MAPPFinder 1.0 Results for the Gene Ontology File: C:\MAPPFinder Additional Files\FVBN Developmental Data from CardioGenomics.gex !date: Mon May 06 14:10:59 EDT 2002 Statistics: 3994 Genes met the ([Embryo fold] > 1.2 and [Embryo permute p] < 0.05) or ([Embryo fold] < -1.2 and [Embryo permute p] < 0.05) criteria. 1522 Genes did not link to a MGI term. 362 Genes did not link to a GO term. 3632 genes were used to calculate the results shown below. The z score is based on an N of 4574 and a R of 1931 distinct genes. GOID GO Name GO Type Number Changed Number Measured Number in GO Percent Changed Percent Present Number Changed in Hierarchy Number Measured in Hierarchy Number in GO Hierarchy Percent Changed in Hierarchy Percent Present in Hierarchy z Score 0005737 cytoplasm C 53 107 188 49.5 56.9 469 903 1291 51.9 69.9 6.601 0000278 mitotic cell cycle P 1 1 1 100 100 49 70 89 70 78.7 4.742 0006092 main pathways of carbohydrate metabolism P 0 0 0 0 0 31 39 50 79.5 78 4.732 0005739 mitochondrion C 92 155 243 59.4 63.8 110 187 293 58.8 63.8 4.694 0008152 metabolism P 49 89 102 55.1 87.3 831 1789 2348 46.5 76.2 4.646 0006371 mRNA splicing P 16 17 26 94.1 65.4 19 21 30 90.5 70 4.487 0008380 RNA splicing P 0 0 0 0 0 19 21 30 90.5 70 4.487 0007049 cell cycle P 56 90 107 62.2 84.1 134 240 291 55.8 82.5 4.387 0008151 cell growth and/or maintenance P 59 140 162 42.1 86.4 1172 2606 3511 45 74.2 4.343 0006095 catabolic carbohydrate metabolism P 0 0 0 0 0 28 36 45 77.8 80 4.337 0015980 energy derivation by oxidation of organic compounds P 0 0 0 0 0 36 50 66 72 75.8 4.287 0006091 energy pathways P 0 0 0 0 0 36 50 66 72 75.8 4.287 0006631 fatty acid metabolism P 13 16 19 81.2 84.2 24 30 41 80 73.2 4.203 0016070 RNA metabolism P 0 0 1 0 0 32 44 66 72.7 66.7 4.117 0006259 DNA metabolism P 5 7 9 71.4 77.8 80 135 163 59.3 82.8 4.069 0006396 RNA processing P 4 6 11 66.7 54.5 30 41 60 73.2 68.3 4.031 0019318 hexose metabolism P 0 0 0 0 0 30 41 49 73.2 83.7 4.031 0005996 monosaccharide metabolism P 0 0 0 0 0 30 41 49 73.2 83.7 4.031 0016043 cell organization and biogenesis P 0 0 0 0 0 115 207 294 55.6 70.4 3.976 0006397 mRNA processing P 12 14 20 85.7 70 25 33 45 75.8 73.3 3.915 0005681 spliceosome C 17 20 41 85 48.8 17 20 42 85 47.6 3.882 0000067 DNA replication and chromosome cycle P 0 0 0 0 0 34 49 62 69.4 79 3.871 0006412 protein biosynthesis P 55 90 110 61.1 81.8 63 104 152 60.6 68.4 3.834 0005829 cytosol C 13 27 41 48.1 65.9 53 85 112 62.4 75.9 3.794 0005622 intracellular C 111 236 285 47 82.8 1045 2326 3364 44.9 69.1 3.774 0006260 DNA replication P 26 37 42 70.3 88.1 32 46 