MAPPFinder 1.0 Results for the Gene Ontology File: C:\MAPPFinder Additional Files\FVBN Developmental Data from CardioGenomics.gex !date: Mon May 06 14:10:59 EDT 2002 Statistics: 2219 Genes met the [Embryo fold] > 1.2 AND[embryo permute p] < 0.05 criteria. 878 Genes did not link to a MGI term. 218 Genes did not link to a GO term. 2001 genes were used to calculate the results shown below. The z score is based on an N of 4574 and a R of 1027 distinct genes. GOID GO Name GO Type Number Changed Number Measured Number in GO Percent Changed Percent Present Number Changed in Hierarchy Number Measured in Hierarchy Number in GO Hierarchy Percent Changed in Hierarchy Percent Present in Hierarchy z Score 0000278 mitotic cell cycle P 1 1 1 100 100 44 70 89 62.9 78.7 8.163 0006259 DNA metabolism P 4 7 9 57.1 77.8 67 135 163 49.6 82.8 7.681 0005634 nucleus C 280 898 1211 31.2 74.2 300 949 1326 31.6 71.6 7.595 0006371 mRNA splicing P 16 17 26 94.1 65.4 19 21 30 90.5 70 7.487 0008380 RNA splicing P 0 0 0 0 0 19 21 30 90.5 70 7.487 0006396 RNA processing P 4 6 11 66.7 54.5 29 41 60 70.7 68.3 7.441 0016070 RNA metabolism P 0 0 1 0 0 30 44 66 68.2 66.7 7.304 0007049 cell cycle P 49 90 107 54.4 84.1 98 240 291 40.8 82.5 7.01 0006397 mRNA processing P 11 14 20 78.6 70 24 33 45 72.7 73.3 6.946 0006412 protein biosynthesis P 46 90 110 51.1 81.8 52 104 152 50 68.4 6.81 0005681 spliceosome C 17 20 41 85 48.8 17 20 42 85 47.6 6.717 0009059 macromolecule biosynthesis P 0 0 0 0 0 57 121 172 47.1 70.3 6.586 0006260 DNA replication P 23 37 42 62.2 88.1 28 46 55 60.9 83.6 6.275 0000084 S phase of mitotic cell cycle P 0 0 0 0 0 28 46 55 60.9 83.6 6.275 0005830 cytosolic ribosome (sensu Eukarya) C 19 26 32 73.1 81.2 19 26 33 73.1 78.8 6.203 0000067 DNA replication and chromosome cycle P 0 0 0 0 0 29 49 62 59.2 79 6.194 0003723 RNA binding F 44 94 121 46.8 77.7 51 113 155 45.1 72.9 5.85 0007046 ribosome biogenesis P 19 27 33 70.4 81.8 19 28 37 67.9 75.7 5.775 0042254 ribosome biogenesis and assembly P 0 0 0 0 0 19 28 37 67.9 75.7 5.775 0004693 cyclin-dependent protein kinase F 5 7 10 71.4 70 17 24 33 70.8 72.7 5.694 0009058 biosynthesis P 2 8 11 25 72.7 89 242 334 36.8 72.5 5.487 0005829 cytosol C 7 27 41 25.9 65.9 40 85 112 47.1 75.9 5.487 0005840 ribosome C 31 48 56 64.6 85.7 35 71 93 49.3 76.3 5.462 0003735 structural constituent of ribosome F 39 83 101 47 82.2 39 83 101 47 82.2 5.405 0008152 metabolism P 15 89 102 16.9 87.3 472 1789 2348 26.4 76.2 5.105 0007067 mitosis P 13 18 23 72.2 78.3 13 18 24 72.2 75 5.07 0006261 DNA dependent DNA replication P 0 0 1 0 0 13 18 22 72.2 81.8 5.07 0000087 M phase of mitotic cell cycle P 1 3 3 33.3 100 13 18 24 72.2 75 5.07 0005488 ligand binding or carrier F 9 24 29 37.5 82.8 521 2012 2877 25.9 69.9 4.943 0000280 nuclear division P 0 0 0 0 0 14 21 30 66.7 70 4.866 0003676 nucleic acid binding F 55 141 181 39 77.9 250 877 1264 28.5 69.4 4.778 0006323 DNA packaging P 7 9 11 77.8 81.8 20 36 46 55.6 78.3 4.778 0016538 cyclin-dependent protein kinase, regulator F 12 17 24 70.6 70.8 12 17 24 70.6 70.8 4.765 0016043 cell organization and biogenesis P 0 0 0 0 0 74 207 294 35.7 70.4 4.691 0005622 intracellular C 74 236 285 31.4 82.8 587 2326 3364 25.2 69.1 4.589 0000279 M phase P 0 0 0 0 0 15 25 36 60 69.4 4.511 0005198 structural molecule F 9 36 47 25 76.6 77 223 278 34.5 80.2 4.431 0008248 pre-mRNA splicing factor F 7 8 12 87.5 66.7 7 8 12 87.5 66.7 4.413 0006376 mRNA splice site selection P 7 8 8 87.5 100 7 8 8 87.5 100 4.413 0003729 mRNA binding F 1 2 2 50 100 10 14 19 71.4 73.7 4.398 0005694 chromosome C 1 1 1 100 100 19 36 55 52.8 65.5 4.377 0042175 nuclear envelope-endoplasmic reticulum network C 0 0 0 0 0 9 12 17 75 70.6 4.368 0006411 protein metabolism and modification P 2 2 4 100 50 183 633 811 28.9 78.1 4.194 0008151 cell growth and/or maintenance P 32 140 162 22.9 86.4 643 2606 3511 24.7 74.2 4.142 0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism P 0 1 2 0 0 211 748 981 28.2 76.2 4.124 0006270 DNA replication initiation P 6 7 7 85.7 100 6 7 7 85.7 100 4.014 0005912 adherens junction C 1 1 3 100 33.3 6 7 14 85.7 50 4.014 0005789 endoplasmic reticulum membrane C 5 7 11 71.4 63.6 7 9 13 77.8 69.2 3.981 0005717 chromatin C 11 17 21 64.7 81 15 28 41 53.6 68.3 3.958 0004674 protein serine/threonine kinase F 47 153 205 30.7 74.6 62 181 243 34.3 74.5 3.882 0007001 chromosome organization and biogenesis (sensu Eukarya) P 9 20 27 45 74.1 18 37 51 48.6 72.5 3.834 0016772 transferase, transferring phosphorus-containing groups F 1 3 5 33.3 60 105 342 431 30.7 79.4 3.8 0003779 actin binding F 25 57 78 43.9 73.1 25 58 83 43.1 69.9 3.793 0006281 DNA repair P 20 43 48 46.5 89.6 21 46 53 45.7 86.8 3.789 0016740 transferase F 3 6 8 50 75 140 478 613 29.3 78 3.784 0030055 cell-matrix junction C 0 0 0 0 0 4 4 6 100 66.7 3.718 0016585 chromatin remodeling complex C 2 2 2 100 100 4 4 6 100 66.7 3.718 0005924 cell-substrate adherens junction C 0 0 0 0 0 4 4 6 100 66.7 3.718 0005925 focal adhesion C 4 4 6 100 66.7 4 4 6 100 66.7 3.718 0004299 proteasome endopeptidase F 11 19 19 57.9 100 11 19 19 57.9 100 3.71 0004298 threonine endopeptidase F 0 0 0 0 0 11 19 19 57.9 100 3.71 0006997 nuclear organization and biogenesis P 0 1 2 0 0 18 38 53 47.4 71.7 3.696 0005737 cytoplasm C 29 107 188 27.1 56.9 244 903 1291 27 69.9 3.672 0006457 protein folding P 12 22 31 54.5 71 12 22 31 54.5 71 3.616 0019887 protein kinase regulator F 0 0 0 0 0 12 22 30 54.5 73.3 3.616 0003931 RHO small monomeric GTPase F 7 10 10 70 100 7 10 10 70 100 3.607 0003887 DNA-directed DNA polymerase F 6 9 12 66.7 75 7 10 15 70 66.7 3.607 0016779 nucleotidyltransferase F 0 1 1 0 0 16 33 41 48.5 80.5 3.596 0017076 purine nucleotide binding F 0 0 0 0 0 171 613 877 27.9 69.9 3.47 0000166 nucleotide binding F 4 21 26 19 80.8 171 614 878 27.9 69.9 3.444 0007028 cytoplasm organization and biogenesis P 0 1 2 0 0 56 169 241 33.1 70.1 3.391 0008372 cellular_component unknown C 41 117 291 35 40.2 41 117 291 35 40.2 3.306 0006352 transcription initiation P 0 0 0 0 0 3 3 3 100 100 3.22 0000158 protein phosphatase type 2A F 0 0 0 0 0 3 3 5 100 60 3.22 0005732 small nucleolar ribonucleoprotein C 3 3 11 100 27.3 3 3 11 100 27.3 3.22 0030529 ribonucleoprotein C 0 0 0 0 0 3 3 12 100 25 3.22 0006367 transcription initiation, from Pol II promoter P 3 3 3 100 100 3 3 3 100 100 3.22 0008641 small protein activating enzyme F 0 0 0 0 0 3 3 4 100 75 3.22 0006325 establishment and/or maintenance of chromatin architecture P 1 2 3 50 66.7 13 27 35 48.1 77.1 3.209 0006414 protein synthesis elongation P 6 9 37 66.7 24.3 6 9 37 66.7 24.3 3.182 0019207 kinase regulator F 0 0 0 0 0 15 33 42 45.5 78.6 3.178 0005730 nucleolus C 5 13 19 38.5 68.4 10 19 34 52.6 55.9 3.159 0008094 DNA dependent adenosinetriphosphatase F 6 10 11 60 90.9 8 14 16 57.1 87.5 3.115 0005837 26S proteasome C 1 2 3 50 66.7 11 22 23 50 95.7 3.104 0008092 cytoskeletal protein binding F 1 2 3 50 66.7 33 93 144 35.5 64.6 3.042 0006333 chromatin assembly/disassembly P 4 6 8 66.7 75 10 20 25 50 80 2.959 0000004 biological_process unknown P 34 98 250 34.7 39.2 34 98 250 34.7 39.2 2.935 0003685 DNA repair protein F 7 16 19 43.8 84.2 11 23 27 47.8 85.2 2.923 0008135 translation factor, nucleic acid binding F 0 0 0 0 0 14 32 43 43.8 74.4 2.897 0045182 translation regulator F 0 0 0 0 0 14 32 43 43.8 74.4 2.897 0005783 endoplasmic reticulum C 33 101 119 32.7 84.9 39 117 141 33.3 83 2.857 0003713 transcription co-activator F 6 10 14 60 71.4 6 10 14 60 71.4 2.848 0030554 adenyl nucleotide binding F 0 0 0 0 0 127 462 663 27.5 69.7 2.736 0005524 ATP binding F 125 446 635 28 70.2 127 462 663 27.5 69.7 2.736 0003682 chromatin binding F 5 8 11 62.5 72.7 5 8 11 62.5 72.7 2.717 0016301 kinase F 2 6 11 33.3 54.5 89 311 394 28.6 78.9 2.698 0019941 protein-ligand dependent protein degradation P 0 0 0 0 0 17 43 58 39.5 74.1 2.697 0016773 phosphotransferase, alcohol group as acceptor F 0 0 0 0 0 87 305 386 28.5 79 2.63 0005659 delta DNA polymerase C 1 1 1 100 100 2 2 2 100 100 2.628 0004758 serine C-palmitoyltransferase F 2 2 2 100 100 2 2 2 100 100 2.628 0000123 histone acetyltransferase complex C 0 0 0 0 0 2 2 2 100 100 2.628 0008642 ubiquitin-like activating enzyme F 1 1 1 100 100 2 2 2 100 100 2.628 0007020 microtubule nucleation P 1 1 1 100 100 2 2 2 100 100 2.628 0000059 protein-nucleus import, docking P 2 2 2 100 100 2 2 2 100 100 2.628 0008430 selenium binding F 2 2 2 100 100 2 2 2 100 100 2.628 0016725 oxidoreductase, acting on CH2 groups F 0 0 0 0 0 2 2 3 100 66.7 2.628 0019212 phosphatase inhibitor F 1 1 1 100 100 2 2 3 100 66.7 2.628 0004748 ribonucleoside-diphosphate reductase F 2 2 3 100 66.7 2 2 3 100 66.7 2.628 0005971 ribonucleoside-diphosphate reductase C 2 2 2 100 100 2 2 2 100 100 2.628 0008247 2-acetyl-1-alkylglycerophosphocholine esterase C 2 2 2 100 100 2 2 2 100 100 2.628 0016514 SWI/SNF complex C 2 2 4 100 50 2 2 4 100 50 2.628 0005669 TFIID complex C 2 2 2 100 100 2 2 2 100 100 2.628 0016728 oxidoreductase, acting on CH2 groups, disulfide as acceptor F 0 0 0 0 0 2 2 3 100 66.7 2.628 0016454 C-palmitoyltransferase F 0 0 0 0 0 2 2 2 100 100 2.628 0005646 importin C 0 0 0 0 0 2 2 2 100 100 2.628 0005648 importin, beta-subunit C 2 2 2 100 100 2 2 2 100 100 2.628 0003918 DNA topoisomerase (ATP-hydrolyzing) F 2 2 3 100 66.7 2 2 3 100 66.7 2.628 0016582 non-covalent chromatin modification P 0 0 0 0 0 2 2 4 100 50 2.628 0000012 single-strand break repair P 2 2 2 100 100 2 2 2 100 100 2.628 0006338 chromatin modeling P 2 2 2 100 100 2 2 4 100 50 2.628 0030176 endoplasmic reticulum membrane, integral protein C 2 2 2 100 100 2 2 2 100 100 2.628 0008600 protein phosphatase type 2A, catalyst F 2 2 2 100 100 2 2 2 100 100 2.628 0008934 myo-inositol-1(or 4)-monophosphatase F 2 2 2 100 100 2 2 2 100 100 2.628 0005839 20S core proteasome C 9 17 17 52.9 100 9 19 19 47.4 100 2.608 0015035 protein disulfide oxidoreductase F 4 6 6 66.7 100 4 6 6 66.7 100 2.597 0004672 protein kinase F 46 171 206 26.9 83 76 263 336 28.9 78.3 2.58 0004527 exonuclease F 3 4 7 75 57.1 6 11 15 54.5 73.3 2.554 0005635 nuclear membrane C 1 3 4 33.3 75 6 11 18 54.5 61.1 2.554 0003925 small monomeric GTPase F 14 36 42 38.9 85.7 15 38 46 39.5 82.6 2.525 0045005 maintenance of fidelity during DNA dependent DNA replication P 0 0 0 0 0 3 4 5 75 80 2.519 0005657 replication fork C 0 0 0 0 0 3 4 4 75 100 2.519 0000264 heterotrimeric G-protein GTPase, beta-subunit F 3 4 5 75 80 3 4 5 75 80 2.519 0005643 nuclear pore C 1 2 5 50 40 3 4 9 75 44.4 2.519 0019888 protein phosphatase regulator F 0 0 0 0 0 3 4 8 75 50 2.519 0006298 mismatch repair P 3 4 5 75 80 3 4 5 75 80 2.519 0006511 ubiquitin-dependent protein degradation P 13 39 51 33.3 76.5 16 42 57 38.1 73.7 2.44 0006606 protein-nucleus import P 3 7 8 42.9 87.5 5 9 10 55.6 90 2.382 0005525 GTP binding F 37 123 175 30.1 70.3 43 141 201 30.5 70.1 2.325 0005856 cytoskeleton C 33 108 142 30.6 76.1 64 223 306 28.7 72.9 2.292 0016859 cis-trans isomerase F 0 0 0 0 0 6 12 16 50 75 2.29 0003746 translation elongation factor F 6 12 16 50 75 6 12 16 50 75 2.29 0006913 nucleocytoplasmic transport P 1 3 6 33.3 50 6 12 17 50 70.6 2.29 0016482 cytoplasmic transport P 0 0 0 0 0 6 12 17 50 70.6 2.29 0003755 peptidylprolyl cis-trans isomerase F 6 12 16 50 75 6 12 16 50 75 2.29 0030029 actin filament-based process P 0 0 1 0 0 6 12 20 50 60 2.29 0030036 actin cytoskeleton organization and biogenesis P 4 6 10 66.7 60 6 12 19 50 63.2 2.29 0006512 ubiquitin cycle P 5 11 14 45.5 78.6 6 12 16 50 75 2.29 0008134 transcription factor binding F 2 2 3 100 66.7 11 27 43 40.7 62.8 2.284 0005768 endosome C 3 4 5 75 80 4 7 8 57.1 87.5 2.201 0040029 epigenetic control of gene expression P 0 0 0 0 0 4 7 9 57.1 77.8 2.201 0006306 DNA methylation P 4 7 9 57.1 77.8 4 7 9 57.1 77.8 2.201 0006305 DNA alkylation P 0 0 1 0 0 4 7 10 57.1 70 2.201 0005815 microtubule organizing center C 0 0 0 0 0 4 7 8 57.1 87.5 2.201 0019001 guanyl nucleotide binding F 0 0 0 0 0 46 155 219 29.7 70.8 2.193 0004002 adenosinetriphosphatase F 0 3 4 0 0 12 31 38 38.7 81.6 2.176 0005554 molecular_function unknown F 29 91 230 31.9 39.6 29 91 230 31.9 39.6 2.174 0005515 protein binding F 46 183 275 25.1 