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   <ui>gb-spotlight-20000921-03</ui>
   <ji>GBJ</ji>
   <fm>
      <dochead>Research news</dochead>
      <bibl>
         <title>
            <p>A map of smells</p>
         </title>
         <aug>
            <au id="A1">
               <snm>Wells</snm>
               <fnm>William</fnm>
               <email>wells@biotext.com</email>
            </au>
         </aug>
         <source>Genome Biology</source>
         <issn>1465-6906</issn>
         <pubdate>2000</pubdate>
         <volume>1</volume>
         <fpage>spotlight-20000921-03</fpage>
         <xrefbib>
            <pubid idtype="doi">10.1186/gb-spotlight-20000921-03</pubid>
         </xrefbib>
      </bibl>
      <history>
         <pub>
            <date>
               <day>21</day>
               <month>09</month>
               <year>2000</year>
            </date>
         </pub>
      </history>
      <cpyrt>
         <year>2000</year>
         <collab>BioMed Central Ltd</collab>
      </cpyrt>
      <shortabs>
         <p>Odorants with different functional groups are detected by different areas of the brain's olfactory bulb.</p>
      </shortabs>
   </fm>
   <meta>
      <classifications>
         <classification type="STATUS">Archive</classification>
      </classifications>
   </meta>
   <bdy>
      <sec>
         <st>
            <p/>
         </st>
         <p>Odorants are detected by a <abbr bid="B1">vast collection</abbr> of receptors in the nose. Individual sensory neurons probably express a <abbr bid="B2">single receptor</abbr>, and all the neurons that express a particular receptor <abbr bid="B3">converge</abbr> on a few topographically fixed glomeruli in the brain's olfactory bulb (OB). Researchers are keen to see whether there is any functional sorting of olfactory information during this projection process, and now in the October <abbr bid="B4"><it>Nature Neuroscience</it></abbr> Uchida <it>et al</it>. find that, indeed, odorants with different functional groups are detected by different areas of the brain's olfactory bulb (<it>Nat. Neuro.</it> 2000, <b>3</b>:1035-1043). Carboxylic acids and aldehydes are detected in an anteromedial domain, whereas alcohols and ketones are detected in a lateral domain. Especially within the anteromedial domain, odorants of increasing carbon chain length are detected by clusters of glomeruli that are nested in more anterior and lateral positions. This is in agreement with <abbr bid="B5">data</abbr> demonstrating that olfactory neurons expressing related receptors project to neighboring glomeruli. The only question now is how this sorting takes place.</p>
      </sec>
   </bdy>
   <bm>
      <refgrp>
         <bibl id="B1">
            <note>Molecular biology of odorant receptors in vertebrates.</note>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">10202546</pubid>
            </xrefbib>
         </bibl>
         <bibl id="B2">
            <note>Combinatorial receptor codes for odors.</note>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">10089886</pubid>
            </xrefbib>
         </bibl>
         <bibl id="B3">
            <note>Information coding in the olfactory system: evidence for a stereotyped and highly organized epitope map in the olfactory bulb.</note>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">7528109</pubid>
            </xrefbib>
         </bibl>
         <bibl id="B4">
            <url>http://www.nature.com/neuro/</url>
            <note>Nature Neuroscience</note>
         </bibl>
         <bibl id="B5">
            <note>Olfactory neurons expressing closely linked and homologous odorant receptor genes tend to project their axons to neighboring glomeruli on the olfactory bulb.</note>
            <xrefbib>
               <pubid idtype="pmpid" link="fulltext">10493742</pubid>
            </xrefbib>
         </bibl>
      </refgrp>
   </bm>
</art>
