Genome Biology | Volume 6 Issue 2

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	Volume 6 Issue 2
	Comment
	Comment Tsunami Gregory A Petsko Genome Biology 2005, 6:104 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary I believed that genomics was like a tsunami: a force that, when it crested, would change everything.
	Review
	Protein family review The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease David IR Holmes, Ian Zachary Genome Biology 2005, 6:209 (1 February 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Vascular endothelial growth factors (VEGFs) are a family of polypeptides with a highly conserved structure. In mammals, VEGFs have roles in vascular development, development of lymphatic vessels and disease-related angiogenesis.The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions.
	Minireview Temporal and spatial patterning of an organ by a single transcription factor Diya Banerjee, Frank J Slack Genome Biology 2005, 6:205 (25 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The nematode transcription factor PHA-4 functions together with various cis regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.
	Minireview Genome-wide analysis of the context-dependence of regulatory networks Balázs Papp, Stephen Oliver Genome Biology 2005, 6:206 (27 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Two recent studies in yeast have helped reveal the relatively small number of transcription-factor control strategies that cells employ to maximize their regulatory options using only a small number of components.
	Minireview Insights into vertebrate evolution from the chicken genome sequence Rebecca F Furlong Genome Biology 2005, 6:207 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The recently completed chicken genome revealed unique features such as expanded gene families involved in egg and feather production, and comparisons with other vertebrate genomes move us closer to defining a set of essential vertebrate genes.
	Minireview A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea Ludmila Chistoserdova, Julia A Vorholt, Mary E Lidstrom Genome Biology 2005, 6:208 (1 February 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent sequencing of the genome and proteomic analysis of a model aerobic methanotrophic bacterium, Methylococcus capsulatus (Bath) has revealed a highly versatile metabolic potential. In parallel, environmental genomics has provided glimpses into anaerobic methane oxidation by certain archaea, further supporting the hypothesis of reverse methanogenesis.
	Report
	Paper report Articles selected by Faculty of 1000: nuclear microRNA processing; transposon mutagenesis in Helicobacter; Saccharomyces gene expression regulation; molecular convergent evolution; linkage disequilibrium in dogs Genome Biology 2005, 6:308 (6 January 2005) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering nuclear microRNA processing; transposon mutagenesis in Helicobacter; Saccharomyces gene expression regulation; molecular convergent evolution; linkage disequilibrium in dogs.
	Paper report Articles selected by Faculty of 1000: plant comparative mitochondrial genomics; open source proteomics database; identifying disease-associated enzymes; predicting microRNA targets; genome annotation using polymorphisms Genome Biology 2005, 6:309 (21 January 2005) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering plant comparative mitochondrial genomics; open source proteomics database; identifying disease-associated enzymes; predicting microRNA targets; genome annotation using polymorphisms.
	Meeting report Histones: should I stay or should I go? Bing Li, Chun Ruan, Jerry L Workman Genome Biology 2005, 6:306 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the American Society for Biochemistry and Molecular Biology symposium 'Transcriptional Regulation by Chromatin and RNA polymerase II', Lake Tahoe, USA, 29 October-1 November 2004.
	Meeting report Living on the edge Gino Poulin, Julie Ahringer Genome Biology 2005, 6:307 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Second EMBL/EMBO Symposium on Functional Genomics: 'Exploring the Edges of Omics', European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 16-19 October 2004.
	Deposited research article Phylogeny of the M superhaplogroup inferred from complete mitochondrial genome sequence of Indian specific lineages Revathi Rajkumar, Jheelam Banerjee, Hima Gunturi, R Trivedi, VK Kashyap Genome Biology 2004, 6:P3 (23 December 2004) Abstract \| Full text \| PDF \| Editor’s summary A phylogenetic tree constructed from sequencing information of 24 whole human mtDNA genomes revealed novel substitutions in the previously defined M2a and M6 lineages in East Asia. Seven new basal mutations and fourteen lineages that substantially contribute to the present understanding of superhaplogroup M were identified.