66.5 99 368 539 26.9 68.3 2.133 0003754 chaperone F 15 37 53 40.5 69.8 16 45 62 35.6 72.6 2.117 0030020 extracellular matrix structural constituent conferring tensile strength F 10 25 31 40 80.6 10 25 31 40 80.6 2.108 0007178 transmembrane receptor protein serine/threonine kinase signaling pathway P 3 7 9 42.9 77.8 10 25 31 40 80.6 2.108 0005581 collagen C 10 25 31 40 80.6 10 25 31 40 80.6 2.108 0003899 DNA-directed RNA polymerase F 5 10 11 50 90.9 5 10 11 50 90.9 2.09 0005200 structural constituent of cytoskeleton F 21 63 79 33.3 79.7 21 63 79 33.3 79.7 2.084 0016741 transferase, transferring one-carbon groups F 0 0 0 0 0 8 19 29 42.1 65.5 2.057 0003924 GTPase F 3 18 21 16.7 85.7 25 78 95 32.1 82.1 2.049 0016853 isomerase F 0 0 0 0 0 12 32 42 37.5 76.2 2.047 0012502 induction of programmed cell death P 0 0 0 0 0 7 16 24 43.8 66.7 2.045 0006917 induction of apoptosis P 6 13 21 46.2 61.9 7 16 24 43.8 66.7 2.045 0000139 Golgi membrane C 7 16 18 43.8 88.9 7 16 18 43.8 88.9 2.045 0003824 enzyme F 28 95 111 29.5 85.6 335 1375 1896 24.4 72.5 2.03 0003677 DNA binding F 165 662 933 24.9 71 187 739 1069 25.3 69.1 2.029 0015629 actin cytoskeleton C 7 17 23 41.2 73.9 16 46 63 34.8 73 2.014 0008408 3’-5’ exonuclease F 3 5 6 60 83.3 3 5 7 60 71.4 2.013 0016873 other isomerase F 0 0 0 0 0 3 5 7 60 71.4 2.013 0003916 DNA topoisomerase F 3 5 6 60 83.3 3 5 7 60 71.4 2.013 0019208 phosphatase regulator F 0 1 2 0 0 3 5 10 60 50 2.013 0005941 unlocalized C 0 0 0 0 0 17 51 58 33.3 87.9 1.872 0006731 coenzymes and prosthetic group metabolism P 0 0 0 0 0 11 30 40 36.7 75 1.872 0006779 porphyrin biosynthesis P 3 6 7 50 85.7 4 8 9 50 88.9 1.869 0009306 protein secretion P 3 5 5 60 100 4 8 12 50 66.7 1.869 0006766 vitamin metabolism P 1 1 1 100 100 4 8 10 50 80 1.869 0015036 disulfide oxidoreductase F 0 2 3 0 0 4 8 9 50 88.9 1.869 0006783 heme biosynthesis P 4 8 9 50 88.9 4 8 9 50 88.9 1.869 0007264 small GTPase mediated signal transduction P 18 48 56 37.5 85.7 20 62 74 32.3 83.8 1.863 0004486 methylenetetrahydrofolate dehydrogenase F 0 0 0 0 0 1 1 1 100 100 1.858 0003946 N-acetyllactosaminide alpha-1,3-galactosyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0009396 folic acid and derivative biosynthesis P 1 1 2 100 50 1 1 2 100 50 1.858 0017172 cysteine dioxygenase F 1 1 1 100 100 1 1 1 100 100 1.858 0008120 ceramide glucosyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0004488 methylenetetrahydrofolate dehydrogenase (NADP+) F 1 1 1 100 100 1 1 1 100 100 1.858 0004850 uridine phosphorylase F 1 1 1 100 100 1 1 1 100 100 1.858 0005660 delta-DNA polymerase cofactor C 1 1 1 100 100 1 1 1 100 100 1.858 0030018 Z disc C 1 1 2 100 50 1 1 2 100 50 1.858 0004312 fatty-acid synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0008299 isoprenoid biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0005778 peroxisomal membrane C 1 1 1 100 100 1 1 1 100 100 1.858 0030497 fatty acid elongation P 1 1 2 100 50 1 1 2 100 50 1.858 0004343 glucosamine-phosphate N-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0016363 nuclear matrix C 1 1 2 100 50 1 1 2 100 50 1.858 0005645 RAN-binding protein C 1 1 3 100 33.3 1 1 3 100 33.3 1.858 0016842 amidine-lyase F 0 0 0 0 0 1 1 1 100 100 1.858 0004801 transaldolase F 1 1 1 100 100 1 1 1 100 100 1.858 0004839 ubiquitin activating enzyme F 1 1 2 100 50 1 1 2 100 50 1.858 0003979 UDP-glucose 6-dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.858 0004337 geranyltranstransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0016646 oxidoreductase, acting on the CH-NH group of donors, NAD or NADP as acceptor F 0 0 0 0 0 1 1 3 100 33.3 1.858 0016902 oxidoreductase, acting on the CH-OH group of donors, other acceptors F 0 0 0 0 0 1 1 1 100 100 1.858 0004368 glycerol-3-phosphate dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.858 0004766 spermidine synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0016768 spermine synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0019781 NEDD8 activating enzyme F 1 1 1 100 100 1 1 1 100 100 1.858 0003835 beta-galactosamide alpha-2,6-sialyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0004420 hydroxymethylglutaryl-CoA reductase (NADPH) F 1 1 1 100 100 1 1 1 100 100 1.858 0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0015030 Cajal body C 1 1 2 100 50 1 1 2 100 50 1.858 0016604 nuclear body C 0 0 0 0 0 1 1 2 100 50 1.858 0005658 alpha DNA polymerase:primase complex C 1 1 1 100 100 1 1 1 100 100 1.858 0030148 sphingolipid biosynthesis P 1 1 2 100 50 1 1 2 100 50 1.858 0004335 galactokinase F 1 1 1 100 100 1 1 1 100 100 1.858 0019448 L-cysteine catabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0008116 prostaglandin-I synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0006527 arginine catabolism P 1 1 1 100 100 1 1 1 100 100 1.858 0004348 glucosylceramidase F 1 1 1 100 100 1 1 1 100 100 1.858 0004067 asparaginase F 0 0 1 0 0 1 1 2 100 50 1.858 0004082 bisphosphoglycerate mutase F 1 1 1 100 100 1 1 1 100 100 1.858 0004619 phosphoglycerate mutase F 1 1 2 100 50 1 1 2 100 50 1.858 0009065 glutamine family amino acid catabolism P 0 0 0 0 0 1 1 2 100 50 1.858 0008418 protein N-terminal asparagine amidohydrolase F 1 1 1 100 100 1 1 1 100 100 1.858 0008409 5’-3’ exonuclease F 1 1 1 100 100 1 1 1 100 100 1.858 0003726 double-stranded RNA adenosine deaminase F 1 1 2 100 50 1 1 2 100 50 1.858 0004477 methenyltetrahydrofolate cyclohydrolase F 1 1 1 100 100 1 1 1 100 100 1.858 0004749 ribose-phosphate pyrophosphokinase F 1 1 1 100 100 1 1 1 100 100 1.858 0016305 phosphatidylinositol 3-kinase, class II F 1 1 1 100 100 1 1 1 100 100 1.858 0004137 deoxycytidine kinase F 1 1 1 100 100 1 1 1 100 100 1.858 0004798 thymidylate kinase F 1 1 1 100 100 1 1 1 100 100 1.858 0004676 3-phosphoinositide-dependent protein kinase F 1 1 1 100 100 1 1 1 100 100 1.858 0006528 asparagine metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0016868 intramolecular transferase, phosphotransferases F 0 0 0 0 0 1 1 2 100 50 1.858 0003875 ADP-ribosylarginine hydrolase F 1 1 1 100 100 1 1 1 100 100 1.858 0004195 renin F 1 1 2 100 50 1 1 2 100 50 1.858 0004193 cathepsin E F 1 1 1 100 100 1 1 1 100 100 1.858 0008129 actinidain F 1 1 1 100 100 1 1 1 100 100 1.858 0004230 glutamyl aminopeptidase F 1 1 1 100 100 1 1 1 100 100 1.858 0004208 caspase-3 F 1 1 1 100 100 1 1 1 100 100 1.858 0004207 effector caspase F 0 0 0 0 0 1 1 1 100 100 1.858 0004565 beta-galactosidase F 1 1 1 100 100 1 1 1 100 100 1.858 0019452 L-cysteine catabolism to taurine P 1 1 1 100 100 1 1 1 100 100 1.858 0003905 DNA-3-methyladenine glycosidase II F 1 1 1 100 100 1 1 1 100 100 1.858 0004703 G-protein coupled receptor kinase F 1 1 2 100 50 1 1 2 100 50 1.858 0004251 Xaa-Pro dipeptidase F 1 1 1 100 100 1 1 1 100 100 1.858 0016802 thioether hydrolase F 0 0 0 0 0 1 1 1 100 100 1.858 0004013 adenosylhomocysteinase F 1 1 1 100 100 1 1 1 100 100 1.858 0008130 neutrophil collagenase F 1 1 1 100 100 1 1 1 100 100 1.858 0008601 protein phosphatase type 2A, regulator F 1 1 3 100 33.3 1 1 3 100 33.3 1.858 0030308 negative regulation of cell growth P 1 1 1 100 100 1 1 1 100 100 1.858 0004296 T-plasminogen activator F 1 1 1 100 100 1 1 1 100 100 1.858 0000147 actin cortical patch assembly P 1 1 1 100 100 1 1 1 100 100 1.858 0004214 dipeptidyl-peptidase I F 1 1 1 100 100 1 1 1 100 100 1.858 0004325 ferrochelatase F 1 1 1 100 100 1 1 1 100 100 1.858 0003923 GPI-anchor transamidase F 1 1 1 100 100 1 1 1 100 100 1.858 0004018 adenylosuccinate lyase F 1 1 1 100 100 1 1 1 100 100 1.858 0004418 hydroxymethylbilane synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0005853 eukaryotic translation elongation factor 1 C 1 1 3 100 33.3 1 1 3 100 33.3 1.858 0008124 4a-hydroxytetrahydrobiopterin dehydratase F 1 1 1 100 100 1 1 1 100 100 1.858 0003994 aconitate hydratase F 1 1 1 100 100 1 1 1 100 100 1.858 0005902 microvillus C 1 1 1 100 100 1 1 1 100 100 1.858 0004853 uroporphyrinogen decarboxylase F 1 1 1 100 100 1 1 1 100 100 1.858 0016839 other carbon-oxygen lyase F 0 0 0 0 0 1 1 1 100 100 1.858 0016832 aldehyde-lyase F 0 0 0 0 0 1 1 4 100 25 1.858 0016850 other lyase F 0 0 0 0 0 1 1 1 100 100 1.858 0004506 squalene monooxygenase F 1 1 1 100 100 1 1 1 100 100 1.858 0004511 tyrosine 3-monooxygenase F 1 1 1 100 100 1 1 1 100 100 1.858 0006534 cysteine metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0019007 N-acetylneuraminic acid phosphate synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0008379 thioredoxin peroxidase F 1 1 1 100 100 1 1 1 100 100 1.858 0007157 heterophilic cell adhesion P 1 1 2 100 50 1 1 2 100 50 1.858 0006055 CMP-N-acetylneuraminate biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0003906 DNA-(apurinic or apyrimidinic site) lyase F 1 1 1 100 100 1 1 1 100 100 1.858 0030022 extracellular matrix constituent, adhesive F 1 1 1 100 100 1 1 1 100 100 1.858 0009093 cysteine catabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0004715 non-membrane spanning protein tyrosine kinase F 1 1 1 100 100 1 1 1 100 100 1.858 0000247 C-8 sterol isomerase F 1 1 1 100 100 1 1 1 100 100 1.858 0016228 aldolase F 0 0 0 0 0 1 1 4 100 25 1.858 0008117 sphinganine-1-phosphate aldolase F 1 1 1 100 100 1 1 1 100 100 1.858 0007022 chaperonin-mediated tubulin folding P 1 1 1 100 100 1 1 1 100 100 1.858 0007021 tubulin folding P 0 0 0 0 0 1 1 1 100 100 1.858 0009071 serine family amino acid catabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0003772 cochaperonin F 1 1 1 100 100 1 1 1 100 100 1.858 0017053 transcriptional repressor complex C 1 1 1 100 100 1 1 1 100 100 1.858 0004066 asparagine synthase (glutamine-hydrolyzing) F 1 1 1 100 100 1 1 1 100 100 1.858 0016884 carbon-nitrogen ligase, with glutamine as amido-N-donor F 0 0 0 0 0 1 1 1 100 100 1.858 0005055 laminin receptor F 1 1 2 100 50 1 1 2 100 50 1.858 0016505 apoptotic protease activator F 1 1 2 100 50 1 1 2 100 50 1.858 0004821 histidine-tRNA ligase F 1 1 1 100 100 1 1 1 100 100 1.858 0000159 protein phosphatase type 2A C 1 1 2 100 50 1 1 2 100 50 1.858 0009341 beta-galactosidase C 1 1 1 100 100 1 1 1 100 100 1.858 0003963 RNA-3’-phosphate cyclase F 1 1 2 100 50 1 1 2 100 50 1.858 0017072 tubulin folding F 1 1 1 100 100 1 1 1 100 100 1.858 0006601 creatine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0003790 actin modulating F 1 1 1 100 100 1 1 1 100 100 1.858 0015694 mercury ion transport P 1 1 1 100 100 1 1 1 100 100 1.858 0008320 protein carrier F 1 1 1 100 100 1 1 1 100 100 1.858 0008022 protein C-terminus binding F 1 1 1 100 100 1 1 1 100 100 1.858 0019943 RUB1-protein conjugation P 1 1 1 100 100 1 1 1 100 100 1.858 0019942 RUB1-dependent protein degradation P 1 1 1 100 100 1 1 1 100 100 1.858 0003719 transcription factor, cytoplasmic sequestering F 1 1 1 100 100 1 1 1 100 100 1.858 0030218 erythrocyte differentiation P 1 1 1 100 100 1 1 1 100 100 1.858 0005555 blood group antigen F 1 1 1 100 100 1 1 1 100 100 1.858 0019962 interferon-alpha/beta binding F 0 0 0 0 0 1 1 1 100 100 1.858 0006600 creatine metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0009487 glutaredoxin F 1 1 1 100 100 1 1 1 100 100 1.858 0007094 mitotic spindle checkpoint P 1 1 1 100 100 1 1 1 100 100 1.858 0006892 post Golgi transport P 0 0 0 0 0 1 1 2 100 50 1.858 0006896 Golgi to vacuole transport P 1 1 1 100 100 1 1 1 100 100 1.858 0018212 peptidyl-tyrosine modification P 0 0 0 0 0 1 1 1 100 100 1.858 0042080 GPI/GSI anchor synthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0000209 polyubiquitylation P 1 1 1 100 100 1 1 1 100 100 1.858 0006585 dopamine biosynthesis, from tyrosine P 1 1 1 100 100 1 1 1 100 100 1.858 0030350 iron-responsive element binding F 1 1 2 100 50 1 1 2 100 50 1.858 0007603 phototransduction, visible light P 1 1 1 100 100 1 1 1 100 100 1.858 0000049 tRNA binding F 1 1 1 100 100 1 1 1 100 100 1.858 0009584 perception of visible light P 0 0 0 0 0 1 1 1 100 100 1.858 0008494 translation activator F 1 1 1 100 100 1 1 1 100 100 1.858 0030371 translation repressor F 1 1 2 100 50 1 1 2 100 50 1.858 0008631 induction of apoptosis by oxidative stress P 1 1 1 100 100 1 1 1 100 100 1.858 0007093 mitotic checkpoint P 0 0 0 0 0 1 1 1 100 100 