Genome Biology
Volume 8
Issue 11 |
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 ReviewChromatin, gene silencing and HIV latencyHoi-Ping Mok and Andrew ML Lever  Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.  author email corresponding author email
Genome Biology 2007,
8:228doi:10.1186/gb-2007-8-11-228
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23 November 2007 |
Subject areas: Virology, Molecular biology, Genome studies, Medicine Abstract
One of the cellular defenses against virus infection is the silencing of viral gene expression. There is evidence that at least two gene-silencing mechanisms are used against the human immuno-deficiency virus (HIV). Paradoxically, this cellular defense mechanism contributes to viral latency and persistence, and we review here the relationship of viral latency to gene-silencing mechanisms. | 
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