This file is supplementary table 3 for Ohler et al, Computational analysis of core promoters in the Drosophila genome. It contains lists of the most frequent GO terms associated with genes whose core promoters contain a binding site for one of the 10 identified core promoter motifs. The lists are split in the three main GO categories: function, process, and cellular location. ----------------------------------------------------------------------------- Motif 1: ----------------------------------------------------------------------------- total number of functional terms found in set: 176 total number of genes with functional terms: 226 most frequent terms: 11 structural constituent of ribosome 11 RNA binding 9 protein serine/threonine kinase 7 pre-mRNA splicing factor 6 transcription factor total number of process terms found in set: 106 total number of genes with process terms: 111 most frequent terms: 14 protein biosynthesis 10 protein amino acid phosphorylation 8 mRNA splicing 5 protein amino acid dephosphorylation 5 microtubule-based movement total number of component terms found in set: 78 total number of genes with component terms: 132 most frequent terms: 21 nucleus 15 plasma membrane 10 cytoplasm 8 mitochondrion 7 spliceosome complex ----------------------------------------------------------------------------- Motif 2: ----------------------------------------------------------------------------- total number of functional terms found in set: 193 total number of genes with functional terms: 244 most frequent terms: 16 structural constituent of ribosome 11 RNA binding 10 actin binding 9 protein serine/threonine kinase 6 transcription factor total number of process terms found in set: 135 total number of genes with process terms: 129 most frequent terms: 15 protein biosynthesis 9 protein amino acid phosphorylation 6 defense response 6 cytoskeleton organization and biogenesis 5 neurotransmitter release total number of component terms found in set: 76 total number of genes with component terms: 139 most frequent terms: 30 nucleus 10 plasma membrane 8 cytoplasm 7 mitochondrion 5 cytosolic small ribosomal subunit (sensu Eukarya) ----------------------------------------------------------------------------- Motif 3: ----------------------------------------------------------------------------- total number of functional terms found in set: 131 total number of genes with functional terms: 174 most frequent terms: 11 serine-type endopeptidase 8 structural constituent of larval cuticle (sensu Insecta) 7 cytochrome P450 4 structural constituent of cuticle (sensu Insecta) 4 RNA binding total number of process terms found in set: 56 total number of genes with process terms: 50 most frequent terms: 4 phototransduction 3 mRNA splicing 3 microtubule-based movement 3 G-protein coupled receptor protein signaling pathway 3 defense response total number of component terms found in set: 45 total number of genes with component terms: 64 most frequent terms: 9 nucleus 8 microsome 5 plasma membrane 4 integral membrane protein 4 extracellular ----------------------------------------------------------------------------- Motif 4: ----------------------------------------------------------------------------- total number of functional terms found in set: 185 total number of genes with functional terms: 239 most frequent terms: 14 transcription factor 11 specific RNA polymerase II transcription factor 9 serine-type endopeptidase 7 cytochrome P450 6 RNA polymerase II transcription factor total number of process terms found in set: 87 total number of genes with process terms: 62 most frequent terms: 6 defense response 4 homophilic cell adhesion 4 eye morphogenesis (sensu Drosophila) 4 axonogenesis 4 axon guidance total number of component terms found in set: 43 total number of genes with component terms: 109 most frequent terms: 36 nucleus 21 plasma membrane 9 integral membrane protein 9 extracellular 8 microsome ----------------------------------------------------------------------------- Motif 5: ----------------------------------------------------------------------------- total number of functional terms found in set: 143 total number of genes with functional terms: 158 most frequent terms: 8 structural constituent of ribosome 6 serine-type endopeptidase 4 transcription factor 4 specific RNA polymerase II transcription factor 4 RNA polymerase II transcription factor total number of process terms found in set: 75 total number of genes with process terms: 69 most frequent terms: 9 protein biosynthesis 7 neurotransmitter release 6 mRNA splicing 5 synaptic vesicle fusion 3 synaptic vesicle exocytosis total number of component terms found in set: 57 total number of