Genome Biology
Volume 9
Issue 1 |
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 ReviewAnchoring the genomeDiego Ottaviani1, Elliott Lever2, Petros Takousis2 and Denise Sheer2  1Cancer Research UK London Research Institute, Lincoln's Inn Fields, London WC2A 3PX, UK 2Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Newark St, London E1 2AT, UK  author email corresponding author email
Genome Biology 2008,
9:201doi:10.1186/gb-2008-9-1-201
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| Published: |
22 January 2008 |
Subject areas: Cancer, Cell biology, Genetics, Genome studies, Molecular biology Abstract
Although the principles governing chromosomal architecture are largely unresolved, there is evidence that higher-order chromatin folding is mediated by the anchoring of specific DNA sequences to the nuclear matrix. These genome anchors are also crucial regulators of gene expression and DNA replication, and play a role in pathogenesis. | 
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