Intron mis-splicing: no alternative?

Scott William Roy¹ and Manuel Irimia²

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20814, USA

²Departament de Genètica, Universitat de Barcelona, Barcelona 08028, Spain

author email corresponding author email

Genome Biology 2008, 9:208doi:10.1186/gb-2008-9-2-208


Published:	19 February 2008

Subject areas: Evolution, Genome studies, Molecular biology

Abstract

A recent report reveals widespread mis-splicing of RNA transcripts in eukaryotes, with mis-spliced RNA destroyed by nonsense-mediated mRNA decay. This striking inefficiency deepens the mystery of the proliferation and persistence of introns.