Genome Biology
Volume 8
Issue 10 |
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 OpinionMaking the most of high-throughput protein-interaction dataRobert Gentleman1  and Wolfgang Huber2  1Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA 2European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, UK  author email corresponding author email
Genome Biology 2007,
8:112doi:10.1186/gb-2007-8-10-112
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2 November 2007 |
Subject areas: Bioinformatics, Genome studies, Biochemistry and structural biology Abstract
We review the estimation of coverage and error rate in high-throughput protein-protein interaction datasets and argue that reports of the low quality of such data are to a substantial extent based on misinterpretations. Probabilistic statistical models and methods can be used to estimate properties of interest and to make the best use of the available data. | 
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