1.858 0006909 phagocytosis P 1 1 2 100 50 1 1 3 100 33.3 1.858 0004608 phosphatidylethanolamine N-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0006656 phosphatidylcholine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0015988 energy coupled proton transport, against the electrochemical gradient P 0 0 0 0 0 1 1 2 100 50 1.858 0015991 ATP hydrolysis coupled proton transport P 1 1 2 100 50 1 1 2 100 50 1.858 0007088 control of mitosis P 0 0 0 0 0 1 1 1 100 100 1.858 0000075 cell cycle checkpoint P 0 0 0 0 0 1 1 2 100 50 1.858 0004905 interferon-alpha/beta receptor F 1 1 1 100 100 1 1 1 100 100 1.858 0005793 ER-Golgi intermediate compartment C 1 1 1 100 100 1 1 1 100 100 1.858 0016601 RAC protein signal transduction P 1 1 1 100 100 1 1 1 100 100 1.858 0009052 pentose-phosphate shunt, non-oxidative branch P 1 1 1 100 100 1 1 1 100 100 1.858 0008307 structural constituent of muscle F 1 1 1 100 100 1 1 1 100 100 1.858 0006506 GPI anchor synthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0009139 pyrimidine nucleoside diphosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0005091 guanyl-nucleotide exchange factor adaptor F 1 1 1 100 100 1 1 1 100 100 1.858 0009196 pyrimidine deoxyribonucleoside diphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0009197 pyrimidine deoxyribonucleoside diphosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0006233 dTDP biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0009176 pyrimidine deoxyribonucleoside monophosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0009130 pyrimidine nucleoside monophosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0006231 dTMP biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0030159 receptor signaling complex scaffold protein F 1 1 2 100 50 1 1 4 100 25 1.858 0009132 nucleoside diphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0009186 deoxyribonucleoside diphosphate metabolism P 1 1 1 100 100 1 1 1 100 100 1.858 0015074 DNA integration P 1 1 1 100 100 1 1 1 100 100 1.858 0005432 calcium:sodium antiporter F 1 1 2 100 50 1 1 2 100 50 1.858 0015368 calcium:cation antiporter F 0 0 0 0 0 1 1 2 100 50 1.858 0009067 aspartate family amino acid biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0006129 protein-disulfide reduction P 1 1 1 100 100 1 1 1 100 100 1.858 0015097 mercury ion transporter F 1 1 1 100 100 1 1 1 100 100 1.858 0009177 pyrimidine deoxyribonucleoside monophosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0006403 RNA localization P 0 0 0 0 0 1 1 3 100 33.3 1.858 0004904 interferon receptor F 0 0 0 0 0 1 1 1 100 100 1.858 0006599 phosphogen metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0019530 taurine metabolism P 1 1 1 100 100 1 1 1 100 100 1.858 0006529 asparagine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0016922 ligand-dependent nuclear receptor interactor F 1 1 3 100 33.3 1 1 3 100 33.3 1.858 0016553 base conversion/substitution editing P 1 1 1 100 100 1 1 1 100 100 1.858 0009395 phospholipid catabolism P 1 1 2 100 50 1 1 2 100 50 1.858 0009138 pyrimidine nucleoside diphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0004962 endothelin receptor F 0 0 0 0 0 1 1 1 100 100 1.858 0018108 peptidyl-tyrosine phosphorylation P 1 1 1 100 100 1 1 1 100 100 1.858 0004991 parathyroid hormone receptor F 1 1 1 100 100 1 1 1 100 100 1.858 0006405 nuclear RNA-nucleus export P 1 1 2 100 50 1 1 3 100 33.3 1.858 0006221 pyrimidine nucleotide biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0009211 pyrimidine deoxyribonucleoside triphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0009212 pyrimidine deoxyribonucleoside triphosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.858 0004998 transferrin receptor F 1 1 2 100 50 1 1 2 100 50 1.858 0007212 dopamine receptor signaling pathway P 1 1 2 100 50 1 1 2 100 50 1.858 0006235 dTTP biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0001600 endothelin-B receptor F 1 1 1 100 100 1 1 1 100 100 1.858 0016126 sterol biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0003891 delta DNA polymerase F 1 1 1 100 100 1 1 1 100 100 1.858 0030337 DNA polymerase processivity factor F 1 1 1 100 100 1 1 1 100 100 1.858 0005099 RAS GTPase activator F 1 1 1 100 100 1 1 1 100 100 1.858 0005838 19S proteasome regulatory particle C 1 1 1 100 100 1 1 1 100 100 1.858 0019209 kinase activator F 0 0 0 0 0 1 1 1 100 100 1.858 0005819 spindle C 0 0 1 0 0 1 1 2 100 50 1.858 0005699 kinetochore C 1 1 1 100 100 1 1 1 100 100 1.858 0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase F 1 1 1 100 100 1 1 1 100 100 1.858 0006047 UDP-N-acetylglucosamine metabolism P 0 0 0 0 0 1 1 1 100 100 1.858 0003889 alpha DNA polymerase F 1 1 1 100 100 1 1 1 100 100 1.858 0016780 phosphotransferase, for other substituted phosphate groups F 0 0 0 0 0 1 1 1 100 100 1.858 0003894 zeta DNA polymerase F 1 1 1 100 100 1 1 1 100 100 1.858 0030615 spindle pole C 0 0 0 0 0 1 1 1 100 100 1.858 0007113 endomitotic cell cycle P 1 1 1 100 100 1 1 1 100 100 1.858 0000090 mitotic anaphase P 0 0 0 0 0 1 1 1 100 100 1.858 0019961 interferon binding F 0 0 0 0 0 1 1 1 100 100 1.858 0005862 muscle thin filament tropomyosin C 1 1 2 100 50 1 1 2 100 50 1.858 0016565 general transcriptional repressor F 1 1 1 100 100 1 1 1 100 100 1.858 0005816 spindle pole body C 1 1 1 100 100 1 1 1 100 100 1.858 0004864 protein phosphatase inhibitor F 1 1 2 100 50 1 1 2 100 50 1.858 0004865 type 1 serine/threonine specific protein phosphatase inhibitor F 1 1 2 100 50 1 1 2 100 50 1.858 0030295 protein kinase activator F 1 1 1 100 100 1 1 1 100 100 1.858 0006048 UDP-N-acetylglucosamine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.858 0004799 thymidylate synthase F 1 1 1 100 100 1 1 1 100 100 1.858 0007607 taste P 1 1 2 100 50 1 1 2 100 50 1.858 0015068 glycine amidinotransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0008781 acylneuraminate cytidylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0005770 late endosome C 1 1 1 100 100 1 1 1 100 100 1.858 0000070 mitotic chromosome segregation P 1 1 1 100 100 1 1 1 100 100 1.858 0006275 DNA replication regulation P 1 1 1 100 100 1 1 1 100 100 1.858 0004084 branched-chain amino acid aminotransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0015067 amidinotransferase F 0 0 0 0 0 1 1 1 100 100 1.858 0030099 myeloid blood cell differentiation P 0 0 2 0 0 1 1 3 100 33.3 1.858 0007500 mesoderm determination P 1 1 1 100 100 1 1 1 100 100 1.858 0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase F 0 0 0 0 0 1 1 1 100 100 1.858 0006488 oligosaccharide-PP-dolichol assembly P 1 1 1 100 100 1 1 1 100 100 1.858 0008119 thiopurine S-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.858 0007281 germ-cell development P 1 1 1 100 100 1 1 1 100 100 1.858 0005484 SNAP receptor F 1 1 1 100 100 1 1 1 100 100 1.858 0005874 microtubule C 6 11 13 54.5 84.6 7 17 21 41.2 81 1.853 0008168 methyltransferase F 0 3 3 0 0 7 17 27 41.2 63 1.853 0003950 NAD(+) ADP-ribosyltransferase F 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0003847 2-acetyl-1-alkylglycerophosphocholine esterase F 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0015027 coreceptor, soluble ligand F 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0005637 nuclear inner membrane C 0 0 0 0 0 2 3 4 66.7 75 1.836 0004576 oligosaccharyl transferase F 1 1 1 100 100 2 3 4 66.7 75 1.836 0005224 ATP-binding and phosphorylation-dependent chloride channel F 2 3 4 66.7 75 2 3 4 66.7 75 1.836 0009451 RNA modification P 0 0 0 0 0 2 3 3 66.7 100 1.836 0003900 DNA-directed RNA polymerase I F 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0006650 glycerophospholipid metabolism P 1 1 1 100 100 2 3 5 66.7 60 1.836 0016408 C-acyltransferase F 0 0 0 0 0 2 3 3 66.7 100 1.836 0006740 NADPH regeneration P 0 0 0 0 0 2 3 3 66.7 100 1.836 0019362 pyridine nucleotide metabolism P 0 0 0 0 0 2 3 3 66.7 100 1.836 0016409 palmitoyltransferase F 0 0 0 0 0 2 3 4 66.7 75 1.836 0006769 nicotinamide metabolism P 0 0 0 0 0 2 3 3 66.7 100 1.836 0006739 NADPH metabolism P 0 0 0 0 0 2 3 3 66.7 100 1.836 0003886 DNA (cytosine-5-)-methyltransferase F 2 3 4 66.7 75 2 3 4 66.7 75 1.836 0016547 RNA editing P 0 0 0 0 0 2 3 3 66.7 100 1.836 0005736 DNA-directed RNA polymerase I C 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0016591 DNA-directed RNA polymerase II, holoenzyme C 0 0 0 0 0 2 3 4 66.7 75 1.836 0016506 apoptosis activator F 1 2 3 50 66.7 2 3 5 66.7 60 1.836 0006445 translational regulation P 1 1 2 100 50 2 3 4 66.7 75 1.836 0005638 lamin filament C 2 3 4 66.7 75 2 3 4 66.7 75 1.836 0006020 myo-inositol metabolism P 2 3 4 66.7 75 2 3 4 66.7 75 1.836 0005501 retinoid binding F 2 3 4 66.7 75 2 3 4 66.7 75 1.836 0005698 centromere C 2 3 4 66.7 75 2 3 4 66.7 75 1.836 0019840 isoprenoid binding F 0 0 0 0 0 2 3 4 66.7 75 1.836 0016840 carbon-nitrogen lyase F 0 0 0 0 0 2 3 4 66.7 75 1.836 0006098 pentose-phosphate shunt P 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0007431 salivary gland development P 0 0 0 0 0 2 3 3 66.7 100 1.836 0007435 salivary gland morphogenesis P 2 3 3 66.7 100 2 3 3 66.7 100 1.836 0005217 intracellular ligand-gated ion channel F 0 0 0 0 0 2 3 4 66.7 75 1.836 0006334 nucleosome assembly P 6 14 17 42.9 82.4 6 14 17 42.9 82.4 1.832 0004199 caspase F 5 11 11 45.5 100 5 11 11 45.5 100 1.83 0030017 sarcomere C 0 0 0 0 0 5 11 15 45.5 73.3 1.83 0030016 myofibril C 0 0 0 0 0 5 11 15 45.5 73.3 1.83 0030484 muscle fiber C 0 0 0 0 0 5 11 16 45.5 68.8 1.83 0003927 heterotrimeric G-protein GTPase F 6 12 18 50 66.7 10 27 35 37 77.1 1.821 0000074 cell cycle control P 31 111 132 27.9 84.1 36 124 146 29 84.9 1.78 0008565 protein transporter F 6 17 18 35.3 94.4 9 24 25 37.5 96 1.771 0007010 cytoskeleton organization and biogenesis P 13 53 73 24.5 72.6 34 117 175 29.1 66.9 1.735 0019898 extrinsic membrane protein C 0 0 0 0 0 7 18 26 38.9 69.2 1.674 0007179 TGFbeta receptor signaling pathway P 6 14 16 42.9 87.5 7 18 22 38.9 81.8 1.674 0019897 extrinsic plasma membrane protein C 1 3 5 33.3 60 7 18 26 38.9 69.2 1.674 0004722 protein serine/threonine phosphatase F 6 16 19 37.5 84.2 7 18 27 38.9 66.7 1.674 0005834 heterotrimeric G-protein complex C 6 15 21 40 71.4 6 15 21 40 71.4 1.631 0005884 actin filament C 3 6 7 50 85.7 3 6 7 50 85.7 1.618 0008016 control of heart P 3 6 6 50 100 3 6 6 50 100 1.618 0007126 meiosis P 3 6 8 50 75 3 6 9 50 66.7 1.618 0030006 heavy metal ion homeostasis P 0 0 0 0 0 3 6 11 50 54.5 1.618 0006879 iron homeostasis P 3 6 11 50 54.5 3 6 11 50 54.5 1.618 0016886 ligase, forming phosphoric ester bonds F 0 0 0 0 0 3 6 8 50 75 1.618 0009129 pyrimidine nucleoside monophosphate metabolism P 0 0 0 0 0 3 6 7 50 85.7 1.618 0006220 pyrimidine nucleotide metabolism P 0 0 0 0 0 3 6 7 50 85.7 1.618 0003725 double-stranded RNA binding F 2 5 6 40 83.3 3 6 8 50 75 1.618 0005813 centrosome C 3 5 6 60 83.3 3 6 7 50 85.7 1.618 0006304 DNA modification P 0 2 2 0 0 4 9 12 44.4 75 1.582 0008303 caspase C 4 9 9 44.4 100 4 9 9 44.4 100 1.582 0006778 porphyrin metabolism P 0 0 0 0 0 4 9 11 44.4 81.8 1.582 0042168 heme metabolism P 0 0 0 0 0 4 9 11 44.4 81.8 1.582 0007229 integrin-mediated signaling pathway P 9 26 32 34.6 81.2 9 26 32 34.6 81.2 1.49 0005201 extracellular matrix structural constituent F 9 35 38 25.7 92.1 15 48 54 31.2 88.9 1.468 0008287 protein serine/threonine phosphatase C 5 15 18 33.3 83.3 6 16 20 37.5 80 1.445 0016818 hydrolase, acting on acid anhydrides, in phosphorus-containing anhydrides F 0 0 0 0 0 43 159 217 27 73.3 1.412 0016817 hydrolase, acting on acid anhydrides F 0 0 0 0 0 43 159 217 27 73.3 1.412 0005543 phospholipid binding F 1 1 2 100 50 5 13 18 38.5 72.2 1.385 0004702 receptor signaling protein serine/threonine kinase F 3 5 5 60 100 5 13 18 38.5 72.2 1.385 0006468 protein amino acid phosphorylation P 47 174 209 27 83.3 49 185 221 26.5 83.7 1.342 0005865 striated muscle thin filament C 0 1 3 0 0 4 10 13 40 76.9 1.331 0006164 purine nucleotide biosynthesis P 3 6 8 50 75 4 10 13 40 76.9 1.331 0003993 acid phosphatase F 2 4 4 50 100 2 4 4 50 100 1.321 0006919 caspase activation P 2 3 3 66.7 100 2 4 4 50 100 1.321 0007507 heart development P 2 4 6 50 66.7 