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Highly AccessReview

RNA polymerase II stalling: loading at the start prepares genes for a sprint

Jia Qian Wu1 and Michael Snyder1,2 email

1Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, New Haven, CT 06511, USA

2Molecular Biophysics and Biochemistry Department, Yale University, PO Box 208103, New Haven, CT 06511, USA

author email corresponding author email

Genome Biology 2008, 9:220doi:10.1186/gb-2008-9-5-220

Published: 2 May 2008

Subject areas: Genetics, Genome studies, Molecular biology

Abstract

Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received.


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