	Research news Epigenetics lives on in clones Melissa Phillips Genome Biology 2005, 6:spotlight-20050204-01 (4 February 2005) Abstract \| Full text \| Editor’s summary Genes active at time of Xenopus nuclei transfer are also overexpressed in cloned embryos
	Research news E. coli ages Graciela Flores Genome Biology 2005, 6:spotlight-20050204-02 (4 February 2005) Abstract \| Full text \| Editor’s summary Researchers hope the simple bacterium could be a model for human aging
	Research news Ernst Mayr dies Leslie A Pray Genome Biology 2005, 6:spotlight-20050208-01 (8 February 2005) Abstract \| Full text \| Editor’s summary Towering figure of 20th century evolutionary biology was 100
	Research news Silencing paradox resolved Trevor Stokes Genome Biology 2005, 6:spotlight-20050210-01 (10 February 2005) Abstract \| Full text \| Editor’s summary RNA polymerase in Arabidopsis does double duty in RNA- and DNA-mediated silencing
	Research news Melatonin's action in the brain Charles Q Choi Genome Biology 2005, 6:spotlight-20050210-02 (10 February 2005) Abstract \| Full text \| Editor’s summary The molecule regulates a neuropeptide involved in controlling reproduction, new report shows
	Research news DNA palindromes found in cancer Charles Q Choi Genome Biology 2005, 6:spotlight-20050216-01 (16 February 2005) Abstract \| Full text \| Editor’s summary A study in Nature Genetics finds large inverted repeats in colon and breast tumors
	Research news How old cells can regain youth Laura M Hrastar Genome Biology 2005, 6:spotlight-20050218-01 (18 February 2005) Abstract \| Full text \| Editor’s summary Researchers find a youthful environment invigorates regeneration in old tissue
	Research
	Research Accelerated evolution associated with genome reduction in a free-living prokaryote Alexis Dufresne, Laurence Garczarek, Frédéric Partensky Genome Biology 2005, 6:R14 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Prochlorococcus sp. are marine bacteria with very small genomes. The mechanisms by which these reduced genomes have evolved appears, however, to be distinct from those that have led to small genome size in intracellular bacteria.
	Research Polarized monocyte response to cytokine stimulation Dirk Nagorsen, Sara Deola, Kina Smith, Ena Wang, Vladia Monsurro, Paola Zanovello, Francesco M Marincola, Monica C Panelli Genome Biology 2005, 6:R15 (21 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comprehensive study of the transcriptional response of mononuclear phagocytes to cytokines reveals distinct classes of cytokines that elicit either the classical or alternative pathway of monocyte activation.
	Research Variation in tissue-specific gene expression among natural populations Andrew Whitehead, Douglas L Crawford Genome Biology 2005, 6:R13 (26 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The expression of a selected suite of 192 metabolic genes in brain, heart and liver in three populations of the teleost fish Fundulus heteroclitus was examined. Only a small subset (31%) of tissue-specific differences was consistent in all three populations, indicating that many tissue-specific differences in gene expression are unique to one population and thus are unlikely to contribute to fundamental differences between tissue types.
	Research Identifying genetic networks underlying myometrial transition to labor Nathan Salomonis, Nathalie Cotte, Alexander C Zambon, Katherine S Pollard, Karen Vranizan, Scott W Doniger, Gregory Dolganov, Bruce R Conklin Genome Biology 2005, 6:R12 (28 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A time course of gene expression at the onset of labor reveals transcriptional networks associated with activation of the uterine muscle and identifies targets for drugs to prevent premature labor.
	Research Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset Sung E Choe, Michael Boutros, Alan M Michelson, George M Church, Marc S Halfon Genome Biology 2005, 6:R16 (28 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A 'spike-in' experiment for Affymetrix GeneChips is described that provides a defined dataset of 3,860 RNA species. A 'best route' combination of analysis methods is presented which allows detection of approximately 70% of true positives before reaching a 10% false discovery rate.
	Research Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae Gaetano Tripoli, Domenica D'Elia, Paolo Barsanti, Corrado Caggese Genome Biology 2005, 6:R11 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An analysis of nuclear-encoded oxidative phosphorylation genes in Drosophila and Anopheles reveals that pairs of duplicated genes have strikingly different expression patterns.
