactions from as few as 500 molecules
	Research news How bacteria fight antibiotics Cathy Holding Genome Biology 2004, 5:spotlight-20040513-01 (13 August 2004) Abstract \| Full text \| Editor’s summary Two mechanisms of antibiotic tolerance are demonstrated in separate studies in Science
	Research news Second RNAi pathway emerges Jack Lucentini Genome Biology 2004, 5:spotlight-20040517-01 (17 August 2004) Abstract \| Full text \| Editor’s summary Nature and Science papers find a mechanism at work at the transcriptional level in human cells
	Research news Different codons, same amino acid Melissa Phillips Genome Biology 2004, 5:spotlight-20040518-01 (18 August 2004) Abstract \| Full text \| Editor’s summary A study shows that synonymous codon usage varies in human tissues, perhaps due to evolution
	Research news Bacteria help Drosophila Melissa Phillips Genome Biology 2004, 5:spotlight-20040524-02 (24 August 2004) Abstract \| Full text \| Editor’s summary Fly lifespan is boosted by early exposure to bacteria, but curbed by presence late in life
	Research news Cycling without cyclins Cathy Holding Genome Biology 2004, 5:spotlight-20040824-01 (24 August 2004) Abstract \| Full text \| Editor’s summary Reports based on D-type cyclin knockouts show cell cycle is not cyclin dependent
	Research news First dog cloned Ivan Oransky Genome Biology 2004, 5:spotlight-20050818-02 (18 August 2005) Abstract \| Full text \| Editor’s summary South Korean team overcomes challenges of canine cloning to create Snuppy
	Research news UK consults on embryo law Stephen Pincock Genome Biology 2004, 5:spotlight-20050818-01 (18 August 2005) Abstract \| Full text \| Editor’s summary A major review will examine regulation of assisted reproduction and embryology research
	Research news New function for telomerase? Graciela Flores Genome Biology 2004, 5:spotlight-20050819-02 (19 August 2005) Abstract \| Full text \| Editor’s summary The enzyme promotes resting stem cells to proliferate, without extending telomeres, study shows
	Research news Insects may have complex immunity Charles Q Choi Genome Biology 2004, 5:spotlight-20050819-01 (19 August 2005) Abstract \| Full text \| Editor’s summary Thanks to alternate splicing of Dscam, they could possess up to 18,000 immune receptors
	Research
	Research Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1 Richard Bonneau, Nitin S Baliga, Eric W Deutsch, Paul Shannon, Leroy Hood Genome Biology 2004, 5:R52 (12 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Simultaneous analysis of the association network, coordinated mRNA level changes in microarray experiments and genome-wide structure prediction of the three-dimensional structure of 1,185 proteins and protein domains provided insights into the roles of several Halobacterium NRC-1 proteins of previously unknown function.
	Research Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots Matthew E Hurles, David Willey, Lucy Matthews, Syed Hussain Genome Biology 2004, 5:R55 (14 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Two hotspots of non-allelic homologous recombination on the Y chromosome are characterized by signatures of concerted evolution, but neighbouring sequences do not.
	Research Phylogenetic profiling of the Arabidopsis thaliana proteome: what proteins distinguish plants from other organisms? Rodrigo A Gutiérrez, Pamela J Green, Kenneth Keegstra, John B Ohlrogge Genome Biology 2004, 5:R53 (15 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A classification of Arabidopsis gene products on the basis of their sequence similarity to other organisms has identified a set of potential plant specific genes.
	Research System-based proteomic analysis of the interferon response in human liver cells Wei Yan, Hookeun Lee, Eugene C Yi, David Reiss, Paul Shannon, Bartlomiej K Kwieciszewski, Carlos Coito, Xiao-jun Li, Andrew Keller, Jimmy Eng, Timothy Galitski, David R Goodlett, Ruedi Aebersold, Michael G Katze Genome Biology 2004, 5:R54 (22 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A global quantitative proteomic analysis in a human hepatoma cell line in the presence and absence of interferon treatment using the isotope coded affinity tag method and tandem mass spectrometry identified several novel regulatory components of the interferon response.
	Research Identifying combinatorial regulation of transcription factors and binding motifs Mamoru Kato, Naoya Hata, Nilanjana Banerjee, Bruce Futcher, Michael Q Zhang Genome Biology 2004, 5:R56 (28 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel method that integrates chromatin immunoprecipitation data with microarray expression data and combinatorial TF-motif analysis was used to systematically identify combinations of transcription factors and of motifs and to reconstruct a new combinatorial regulatory map of the yeast cell cycle.