2 4 6 50 66.7 1.321 0016801 hydrolase, acting on ether bonds F 0 0 0 0 0 2 4 4 50 100 1.321 0006265 DNA topological change P 2 4 6 50 66.7 2 4 6 50 66.7 1.321 0006733 oxidoreduction coenzyme metabolism P 0 0 0 0 0 2 4 4 50 100 1.321 0016811 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides F 0 0 0 0 0 2 4 9 50 44.4 1.321 0016469 hydrogen-transporting two-sector ATPase C 2 3 4 66.7 75 2 4 6 50 66.7 1.321 0004179 membrane alanyl aminopeptidase F 2 4 4 50 100 2 4 4 50 100 1.321 0016284 alanine aminopeptidase F 0 0 0 0 0 2 4 4 50 100 1.321 0004003 ATP dependent DNA helicase F 2 4 5 50 80 2 4 5 50 80 1.321 0004194 pepsin A F 2 4 6 50 66.7 2 4 6 50 66.7 1.321 0019136 deoxynucleoside kinase F 0 0 0 0 0 2 4 4 50 100 1.321 0006040 aminosugar metabolism P 0 0 0 0 0 2 4 4 50 100 1.321 0003686 DNA repair enzyme F 2 3 4 66.7 75 2 4 5 50 80 1.321 0004396 hexokinase F 2 4 4 50 100 2 4 4 50 100 1.321 0016310 phosphorylation P 0 0 0 0 0 49 186 228 26.3 81.6 1.298 0005211 plasma glycoprotein F 3 7 7 42.9 100 3 7 7 42.9 100 1.295 0004407 histone deacetylase F 3 6 9 50 66.7 3 7 10 42.9 70 1.295 0003743 translation initiation factor F 3 7 10 42.9 70 3 7 10 42.9 70 1.295 0005344 oxygen transporter F 3 7 9 42.9 77.8 3 7 9 42.9 77.8 1.295 0008080 N-acetyltransferase F 1 3 4 33.3 75 3 7 8 42.9 87.5 1.295 0006413 protein synthesis initiation P 3 7 10 42.9 70 3 7 10 42.9 70 1.295 0006695 cholesterol biosynthesis P 3 7 8 42.9 87.5 3 7 8 42.9 87.5 1.295 0015671 oxygen transport P 3 7 8 42.9 87.5 3 7 8 42.9 87.5 1.295 0015450 protein translocase F 3 7 7 42.9 100 3 7 7 42.9 100 1.295 0006633 fatty acid biosynthesis P 2 6 9 33.3 66.7 3 7 11 42.9 63.6 1.295 0000041 transition metal transport P 0 0 0 0 0 3 7 10 42.9 70 1.295 0015669 gas transport P 0 0 0 0 0 3 7 8 42.9 87.5 1.295 0007626 locomotory behavior P 2 4 6 50 66.7 3 7 9 42.9 77.8 1.295 0003712 transcription co-factor F 0 5 8 0 0 8 24 39 33.3 61.5 1.281 0016810 hydrolase, acting on carbon-nitrogen (but not peptide) bonds F 1 2 2 50 100 6 17 28 35.3 60.7 1.271 0019320 hexose catabolism P 0 0 0 0 0 9 28 34 32.1 82.4 1.232 0016052 carbohydrate catabolism P 0 0 0 0 0 9 28 35 32.1 80 1.232 0006007 glucose catabolism P 0 0 0 0 0 9 28 34 32.1 82.4 1.232 0004518 nuclease F 2 16 23 12.5 69.6 10 32 50 31.2 64 1.197 0006644 phospholipid metabolism P 1 4 4 25 100 5 14 19 35.7 73.7 1.191 0006643 membrane lipid metabolism P 0 0 0 0 0 5 14 19 35.7 73.7 1.191 0016049 cell growth P 1 3 4 33.3 75 5 14 19 35.7 73.7 1.191 0006996 organelle organization and biogenesis P 0 0 0 0 0 37 140 203 26.4 69 1.145 0007017 microtubule-based process P 14 44 70 31.8 62.9 15 52 82 28.8 63.4 1.111 0008026 ATP dependent helicase F 4 15 18 26.7 83.3 6 18 23 33.3 78.3 1.108 0008639 small protein conjugating enzyme F 0 0 0 0 0 4 11 13 36.4 84.6 1.107 0016763 transferase, transferring pentosyl groups F 0 0 0 0 0 4 11 13 36.4 84.6 1.107 0004840 ubiquitin conjugating enzyme F 4 11 13 36.4 84.6 4 11 13 36.4 84.6 1.107 0001558 regulation of cell growth P 3 10 14 30 71.4 4 11 15 36.4 73.3 1.107 0005718 nucleosome C 4 11 18 36.4 61.1 4 11 18 36.4 61.1 1.107 0008235 metalloexopeptidase F 2 3 3 66.7 100 4 11 12 36.4 91.7 1.107 0019200 carbohydrate kinase F 0 0 0 0 0 4 11 11 36.4 100 1.107 0007160 cell-matrix adhesion P 7 22 23 31.8 95.7 7 22 23 31.8 95.7 1.055 0019318 hexose metabolism P 0 0 0 0 0 12 41 49 29.3 83.7 1.05 0005996 monosaccharide metabolism P 0 0 0 0 0 12 41 49 29.3 83.7 1.05 0015630 microtubule cytoskeleton C 1 1 1 100 100 14 49 77 28.6 63.6 1.032 0006418 amino acid activation P 3 8 11 37.5 72.7 3 8 11 37.5 72.7 1.021 0005861 troponin complex C 3 8 8 37.5 100 3 8 8 37.5 100 1.021 0008189 apoptosis inhibitor F 3 8 13 37.5 61.5 3 8 13 37.5 61.5 1.021 0006823 heavy metal ion transport P 1 3 4 33.3 75 3 8 12 37.5 66.7 1.021 0003854 3-beta-hydroxy-delta(5)-steroid dehydrogenase F 3 8 8 37.5 100 3 8 8 37.5 100 1.021 0006464 protein modification P 5 21 23 23.8 91.3 70 281 336 24.9 83.6 1.019 0008234 cysteine-type peptidase F 9 30 47 30 63.8 11 38 57 28.9 66.7 0.963 0015297 antiporter F 0 0 0 0 0 2 5 8 40 62.5 0.941 0006885 pH regulation P 2 4 5 50 80 2 5 6 40 83.3 0.941 0000082 G1/S transition of mitotic cell cycle P 2 3 5 66.7 60 2 5 7 40 71.4 0.941 0007548 sex differentiation P 2 5 5 40 100 2 5 5 40 100 0.941 0006767 water-soluble vitamin metabolism P 0 0 0 0 0 2 5 5 40 100 0.941 0016814 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines F 0 2 2 0 0 2 5 9 40 55.6 0.941 0003727 single-stranded RNA binding F 1 2 4 50 50 2 5 7 40 71.4 0.941 0007585 respiration P 2 5 8 40 62.5 2 5 8 40 62.5 0.941 0000051 urea cycle intermediate metabolism P 0 0 0 0 0 2 5 5 40 100 0.941 0015026 coreceptor F 0 2 3 0 0 2 5 6 40 83.3 0.941 0007492 endoderm development P 2 3 7 66.7 42.9 2 5 9 40 55.6 0.941 0016568 chromatin modification P 0 1 1 0 0 2 5 8 40 62.5 0.941 0030004 monovalent inorganic cation homeostasis P 0 0 0 0 0 2 5 7 40 71.4 0.941 0006525 arginine metabolism P 1 2 2 50 100 2 5 5 40 100 0.941 0005833 hemoglobin C 2 5 6 40 83.3 2 5 6 40 83.3 0.941 0003782 F-actin capping F 2 5 8 40 62.5 2 5 8 40 62.5 0.941 0008290 actin capping protein C 2 5 7 40 71.4 2 5 7 40 71.4 0.941 0007215 glutamate signaling pathway P 1 3 3 33.3 100 2 5 7 40 71.4 0.941 0009147 pyrimidine nucleoside triphosphate metabolism P 0 0 0 0 0 2 5 6 40 83.3 0.941 0009148 pyrimidine nucleoside triphosphate biosynthesis P 0 0 0 0 0 2 5 6 40 83.3 0.941 0016841 ammonia-lyase F 0 0 0 0 0 1 2 3 50 66.7 0.934 0006720 isoprenoid metabolism P 0 0 0 0 0 1 2 2 50 100 0.934 0005889 hydrogen/potassium-exchanging ATPase C 1 2 2 50 100 1 2 2 50 100 0.934 0003756 protein disulfide isomerase F 1 2 2 50 100 1 2 2 50 100 0.934 0019217 regulation of fatty acid metabolism P 1 2 2 50 100 1 2 2 50 100 0.934 0006269 DNA replication, priming P 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0007059 chromosome segregation P 0 1 1 0 0 1 2 2 50 100 0.934 0004019 adenylosuccinate synthase F 1 2 2 50 100 1 2 2 50 100 0.934 0006760 folic acid and derivative metabolism P 0 1 1 0 0 1 2 3 50 66.7 0.934 0005903 brush border C 1 2 2 50 100 1 2 2 50 100 0.934 0007252 phosphorylation of I-kappaB P 1 2 2 50 100 1 2 2 50 100 0.934 0005548 phospholipid transporter F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0005375 copper ion transporter F 0 0 0 0 0 1 2 2 50 100 0.934 0003910 DNA ligase (ATP) F 1 2 2 50 100 1 2 2 50 100 0.934 0015300 solute:solute antiporter F 0 0 0 0 0 1 2 3 50 66.7 0.934 0005074 inhibitory SMAD protein F 1 2 2 50 100 1 2 2 50 100 0.934 0007040 lysosome organization and biogenesis P 1 1 1 100 100 1 2 2 50 100 0.934 0015645 fatty-acid ligase F 0 0 0 0 0 1 2 2 50 100 0.934 0005545 phosphatidylinositol binding F 0 0 2 0 0 1 2 5 50 40 0.934 0015298 solute:cation antiporter F 0 0 0 0 0 1 2 3 50 66.7 0.934 0006776 vitamin A metabolism P 0 0 1 0 0 1 2 4 50 50 0.934 0006775 fat-soluble vitamin metabolism P 0 0 0 0 0 1 2 4 50 50 0.934 0001523 retinoid metabolism P 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0003909 DNA ligase F 0 0 0 0 0 1 2 2 50 100 0.934 0008435 anticoagulant F 1 2 2 50 100 1 2 2 50 100 0.934 0007613 memory P 1 2 2 50 100 1 2 2 50 100 0.934 0001633 secretin-like receptor F 0 0 0 0 0 1 2 2 50 100 0.934 0005758 mitochondrial intermembrane space C 1 2 2 50 100 1 2 2 50 100 0.934 0007216 metabotropic glutamate receptor signaling pathway P 1 2 4 50 50 1 2 4 50 50 0.934 0016003 glutamine amidotransferase F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0004372 glycine hydroxymethyltransferase F 1 1 1 100 100 1 2 5 50 40 0.934 0000228 nuclear chromosome C 1 2 4 50 50 1 2 4 50 50 0.934 0016778 diphosphotransferase F 0 0 0 0 0 1 2 4 50 50 0.934 0001664 G-protein coupled receptor ligand F 1 2 2 50 100 1 2 2 50 100 0.934 0003938 IMP dehydrogenase F 1 2 2 50 100 1 2 2 50 100 0.934 0004779 sulfate adenylyltransferase F 0 0 0 0 0 1 2 2 50 100 0.934 0009127 purine nucleoside monophosphate biosynthesis P 0 0 0 0 0 1 2 3 50 66.7 0.934 0006381 mRNA editing P 1 2 2 50 100 1 2 2 50 100 0.934 0016556 mRNA modification P 0 0 0 0 0 1 2 2 50 100 0.934 0016504 protease activator F 0 1 1 0 0 1 2 3 50 66.7 0.934 0007219 N receptor signaling pathway P 1 2 6 50 33.3 1 2 6 50 33.3 0.934 0007256 activation of JUN kinase kinase P 1 2 2 50 100 1 2 2 50 100 0.934 0008046 axon guidance receptor F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0006354 RNA elongation P 1 2 2 50 100 1 2 2 50 100 0.934 0005178 integrin ligand F 1 2 7 50 28.6 1 2 7 50 28.6 0.934 0004781 sulfate adenylyltransferase (ATP) F 1 2 2 50 100 1 2 2 50 100 0.934 0015175 neutral amino acid transporter F 1 2 2 50 100 1 2 2 50 100 0.934 0004768 stearoyl-CoA desaturase F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0016215 CoA desaturase F 0 0 0 0 0 1 2 3 50 66.7 0.934 0030282 bone mineralization P 1 2 2 50 100 1 2 3 50 66.7 0.934 0006825 copper ion transport P 1 2 2 50 100 1 2 2 50 100 0.934 0004345 glucose-6-phosphate 1-dehydrogenase F 1 2 2 50 100 1 2 2 50 100 0.934 0006072 glycerol-3-phosphate metabolism P 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0008104 protein localization P 1 2 6 50 33.3 1 2 6 50 33.3 0.934 0004467 long-chain-fatty-acid-CoA-ligase F 1 2 2 50 100 1 2 2 50 100 0.934 0009152 purine ribonucleotide biosynthesis P 0 0 0 0 0 1 2 2 50 100 0.934 0006284 base-excision repair P 1 2 4 50 50 1 2 4 50 50 0.934 0009167 purine ribonucleoside monophosphate metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.934 0003969 RNA editase F 0 1 1 0 0 1 2 4 50 50 0.934 0003870 5-aminolevulinate synthase F 1 2 2 50 100 1 2 2 50 100 0.934 0009116 nucleoside metabolism P 1 2 4 50 50 1 2 4 50 50 0.934 0006177 GMP biosynthesis P 1 2 2 50 100 1 2 2 50 100 0.934 0009168 purine ribonucleoside monophosphate biosynthesis P 0 0 0 0 0 1 2 3 50 66.7 0.934 0016745 transketolase and transaldolase F 0 0 0 0 0 1 2 2 50 100 0.934 0016744 transferase, transferring aldehyde or ketonic groups F 0 0 0 0 0 1 2 2 50 100 0.934 0005913 cell-cell adherens junction C 1 1 2 100 50 1 2 5 50 40 0.934 0006518 peptide metabolism P 1 2 2 50 100 1 2 2 50 100 0.934 0016866 intramolecular transferase F 0 0 0 0 0 1 2 3 50 66.7 0.934 0006054 N-acetylneuraminate metabolism P 0 1 1 0 0 1 2 2 50 100 0.934 0004007 heavy metal-exporting ATPase F 0 0 0 0 0 1 2 2 50 100 0.934 0000103 sulfate assimilation P 1 2 2 50 100 1 2 2 50 100 0.934 0004622 lysophospholipase F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0005487 nucleocytoplasmic transporter F 1 2 4 50 50 1 2 4 50 50 0.934 0009331 glycerol-3-phosphate dehydrogenase C 1 2 2 50 100 1 2 2 50 100 0.934 0006012 galactose metabolism P 1 2 2 50 100 1 2 2 50 100 0.934 0008900 hydrogen/potassium-exchanging ATPase F 1 2 2 50 100 1 2 2 50 100 0.934 0004618 phosphoglycerate kinase F 1 2 2 50 100 1 2 2 50 100 0.934 0004743 pyruvate kinase F 1 2 2 50 100 1 2 2 50 100 0.934 0004806 triacylglycerol lipase F 1 2 2 50 100 1 2 2 50 100 0.934 0006446 translational regulation, initiation P 1 2 2 50 100 1 2 2 50 100 0.934 0004287 prolyl oligopeptidase F 1 2 2 50 100 1 2 2 50 100 0.934 0004000 adenosine deaminase F 0 1 1 0 0 1 2 4 50 50 0.934 0008629 induction of apoptosis by intracellular signals P 0 0 0 0 0 1 2 2 50 100 0.934 0019238 cyclohydrolase F 0 0 0 0 0 1 2 3 50 66.7 0.934 0001505 neurotransmitter maintenance P 0 0 1 0 0 1 2 7 50 28.6 0.934 0004797 thymidine kinase F 1 2 2 50 100 1 2 2 50 100 0.934 0007269 neurotransmitter release P 1 1 3 100 33.3 1 2 5 50 40 0.934 0006791 sulfur utilization P 0 0 0 0 0 1 2 2 50 100 0.934 0008536 RAN protein binding F 1 2 4 50 50 1 2 4 50 50 0.934 0030318 melanocyte differentiation P 1 2 2 50 100 1 2 2 50 100 0.934 0006790 sulfur metabolism P 0 0 0 0 0 1 2 2 50 100 0.934 0017040 ceramidase F 0 0 1 0 0 1 2 3 50 66.7 0.934 0005005 transmembrane-ephrin receptor F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0004239 methionyl aminopeptidase F 1 2 2 50 100 1 2 2 50 100 0.934 0004217 cathepsin L F 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0006824 cobalt ion transport P 1 2 2 50 100 1 2 2 50 100 0.934 0015925 galactosidase F 0 0 0 0 0 1 2 2 50 100 0.934 0008578 DNA glycosylase F 0 0 0 0 0 1 2 2 50 100 0.934 0006979 oxidative stress response P 