	Method An ontology for cell types Jonathan Bard, Seung Y Rhee, Michael Ashburner Genome Biology 2005, 6:R21 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An ontology for cell types that covers the prokaryotic, fungal, animal and plant worlds is described. It includes over 680 cell types. These cell types are classified under several generic categories and are organized as a directed acyclic graph.
	Method A universal method for automated gene mapping Peder Zipperlen, Knud Nairz, Ivo Rimann, Konrad Basler, Ernst Hafen, Michael Hengartner, Alex Hajnal Genome Biology 2005, 6:R19 (17 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A high-throughput method for genotyping by mapping InDels. This method has been used to create fragment-length polymorphism maps for Drosophila and C. elegans.
	Method Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach Olivier Elemento, Saeed Tavazoie Genome Biology 2005, 6:R18 (26 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The authors describe a powerful approach for discovering globally conserved regulatory elements between two genomes that does not require alignments. Its application to pairs of yeasts, worm, flies and mammals, yields a large number of known and novel putative regulatory elements, many of which show surprising conservation across large phylogenetic distances.
	Method Identification of ciliated sensory neuron-expressed genes in Caenorhabditis elegans using targeted pull-down of poly(A) tails Hirofumi Kunitomo, Hiroko Uesugi, Yuji Kohara, Yuichi Iino Genome Biology 2005, 6:R17 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An mRNA-tagging method was used to selectively isolate mRNA from a small number of cells for subsequent cDNA microarray analysis. The approach was used to identify genes specifically expressed in ciliated sensory neurons of Caenorhabditis elegans.
	Method Genomic analysis of early murine mammary gland development using novel probe-level algorithms Stephen R Master, Alexander J Stoddard, L Charles Bailey, Tien-Chi Pan, Katherine D Dugan, Lewis A Chodosh Genome Biology 2005, 6:R20 (1 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel algorithm (ChipStat) is presented for detecting gene-expression changes from Affymetrix microarray data. The method is used to identify changes in murine mammary development.

	Volume 6 Issue 2
	Comment
	Comment Tsunami Gregory A Petsko Genome Biology 2005, 6:104 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary I believed that genomics was like a tsunami: a force that, when it crested, would change everything.
	Review
	Protein family review The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease David IR Holmes, Ian Zachary Genome Biology 2005, 6:209 (1 February 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Vascular endothelial growth factors (VEGFs) are a family of polypeptides with a highly conserved structure. In mammals, VEGFs have roles in vascular development, development of lymphatic vessels and disease-related angiogenesis.The existence of VEGF-like molecules and their receptors in simple invertebrates without a vascular system indicates that this family of growth factors emerged at a very early stage in the evolution of multicellular organisms to mediate primordial developmental functions.
	Minireview Temporal and spatial patterning of an organ by a single transcription factor Diya Banerjee, Frank J Slack Genome Biology 2005, 6:205 (25 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The nematode transcription factor PHA-4 functions together with various cis regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.
	Minireview Genome-wide analysis of the context-dependence of regulatory networks Balázs Papp, Stephen Oliver Genome Biology 2005, 6:206 (27 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Two recent studies in yeast have helped reveal the relatively small number of transcription-factor control strategies that cells employ to maximize their regulatory options using only a small number of components.
	Minireview Insights into vertebrate evolution from the chicken genome sequence Rebecca F Furlong Genome Biology 2005, 6:207 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The recently completed chicken genome revealed unique features such as expanded gene families involved in egg and feather production, and comparisons with other vertebrate genomes move us closer to defining a set of essential vertebrate genes.
	Minireview A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea Ludmila Chistoserdova, Julia A Vorholt, Mary E Lidstrom Genome Biology 2005, 6:208 (1 February 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent sequencing of the genome and proteomic analysis of a model aerobic methanotrophic bacterium, Methylococcus capsulatus (Bath) has revealed a highly versatile metabolic potential. In parallel, environmental genomics has provided glimpses into anaerobic methane oxidation by certain archaea, further supporting the hypothesis of reverse methanogenesis.
	Report
	Paper report Articles selected by Faculty of 1000: nuclear microRNA processing; transposon mutagenesis in Helicobacter; Saccharomyces gene expression regulation; molecular convergent evolution; linkage disequilibrium in dogs Genome Biology 2005, 6:308 (6 January 2005) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering nuclear microRNA processing; transposon mutagenesis in Helicobacter; Saccharomyces gene expression regulation; molecular convergent evolution; linkage disequilibrium in dogs.
