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Deciphering histone 2A deubiquitination

Michael J Clague email, Judy M Coulson and Sylvie Urbé email

Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK

author email corresponding author email

Genome Biology 2008, 9:202doi:10.1186/gb-2008-9-1-202

Published: 23 January 2008

Subject areas: Biochemistry and structural biology, Genome studies, Molecular biology

Abstract

Three recent papers have identified distinct enzymes that can remove ubiquitin from mammalian histone 2A (H2A). Functions in transcriptional activation, DNA repair and control of the cell cycle have been proposed for these enzymes.


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