55 69.6 83.6 3.774 0000084 S phase of mitotic cell cycle P 0 0 0 0 0 32 46 55 69.6 83.6 3.774 0005198 structural molecule F 18 36 47 50 76.6 121 223 278 54.3 80.2 3.733 0003735 structural constituent of ribosome F 51 83 101 61.4 82.2 51 83 101 61.4 82.2 3.579 0008092 cytoskeletal protein binding F 2 2 3 100 66.7 56 93 144 60.2 64.6 3.55 0006007 glucose catabolism P 0 0 0 0 0 21 28 34 75 82.4 3.523 0019320 hexose catabolism P 0 0 0 0 0 21 28 34 75 82.4 3.523 0016052 carbohydrate catabolism P 0 0 0 0 0 21 28 35 75 80 3.523 0003824 enzyme F 56 95 111 58.9 85.6 634 1375 1896 46.1 72.5 3.494 0015077 monovalent inorganic cation transporter F 0 0 1 0 0 13 15 34 86.7 44.1 3.491 0015078 hydrogen ion transporter F 0 0 0 0 0 13 15 33 86.7 45.5 3.491 0042175 nuclear envelope-endoplasmic reticulum network C 0 0 0 0 0 11 12 17 91.7 70.6 3.472 0005856 cytoskeleton C 65 108 142 60.2 76.1 119 223 306 53.4 72.9 3.455 0009059 macromolecule biosynthesis P 0 0 0 0 0 69 121 172 57 70.3 3.342 0006006 glucose metabolism P 4 8 8 50 100 25 36 42 69.4 85.7 3.32 0016740 transferase F 3 6 8 50 75 235 478 613 49.2 78 3.249 0006096 glycolysis P 16 23 28 69.6 82.1 19 26 32 73.1 81.2 3.195 0005830 cytosolic ribosome (sensu Eukarya) C 19 26 32 73.1 81.2 19 26 33 73.1 78.8 3.195 0004674 protein serine/threonine kinase F 78 153 205 51 74.6 97 181 243 53.6 74.5 3.161 0005840 ribosome C 33 48 56 68.8 85.7 43 71 93 60.6 76.3 3.154 0042254 ribosome biogenesis and assembly P 0 0 0 0 0 20 28 37 71.4 75.7 3.139 0007046 ribosome biogenesis P 20 27 33 74.1 81.8 20 28 37 71.4 75.7 3.139 0007028 cytoplasm organization and biogenesis P 1 1 2 100 50 91 169 241 53.8 70.1 3.119 0005912 adherens junction C 1 1 3 100 33.3 7 7 14 100 50 3.097 0003779 actin binding F 35 57 78 61.4 73.1 36 58 83 62.1 69.9 3.08 0009058 biosynthesis P 4 8 11 50 72.7 125 242 334 51.7 72.5 3.054 0005634 nucleus C 418 898 1211 46.5 74.2 442 949 1326 46.6 71.6 3.053 0003754 chaperone F 25 37 53 67.6 69.8 29 45 62 64.4 72.6 3.034 0016772 transferase, transferring phosphorus-containing groups F 1 3 5 33.3 60 171 342 431 50 79.4 3.029 0019866 inner membrane C 0 0 0 0 0 24 36 60 66.7 60 2.982 0005743 mitochondrial inner membrane C 7 13 16 53.8 81.2 24 36 60 66.7 60 2.982 0005694 chromosome C 1 1 1 100 100 24 36 55 66.7 65.5 2.982 0005740 mitochondrial membrane C 3 5 7 60 71.4 26 40 72 65 55.6 2.93 0006457 protein folding P 16 22 31 72.7 71 16 22 31 72.7 71 2.904 0015035 protein disulfide oxidoreductase F 6 6 6 100 100 6 6 6 100 100 2.867 0004693 cyclin-dependent protein kinase F 5 7 10 71.4 70 17 24 33 70.8 72.7 2.846 0005789 endoplasmic