	Method Modular decomposition of protein-protein interaction networks Julien Gagneur, Roland Krause, Tewis Bouwmeester, Georg Casari Genome Biology 2004, 5:R57 (21 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary This article introduces an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules.
	Method POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer Christopher Lausted, Timothy Dahl, Charles Warren, Kimberly King, Kimberly Smith, Michael Johnson, Ramsey Saleem, John Aitchison, Lee Hood, Stephen R Lasky Genome Biology 2004, 5:R58 (27 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An open-source inkjet arrayer is described here capable of rapidly producing sets of unique 9,800-feature arrays.
	Method Statistical modeling for selecting housekeeper genes Aniko Szabo, Charles M Perou, Mehmet Karaca, Laurent Perreard, John F Quackenbush, Philip S Bernard Genome Biology 2004, 5:R59 (29 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Statistical models are presented for selecting the best housekeepers to normalize quantitative data within a given tissue type and across different types of tissue samples.
	Method Model selection and efficiency testing for normalization of cDNA microarray data Matthias Futschik, Toni Crompton Genome Biology 2004, 5:R60 (30 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study presents two novel normalization schemes for cDNA microarrays. They are based on iterative local regression and optimization of model parameters by generalized cross-validation.
	Correspondence
	Open letter Call for an enzyme genomics initiative Peter D Karp Genome Biology 2004, 5:401 (30 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An Enzyme Genomics Initiative is proposed, the goal of which is to obtain at least one protein sequence for each enzyme that has previously been characterized biochemically.

	Volume 5 Issue 8
	Comment
	Comment A drop in the bucket Gregory A Petsko Genome Biology 2004, 5:112 (22 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary With $151 billion, all world-wide AIDS programs could be fully funded for the next 12 years.
	Review
	Minireview The imbalanced supertree of flowering-plant phylogeny Sean W Graham, Quentin CB Cronk Genome Biology 2004, 5:236 (15 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A recent study has produced the most complete phylogeny yet of flowering plant families.
	Minireview What makes us human? Tarjei S Mikkelsen Genome Biology 2004, 5:238 (27 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The sequence of chimpanzee chromosome 22 is starting to help us to define the set of genetic attributes that are unique to humans, but interpreting the biological consequences of these remains a major challenge.
	Minireview Chipping away at 'stemness' April D Pyle, Peter J Donovan, Leslie F Lock Genome Biology 2004, 5:235 (29 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Gene-expression analyses of human embryonic stem cells identify new candidate regulators of stem-cell growth but the expression pattern of genes that is common to all stem cells remains unclear.
	Minireview Success for gene therapy: render unto Caesar that which is Caesar's Jian Qiao, Rosa Diaz, Richard G Vile Genome Biology 2004, 5:237 (29 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Two reports now take away some of the mystery as to why two young children developed leukemia after being treated for immunodeficiency with their own retrovirally modified bone-marrow cell and allay fears for the safety of gene therapy.
	Opinion Molecular tumor profiling: translating genomic insights into clinical advances Alison H Trainer Genome Biology 2004, 5:113 (15 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Molecular profiling of the transcripts or proteins within an individual tumor may in future provide important prognostic and therapeutic information, but for the time being traditional genetics and pathology retain their place in the clinic.
	Report
	Paper report Articles selected by Faculty of 1000: proteomics of sumoylation; single-molecule sequencing; membrane glycoproteomics; MHC haplotype sequencing; transcriptome evolution Genome Biology 2004, 5:340 (9 July 2004) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering the proteomics of sumoylation; sequencing single-molecules; membrane glycoproteomics; MHC haplotype sequencing; transcriptome evolution.
	Paper report Articles selected by Faculty of 1000: Arabidopsis transcription factors; aminoglycoside microarrays; plant microRNAs; the serum interactome; haplotype tagging methods Genome Biology 2004, 5:341 (19 July 2004) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering Arabidopsis transcription factors; aminoglycoside microarrays; plant microRNAs; the serum interactome; haplotype tagging methods.
	Meeting report Addressing the age-old question of old age Joshua J McElwee Genome Biology 2004, 5:337 (14 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Second International Conference on Functional Genomics of Ageing, Hersonissos, Greece, 28 April-1 May 2004.