genes with component terms: 87 most frequent terms: 15 nucleus 10 plasma membrane 6 integral membrane protein 6 cytoplasm 5 spliceosome complex ----------------------------------------------------------------------------- Motif 6: ----------------------------------------------------------------------------- total number of functional terms found in set: 123 total number of genes with functional terms: 146 most frequent terms: 8 structural constituent of ribosome 8 RNA binding 6 general RNA polymerase II transcription factor 5 ATP dependent RNA helicase 5 actin binding total number of process terms found in set: 60 total number of genes with process terms: 59 most frequent terms: 10 protein biosynthesis 4 mRNA splicing 3 synaptic vesicle endocytosis 3 neurotransmitter release 3 microtubule-based movement total number of component terms found in set: 53 total number of genes with component terms: 84 most frequent terms: 18 nucleus 7 cytoplasm 6 plasma membrane 4 spliceosome complex 4 cytosolic large ribosomal subunit (sensu Eukarya) ----------------------------------------------------------------------------- Motif 7: ----------------------------------------------------------------------------- total number of functional terms found in set: 167 total number of genes with functional terms: 205 most frequent terms: 13 structural constituent of ribosome 10 RNA binding 9 actin binding 5 transcription factor 5 protein serine/threonine kinase total number of process terms found in set: 116 total number of genes with process terms: 109 most frequent terms: 13 protein biosynthesis 8 protein amino acid phosphorylation 6 mRNA splicing 5 neurotransmitter release 4 synaptic vesicle exocytosis total number of component terms found in set: 76 total number of genes with component terms: 122 most frequent terms: 23 nucleus 10 plasma membrane 9 cytoplasm 6 mitochondrion 5 cytosolic large ribosomal subunit (sensu Eukarya) ----------------------------------------------------------------------------- Motif 8: ----------------------------------------------------------------------------- total number of functional terms found in set: 185 total number of genes with functional terms: 215 most frequent terms: 10 transcription factor 6 structural constituent of ribosome 6 specific RNA polymerase II transcription factor 6 RNA polymerase II transcription factor 5 RNA binding total number of process terms found in set: 105 total number of genes with process terms: 83 most frequent terms: 7 protein biosynthesis 6 neurotransmitter release 4 protein amino acid phosphorylation 3 synaptic vesicle fusion 3 mRNA splicing total number of component terms found in set: 59 total number of genes with component terms: 110 most frequent terms: 32 nucleus 13 plasma membrane 9 cytoplasm 8 mitochondrion 7 integral membrane protein ----------------------------------------------------------------------------- Motif 9: ----------------------------------------------------------------------------- total number of functional terms found in set: 89 total number of genes with functional terms: 79 most frequent terms: 4 transcription factor 3 alpha-mannosidase 2 specific RNA polymerase II transcription factor 2 serine-type endopeptidase 2 RNA polymerase II transcription factor total number of process terms found in set: 37 total number of genes with process terms: 22 most frequent terms: 2 Wnt receptor signaling pathway 2 synaptic vesicle fusion 2 signal transduction 2 protein amino acid phosphorylation 2 neurotransmitter release total number of component terms found in set: 23 total number of genes with component terms: 42 most frequent terms: 11 nucleus 9 plasma membrane 3 integral membrane protein 2 microsome 2 lysosome ----------------------------------------------------------------------------- Motif 10: ----------------------------------------------------------------------------- total number of functional terms found in set: 88 total number of genes with functional terms: 73 most frequent terms: 3 specific RNA polymerase II transcription factor 2 transmembrane receptor 2 tocopherol binding 2 structural constituent of peritrophic membrane (sensu Insecta) 2 structural constituent of larval cuticle (sensu Insecta) total number of process terms found in set: 48 total number of genes with process terms: 30 most frequent terms: 3 protein amino acid dephosphorylation 3 phototransduction 3 neurotransmitter release 3 G-protein coupled receptor protein signaling pathway 2 synaptic vesicle fusion total number of component terms found in set: 26 total number of genes with component terms: 29 most frequent terms: 7 plasma membrane 6 nucleus 5 integral membrane protein 2 microsome 2 inaD signaling complex