reticulum membrane C 6 7 11 85.7 63.6 8 9 13 88.9 69.2 2.837 0006629 lipid metabolism P 10 15 19 66.7 78.9 69 127 167 54.3 76 2.803 0004298 threonine endopeptidase F 0 0 0 0 0 14 19 19 73.7 100 2.783 0004299 proteasome endopeptidase F 14 19 19 73.7 100 14 19 19 73.7 100 2.783 0005746 mitochondrial electron transport chain complex C 2 4 7 50 57.1 11 14 32 78.6 43.8 2.758 0003723 RNA binding F 54 94 121 57.4 77.7 62 113 155 54.9 72.9 2.757 0017076 purine nucleotide binding F 0 0 0 0 0 290 613 877 47.3 69.9 2.742 0005975 carbohydrate metabolism P 15 32 49 46.9 65.3 53 95 135 55.8 70.4 2.706 0000166 nucleotide binding F 10 21 26 47.6 80.8 290 614 878 47.2 69.9 2.703 0016853 isomerase F 0 0 0 0 0 21 32 42 65.6 76.2 2.69 0019205 nucleobase, nucleoside, nucleotide kinase F 0 0 0 0 0 12 16 19 75 84.2 2.659 0006323 DNA packaging P 7 9 11 77.8 81.8 23 36 46 63.9 78.3 2.643 0008324 cation transporter F 1 3 4 33.3 75 23 36 61 63.9 59 2.643 0006997 nuclear organization and biogenesis P 1 1 2 100 50 24 38 53 63.2 71.7 2.624 0005751 respiratory chain complex IV C 0 0 0 0 0 7 8 16 87.5 50 2.595 0015002 heme-copper terminal oxidase F 0 0 0 0 0 7 8 16 87.5 50 2.595 0004129 cytochrome c oxidase F 7 8 16 87.5 50 7 8 16 87.5 50 2.595 0006376 mRNA splice site selection P 7 8 8 87.5 100 7 8 8 87.5 100 2.595 0008248 pre-mRNA splicing factor F 7 8 12 87.5 66.7 7 8 12 87.5 66.7 2.595 0016675 oxidoreductase, acting on heme group of donors F 0 0 0 0 0 7 8 16 87.5 50 2.595 0005752 cytochrome c oxidase C 7 8 16 87.5 50 7 8 16 87.5 50 2.595 0016676 oxidoreductase, acting on heme group of donors, oxygen as acceptor F 0 0 0 0 0 7 8 16 87.5 50 2.595 0006099 tricarboxylic acid cycle P 7 8 10 87.5 80 7 8 10 87.5 80 2.595 0015036 disulfide oxidoreductase F 1 2 3 50 66.7 7 8 9 87.5 88.9 2.595 0006261 DNA dependent DNA replication P 0 0 1 0 0 13 18 22 72.2 81.8 2.582 0000087 M phase of mitotic cell cycle P 1 3 3 33.3 100 13 18 24 72.2 75 2.582 0007067 mitosis P 13 18 23 72.2 78.3 13 18 24 72.2 75 2.582 0006936 muscle contraction P 3 4 7 75 57.1 14 20 28 70 71.4 2.521 0016779 nucleotidyltransferase F 1 1 1 100 100 21 33 41 63.6 80.5 2.5 0019887 protein kinase regulator F 0 0 0 0 0 15 22 30 68.2 73.3 2.471 0005837 26S proteasome C 1 2 3 50 66.7 15 22 23 68.2 95.7 2.471 0007001 chromosome organization and biogenesis (sensu Eukarya) P 12 20 27 60 74.1 23 37 51 62.2 72.5 2.466 0016776 phosphotransferase, phosphate group as acceptor F 0 0 0 0 0 8 10 13 80 76.9 2.421 0003931 RHO small monomeric GTPase F 8 10 10 80 100 8 10 10 80 100 2.421 0016538 cyclin-dependent protein kinase, regulator F 12 17 24 