Reduced-representation methylation mapping

Jeffrey A Jeddeloh¹ , John M Greally² and Oliver J Rando³

¹Roche NimbleGen Inc., Research and Development, 500 S. Rosa Rd, Madison, WI 53719, USA

²Center for Epigenomics and Department of Genetics (Division of Computational Genetics), Albert Einstein College of Medicine, 1300 Morris Park Avenue, New York, NY 10461, USA

³Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Worcester, MA 01605, USA

author email corresponding author email

Genome Biology 2008, 9:231doi:10.1186/gb-2008-9-8-231


Published:	1 September 2008

Subject areas: Cell biology, Genome studies, Molecular biology

Abstract

The power of massively parallel sequencing has been harnessed to map cytosine methylation patterns in the mouse genome, allowing insights into the relationship of methylation with DNA sequence, histone modifications, transcriptional activity and dynamic changes in methylation status during differentiation.