Genome Biology Volume 9 Issue 5 |
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ReviewRNA polymerase II stalling: loading at the start prepares genes for a sprintJia Qian Wu1 and Michael Snyder1,2  1Molecular, Cellular and Developmental Biology Department, Yale University, PO Box 208103, New Haven, CT 06511, USA 2Molecular Biophysics and Biochemistry Department, Yale University, PO Box 208103, New Haven, CT 06511, USA author email corresponding author email
Genome Biology 2008,
9:220doi:10.1186/gb-2008-9-5-220
Subject areas: Genetics, Genome studies, Molecular biology Abstract
Stalling of RNA polymerase II near the promoter has recently been found to be much more common than previously thought. Genome-wide surveys of the phenomenon suggest that it is likely to be a rate-limiting control on gene activation that poises developmental and stimulus-responsive genes for prompt expression when inducing signals are received. |