Genome Biology
Volume 9
Issue 3 |
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MinireviewOn the nature of thumbsGünter P Wagner  and Alexander O Vargas Department of Ecology and Evolutionary Biology, Yale University, Prospect Street, New Haven, CT 06520-8106, USA.  author email corresponding author email
Genome Biology 2008,
9:213doi:10.1186/gb-2008-9-3-213
Subject areas: Development, Genetics Abstract
Asymmetric regulation of Hox gene expression pre-dates the appearance of tetrapod digits, and was co-opted in the development of 'thumbness'. This asymmetric expression correlates with independent morphological evolutionary variation of digit 1. | 
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