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0004843 ubiquitin-specific protease F 1 2 4 50 50 1 2 4 50 50 0.934 0016806 dipeptidyl-peptidase and tripeptidyl-peptidase F 0 0 0 0 0 1 2 2 50 100 0.934 0009066 aspartate family amino acid metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.934 0009069 serine family amino acid metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.934 0004008 copper-exporting ATPase F 1 2 2 50 100 1 2 2 50 100 0.934 0007369 gastrulation P 1 2 2 50 100 1 2 2 50 100 0.934 0004053 arginase F 1 2 2 50 100 1 2 2 50 100 0.934 0006725 aromatic compound metabolism P 1 2 2 50 100 1 2 2 50 100 0.934 0008610 lipid biosynthesis P 0 0 0 0 0 1 2 4 50 50 0.934 0000163 protein phosphatase type 1 F 0 0 1 0 0 1 2 7 50 28.6 0.934 0017018 myosin phosphatase F 0 0 0 0 0 1 2 6 50 33.3 0.934 0017020 myosin phosphatase, regulator F 0 0 0 0 0 1 2 6 50 33.3 0.934 0042132 fructose-1,6-bisphosphatase F 1 2 2 50 100 1 2 2 50 100 0.934 0008243 plasminogen activator F 0 0 0 0 0 1 2 2 50 100 0.934 0015279 store-operated calcium channel F 1 2 2 50 100 1 2 2 50 100 0.934 0006898 receptor mediated endocytosis P 1 2 3 50 66.7 1 2 3 50 66.7 0.934 0000096 sulfur amino acid metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.934 0019825 oxygen binding F 0 0 0 0 0 4 12 17 33.3 70.6 0.904 0006916 anti-apoptosis P 4 12 19 33.3 63.2 4 12 19 33.3 63.2 0.904 0006163 purine nucleotide metabolism P 0 0 0 0 0 4 12 16 33.3 75 0.904 0007050 cell cycle arrest P 4 12 12 33.3 100 4 12 12 33.3 100 0.904 0008150 biological_process P 0 0 0 0 0 806 3544 4962 22.7 71.4 0.871 0006092 main pathways of carbohydrate metabolism P 0 0 0 0 0 11 39 50 28.2 78 0.864 0016757 transferase, transferring glycosyl groups F 0 0 0 0 0 14 51 64 27.5 79.7 0.86 0007018 microtubule-based movement P 5 14 18 35.7 77.8 5 16 20 31.2 80 0.845 0008015 circulation P 0 1 1 0 0 5 16 17 31.2 94.1 0.845 0019205 nucleobase, nucleoside, nucleotide kinase F 0 0 0 0 0 5 16 19 31.2 84.2 0.845 0006732 coenzyme metabolism P 0 0 0 0 0 5 16 22 31.2 72.7 0.845 0005057 receptor signaling protein F 1 5 7 20 71.4 22 84 128 26.2 65.6 0.828 0006886 intracellular protein transport P 26 90 113 28.9 79.6 36 143 178 25.2 80.3 0.792 0006796 phosphate metabolism P 0 0 0 0 0 56 228 278 24.6 82 0.783 0005905 coated pit C 3 9 16 33.3 56.2 3 9 16 33.3 56.2 0.783 0005024 transforming growth factor-beta receptor F 3 9 9 33.3 100 3 9 9 33.3 100 0.783 0016407 acetyltransferase F 1 3 3 33.3 100 3 9 14 33.3 64.3 0.783 0006730 one-carbon compound metabolism P 3 9 13 33.3 69.2 3 9 13 33.3 69.2 0.783 0009064 glutamine family amino acid metabolism P 0 0 0 0 0 3 9 11 33.3 81.8 0.783 0008632 apoptotic program P 1 3 3 33.3 100 3 9 9 33.3 100 0.783 0006752 group transfer coenzyme metabolism P 0 0 0 0 0 3 9 14 33.3 64.3 0.783 0016747 transferase, transferring groups other than amino-acyl groups F 1 2 2 50 100 8 28 38 28.6 73.7 0.778 0003678 DNA helicase F 9 32 55 28.1 58.2 9 32 55 28.1 58.2 0.772 0004386 helicase F 5 15 18 33.3 83.3 9 32 57 28.1 56.1 0.772 0006694 steroid biosynthesis P 6 23 29 26.1 79.3 9 32 42 28.1 76.2 0.772 0003774 motor F 12 40 64 30 62.5 12 44 72 27.3 61.1 0.77 0006006 glucose metabolism P 1 8 8 12.5 100 10 36 42 27.8 85.7 0.769 0006095 catabolic carbohydrate metabolism P 0 0 0 0 0 10 36 45 27.8 80 0.769 0005516 calmodulin binding F 10 36 46 27.8 78.3 10 36 46 27.8 78.3 0.769 0007167 enzyme linked receptor protein signaling pathway P 0 1 1 0 0 21 81 103 25.9 78.6 0.756 0006937 muscle contraction regulation P 4 13 13 30.8 100 4 13 13 30.8 100 0.72 0019538 protein metabolism P 0 0 1 0 0 5 17 22 29.4 77.3 0.689 0006873 ion homeostasis P 0 0 1 0 0 5 17 28 29.4 60.7 0.689 0009100 glycoprotein metabolism P 0 0 0 0 0 5 17 21 29.4 81 0.689 0006486 protein amino acid glycosylation P 4 12 14 33.3 85.7 5 17 20 29.4 85 0.689 0030003 cation homeostasis P 0 0 0 0 0 5 17 27 29.4 63 0.689 0009101 glycoprotein biosynthesis P 0 0 0 0 0 5 17 20 29.4 85 0.689 0005794 Golgi apparatus C 20 87 108 23 80.6 26 103 133 25.2 77.4 0.686 0019199 transmembrane receptor protein kinase F 0 0 0 0 0 12 45 49 26.7 91.8 0.681 0004197 cysteine-type endopeptidase F 4 18 24 22.2 75 9 33 41 27.3 80.5 0.666 0006366 transcription, from Pol II promoter P 1 6 11 16.7 54.5 7 25 50 28 50 0.666 0016874 ligase F 0 0 0 0 0 8 29 40 27.6 72.5 0.665 0007182 common-partner SMAD protein phosphorylation P 2 6 7 33.3 85.7 2 6 7 33.3 85.7 0.639 0019748 secondary metabolism P 0 0 0 0 0 2 6 8 33.3 75 0.639 0008360 cell shape control P 2 6 8 33.3 75 2 6 8 33.3 75 0.639 0004437 inositol/phosphatidylinositol phosphatase F 1 4 5 25 80 2 6 9 33.3 66.7 0.639 0004861 cyclin-dependent protein kinase inhibitor F 2 6 7 33.3 85.7 2 6 7 33.3 85.7 0.639 0000226 microtubule cytoskeleton organization and biogenesis P 0 2 2 0 0 2 6 7 33.3 85.7 0.639 0016799 hydrolase, hydrolyzing N-glycosyl compounds F 0 0 0 0 0 2 6 6 33.3 100 0.639 0001524 globin F 2 6 7 33.3 85.7 2 6 7 33.3 85.7 0.639 0009126 purine nucleoside monophosphate metabolism P 0 0 0 0 0 2 6 8 33.3 75 0.639 0003724 RNA helicase F 2 6 8 33.3 75 2 6 8 33.3 75 0.639 0004190 aspartic-type endopeptidase F 2 6 10 33.3 60 2 6 10 33.3 60 0.639 0019206 nucleoside kinase F 0 0 0 0 0 2 6 6 33.3 100 0.639 0006471 protein amino acid ADP-ribosylation P 2 6 6 33.3 100 2 6 6 33.3 100 0.639 0019201 nucleotide kinase F 0 0 0 0 0 2 6 8 33.3 75 0.639 0006417 general regulation of protein biosynthesis P 2 6 6 33.3 100 2 6 6 33.3 100 0.639 0006595 polyamine metabolism P 1 3 4 33.3 75 2 6 8 33.3 75 0.639 0006091 energy pathways P 0 0 0 0 0 13 50 66 26 75.8 0.604 0015980 energy derivation by oxidation of organic compounds P 0 0 0 0 0 13 50 66 26 75.8 0.604 0008643 carbohydrate transport P 2 7 8 28.6 87.5 3 10 12 30 83.3 0.573 0019222 regulation of metabolism P 0 2 2 0 0 3 10 11 30 90.9 0.573 0016776 phosphotransferase, phosphate group as acceptor F 0 0 0 0 0 3 10 13 30 76.9 0.573 0008757 S-adenosylmethionine-dependent methyltransferase F 1 3 4 33.3 75 3 10 12 30 83.3 0.573 0030097 hemopoiesis P 2 7 9 28.6 77.8 3 10 15 30 66.7 0.573 0004177 aminopeptidase F 1 8 10 12.5 80 3 10 12 30 83.3 0.573 0005544 calcium-dependent phospholipid binding F 3 10 11 30 90.9 3 10 11 30 90.9 0.573 0008373 sialyltransferase F 3 8 8 37.5 100 3 10 10 30 100 0.573 0016410 N-acyltransferase F 0 1 1 0 0 3 10 11 30 90.9 0.573 0016764 transferase, transferase, transferring other glycosyl groups F 0 0 0 0 0 3 10 10 30 100 0.573 0004675 transmembrane receptor protein serine/threonine kinase F 3 10 10 30 100 3 10 10 30 100 0.573 0009117 nucleotide metabolism P 0 3 3 0 0 7 26 35 26.9 74.3 0.548 0006096 glycolysis P 6 23 28 26.1 82.1 7 26 32 26.9 81.2 0.548 0007276 gametogenesis P 1 1 2 100 50 7 26 37 26.9 70.3 0.548 0003777 microtubule motor F 6 21 40 28.6 52.5 6 22 44 27.3 50 0.543 0009266 temperature response P 0 0 0 0 0 6 22 31 27.3 71 0.543 0006951 heat shock response P 6 22 31 27.3 71 6 22 31 27.3 71 0.543 0006575 amino acid derivative metabolism P 0 0 0 0 0 5 18 25 27.8 72 0.542 0016192 vesicle-mediated transport P 5 15 24 33.3 62.5 9 35 55 25.7 63.6 0.464 0004714 transmembrane receptor protein tyrosine kinase F 5 21 22 23.8 95.5 9 35 39 25.7 89.7 0.464 0040014 regulation of body size P 1 2 3 50 66.7 1 3 4 33.3 75 0.452 0018193 peptidyl-amino acid modification P 0 0 0 0 0 1 3 3 33.3 100 0.452 0006584 catecholamine metabolism P 1 3 6 33.3 50 1 3 6 33.3 50 0.452 0008366 nerve ensheathment P 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0006826 iron transport P 1 3 6 33.3 50 1 3 6 33.3 50 0.452 0030198 extracellular matrix organization and biogenesis P 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0040007 growth P 0 0 0 0 0 1 3 4 33.3 75 0.452 0007286 spermatid development P 1 3 4 33.3 75 1 3 5 33.3 60 0.452 0006066 alcohol metabolism P 0 0 0 0 0 1 3 4 33.3 75 0.452 0008215 spermine metabolism P 1 1 1 100 100 1 3 3 33.3 100 0.452 0005696 telomere C 1 2 3 50 66.7 1 3 4 33.3 75 0.452 0030137 COPI-coated vesicle C 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0006071 glycerol metabolism P 0 1 1 0 0 1 3 4 33.3 75 0.452 0008143 poly(A) binding F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0008199 ferric iron binding F 1 3 5 33.3 60 1 3 5 33.3 60 0.452 0009405 pathogenesis P 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0016714 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen F 0 0 0 0 0 1 3 3 33.3 100 0.452 0008637 apoptotic mitochondrial changes P 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0006268 DNA unwinding P 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0015992 proton transport P 0 0 0 0 0 1 3 5 33.3 60 0.452 0005172 vascular endothelial growth factor receptor ligand F 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0045045 secretory pathway P 0 0 0 0 0 1 3 7 33.3 42.9 0.452 0006596 polyamine biosynthesis P 1 1 2 100 50 1 3 4 33.3 75 0.452 0016916 inhibin F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0004859 phospholipase inhibitor F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0016877 ligase, forming carbon-sulfur bonds F 0 0 0 0 0 1 3 5 33.3 60 0.452 0005452 inorganic anion exchanger F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0015380 anion exchanger F 0 0 1 0 0 1 3 4 33.3 75 0.452 0015427 ABC-type efflux porter F 0 0 0 0 0 1 3 3 33.3 100 0.452 0005006 epidermal growth factor receptor F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0016645 oxidoreductase, acting on the CH-NH group of donors F 0 0 0 0 0 1 3 6 33.3 50 0.452 0005007 fibroblast growth factor receptor F 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0003767 cochaperone F 0 2 2 0 0 1 3 3 33.3 100 0.452 0006638 neutral lipid metabolism P 0 0 0 0 0 1 3 5 33.3 60 0.452 0000265 heterotrimeric G-protein GTPase, gamma-subunit F 1 3 5 33.3 60 1 3 5 33.3 60 0.452 0006641 triacylglycerol metabolism P 0 0 0 0 0 1 3 5 33.3 60 0.452 0008042 iron-sulfur electron transfer carrier F 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0015301 anion:anion antiporter F 0 0 0 0 0 1 3 4 33.3 75 0.452 0016876 ligase, forming aminoacyl-tRNA and related compounds F 0 0 0 0 0 1 3 4 33.3 75 0.452 0016875 ligase, forming carbon-oxygen bonds F 0 0 0 0 0 1 3 4 33.3 75 0.452 0005890 sodium/potassium-exchanging ATPase C 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0000002 mitochondrial genome maintenance P 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0000151 ubiquitin ligase complex C 1 3 7 33.3 42.9 1 3 7 33.3 42.9 0.452 0007032 endosome organization and biogenesis P 0 0 0 0 0 1 3 3 33.3 100 0.452 0016197 endosome transport P 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0008452 RNA ligase F 0 0 0 0 0 1 3 4 33.3 75 0.452 0006639 acylglycerol metabolism P 0 0 0 0 0 1 3 5 33.3 60 0.452 0004463 leukotriene-A4 hydrolase F 1 1 1 100 100 1 3 3 33.3 100 0.452 0007611 learning and memory P 0 1 1 0 0 1 3 4 33.3 75 0.452 0001533 cornified envelope C 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0008344 adult locomotory behavior P 1 2 2 50 100 1 3 3 33.3 100 0.452 0016774 phosphotransferase, carboxyl group as acceptor F 0 0 0 0 0 1 3 3 33.3 100 0.452 0016805 dipeptidase F 0 0 0 0 0 1 3 3 33.3 100 0.452 0004652 polynucleotide adenylyltransferase F 1 3 5 33.3 60 1 3 5 33.3 60 0.452 0005945 6-phosphofructokinase C 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0007204 cytosolic calcium ion concentration elevation P 1 3 5 33.3 60 1 3 5 33.3 60 0.452 0008170 N-methyltransferase F 0 0 1 0 0 1 3 4 33.3 75 0.452 0008286 insulin receptor signaling pathway P 1 3 5 33.3 60 1 3 5 33.3 60 0.452 0016803 ether hydrolase F 0 0 0 0 0 1 3 3 33.3 100 0.452 0004812 tRNA ligase F 1 3 4 33.3 75 1 3 4 33.3 75 0.452 0016291 acyl-CoA thioesterase F 1 3 7 33.3 42.9 1 3 7 33.3 42.9 0.452 0006487 N-linked glycosylation P 0 2 3 0 0 1 3 4 33.3 75 0.452 0005080 protein kinase C binding F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0016865 intramolecular isomerase, other intramolecular oxidoreductases F 0 0 0 0 0 1 3 4 33.3 75 0.452 0004769 steroid delta-isomerase F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0019239 deaminase F 0 0 0 0 0 1 3 6 33.3 50 0.452 0003872 6-phosphofructokinase F 