70.6 70.8 12 17 24 70.6 70.8 2.373 0000122 repression of transcription, from Pol II promoter P 4 4 11 100 36.4 4 4 11 100 36.4 2.341 0030055 cell-matrix junction C 0 0 0 0 0 4 4 6 100 66.7 2.341 0005925 focal adhesion C 4 4 6 100 66.7 4 4 6 100 66.7 2.341 0016289 CoA hydrolase F 0 0 0 0 0 4 4 8 100 50 2.341 0006637 acyl-CoA metabolism P 4 4 8 100 50 4 4 8 100 50 2.341 0005924 cell-substrate adherens junction C 0 0 0 0 0 4 4 6 100 66.7 2.341 0016585 chromatin remodeling complex C 2 2 2 100 100 4 4 6 100 66.7 2.341 0016801 hydrolase, acting on ether bonds F 0 0 0 0 0 4 4 4 100 100 2.341 0005815 microtubule organizing center C 0 0 0 0 0 6 7 8 85.7 87.5 2.332 0006270 DNA replication initiation P 6 7 7 85.7 100 6 7 7 85.7 100 2.332 0005839 20S core proteasome C 12 17 17 70.6 100 13 19 19 68.4 100 2.317 0016773 phosphotransferase, alcohol group as acceptor F 0 0 0 0 0 148 305 386 48.5 79 2.308 0016482 cytoplasmic transport P 0 0 0 0 0 9 12 17 75 70.6 2.302 0006913 nucleocytoplasmic transport P 2 3 6 66.7 50 9 12 17 75 70.6 2.302 0016859 cis-trans isomerase F 0 0 0 0 0 9 12 16 75 75 2.302 0003755 peptidylprolyl cis-trans isomerase F 9 12 16 75 75 9 12 16 75 75 2.302 0015399 primary active transporter F 0 0 0 0 0 36 64 107 56.2 59.8 2.289 0015629 actin cytoskeleton C 11 17 23 64.7 73.9 27 46 63 58.7 73 2.274 0008283 cell proliferation P 11 16 22 68.8 72.7 14 21 34 66.7 61.8 2.273 0000280 nuclear division P 0 0 0 0 0 14 21 30 66.7 70 2.273 0016301 kinase F 3 6 11 50 54.5 150 311 394 48.2 78.9 2.224 0016049 cell growth P 3 3 4 100 75 10 14 19 71.4 73.7 2.216 0003729 mRNA binding F 1 2 2 50 100 10 14 19 71.4 73.7 2.216 0030554 adenyl nucleotide binding F 0 0 0 0 0 217 462 663 47 69.7 2.181 0005524 ATP binding F 210 446 635 47.1 70.2 217 462 663 47 69.7 2.181 0005777 peroxisome C 18 29 42 62.1 69 18 29 42 62.1 69 2.171 0015662 P-type ATPase F 2 3 4 66.7 75 7 9 11 77.8 81.8 2.162 0016407 acetyltransferase F 1 3 3 33.3 100 7 9 14 77.8 64.3 2.162 0006606 protein-nucleus import P 5 7 8 71.4 87.5 7 9 10 77.8 90 2.162 0006414 protein synthesis elongation P 7 9 37 77.8 24.3 7 9 37 77.8 24.3 2.162 0005525 GTP binding F 60 123 175 48.8 70.3 72 141 201 51.1 70.1 2.16 0005200 structural constituent of cytoskeleton F 35 63 79 55.6 79.7 35 63 79 55.6 79.7 2.158 0019207 kinase regulator F 0 0 0 0 0 20 33 42 60.6 78.6 2.146 0015075 ion transporter F 0 0 0 0 0 25 43 79 58.1 54.4 2.124 0030484 muscle fiber C 0 0 0 0 0 8 11 16 72.7 68.8 2.051 0030016 myofibril C 0 0 0 0 0 8 11 15 72.7 73.3 2.051 0030017 sarcomere C 0 0 0 0 0 8 11 15 72.7 73.3 2.051 0006220 pyrimidine nucleotide