Genome Biology
Volume 9
Issue 5 |
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MinireviewA role for Numb in p53 stabilizationStephanie Carter and Karen H Vousden  The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK  author email corresponding author email
Genome Biology 2008,
9:221doi:10.1186/gb-2008-9-5-221
Subject areas: Biochemistry and structural biology, Cancer, Cell biology, Development Abstract
The cell-fate determinant Numb has recently been shown to help activate the tumor suppressor protein p53. Loss of Numb in breast cancers would result, therefore, in both the activation of the potential oncogene Notch and the diminution of tumor suppression by p53. | 
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