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0005744 mitochondrial inner membrane translocase complex C 1 3 3 33.3 100 1 3 3 33.3 100 0.452 0009055 electron carrier F 0 0 0 0 0 1 3 4 33.3 75 0.452 0008239 dipeptidyl-peptidase F 0 1 1 0 0 1 3 3 33.3 100 0.452 0016329 apoptosis regulator F 3 21 27 14.3 77.8 8 31 43 25.8 72.1 0.449 0015631 tubulin binding F 0 0 0 0 0 7 27 50 25.9 54 0.434 0008017 microtubule binding F 1 5 6 20 83.3 7 27 50 25.9 54 0.434 0005764 lysosome C 11 41 53 26.8 77.4 11 44 57 25 77.2 0.407 0016789 carboxylic ester hydrolase F 1 6 7 16.7 85.7 5 19 22 26.3 86.4 0.404 0004895 cell adhesion receptor F 4 18 20 22.2 90 5 19 22 26.3 86.4 0.404 0019725 homeostasis P 0 0 0 0 0 5 19 30 26.3 63.3 0.404 0015031 protein transport P 5 19 23 26.3 82.6 38 160 207 23.8 77.3 0.4 0000263 heterotrimeric G-protein GTPase, alpha-subunit F 4 15 16 26.7 93.8 4 15 16 26.7 93.8 0.392 0007610 behavior P 0 1 3 0 0 4 15 21 26.7 71.4 0.392 0008238 exopeptidase F 0 0 0 0 0 4 15 18 26.7 83.3 0.392 0016835 carbon-oxygen lyase F 0 0 0 0 0 4 15 23 26.7 65.2 0.392 0003773 heat shock protein F 4 15 18 26.7 83.3 4 15 18 26.7 83.3 0.392 0006753 nucleoside phosphate metabolism P 0 0 0 0 0 2 7 11 28.6 63.6 0.388 0019936 inositol phospholipid-mediated signaling P 0 0 1 0 0 2 7 14 28.6 50 0.388 0005373 heavy metal ion porter F 0 0 0 0 0 2 7 8 28.6 87.5 0.388 0007200 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) P 1 3 5 33.3 60 2 7 13 28.6 53.8 0.388 0004928 frizzled receptor F 2 7 9 28.6 77.8 2 7 9 28.6 77.8 0.388 0006665 sphingolipid metabolism P 1 3 3 33.3 100 2 7 9 28.6 77.8 0.388 0005160 transforming growth factor-beta receptor ligand F 1 4 4 25 100 2 7 7 28.6 100 0.388 0015082 di-, tri-valent inorganic cation transporter F 0 0 0 0 0 2 7 8 28.6 87.5 0.388 0005478 intracellular transporter F 0 4 5 0 0 2 7 10 28.6 70 0.388 0016481 repression of transcription P 1 3 9 33.3 33.3 2 7 19 28.6 36.8 0.388 0008378 galactosyltransferase F 1 1 2 100 50 2 7 11 28.6 63.6 0.388 0005076 receptor signaling protein serine/threonine kinase signaling protein F 0 0 0 0 0 2 7 10 28.6 70 0.388 0015076 heavy metal ion transporter F 0 0 1 0 0 2 7 9 28.6 77.8 0.388 0005540 hyaluronic acid binding F 2 7 8 28.6 87.5 2 7 8 28.6 87.5 0.388 0006754 ATP biosynthesis P 2 7 11 28.6 63.6 2 7 11 28.6 63.6 0.388 0016718 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous F 0 0 0 0 0 2 7 10 28.6 70 0.388 0007148 cell shape and cell size control P 0 2 2 0 0 2 7 9 28.6 77.8 0.388 0007155 cell adhesion P 37 164 206 22.6 79.6 40 169 216 23.7 78.2 0.386 0009309 amine biosynthesis P 0 0 0 0 0 3 11 12 27.3 91.7 0.384 0006700 C21-steroid hormone biosynthesis P 3 11 13 27.3 84.6 3 11 13 27.3 84.6 0.384 0008207 C21-steroid metabolism P 0 0 0 0 0 3 11 13 27.3 84.6 0.384 0008203 cholesterol metabolism P 1 5 6 20 83.3 3 11 14 27.3 78.6 0.384 0016125 sterol metabolism P 0 0 0 0 0 3 11 14 27.3 78.6 0.384 0005003 ephrin receptor F 3 11 12 27.3 91.7 3 11 13 27.3 84.6 0.384 0006807 nitrogen metabolism P 1 2 2 50 100 3 11 11 27.3 100 0.384 0008079 translation termination factor F 0 0 0 0 0 3 11 14 27.3 78.6 0.384 0004428 inositol/phosphatidylinositol kinase F 2 6 8 33.3 75 3 11 14 27.3 78.6 0.384 0019838 growth factor binding F 0 0 0 0 0 3 11 13 27.3 84.6 0.384 0005520 insulin-like growth factor binding F 3 11 13 27.3 84.6 3 11 13 27.3 84.6 0.384 0003747 translation release factor F 0 0 0 0 0 3 11 14 27.3 78.6 0.384 0019839 guanyl-nucleotide release factor F 3 11 14 27.3 78.6 3 11 14 27.3 78.6 0.384 0005194 cell adhesion molecule F 8 34 43 23.5 79.1 17 70 91 24.3 76.9 0.37 0004519 endonuclease F 6 24 30 25 80 6 24 33 25 72.7 0.3 0007283 spermatogenesis P 5 21 29 23.8 72.4 6 24 34 25 70.6 0.3 0008415 acyltransferase F 0 7 8 0 0 6 24 34 25 70.6 0.3 0007169 transmembrane receptor protein tyrosine kinase signaling pathway P 9 36 44 25 81.8 10 41 52 24.4 78.8 0.299 0005083 small GTPase regulatory/interacting protein F 3 10 18 30 55.6 13 54 78 24.1 69.2 0.287 0006936 muscle contraction P 1 4 7 25 57.1 5 20 28 25 71.4 0.274 0016337 cell-cell adhesion P 1 4 5 25 80 5 20 30 25 66.7 0.274 0016746 transferase, transferring acyl groups F 0 0 0 0 0 8 33 43 24.2 76.7 0.247 0008305 integrin C 4 16 17 25 94.1 4 16 17 25 94.1 0.245 0007582 physiological processes P 3 8 12 37.5 66.7 14 59 75 23.7 78.7 0.236 0008289 lipid binding F 6 28 33 21.4 84.8 10 42 51 23.8 82.4 0.212 0009108 coenzyme biosynthesis P 0 0 0 0 0 3 12 18 25 66.7 0.212 0006818 hydrogen transport P 2 9 12 22.2 75 3 12 17 25 70.6 0.212 0006875 metal ion homeostasis P 0 0 0 0 0 3 12 21 25 57.1 0.212 0030154 cell differentiation P 1 7 9 14.3 77.8 3 12 18 25 66.7 0.212 0030005 di-, tri-valent inorganic cation homeostasis P 0 0 0 0 0 3 12 20 25 60 0.212 0016829 lyase F 0 0 1 0 0 9 38 57 23.7 66.7 0.183 0004289 subtilase F 2 8 8 25 100 2 8 8 25 100 0.173 0007409 axonogenesis P 1 1 6 100 16.7 2 8 17 25 47.1 0.173 0016459 myosin C 2 8 11 25 72.7 2 8 12 25 66.7 0.173 0005975 carbohydrate metabolism P 6 32 49 18.8 65.3 22 95 135 23.2 70.4 0.166 0005623 cell C 0 0 0 0 0 648 2876 4096 22.5 70.2 0.165 0030054 cell junction C 0 0 0 0 0 8 34 48 23.5 70.8 0.151 0015674 di-, tri-valent inorganic cation transport P 0 0 0 0 0 5 21 28 23.8 75 0.149 0009056 catabolism P 1 1 1 100 100 53 232 300 22.8 77.3 0.147 0016887 ATPase F 1 2 5 50 40 18 78 114 23.1 68.4 0.133 0009208 pyrimidine ribonucleoside triphosphate metabolism P 0 0 0 0 0 1 4 5 25 80 0.122 0005881 cytoplasmic microtubule C 0 0 0 0 0 1 4 5 25 80 0.122 0005070 SH3/SH2 adaptor protein F 1 4 8 25 50 1 4 8 25 50 0.122 0006505 GPI anchor metabolism P 0 0 1 0 0 1 4 5 25 80 0.122 0005075 pathway-specific SMAD protein F 1 4 4 25 100 1 4 4 25 100 0.122 0042079 GPI/GSI anchor metabolism P 0 0 0 0 0 1 4 5 25 80 0.122 0005964 phosphorylase kinase C 1 4 4 25 100 1 4 4 25 100 0.122 0004032 aldehyde reductase F 1 4 4 25 100 1 4 4 25 100 0.122 0007222 frizzled receptor signaling pathway P 1 4 5 25 80 1 4 5 25 80 0.122 0015070 toxin F 1 4 4 25 100 1 4 4 25 100 0.122 0006637 acyl-CoA metabolism P 1 4 8 25 50 1 4 8 25 50 0.122 0004602 glutathione peroxidase F 1 4 5 25 80 1 4 5 25 80 0.122 0009145 purine nucleoside triphosphate biosynthesis P 0 0 0 0 0 1 4 5 25 80 0.122 0000050 urea cycle P 1 4 4 25 100 1 4 4 25 100 0.122 0007254 JNK cascade P 0 1 5 0 0 1 4 9 25 44.4 0.122 0004060 arylamine N-acetyltransferase F 1 4 4 25 100 1 4 4 25 100 0.122 0004659 prenyltransferase F 0 2 2 0 0 1 4 4 25 100 0.122 0006183 GTP biosynthesis P 1 4 5 25 80 1 4 5 25 80 0.122 0016288 cytokinesis P 1 4 6 25 66.7 1 4 6 25 66.7 0.122 0000122 repression of transcription, from Pol II promoter P 1 4 11 25 36.4 1 4 11 25 36.4 0.122 0009144 purine nucleoside triphosphate metabolism P 0 0 0 0 0 1 4 5 25 80 0.122 0016564 transcriptional repressor F 0 3 13 0 0 1 4 14 25 28.6 0.122 0007622 rhythmic behavior P 1 4 5 25 80 1 4 5 25 80 0.122 0006541 glutamine metabolism P 1 3 4 33.3 75 1 4 5 25 80 0.122 0016289 CoA hydrolase F 0 0 0 0 0 1 4 8 25 50 0.122 0009209 pyrimidine ribonucleoside triphosphate biosynthesis P 0 0 0 0 0 1 4 5 25 80 0.122 0006228 UTP biosynthesis P 1 4 5 25 80 1 4 5 25 80 0.122 0004550 nucleoside-diphosphate kinase F 1 4 5 25 80 1 4 5 25 80 0.122 0008172 S-methyltransferase F 0 0 0 0 0 1 4 4 25 100 0.122 0004017 adenylate kinase F 1 4 4 25 100 1 4 4 25 100 0.122 0003964 RNA-directed DNA polymerase F 1 4 4 25 100 1 4 4 25 100 0.122 0005391 sodium/potassium-exchanging ATPase F 1 4 5 25 80 1 4 5 25 80 0.122 0007605 hearing P 1 4 7 25 57.1 1 4 7 25 57.1 0.122 0008375 acetylglucosaminyltransferase F 1 2 2 50 100 1 4 5 25 80 0.122 0006974 DNA damage response P 1 2 2 50 100 1 4 5 25 80 0.122 0005868 cytoplasmic dynein C 1 4 5 25 80 1 4 5 25 80 0.122 0009592 perception of sound P 0 0 0 0 0 1 4 7 25 57.1 0.122 0007183 SMAD protein heteromerization P 1 4 4 25 100 1 4 4 25 100 0.122 0006241 CTP biosynthesis P 1 4 5 25 80 1 4 5 25 80 0.122 0005079 protein kinase A anchor protein F 1 4 6 25 66.7 1 4 6 25 66.7 0.122 0004091 carboxylesterase F 1 3 4 33.3 75 1 4 5 25 80 0.122 0004689 phosphorylase kinase F 1 3 3 33.3 100 1 4 4 25 100 0.122 0000003 reproduction P 0 0 0 0 0 7 30 42 23.3 71.4 0.116 0009308 amine metabolism P 0 0 0 0 0 4 17 24 23.5 70.8 0.107 0003928 RAB small monomeric GTPase F 4 17 23 23.5 73.9 4 17 23 23.5 73.9 0.107 0005871 kinesin C 4 17 38 23.5 44.7 4 17 38 23.5 44.7 0.107 0005506 iron binding F 2 10 12 20 83.3 3 13 17 23.1 76.5 0.054 0030234 enzyme regulator F 0 0 0 0 0 32 142 192 22.5 74 0.024 0004713 protein tyrosine kinase F 22 99 114 22.2 86.8 23 102 118 22.5 86.4 0.024 0016758 transferase, transferring hexosyl groups F 1 3 4 33.3 75 7 31 42 22.6 73.8 0.017 GO Gene Ontology r 0 0 0 0 0 1027 4574 6697 22.5 68.3 0 0005802 Golgi trans-face C 2 9 15 22.2 60 2 9 15 22.2 60 -0.017 0007266 RHO protein signal transduction P 2 9 11 22.2 81.8 2 9 11 22.2 81.8 -0.017 0009063 amino acid catabolism P 0 1 1 0 0 2 9 12 22.2 75 -0.017 0009165 nucleotide biosynthesis P 2 2 3 100 66.7 2 9 13 22.2 69.2 -0.017 0005539 glycosaminoglycan binding F 0 0 0 0 0 2 9 11 22.2 81.8 -0.017 0001508 action potential regulation P 1 2 2 50 100 2 9 11 22.2 81.8 -0.017 0015662 P-type ATPase F 0 3 4 0 0 2 9 11 22.2 81.8 -0.017 0003714 transcription co-repressor F 2 9 17 22.2 52.9 2 9 17 22.2 52.9 -0.017 0007265 RAS protein signal transduction P 2 9 12 22.2 75 2 9 12 22.2 75 -0.017 0008217 blood pressure regulation P 2 9 10 22.2 90 2 9 10 22.2 90 -0.017 0004869 cysteine protease inhibitor F 2 9 13 22.2 69.2 2 9 13 22.2 69.2 -0.017 0005977 glycogen metabolism P 1 6 10 16.7 60 2 9 14 22.2 64.3 -0.017 0004842 ubiquitin-protein ligase F 2 9 11 22.2 81.8 2 9 11 22.2 81.8 -0.017 0016879 ligase, forming carbon-nitrogen bonds F 0 0 0 0 0 4 18 24 22.2 75 -0.024 0016765 transferase, transferring alkyl or aryl (other than methyl) groups F 0 0 0 0 0 4 18 21 22.2 85.7 -0.024 0016766 transferring alkyl or aryl groups, other than methyl groups F 0 0 0 0 0 4 18 21 22.2 85.7 -0.024 0006519 amino acid and derivative metabolism P 0 0 0 0 0 10 45 58 22.2 77.6 -0.037 0005578 extracellular matrix C 4 36 51 11.1 70.6 16 72 94 22.2 76.6 -0.047 0008202 steroid metabolism P 0 5 7 0 0 9 41 53 22 77.4 -0.077 0005575 cellular_component C 0 0 0 0 0 726 3238 4691 22.4 69 -0.08 0016836 hydro-lyase F 1 1 1 100 100 3 14 21 21.4 66.7 -0.092 0016229 steroid dehydrogenase F 0 0 1 0 0 3 14 16 21.4 87.5 -0.092 0005085 guanyl-nucleotide exchange factor F 3 11 15 27.3 73.3 3 14 18 21.4 77.8 -0.092 0016787 hydrolase F 1 16 23 6.2 69.6 128 574 821 22.3 69.9 -0.094 0015749 monosaccharide transport P 0 0 0 0 0 1 5 6 20 83.3 -0.132 0005351 sugar porter F 1 5 6 20 83.3 1 5 6 20 83.3 -0.132 0005514 calcium storage F 1 5 5 20 100 1 5 5 20 100 -0.132 0016638 oxidoreductase, acting on the CH-NH2 group of donors F 1 2 2 50 100 1 5 11 20 45.5 -0.132 0006093 anabolic carbohydrate metabolism P 0 0 0 0 0 1 5 7 20 71.4 -0.132 0006497 fatty acid:protein modification P 0 0 0 0 0 1 5 6 20 83.3 -0.132 0005558 minor histocompatibility antigen F 1 5 7 20 71.4 1 5 7 20 71.4 -0.132 0005381 iron transporter F 1 5 6 20 83.3 1 5 6 20 83.3 -0.132 0008513 organic cation porter F 0 0 0 0 0 1 5 6 20 83.3 -0.132 0005311 sodium:dicarboxylate/tricarboxylate cotransporter F 1 5 5 20 100 1 5 5 20 100 -0.132 0015354 polyspecific organic cation transporter F 0 0 0 0 0 1 5 5 20 100 -0.132 0004212 lysosomal cysteine-type endopeptidase F 0 0 0 0 0 1 5 7 20 71.4 -0.132 0003821 class II major histocompatibility complex antigen F 1 5 7 20 71.4 1 5 7 20 71.4 -0.132 0019203 carbohydrate phosphatase F 0 0 0 0 0 1 5 5 20 100 -0.132 0008645 hexose transport P 0 0 0 0 0 1 5 6 20 83.3 -0.132 0016883 other carbon-nitrogen ligase F 0 0 0 0 0 1 5 5 20 100 -0.132 0008443 phosphofructokinase F 0 0 0 0 0 1 5 5 20 100 -0.132 0016863 intramolecular isomerase, transposing C=C bonds F 0 0 0 0 0 1 5 5 20 100 -0.132 0004623 phospholipase A2 F 1 5 6 20 83.3 1 5 6 20 83.3 -0.132 0007015 actin filament organization P 1 5 8 20 62.5 1 5 8 20 62.5 -0.132 0005310 dicarboxylic acid transporter F 0 0 0 0 0 1 5 6 20 83.3 -0.132 0015142 tricarboxylic acid transporter F 0 0 0 0 0 1 5 5 20 100 -0.132 0015034 cytochrome P450 F 0 0 0 0 0 1 5 8 20 62.5 -0.132 0006094 gluconeogenesis P 1 5 7 20 71.4 