	Meeting report Bacterial comparative genomics Michael B Prentice Genome Biology 2004, 5:338 (28 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on 'Genomes 2004: International Conference on the Analysis of Microbial and Other Genomes', Hinxton, UK, 14-17 April 2004.
	Meeting report Recent advances in Drosophila genomics Melissa B Davis, Kevin P White Genome Biology 2004, 5:339 (28 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the 45th annual Drosophila Research Conference, Washington DC, USA, 23-28 March 2004.
	Deposited research article The influence of RNA integrity, purity and cDNA labelling on glass slide cDNA microarray image quality Dachuan Guo, Belinda Cutri, Daniel R Catchpoole Genome Biology 2004, 5:P13 (16 July 2004) Abstract \| Full text \| PDF \| Editor’s summary This study provides insight into the source of variation in microarray image analysis introduced during sample preparation and may assist in the standardisation of cDNA glass slide microarray protocols.
	Research news MicroRNA microarray disarray? Cathy Holding Genome Biology 2004, 5:spotlight-20040502-02 (2 August 2004) Abstract \| Full text \| Editor’s summary A paper in Proceedings of the National Academy of Sciences USA claims a prognostic use for microarray in CLLs, but others doubt findings
	Research news NIH research to be open access Paula Park Genome Biology 2004, 5:spotlight-20040802-01 (2 August 2004) Abstract \| Full text \| Editor’s summary Publishers and editors meet - Zerhouni plans for publicly available papers with exasperation
	Research news Mexico to open genome center Xavier Bosch Genome Biology 2004, 5:spotlight-20040505-02 (5 August 2004) Abstract \| Full text \| Editor’s summary A 2.4-billion peso center will focus on the health problems of the Mexican population
	Research news Paul Silverman dies Maria W Anderson Genome Biology 2004, 5:spotlight-20040505-01 (5 August 2004) Abstract \| Full text \| Editor’s summary U-C Irvine scientist, administrator founded first human genome research center in Berkeley
	Research news Single-cell enzyme monitoring? Charles Q Choi Genome Biology 2004, 5:spotlight-20040510-01 (10 August 2004) Abstract \| Full text \| Editor’s summary A SERRS-based technique is sensitive enough to measure reactions from as few as 500 molecules
	Research news How bacteria fight antibiotics Cathy Holding Genome Biology 2004, 5:spotlight-20040513-01 (13 August 2004) Abstract \| Full text \| Editor’s summary Two mechanisms of antibiotic tolerance are demonstrated in separate studies in Science
	Research news Second RNAi pathway emerges Jack Lucentini Genome Biology 2004, 5:spotlight-20040517-01 (17 August 2004) Abstract \| Full text \| Editor’s summary Nature and Science papers find a mechanism at work at the transcriptional level in human cells
	Research news Different codons, same amino acid Melissa Phillips Genome Biology 2004, 5:spotlight-20040518-01 (18 August 2004) Abstract \| Full text \| Editor’s summary A study shows that synonymous codon usage varies in human tissues, perhaps due to evolution
	Research news Bacteria help Drosophila Melissa Phillips Genome Biology 2004, 5:spotlight-20040524-02 (24 August 2004) Abstract \| Full text \| Editor’s summary Fly lifespan is boosted by early exposure to bacteria, but curbed by presence late in life
	Research news Cycling without cyclins Cathy Holding Genome Biology 2004, 5:spotlight-20040824-01 (24 August 2004) Abstract \| Full text \| Editor’s summary Reports based on D-type cyclin knockouts show cell cycle is not cyclin dependent
	Research news First dog cloned Ivan Oransky Genome Biology 2004, 5:spotlight-20050818-02 (18 August 2005) Abstract \| Full text \| Editor’s summary South Korean team overcomes challenges of canine cloning to create Snuppy
	Research news UK consults on embryo law Stephen Pincock Genome Biology 2004, 5:spotlight-20050818-01 (18 August 2005) Abstract \| Full text \| Editor’s summary A major review will examine regulation of assisted reproduction and embryology research
	Research news New function for telomerase? Graciela Flores Genome Biology 2004, 5:spotlight-20050819-02 (19 August 2005) Abstract \| Full text \| Editor’s summary The enzyme promotes resting stem cells to proliferate, without extending telomeres, study shows
	Research news Insects may have complex immunity Charles Q Choi Genome Biology 2004, 5:spotlight-20050819-01 (19 August 2005) Abstract \| Full text \| Editor’s summary Thanks to alternate splicing of Dscam, they could possess up to 18,000 immune receptors
	Research
	Research Comprehensive de novo structure prediction in a systems-biology context for the archaea Halobacterium sp. NRC-1 Richard Bonneau, Nitin S Baliga, Eric W Deutsch, Paul Shannon, Leroy Hood Genome Biology 2004, 5:R52 (12 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Simultaneous analysis of the association network, coordinated mRNA level changes in microarray experiments and genome-wide structure prediction of the three-dimensional structure of 1,185 proteins and protein domains provided insights into the roles of several Halobacterium NRC-1 proteins of previously unknown function.