metabolism P 0 0 0 0 0 5 6 7 83.3 85.7 2.04 0006595 polyamine metabolism P 2 3 4 66.7 75 5 6 8 83.3 75 2.04 0005813 centrosome C 5 5 6 100 83.3 5 6 7 83.3 85.7 2.04 0005884 actin filament C 5 6 7 83.3 85.7 5 6 7 83.3 85.7 2.04 0019201 nucleotide kinase F 0 0 0 0 0 5 6 8 83.3 75 2.04 0009129 pyrimidine nucleoside monophosphate metabolism P 0 0 0 0 0 5 6 7 83.3 85.7 2.04 0008284 positive control of cell proliferation P 5 6 10 83.3 60 5 6 10 83.3 60 2.04 0006803 glutathione conjugation reaction P 5 6 7 83.3 85.7 5 6 7 83.3 85.7 2.04 0019748 secondary metabolism P 0 0 0 0 0 5 6 8 83.3 75 2.04 0008016 control of heart P 5 6 6 83.3 100 5 6 6 83.3 100 2.04 0005637 nuclear inner membrane C 0 0 0 0 0 3 3 4 100 75 2.027 0005698 centromere C 3 3 4 100 75 3 3 4 100 75 2.027 0008641 small protein activating enzyme F 0 0 0 0 0 3 3 4 100 75 2.027 0008042 iron-sulfur electron transfer carrier F 3 3 4 100 75 3 3 4 100 75 2.027 0005638 lamin filament C 3 3 4 100 75 3 3 4 100 75 2.027 0016408 C-acyltransferase F 0 0 0 0 0 3 3 3 100 100 2.027 0015427 ABC-type efflux porter F 0 0 0 0 0 3 3 3 100 100 2.027 0030529 ribonucleoprotein C 0 0 0 0 0 3 3 12 100 25 2.027 0005732 small nucleolar ribonucleoprotein C 3 3 11 100 27.3 3 3 11 100 27.3 2.027 0005224 ATP-binding and phosphorylation-dependent chloride channel F 3 3 4 100 75 3 3 4 100 75 2.027 0006638 neutral lipid metabolism P 0 0 0 0 0 3 3 5 100 60 2.027 0006650 glycerophospholipid metabolism P 1 1 1 100 100 3 3 5 100 60 2.027 0006066 alcohol metabolism P 0 0 0 0 0 3 3 4 100 75 2.027 0005217 intracellular ligand-gated ion channel F 0 0 0 0 0 3 3 4 100 75 2.027 0006445 translational regulation P 1 1 2 100 50 3 3 4 100 75 2.027 0003950 NAD(+) ADP-ribosyltransferase F 3 3 3 100 100 3 3 3 100 100 2.027 0006596 polyamine biosynthesis P 1 1 2 100 50 3 3 4 100 75 2.027 0016877 ligase, forming carbon-sulfur bonds F 0 0 0 0 0 3 3 5 100 60 2.027 0006639 acylglycerol metabolism P 0 0 0 0 0 3 3 5 100 60 2.027 0016409 palmitoyltransferase F 0 0 0 0 0 3 3 4 100 75 2.027 0008215 spermine metabolism P 1 1 1 100 100 3 3 3 100 100 2.027 0006641 triacylglycerol metabolism P 0 0 0 0 0 3 3 5 100 60 2.027 0006071 glycerol metabolism P 1 1 1 100 100 3 3 4 100 75 2.027 0016591 DNA-directed RNA polymerase II, holoenzyme C 0 0 0 0 0 3 3 4 100 75 2.027 0016803 ether hydrolase F 0 0 0 0 0 3 3 3 100 100 2.027 0003847 2-acetyl-1-alkylglycerophosphocholine esterase F 3 3 3 100 100 3 3 3 100 100 2.027 0016291 acyl-CoA thioesterase F 3 3 7 100 42.9 3 3 7 100 42.9 2.027 0004463 leukotriene-A4 hydrolase F 1 1 1 100 100 3 3 3 100 100 2.027 0005744 mitochondrial inner