1 5 7 20 71.4 -0.132 0006835 dicarboxylic acid transport P 1 5 6 20 83.3 1 5 6 20 83.3 -0.132 0015101 organic cation transporter F 0 0 0 0 0 1 5 6 20 83.3 -0.132 0015758 glucose transport P 1 5 6 20 83.3 1 5 6 20 83.3 -0.132 0016071 mRNA metabolism P 1 1 1 100 100 1 5 5 20 100 -0.132 0008530 exogenous peptide receptor F 0 0 0 0 0 1 5 7 20 71.4 -0.132 0016529 sarcoplasmic reticulum C 1 5 5 20 100 1 5 5 20 100 -0.132 0007249 NIK-I-kappaB/NF-kappaB cascade P 0 3 6 0 0 1 5 8 20 62.5 -0.132 0005069 transmembrane receptor protein tyrosine kinase docking protein F 0 1 1 0 0 1 5 9 20 55.6 -0.132 0003828 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase F 1 5 5 20 100 1 5 5 20 100 -0.132 0016528 sarcoplasm C 0 0 0 0 0 1 5 5 20 100 -0.132 0016327 apicolateral plasma membrane C 0 0 0 0 0 7 33 45 21.2 73.3 -0.171 0006508 proteolysis and peptidolysis P 20 126 155 15.9 81.3 37 169 215 21.9 78.6 -0.178 0004860 protein kinase inhibitor F 0 4 4 0 0 2 10 11 20 90.9 -0.186 0004926 non-G-protein coupled 7TM receptor F 0 0 0 0 0 2 10 12 20 83.3 -0.186 0005976 polysaccharide metabolism P 0 0 0 0 0 2 10 15 20 66.7 -0.186 0015171 amino acid transporter F 0 0 0 0 0 2 10 13 20 76.9 -0.186 0016881 acid-D-amino acid ligase F 0 0 0 0 0 2 10 16 20 62.5 -0.186 0030163 protein degradation P 1 2 3 50 66.7 37 170 217 21.8 78.3 -0.219 0006520 amino acid metabolism P 1 8 9 12.5 88.9 6 29 36 20.7 80.6 -0.228 0007156 homophilic cell adhesion P 3 15 22 20 68.2 3 15 22 20 68.2 -0.228 0005207 extracellular matrix glycoprotein F 3 15 16 20 93.8 3 15 16 20 93.8 -0.228 0009057 macromolecule catabolism P 0 0 0 0 0 37 171 219 21.6 78.1 -0.26 0007517 muscle development P 7 29 36 24.1 80.6 7 34 43 20.6 79.1 -0.262 0016042 lipid catabolism P 4 18 24 22.2 75 4 20 26 20 76.9 -0.263 0007218 neuropeptide signaling pathway P 4 20 27 20 74.1 4 20 27 20 74.1 -0.263 0005096 GTPase activator F 4 23 34 17.4 67.6 5 25 38 20 65.8 -0.295 0012501 programmed cell death P 0 0 0 0 0 22 104 134 21.2 77.6 -0.321 0006915 apoptosis P 17 88 109 19.3 80.7 22 104 134 21.2 77.6 -0.321 0006629 lipid metabolism P 4 15 19 26.7 78.9 27 127 167 21.3 76 -0.327 0003936 hydrogen-transporting two-sector ATPase F 2 10 14 20 71.4 2 11 16 18.2 68.8 -0.34 0015442 hydrogen-/sodium-translocating ATPase F 0 0 0 0 0 2 11 16 18.2 68.8 -0.34 0006112 metabolism of energy reserves P 0 2 2 0 0 2 11 16 18.2 68.8 -0.34 0016684 oxidoreductase, acting on peroxide as acceptor F 0 0 0 0 0 2 11 13 18.2 84.6 -0.34 0007602 phototransduction P 1 9 14 11.1 64.3 2 11 16 18.2 68.8 -0.34 0005923 tight junction C 2 11 15 18.2 73.3 2 11 15 18.2 73.3 -0.34 0006804 peroxidase reaction P 2 11 14 18.2 78.6 2 11 14 18.2 78.6 -0.34 0016830 carbon-carbon lyase F 0 0 0 0 0 2 11 18 18.2 61.1 -0.34 0004601 peroxidase F 0 6 6 0 0 2 11 12 18.2 91.7 -0.34 0005605 basement lamina C 2 10 10 20 100 2 11 11 18.2 100 -0.34 0019210 kinase inhibitor F 0 1 1 0 0 2 11 12 18.2 91.7 -0.34 0007420 brain development P 1 6 8 16.7 75 1 6 8 16.7 75 -0.34 0030141 secretory granule C 1 6 9 16.7 66.7 1 6 9 16.7 66.7 -0.34 0005753 proton-transporting ATP synthase complex C 1 6 9 16.7 66.7 1 6 9 16.7 66.7 -0.34 0005066 transmembrane receptor protein tyrosine kinase signaling protein F 0 2 5 0 0 1 6 14 16.7 42.9 -0.34 0015250 water channel F 1 6 9 16.7 66.7 1 6 9 16.7 66.7 -0.34 0003930 RAS small monomeric GTPase F 1 6 7 16.7 85.7 1 6 7 16.7 85.7 -0.34 0016303 phosphatidylinositol 3-kinase F 0 5 7 0 0 1 6 8 16.7 75 -0.34 0016813 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines F 0 0 0 0 0 1 6 7 16.7 85.7 -0.34 0042044 fluid transport P 0 0 0 0 0 1 6 9 16.7 66.7 -0.34 0030286 dynein C 0 0 0 0 0 1 6 8 16.7 75 -0.34 0016477 cell migration P 1 2 3 50 66.7 1 6 7 16.7 85.7 -0.34 0016932 glycosyltransferase F 1 6 6 16.7 100 1 6 6 16.7 100 -0.34 0008652 amino acid biosynthesis P 0 1 1 0 0 1 6 7 16.7 85.7 -0.34 0005978 glycogen biosynthesis P 1 6 7 16.7 85.7 1 6 7 16.7 85.7 -0.34 0006839 mitochondrial transport P 1 6 6 16.7 100 1 6 6 16.7 100 -0.34 0015711 organic anion transport P 0 0 0 0 0 1 6 7 16.7 85.7 -0.34 0006833 water transport P 1 6 9 16.7 66.7 1 6 9 16.7 66.7 -0.34 0006691 leukotriene metabolism P 1 6 8 16.7 75 1 6 8 16.7 75 -0.34 0016831 carboxy-lyase F 0 2 3 0 0 1 6 10 16.7 60 -0.34 0008284 positive control of cell proliferation P 1 6 10 16.7 60 1 6 10 16.7 60 -0.34 0006803 glutathione conjugation reaction P 1 6 7 16.7 85.7 1 6 7 16.7 85.7 -0.34 0007005 mitochondrion organization and biogenesis P 0 0 1 0 0 1 6 7 16.7 85.7 -0.34 0006605 protein targeting P 1 4 6 25 66.7 13 63 75 20.6 84 -0.348 0008047 enzyme activator F 0 3 3 0 0 7 35 49 20 71.4 -0.349 0008014 calcium-dependent cell adhesion molecule F 3 16 21 18.8 76.2 3 16 21 18.8 76.2 -0.356 0008219 cell death P 0 2 2 0 0 22 105 135 21 77.8 -0.373 0008283 cell proliferation P 3 16 22 18.8 72.7 4 21 34 19 61.8 -0.375 0001503 ossification P 3 19 20 15.8 95 4 21 24 19 87.5 -0.375 0004721 protein phosphatase F 2 24 27 8.3 88.9 12 59 79 20.3 74.7 -0.392 0016614 oxidoreductase, CH-OH group of donors F 0 0 0 0 0 9 45 51 20 88.2 -0.396 0016791 phosphoric monoester hydrolase F 0 0 0 0 0 16 78 104 20.5 75 -0.414 0006357 transcription regulation, from Pol II promoter P 2 13 27 15.4 48.1 3 17 38 17.6 44.7 -0.476 0005604 basement membrane C 3 16 18 18.8 88.9 3 17 19 17.6 89.5 -0.476 0016860 intramolecular isomerase F 0 0 0 0 0 2 12 13 16.7 92.3 -0.481 0006310 DNA recombination P 2 12 12 16.7 100 2 12 13 16.7 92.3 -0.481 0009653 morphogenesis P 0 3 3 0 0 2 12 15 16.7 80 -0.481 0016790 thiolester hydrolase F 0 0 0 0 0 2 12 24 16.7 50 -0.481 0016788 hydrolase, acting on ester bonds F 2 3 3 66.7 100 34 163 239 20.9 68.2 -0.497 0007272 ionic insulation of neurons by glial cells P 1 7 9 14.3 77.8 1 7 9 14.3 77.8 -0.518 0004005 plasma membrane cation-transporting ATPase F 1 7 14 14.3 50 1 7 14 14.3 50 -0.518 0006693 prostaglandin metabolism P 1 7 8 14.3 87.5 1 7 8 14.3 87.5 -0.518 0009072 aromatic amino acid family metabolism P 1 3 3 33.3 100 1 7 8 14.3 87.5 -0.518 0007411 axon guidance P 1 6 10 16.7 60 1 7 11 14.3 63.6 -0.518 0004293 tissue kallikrein F 1 7 12 14.3 58.3 1 7 12 14.3 58.3 -0.518 0015563 uptake permease F 0 0 0 0 0 1 7 14 14.3 50 -0.518 0015144 carbohydrate transporter F 0 0 0 0 0 1 7 9 14.3 77.8 -0.518 0006692 prostanoid metabolism P 0 0 0 0 0 1 7 8 14.3 87.5 -0.518 0004759 serine esterase F 1 7 10 14.3 70 1 7 10 14.3 70 -0.518 0008483 transaminase F 0 4 4 0 0 1 7 9 14.3 77.8 -0.518 0015646 permease F 0 0 0 0 0 1 7 14 14.3 50 -0.518 0003823 antibody F 1 7 44 14.3 15.9 1 7 44 14.3 15.9 -0.518 0004892 B-cell receptor F 0 0 0 0 0 1 7 44 14.3 15.9 -0.518 0019829 cation-transporting ATPase F 0 0 0 0 0 1 7 14 14.3 50 -0.518 0004198 calpain F 1 7 8 14.3 87.5 1 7 8 14.3 87.5 -0.518 0004707 MAP kinase F 1 7 9 14.3 77.8 1 7 9 14.3 77.8 -0.518 0004683 calmodulin regulated protein kinase F 0 1 2 0 0 1 7 8 14.3 87.5 -0.518 0008037 cell recognition P 0 0 0 0 0 1 7 11 14.3 63.6 -0.518 0006289 nucleotide-excision repair P 1 7 7 14.3 100 1 7 8 14.3 87.5 -0.518 0015406 ABC-type uptake permease F 0 0 0 0 0 1 7 14 14.3 50 -0.518 0004089 carbonate dehydratase F 1 7 11 14.3 63.6 1 7 11 14.3 63.6 -0.518 0016769 transferase, transferring nitrogenous groups F 0 0 0 0 0 1 7 9 14.3 77.8 -0.518 0016265 death P 0 0 0 0 0 22 108 138 20.4 78.3 -0.525 0016616 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor F 0 0 0 0 0 8 42 47 19 89.4 -0.531 0005496 steroid binding F 3 14 16 21.4 87.5 3 18 20 16.7 90 -0.589 0005509 calcium binding F 40 194 266 20.6 72.9 41 198 271 20.7 73.1 -0.602 0006470 protein amino acid dephosphorylation P 8 43 50 18.6 86 8 43 50 18.6 86 -0.608 0016311 dephosphorylation P 0 0 0 0 0 8 43 50 18.6 86 -0.608 0006690 eicosanoid metabolism P 0 0 0 0 0 2 13 16 15.4 81.2 -0.612 0015934 large ribosomal subunit C 0 0 0 0 0 2 13 16 15.4 81.2 -0.612 0000315 organellar large ribosomal subunit C 0 0 0 0 0 2 13 16 15.4 81.2 -0.612 0005762 mitochondrial large ribosomal subunit C 2 13 16 15.4 81.2 2 13 16 15.4 81.2 -0.612 0016298 lipase F 0 1 1 0 0 2 13 17 15.4 76.5 -0.612 0008514 organic anion transporter F 0 2 3 0 0 1 8 11 12.5 72.7 -0.675 0042127 regulation of cell proliferation P 0 0 0 0 0 1 8 15 12.5 53.3 -0.675 0015203 polyamine transporter F 0 0 0 0 0 1 8 9 12.5 88.9 -0.675 0005752 cytochrome c oxidase C 1 8 16 12.5 50 1 8 16 12.5 50 -0.675 0016563 transcriptional activator F 1 8 13 12.5 61.5 1 8 13 12.5 61.5 -0.675 0016675 oxidoreductase, acting on heme group of donors F 0 0 0 0 0 1 8 16 12.5 50 -0.675 0004129 cytochrome c oxidase F 1 8 16 12.5 50 1 8 16 12.5 50 -0.675 0015002 heme-copper terminal oxidase F 0 0 0 0 0 1 8 16 12.5 50 -0.675 0005279 amino acid-polyamine transporter F 1 8 9 12.5 88.9 1 8 9 12.5 88.9 -0.675 0005751 respiratory chain complex IV C 0 0 0 0 0 1 8 16 12.5 50 -0.675 0016676 oxidoreductase, acting on heme group of donors, oxygen as acceptor F 0 0 0 0 0 1 8 16 12.5 50 -0.675 0016702 oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen F 0 0 0 0 0 1 8 10 12.5 80 -0.675 0004221 ubiquitin C-terminal hydrolase F 1 8 14 12.5 57.1 1 8 14 12.5 57.1 -0.675 0006099 tricarboxylic acid cycle P 1 8 10 12.5 80 1 8 10 12.5 80 -0.675 0016798 hydrolase, acting on glycosyl bonds F 0 0 0 0 0 4 24 32 16.7 75 -0.681 0016302 phosphatase F 0 5 5 0 0 16 83 108 19.3 76.9 -0.7 0005654 nucleoplasm C 2 4 7 50 57.1 52 252 329 20.6 76.6 -0.711 0006958 complement activation, classical pathway P 2 14 14 14.3 100 2 14 14 14.3 100 -0.733 0006816 calcium ion transport P 2 14 18 14.3 77.8 2 14 18 14.3 77.8 -0.733 0005740 mitochondrial membrane C 2 5 7 40 71.4 7 40 72 17.5 55.6 -0.754 0005875 microtubule associated protein C 3 21 26 14.3 80.8 6 35 60 17.1 58.3 -0.756 0006631 fatty acid metabolism P 1 16 19 6.2 84.2 5 30 41 16.7 73.2 -0.762 0008270 zinc binding F 5 30 40 16.7 75 5 30 40 16.7 75 -0.762 0007596 blood coagulation P 4 25 28 16 89.3 4 25 28 16 89.3 -0.775 0007243 protein kinase cascade P 1 6 6 16.7 100 3 20 33 15 60.6 -0.8 0008138 protein tyrosine/serine/threonine phosphatase F 1 9 10 11.1 90 1 9 10 11.1 90 -0.816 0008133 collagenase F 0 8 11 0 0 1 9 12 11.1 75 -0.816 0004620 phospholipase F 1 1 1 100 100 1 9 13 11.1 69.2 -0.816 0006865 amino acid transport P 1 9 9 11.1 100 1 9 10 11.1 90 -0.816 0005189 milk protein F 1 9 9 11.1 100 1 9 9 11.1 100 -0.816 0005275 amine/polyamine transporter F 0 0 0 0 0 1 9 11 11.1 81.8 -0.816 0007498 mesoderm development P 2 2 4 100 50 17 90 111 18.9 81.1 -0.818 0015291 porter F 0 0 0 0 0 7 41 56 17.1 73.2 -0.829 0005743 mitochondrial inner membrane C 3 13 16 23.1 81.2 6 36 60 16.7 60 -0.835 0019866 inner membrane C 0 0 0 0 0 6 36 60 16.7 60 -0.835 0008324 cation transporter F 1 3 4 33.3 75 6 36 61 16.7 59 -0.835 0009314 radiation response P 0 0 0 0 0 2 15 21 13.3 71.4 -0.848 0009416 light response P 0 0 0 0 0 2 15 21 13.3 71.4 -0.848 0006897 endocytosis P 0 11 17 0 0 2 15 24 13.3 62.5 -0.848 0009583 perception of light P 0 0 0 0 0 2 15 21 13.3 71.4 -0.848 0015078 hydrogen ion transporter F 0 0 0 0 0 2 15 33 13.3 45.5 -0.848 0015077 monovalent inorganic cation transporter F 0 0 1 0 0 2 15 34 13.3 44.1 -0.848 0005615 extracellular space C 2 15 19 13.3 78.9 2 15 19 13.3 78.9 -0.848 0007599 hemostasis P 0 1 2 0 0 4 26 29 15.4 89.7 -0.866 0006350 transcription P 5 12 15 41.7 80 119 566 743 21 76.2 -0.87 0006800 oxygen and radical metabolism P 1 1 1 100 100 3 21 25 14.3 84 -0.899 0015290 electrochemical potential-driven transporter F 0 1 1 0 0 7 42 57 16.7 73.7 -0.903 0007242 intracellular signaling cascade P 18 123 142 14.6 86.6 45 226 282 19.9 80.1 -0.939 0006576 biogenic amine metabolism P 0 0 0 0 0 1 10 15 10 66.7 -0.945 0006814 sodium transport P 1 10 16 10 62.5 1 10 16 10 62.5 -0.945 0008509 anion transporter F 0 0 1 0 0 1 10 16 10 62.5 -0.945 0004364 glutathione transferase F 1 10 13 10 76.9 1 10 13 10 76.9 -0.945 0005181 glycopeptide hormone F 1 10 10 10 100 1 10 10 10 100 -0.945 0005044 scavenger receptor F 1 10 16 10 62.5 1 10 16 10 62.5 -0.945 0016023 cytoplasmic vesicle C 1 5 9 20 55.6 4 27 45 14.8 60 -0.954 0008246 electron transfer flavoprotein F 2 16 19 12.5 84.2 2 16 19 12.5 84.2 -0.956 0003702 RNA polymerase II transcription factor F 3 7 12 42.9 58.3 8 49 60 16.3 81.7 -1.033 