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Cytoplasmic dynein could be key to understanding neurodegeneration

Gareth T Banks email and Elizabeth MC Fisher email

Department of Neurodegenerative Disease, Institute of Neurology, Queen Square, London WC1N 3BG, UK

author email corresponding author email

Genome Biology 2008, 9:214doi:10.1186/gb-2008-9-3-214

Published: 28 March 2008

Subject areas: Genetics, Medicine, Cell biology

Abstract

A new mouse mutation, Sprawling, highlights an essential role for the dynein heavy chain in sensory neuron function, but it lacks the ability of other known heavy-chain mutations to ameliorate neurodegeneration due to defective superoxide dismutase.


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