membrane translocase complex C 3 3 3 100 100 3 3 3 100 100 2.027 0008286 insulin receptor signaling pathway P 3 3 5 100 60 3 3 5 100 60 2.027 0009055 electron carrier F 0 0 0 0 0 3 3 4 100 75 2.027 0000265 heterotrimeric G-protein GTPase, gamma-subunit F 3 3 5 100 60 3 3 5 100 60 2.027 0006367 transcription initiation, from Pol II promoter P 3 3 3 100 100 3 3 3 100 100 2.027 0006352 transcription initiation P 0 0 0 0 0 3 3 3 100 100 2.027 0000158 protein phosphatase type 2A F 0 0 0 0 0 3 3 5 100 60 2.027 0006020 myo-inositol metabolism P 3 3 4 100 75 3 3 4 100 75 2.027 0005717 chromatin C 11 17 21 64.7 81 17 28 41 60.7 68.3 1.988 0016747 transferase, transferring groups other than amino-acyl groups F 1 2 2 50 100 17 28 38 60.7 73.7 1.988 0005201 extracellular matrix structural constituent F 20 35 38 57.1 92.1 27 48 54 56.2 88.9 1.979 0006937 muscle contraction regulation P 9 13 13 69.2 100 9 13 13 69.2 100 1.975 0006281 DNA repair P 25 43 48 58.1 89.6 26 46 53 56.5 86.8 1.974 0045182 translation regulator F 0 0 0 0 0 19 32 43 59.4 74.4 1.972 0008135 translation factor, nucleic acid binding F 0 0 0 0 0 19 32 43 59.4 74.4 1.972 0007517 muscle development P 17 29 36 58.6 80.6 20 34 43 58.8 79.1 1.968 0016817 hydrolase, acting on acid anhydrides F 0 0 0 0 0 79 159 217 49.7 73.3 1.941 0016818 hydrolase, acting on acid anhydrides, in phosphorus-containing anhydrides F 0 0 0 0 0 79 159 217 49.7 73.3 1.941 0005834 heterotrimeric G-protein complex C 10 15 21 66.7 71.4 10 15 21 66.7 71.4 1.92 0019001 guanyl nucleotide binding F 0 0 0 0 0 77 155 219 49.7 70.8 1.913 0006996 organelle organization and biogenesis P 0 0 0 0 0 70 140 203 50 69 1.894 0006411 protein metabolism and modification P 2 2 4 100 50 289 633 811 45.7 78.1 1.887 0005861 troponin complex C 6 8 8 75 100 6 8 8 75 100 1.879 0042127 regulation of cell proliferation P 0 0 0 0 0 6 8 15 75 53.3 1.879 0016491 oxidoreductase F 15 38 42 39.5 90.5 74 149 207 49.7 72 1.871 0003924 GTPase F 7 18 21 38.9 85.7 41 78 95 52.6 82.1 1.866 0005941 unlocalized C 0 0 0 0 0 28 51 58 54.9 87.9 1.844 0005515 protein binding F 77 183 275 42.1 66.5 172 368 539 46.7 68.3 1.831 0008372 cellular_component unknown C 59 117 291 50.4 40.2 59 117 291 50.4 40.2 1.821 0000279 M phase P 0 0 0 0 0 15 25 36 60 69.4 1.805 0003927 heterotrimeric G-protein GTPase F 8 12 18 66.7 66.7 16 27 35 59.3 77.1 1.798 0006325 establishment and/or maintenance of chromatin architecture P 2 2 3 100 66.7 16 27 35 59.3 77.1 1.798 0008134 transcription factor binding F 2 2 3 100 66.7 16 27 43 59.3 62.8 1.798 0005488 ligand binding or carrier F 15 24 29 62.5 