	Paper report Articles selected by Faculty of 1000: plant comparative mitochondrial genomics; open source proteomics database; identifying disease-associated enzymes; predicting microRNA targets; genome annotation using polymorphisms Genome Biology 2005, 6:309 (21 January 2005) Abstract \| Full text \| Editor’s summary A selection of evaluations from Faculty of 1000 covering plant comparative mitochondrial genomics; open source proteomics database; identifying disease-associated enzymes; predicting microRNA targets; genome annotation using polymorphisms.
	Meeting report Histones: should I stay or should I go? Bing Li, Chun Ruan, Jerry L Workman Genome Biology 2005, 6:306 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the American Society for Biochemistry and Molecular Biology symposium 'Transcriptional Regulation by Chromatin and RNA polymerase II', Lake Tahoe, USA, 29 October-1 November 2004.
	Meeting report Living on the edge Gino Poulin, Julie Ahringer Genome Biology 2005, 6:307 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the Second EMBL/EMBO Symposium on Functional Genomics: 'Exploring the Edges of Omics', European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 16-19 October 2004.
	Deposited research article Phylogeny of the M superhaplogroup inferred from complete mitochondrial genome sequence of Indian specific lineages Revathi Rajkumar, Jheelam Banerjee, Hima Gunturi, R Trivedi, VK Kashyap Genome Biology 2004, 6:P3 (23 December 2004) Abstract \| Full text \| PDF \| Editor’s summary A phylogenetic tree constructed from sequencing information of 24 whole human mtDNA genomes revealed novel substitutions in the previously defined M2a and M6 lineages in East Asia. Seven new basal mutations and fourteen lineages that substantially contribute to the present understanding of superhaplogroup M were identified.
	Research news Epigenetics lives on in clones Melissa Phillips Genome Biology 2005, 6:spotlight-20050204-01 (4 February 2005) Abstract \| Full text \| Editor’s summary Genes active at time of Xenopus nuclei transfer are also overexpressed in cloned embryos
	Research news E. coli ages Graciela Flores Genome Biology 2005, 6:spotlight-20050204-02 (4 February 2005) Abstract \| Full text \| Editor’s summary Researchers hope the simple bacterium could be a model for human aging
	Research news Ernst Mayr dies Leslie A Pray Genome Biology 2005, 6:spotlight-20050208-01 (8 February 2005) Abstract \| Full text \| Editor’s summary Towering figure of 20th century evolutionary biology was 100
	Research news Silencing paradox resolved Trevor Stokes Genome Biology 2005, 6:spotlight-20050210-01 (10 February 2005) Abstract \| Full text \| Editor’s summary RNA polymerase in Arabidopsis does double duty in RNA- and DNA-mediated silencing
	Research news Melatonin's action in the brain Charles Q Choi Genome Biology 2005, 6:spotlight-20050210-02 (10 February 2005) Abstract \| Full text \| Editor’s summary The molecule regulates a neuropeptide involved in controlling reproduction, new report shows
	Research news DNA palindromes found in cancer Charles Q Choi Genome Biology 2005, 6:spotlight-20050216-01 (16 February 2005) Abstract \| Full text \| Editor’s summary A study in Nature Genetics finds large inverted repeats in colon and breast tumors
	Research news How old cells can regain youth Laura M Hrastar Genome Biology 2005, 6:spotlight-20050218-01 (18 February 2005) Abstract \| Full text \| Editor’s summary Researchers find a youthful environment invigorates regeneration in old tissue
	Research
	Research Accelerated evolution associated with genome reduction in a free-living prokaryote Alexis Dufresne, Laurence Garczarek, Frédéric Partensky Genome Biology 2005, 6:R14 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Prochlorococcus sp. are marine bacteria with very small genomes. The mechanisms by which these reduced genomes have evolved appears, however, to be distinct from those that have led to small genome size in intracellular bacteria.
