Innate recognition of non-self nucleic acids

Hongbo Chi¹ and Richard A Flavell²

¹Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA

²Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA

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Genome Biology 2008, 9:211doi:10.1186/gb-2008-9-3-211


Published:	10 March 2008

Subject areas: Cell biology, Immunology, Virology

Abstract

The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.