82.8 879 2012 2877 43.7 69.9 1.785 0000004 biological_process unknown P 50 98 250 51 39.2 50 98 250 51 39.2 1.784 0019222 regulation of metabolism P 1 2 2 50 100 7 10 11 70 90.9 1.781 0005865 striated muscle thin filament C 0 1 3 0 0 7 10 13 70 76.9 1.781 0003899 DNA-directed RNA polymerase F 7 10 11 70 90.9 7 10 11 70 90.9 1.781 0003887 DNA-directed DNA polymerase F 6 9 12 66.7 75 7 10 15 70 66.7 1.781 0006164 purine nucleotide biosynthesis P 4 6 8 66.7 75 7 10 13 70 76.9 1.781 0030029 actin filament-based process P 0 0 1 0 0 8 12 20 66.7 60 1.717 0030036 actin cytoskeleton organization and biogenesis P 4 6 10 66.7 60 8 12 19 66.7 63.2 1.717 0003746 translation elongation factor F 8 12 16 66.7 75 8 12 16 66.7 75 1.717 0003821 class II major histocompatibility complex antigen F 4 5 7 80 71.4 4 5 7 80 71.4 1.711 0009148 pyrimidine nucleoside triphosphate biosynthesis P 0 0 0 0 0 4 5 6 80 83.3 1.711 0009147 pyrimidine nucleoside triphosphate metabolism P 0 0 0 0 0 4 5 6 80 83.3 1.711 0008530 exogenous peptide receptor F 0 0 0 0 0 4 5 7 80 71.4 1.711 0007017 microtubule-based process P 25 44 70 56.8 62.9 28 52 82 53.8 63.4 1.707 0016775 phosphotransferase, nitrogenous group as acceptor F 0 0 0 0 0 2 2 2 100 100 1.655 0004758 serine C-palmitoyltransferase F 2 2 2 100 100 2 2 2 100 100 1.655 0016454 C-palmitoyltransferase F 0 0 0 0 0 2 2 2 100 100 1.655 0019212 phosphatase inhibitor F 1 1 1 100 100 2 2 3 100 66.7 1.655 0006082 organic acid metabolism P 0 0 0 0 0 2 2 6 100 33.3 1.655 0005748 NADH dehydrogenase (ubiquinone) C 2 2 11 100 18.2 2 2 11 100 18.2 1.655 0006100 TCA intermediate metabolism P 0 0 0 0 0 2 2 3 100 66.7 1.655 0005747 respiratory chain complex I C 2 2 2 100 100 2 2 11 100 18.2 1.655 0006084 acetyl-CoA metabolism P 1 1 1 100 100 2 2 5 100 40 1.655 0006083 acetate metabolism P 0 0 1 0 0 2 2 6 100 33.3 1.655 0006012 galactose metabolism P 2 2 2 100 100 2 2 2 100 100 1.655 0016406 carnitine O-acyltransferase F 0 0 0 0 0 2 2 4 100 50 1.655 0016271 tissue death P 0 0 0 0 0 2 2 3 100 66.7 1.655 0005669 TFIID complex C 2 2 2 100 100 2 2 2 100 100 1.655 0006446 translational regulation, initiation P 2 2 2 100 100 2 2 2 100 100 1.655 0005659 delta DNA polymerase C 1 1 1 100 100 2 2 2 100 100 1.655 0000012 single-strand break repair P 2 2 2 100 100 2 2 2 100 100 1.655 0000123 histone acetyltransferase complex C 0 0 0 0 0 2 2 2 100 100 1.655 0000059 protein-nucleus import, docking P 2 2 2 100 100 2 2 2 100 100 1.655 0004301 epoxide hydrolase F 2 2 2 100 100 2 2 2 100 100 1.655 0006825 copper ion transport P 2 2 2 100 100 2 2 2 100 100 1.655 0008600 