0008233 peptidase F 14 43 52 32.6 82.7 41 210 308 19.5 68.2 -1.041 0045111 intermediate filament cytoskeleton C 0 0 0 0 0 7 44 55 15.9 80 -1.045 0005882 intermediate filament C 7 44 55 15.9 80 7 44 55 15.9 80 -1.045 0030135 coated vesicle C 0 0 0 0 0 2 17 27 11.8 63 -1.058 0007417 central nervous system development P 0 6 8 0 0 1 11 15 9.1 73.3 -1.063 0003795 antimicrobial peptide F 1 9 22 11.1 40.9 1 11 24 9.1 45.8 -1.063 0008021 synaptic vesicle C 1 11 18 9.1 61.1 1 11 18 9.1 61.1 -1.063 0005505 heavy metal binding F 2 12 14 16.7 85.7 10 60 81 16.7 74.1 -1.081 0006351 transcription, DNA-dependent P 1 1 3 100 33.3 115 558 732 20.6 76.2 -1.114 0016701 oxidoreductase, acting on single donors with incorporation of molecular oxygen F 0 0 0 0 0 4 29 38 13.8 76.3 -1.121 0000313 organellar ribosome C 0 0 0 0 0 2 18 27 11.1 66.7 -1.155 0004553 hydrolase, hydrolyzing O-glycosyl compounds F 0 3 5 0 0 2 18 26 11.1 69.2 -1.155 0005761 mitochondrial ribosome C 0 0 4 0 0 2 18 27 11.1 66.7 -1.155 0016051 carbohydrate biosynthesis P 1 1 1 100 100 2 18 24 11.1 75 -1.155 0015933 flavin-containing electron transporter F 0 0 0 0 0 2 18 22 11.1 81.8 -1.155 0006355 transcription regulation P 109 539 686 20.2 78.6 113 551 719 20.5 76.6 -1.166 0001501 skeletal development P 4 20 22 20 90.9 6 41 47 14.6 87.2 -1.205 0008237 metallopeptidase F 3 31 46 9.7 67.4 8 52 74 15.4 70.3 -1.228 0015405 P-P-bond-hydrolyzis-driven transporter F 0 0 0 0 0 8 52 78 15.4 66.7 -1.228 0006620 post-translational membrane targeting P 7 47 55 14.9 85.5 7 47 55 14.9 85.5 -1.248 0006612 protein-membrane targeting P 0 0 0 0 0 7 47 56 14.9 83.9 -1.248 0005489 electron transporter F 0 5 5 0 0 3 25 30 12 83.3 -1.256 0006953 acute-phase response P 1 13 13 7.7 100 1 13 13 7.7 100 -1.277 0004725 protein tyrosine phosphatase F 5 37 47 13.5 78.7 5 37 47 13.5 78.7 -1.308 0006956 complement activation P 1 15 16 6.7 93.8 2 20 23 10 87 -1.337 0015075 ion transporter F 0 0 0 0 0 6 43 79 14 54.4 -1.342 0003801 blood coagulation factor F 1 10 10 10 100 1 14 14 7.1 100 -1.375 0004970 ionotropic glutamate receptor F 1 12 12 8.3 100 1 14 15 7.1 93.3 -1.375 0005234 glutamate-gated ion channel F 1 10 10 10 100 1 14 15 7.1 93.3 -1.375 0007606 chemosensory perception P 0 0 24 0 0 1 14 90 7.1 15.6 -1.375 0015293 symporter F 0 0 0 0 0 1 14 21 7.1 66.7 -1.375 0015256 monocarboxylate channel F 0 0 0 0 0 1 14 15 7.1 93.3 -1.375 0005746 mitochondrial electron transport chain complex C 0 4 7 0 0 1 14 32 7.1 43.8 -1.375 0030136 clathrin-coated vesicle C 0 0 0 0 0 1 14 24 7.1 58.3 -1.375 0015259 glutamate channel F 0 0 0 0 0 1 14 15 7.1 93.3 -1.375 0009593 perception of chemical substance P 0 0 0 0 0 1 14 90 7.1 15.6 -1.375 0003674 molecular_function F 0 0 0 0 0 885 3999 5846 22.1 68.4 -1.378 0003707 steroid hormone receptor F 5 38 42 13.2 90.5 5 38 42 13.2 90.5 -1.379 0004879 ligand-dependent nuclear receptor F 4 28 32 14.3 87.5 5 38 42 13.2 90.5 -1.379 0003706 ligand-regulated transcription factor F 0 0 0 0 0 5 38 42 13.2 90.5 -1.379 0004222 metalloendopeptidase F 5 40 55 12.5 72.7 6 44 61 13.6 72.1 -1.408 0005254 chloride channel F 0 0 0 0 0 3 27 38 11.1 71.1 -1.416 0016064 humoral defense mechanism (sensu Vertebrata) P 0 1 1 0 0 2 21 24 9.5 87.5 -1.423 0005180 peptide hormone F 4 23 27 17.4 85.2 5 39 47 12.8 83 -1.448 0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway P 1 15 20 6.7 75 1 15 20 6.7 75 -1.467 0007515 lymph gland development P 1 15 17 6.7 88.2 1 15 17 6.7 88.2 -1.467 0007422 peripheral nervous system development P 1 3 3 33.3 100 1 15 20 6.7 75 -1.467 0004175 endopeptidase F 1 4 5 25 80 6 45 63 13.3 71.4 -1.473 0016491 oxidoreductase F 3 38 42 7.9 90.5 26 149 207 17.4 72 -1.488 0005253 anion channel F 0 0 0 0 0 3 28 41 10.7 68.3 -1.493 0008083 growth factor F 3 25 30 12 83.3 3 28 34 10.7 82.4 -1.493 0005759 mitochondrial matrix C 0 3 4 0 0 2 22 33 9.1 66.7 -1.505 0004950 chemokine receptor F 1 13 14 7.7 92.9 1 16 18 6.2 88.9 -1.556 0008066 glutamate receptor F 0 0 0 0 0 1 16 21 6.2 76.2 -1.556 0001637 G-protein chemoattractant receptor F 0 0 0 0 0 1 16 18 6.2 88.9 -1.556 0019956 chemokine binding F 0 0 0 0 0 1 16 18 6.2 88.9 -1.556 0003811 complement component F 1 14 16 7.1 87.5 1 16 19 6.2 84.2 -1.556 0008081 phosphodiesterase F 1 1 2 100 50 1 16 29 6.2 55.2 -1.556 0005911 intercellular junction C 0 1 2 0 0 3 29 39 10.3 74.4 -1.567 0006928 cell motility P 2 2 4 100 50 10 69 89 14.5 77.5 -1.597 0015399 primary active transporter F 0 0 0 0 0 9 64 107 14.1 59.8 -1.62 0004868 serpin F 3 30 36 10 83.3 3 30 36 10 83.3 -1.64 0003819 major histocompatibility complex antigen F 3 30 54 10 55.6 3 30 54 10 55.6 -1.64 0005162 fibroblast growth factor receptor ligand F 1 17 18 5.9 94.4 1 17 18 5.9 94.4 -1.64 0005262 calcium channel F 1 17 26 5.9 65.4 1 17 26 5.9 65.4 -1.64 0016792 phosphoric diester hydrolase F 0 0 0 0 0 1 18 32 5.6 56.2 -1.721 0005231 excitatory extracellular ligand-gated ion channel F 0 0 0 0 0 1 18 21 5.6 85.7 -1.721 0008009 chemokine F 2 25 32 8 78.1 2 25 32 8 78.1 -1.736 0009582 perception of abiotic stimulus P 0 0 0 0 0 3 32 117 9.4 27.4 -1.779 0016055 Wnt receptor signaling pathway P 0 2 4 0 0 1 19 24 5.3 79.2 -1.799 0004857 enzyme inhibitor F 0 2 3 0 0 12 84 108 14.3 77.8 -1.81 0005319 lipid transporter F 0 16 21 0 0 1 20 27 5 74.1 -1.874 0015276 ligand-gated ion channel F 0 0 0 0 0 5 46 58 10.9 79.3 -1.892 0005667 transcription factor complex C 40 234 303 17.1 77.2 41 236 306 17.4 77.1 -1.92 0004890 GABA-A receptor F 1 21 26 4.8 80.8 1 21 26 4.8 80.8 -1.947 0006805 xenobiotic metabolism P 1 18 33 5.6 54.5 1 21 36 4.8 58.3 -1.947 0005237 inhibitory extracellular ligand-gated ion channel F 0 0 0 0 0 1 21 26 4.8 80.8 -1.947 0005249 voltage-sensitive potassium channel F 1 10 12 10 83.3 1 21 25 4.8 84 -1.947 0016917 GABA receptor F 0 0 0 0 0 1 21 26 4.8 80.8 -1.947 0006118 electron transport P 12 87 106 13.8 82.1 12 87 113 13.8 77 -1.954 0006812 cation transport P 4 38 51 10.5 74.5 14 98 135 14.3 72.6 -1.959 0019932 second-messenger-mediated signaling P 0 0 0 0 0 2 29 42 6.9 69 -2.014 0016820 hydrolase, acting on acid anhydrides, - catalysing transmembrane movement of substances F 0 0 0 0 0 4 42 67 9.5 62.7 -2.017 0042165 neurotransmitter binding F 0 0 0 0 0 1 22 29 4.5 75.9 -2.018 0030594 neurotransmitter receptor F 0 0 0 0 0 1 22 29 4.5 75.9 -2.018 0004009 ATP-binding cassette (ABC) transporter F 1 22 35 4.5 62.9 2 30 50 6.7 60 -2.079 0006959 humoral immune response P 1 16 55 6.2 29.1 3 37 79 8.1 46.8 -2.099 0009628 response to abiotic stimulus P 0 0 0 0 0 10 79 192 12.7 41.1 -2.104 0004867 serine protease inhibitor F 3 45 56 6.7 80.4 5 50 65 10 76.9 -2.122 0008528 peptide receptor, G-protein coupled F 0 2 3 0 0 2 31 35 6.5 88.6 -2.142 0007600 sensory perception P 0 2 4 0 0 2 32 116 6.2 27.6 -2.204 0005386 carrier F 7 46 53 15.2 86.8 19 131 196 14.5 66.8 -2.212 0009410 xenobiotic response P 0 0 0 0 0 1 25 43 4 58.1 -2.217 0004497 monooxygenase F 5 51 74 9.8 68.9 5 52 75 9.6 69.3 -2.231 0009581 perception of external stimulus P 0 0 0 0 0 10 82 197 12.2 41.6 -2.246 0030414 protease inhibitor F 0 0 0 0 0 7 65 86 10.8 75.6 -2.273 0004866 endopeptidase inhibitor F 0 9 11 0 0 7 65 86 10.8 75.6 -2.273 0007389 pattern specification P 3 40 49 7.5 81.6 3 40 49 7.5 81.6 -2.276 0030001 metal ion transport P 0 0 0 0 0 9 77 100 11.7 77 -2.283 0005179 hormone F 2 25 29 8 86.2 5 53 62 9.4 85.5 -2.284 0007398 ectoderm development P 0 0 0 0 0 9 78 110 11.5 70.9 -2.33 0015672 monovalent inorganic cation transport P 0 0 1 0 0 7 67 88 10.4 76.1 -2.372 0006820 anion transport P 1 7 9 14.3 77.8 2 35 49 5.7 71.4 -2.382 0006813 potassium transport P 4 49 60 8.2 81.7 4 49 60 8.2 81.7 -2.41 0005777 peroxisome C 1 29 42 3.4 69 1 29 42 3.4 69 -2.46 0019955 cytokine binding F 0 1 1 0 0 2 37 43 5.4 86 -2.495 0004263 chymotrypsin F 3 44 51 6.8 86.3 3 44 51 6.8 86.3 -2.497 0019226 transmission of nerve impulse P 0 0 0 0 0 6 64 84 9.4 76.2 -2.525 0030528 transcription regulator F 0 0 2 0 0 71 407 544 17.4 74.8 -2.537 0003793 defense/immunity protein F 2 13 27 15.4 48.1 5 58 114 8.6 50.9 -2.54 0005267 potassium channel F 3 44 55 6.8 80 3 45 56 6.7 80.4 -2.55 0004896 hematopoeitin/interferon-class (D200-domain) cytokine receptor F 1 28 29 3.6 96.6 2 38 42 5.3 90.5 -2.55 0006810 transport P 22 159 193 13.8 82.4 83 468 627 17.7 74.6 -2.581 0005557 lymphocyte antigen F 5 59 64 8.5 92.2 5 59 64 8.5 92.2 -2.59 0005792 microsome C 3 46 55 6.5 83.6 3 46 55 6.5 83.6 -2.602 0005230 extracellular ligand-gated ion channel F 1 21 25 4.8 84 2 39 47 5.1 83 -2.604 0007275 developmental processes P 10 80 98 12.5 81.6 60 355 471 16.9 75.4 -2.61 0007399 neurogenesis P 2 41 54 4.9 75.9 7 74 105 9.5 70.5 -2.7 0005529 sugar binding F 2 34 40 5.9 85 2 41 60 4.9 68.3 -2.709 0030246 carbohydrate binding F 0 0 0 0 0 2 41 60 4.9 68.3 -2.709 0007268 synaptic transmission P 3 51 64 5.9 79.7 4 55 73 7.3 75.3 -2.714 0004295 trypsin F 3 49 58 6.1 84.5 3 49 58 6.1 84.5 -2.754 0006935 chemotaxis P 2 42 50 4.8 84 2 42 50 4.8 84 -2.76 0004252 serine-type endopeptidase F 8 77 114 10.4 67.5 8 82 120 9.8 68.3 -2.78 0000267 cell fraction C 0 0 0 0 0 7 76 107 9.2 71 -2.79 0005624 membrane fraction C 4 30 48 13.3 62.5 7 76 106 9.2 71.7 -2.79 0008236 serine-type peptidase F 1 4 8 25 50 8 84 123 9.5 68.3 -2.866 0003700 transcription factor F 59 369 474 16 77.8 64 386 507 16.6 76.1 -2.889 0007397 histogenesis and organogenesis P 9 90 110 10 81.8 33 229 301 14.4 76.1 -2.992 0008369 obsolete F 0 0 0 0 0 19 153 201 12.4 76.1 -3.025 0005244 voltage-gated ion channel F 1 39 55 2.6 70.9 1 41 57 2.4 71.9 -3.085 0001584 rhodopsin-like receptor F 0 0 0 0 0 2 49 107 4.1 45.8 -3.098 0005739 mitochondrion C 19 155 243 12.3 63.8 24 187 293 12.8 63.8 -3.218 0045087 innate immune response P 0 0 0 0 0 1 45 55 2.2 81.8 -3.268 0006954 inflammatory response P 1 44 54 2.3 81.5 1 45 55 2.2 81.8 -3.268 0006811 ion transport P 5 88 115 5.7 76.5 18 155 215 11.6 72.1 -3.29 0005576 extracellular C 17 162 213 10.5 76.1 34 245 321 13.9 76.3 -3.306 0007345 embryogenesis and morphogenesis P 4 34 46 11.8 73.9 37 263 349 14.1 75.4 -3.356 0006950 stress response P 1 6 13 16.7 46.2 14 134 236 10.4 56.8 -3.38 0005261 cation channel F 2 29 34 6.9 85.3 6 88 114 6.8 77.2 -3.549 0005125 cytokine F 9 98 118 9.2 83.1 13 134 163 9.7 82.2 -3.59 0007166 cell surface receptor linked signal transduction P 0 35 44 0 0 63 414 586 15.2 70.6 -3.699 0009611 response to wounding P 0 0 1 0 0 1 56 95 1.8 58.9 -3.729 0007267 cell-cell signaling P 0 30 35 0 0 6 94 119 6.4 79 -3.772 0007186 G-protein coupled receptor protein signaling pathway P 25 206 306 12.1 67.3 31 249 370 12.4 67.3 -3.89 0005216 ion channel F 7 112 148 6.2 75.7 10 128 174 7.8 73.6 -4.026 0009613 response to pest/pathogen/parasite P 0 0 1 0 0 5 97 179 5.2 54.2 -4.126 0007165 signal transduction P 18 146 182 12.3 80.2 110 688 922 16 74.6 -4.408 0015267 channel/pore class transporter F 0 0 0 0 0 11 148 200 7.4 74 -4.451 0015268 alpha-type channel F 0 0 0 0 0 11 148 200 7.4 74 -4.451 0012505 endomembrane system C 0 0 0 0 0 76 520 819 14.6 63.5 -4.549 0005102 ligand F 0 18 26 0 0 20 210 267 9.5 78.7 -4.596 0005215 transporter F 9 76 84 11.8 90.5 50 400 554 12.5 72.2 -4.993 0006955 immune response P 7 95 118 7.4 80.5 11 170 268 6.5 63.4 -5.089 0005887 integral plasma membrane protein C 19 244 412 7.8 59.2 25 271 449 9.2 60.4 -5.38 0004930 G-protein coupled receptor F 10 160 205 6.2 78 10 175 276 5.7 63.4 -5.411 0005886 plasma membrane C 18 162 242 11.1 66.9 61 489 775 12.5 63.1 -5.595 0004872 receptor F 7 42 73 16.7 57.5 50 449 694 11.1 64.7 -6.051 0004888 transmembrane receptor F 3 21 35 14.3 60 35 369 577 9.5 64 -6.226 0009607 response to biotic stimulus P 0 0 0 0 0 21 288 428 7.3 67.3 -6.369 0006952 defense response P 9 131 172 6.9 76.2 19 280 414 6.8 67.6 -6.484 0009605 response to external stimulus P 0 0 1 0 0 30 360 602 8.3 59.8 -6.688 0007154 cell communication P 0 18 19 0 0 173 1160 1631 14.9 71.1 -7.122 0004871 signal transducer F 10 74 98 13.5 75.5 94 779 1132 12.1 68.8 -7.626 0016020 membrane C 65 555 690 11.7 80.4 177 1234 1771 14.3 69.7 -7.988 0016021 integral membrane protein C 127 986 1245 12.9 79.2 136 1079 1479 12.6 73 -8.868