	Research Polarized monocyte response to cytokine stimulation Dirk Nagorsen, Sara Deola, Kina Smith, Ena Wang, Vladia Monsurro, Paola Zanovello, Francesco M Marincola, Monica C Panelli Genome Biology 2005, 6:R15 (21 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comprehensive study of the transcriptional response of mononuclear phagocytes to cytokines reveals distinct classes of cytokines that elicit either the classical or alternative pathway of monocyte activation.
	Research Variation in tissue-specific gene expression among natural populations Andrew Whitehead, Douglas L Crawford Genome Biology 2005, 6:R13 (26 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The expression of a selected suite of 192 metabolic genes in brain, heart and liver in three populations of the teleost fish Fundulus heteroclitus was examined. Only a small subset (31%) of tissue-specific differences was consistent in all three populations, indicating that many tissue-specific differences in gene expression are unique to one population and thus are unlikely to contribute to fundamental differences between tissue types.
	Research Identifying genetic networks underlying myometrial transition to labor Nathan Salomonis, Nathalie Cotte, Alexander C Zambon, Katherine S Pollard, Karen Vranizan, Scott W Doniger, Gregory Dolganov, Bruce R Conklin Genome Biology 2005, 6:R12 (28 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A time course of gene expression at the onset of labor reveals transcriptional networks associated with activation of the uterine muscle and identifies targets for drugs to prevent premature labor.
	Research Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset Sung E Choe, Michael Boutros, Alan M Michelson, George M Church, Marc S Halfon Genome Biology 2005, 6:R16 (28 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A 'spike-in' experiment for Affymetrix GeneChips is described that provides a defined dataset of 3,860 RNA species. A 'best route' combination of analysis methods is presented which allows detection of approximately 70% of true positives before reaching a 10% false discovery rate.
	Research Comparison of the oxidative phosphorylation (OXPHOS) nuclear genes in the genomes of Drosophila melanogaster, Drosophila pseudoobscura and Anopheles gambiae Gaetano Tripoli, Domenica D'Elia, Paolo Barsanti, Corrado Caggese Genome Biology 2005, 6:R11 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An analysis of nuclear-encoded oxidative phosphorylation genes in Drosophila and Anopheles reveals that pairs of duplicated genes have strikingly different expression patterns.
	Method An ontology for cell types Jonathan Bard, Seung Y Rhee, Michael Ashburner Genome Biology 2005, 6:R21 (14 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An ontology for cell types that covers the prokaryotic, fungal, animal and plant worlds is described. It includes over 680 cell types. These cell types are classified under several generic categories and are organized as a directed acyclic graph.
	Method A universal method for automated gene mapping Peder Zipperlen, Knud Nairz, Ivo Rimann, Konrad Basler, Ernst Hafen, Michael Hengartner, Alex Hajnal Genome Biology 2005, 6:R19 (17 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A high-throughput method for genotyping by mapping InDels. This method has been used to create fragment-length polymorphism maps for Drosophila and C. elegans.
	Method Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach Olivier Elemento, Saeed Tavazoie Genome Biology 2005, 6:R18 (26 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The authors describe a powerful approach for discovering globally conserved regulatory elements between two genomes that does not require alignments. Its application to pairs of yeasts, worm, flies and mammals, yields a large number of known and novel putative regulatory elements, many of which show surprising conservation across large phylogenetic distances.
	Method Identification of ciliated sensory neuron-expressed genes in Caenorhabditis elegans using targeted pull-down of poly(A) tails Hirofumi Kunitomo, Hiroko Uesugi, Yuji Kohara, Yuichi Iino Genome Biology 2005, 6:R17 (31 January 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An mRNA-tagging method was used to selectively isolate mRNA from a small number of cells for subsequent cDNA microarray analysis. The approach was used to identify genes specifically expressed in ciliated sensory neurons of Caenorhabditis elegans.
	Method Genomic analysis of early murine mammary gland development using novel probe-level algorithms Stephen R Master, Alexander J Stoddard, L Charles Bailey, Tien-Chi Pan, Katherine D Dugan, Lewis A Chodosh Genome Biology 2005, 6:R20 (1 February 2005) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel algorithm (ChipStat) is presented for detecting gene-expression changes from Affymetrix microarray data. The method is used to identify changes in murine mammary development.

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Volume 6 Issue 2

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