	Research Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFa deletion hotspots Matthew E Hurles, David Willey, Lucy Matthews, Syed Hussain Genome Biology 2004, 5:R55 (14 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Two hotspots of non-allelic homologous recombination on the Y chromosome are characterized by signatures of concerted evolution, but neighbouring sequences do not.
	Research Phylogenetic profiling of the Arabidopsis thaliana proteome: what proteins distinguish plants from other organisms? Rodrigo A Gutiérrez, Pamela J Green, Kenneth Keegstra, John B Ohlrogge Genome Biology 2004, 5:R53 (15 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A classification of Arabidopsis gene products on the basis of their sequence similarity to other organisms has identified a set of potential plant specific genes.
	Research System-based proteomic analysis of the interferon response in human liver cells Wei Yan, Hookeun Lee, Eugene C Yi, David Reiss, Paul Shannon, Bartlomiej K Kwieciszewski, Carlos Coito, Xiao-jun Li, Andrew Keller, Jimmy Eng, Timothy Galitski, David R Goodlett, Ruedi Aebersold, Michael G Katze Genome Biology 2004, 5:R54 (22 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A global quantitative proteomic analysis in a human hepatoma cell line in the presence and absence of interferon treatment using the isotope coded affinity tag method and tandem mass spectrometry identified several novel regulatory components of the interferon response.
	Research Identifying combinatorial regulation of transcription factors and binding motifs Mamoru Kato, Naoya Hata, Nilanjana Banerjee, Bruce Futcher, Michael Q Zhang Genome Biology 2004, 5:R56 (28 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel method that integrates chromatin immunoprecipitation data with microarray expression data and combinatorial TF-motif analysis was used to systematically identify combinations of transcription factors and of motifs and to reconstruct a new combinatorial regulatory map of the yeast cell cycle.
	Method Modular decomposition of protein-protein interaction networks Julien Gagneur, Roland Krause, Tewis Bouwmeester, Georg Casari Genome Biology 2004, 5:R57 (21 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary This article introduces an algorithmic method, termed modular decomposition, that defines the organization of protein-interaction networks as a hierarchy of nested modules.
	Method POSaM: a fast, flexible, open-source, inkjet oligonucleotide synthesizer and microarrayer Christopher Lausted, Timothy Dahl, Charles Warren, Kimberly King, Kimberly Smith, Michael Johnson, Ramsey Saleem, John Aitchison, Lee Hood, Stephen R Lasky Genome Biology 2004, 5:R58 (27 July 2004) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An open-source inkjet arrayer is described here capable of rapidly producing sets of unique 9,800-feature arrays.
	Method Statistical modeling for selecting housekeeper genes Aniko Szabo, Charles M Perou, Mehmet Karaca, Laurent Perreard, John F Quackenbush, Philip S Bernard Genome Biology 2004, 5:R59 (29 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Statistical models are presented for selecting the best housekeepers to normalize quantitative data within a given tissue type and across different types of tissue samples.
	Method Model selection and efficiency testing for normalization of cDNA microarray data Matthias Futschik, Toni Crompton Genome Biology 2004, 5:R60 (30 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary This study presents two novel normalization schemes for cDNA microarrays. They are based on iterative local regression and optimization of model parameters by generalized cross-validation.
	Correspondence
	Open letter Call for an enzyme genomics initiative Peter D Karp Genome Biology 2004, 5:401 (30 July 2004) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An Enzyme Genomics Initiative is proposed, the goal of which is to obtain at least one protein sequence for each enzyme that has previously been characterized biochemically.

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Volume 5 Issue 8

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