protein phosphatase type 2A, catalyst F 2 2 2 100 100 2 2 2 100 100 1.655 0008934 myo-inositol-1(or 4)-monophosphatase F 2 2 2 100 100 2 2 2 100 100 1.655 0042132 fructose-1,6-bisphosphatase F 2 2 2 100 100 2 2 2 100 100 1.655 0004767 sphingomyelin phosphodiesterase F 2 2 3 100 66.7 2 2 3 100 66.7 1.655 0003918 DNA topoisomerase (ATP-hydrolyzing) F 2 2 3 100 66.7 2 2 3 100 66.7 1.655 0008220 necrosis P 2 2 3 100 66.7 2 2 3 100 66.7 1.655 0004143 diacylglycerol kinase F 2 2 2 100 100 2 2 2 100 100 1.655 0007369 gastrulation P 2 2 2 100 100 2 2 2 100 100 1.655 0008900 hydrogen/potassium-exchanging ATPase F 2 2 2 100 100 2 2 2 100 100 1.655 0004007 heavy metal-exporting ATPase F 0 0 0 0 0 2 2 2 100 100 1.655 0004008 copper-exporting ATPase F 2 2 2 100 100 2 2 2 100 100 1.655 0000228 nuclear chromosome C 2 2 4 100 50 2 2 4 100 50 1.655 0016405 CoA-ligase F 0 0 0 0 0 2 2 4 100 50 1.655 0008435 anticoagulant F 2 2 2 100 100 2 2 2 100 100 1.655 0005971 ribonucleoside-diphosphate reductase C 2 2 2 100 100 2 2 2 100 100 1.655 0005913 cell-cell adherens junction C 1 1 2 100 50 2 2 5 100 40 1.655 0009331 glycerol-3-phosphate dehydrogenase C 2 2 2 100 100 2 2 2 100 100 1.655 0008247 2-acetyl-1-alkylglycerophosphocholine esterase C 2 2 2 100 100 2 2 2 100 100 1.655 0030176 endoplasmic reticulum membrane, integral protein C 2 2 2 100 100 2 2 2 100 100 1.655 0006927 killing transformed cells P 2 2 2 100 100 2 2 2 100 100 1.655 0003756 protein disulfide isomerase F 2 2 2 100 100 2 2 2 100 100 1.655 0019395 fatty acid oxidation P 0 0 0 0 0 2 2 4 100 50 1.655 0008642 ubiquitin-like activating enzyme F 1 1 1 100 100 2 2 2 100 100 1.655 0019217 regulation of fatty acid metabolism P 2 2 2 100 100 2 2 2 100 100 1.655 0006720 isoprenoid metabolism P 0 0 0 0 0 2 2 2 100 100 1.655 0004448 isocitrate dehydrogenase F 0 0 0 0 0 2 2 3 100 66.7 1.655 0008943 glyceraldehyde 3-phosphate dehydrogenase F 0 0 0 0 0 2 2 2 100 100 1.655 0004365 glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) F 2 2 2 100 100 2 2 2 100 100 1.655 0005646 importin C 0 0 0 0 0 2 2 2 100 100 1.655 0016215 CoA desaturase F 0 0 0 0 0 2 2 3 100 66.7 1.655 0004768 stearoyl-CoA desaturase F 2 2 3 100 66.7 2 2 3 100 66.7 1.655 0008137 NADH2 dehydrogenase (ubiquinone) F 2 2 10 100 20 2 2 10 100 20 1.655 0016725 oxidoreductase, acting on CH2 groups F 0 0 0 0 0 2 2 3 100 66.7 1.655 0016866 intramolecular transferase F 0 0 0 0 0 2 2 3 100 66.7 1.655 0004748 ribonucleoside-diphosphate reductase F 2 2 3 100 66.7 2 2 3 100 66.7 1.655 0003870 5-aminolevulinate synthase F 2 2 2 100 100 2 2 2 100 100 1.655 0004014 adenosylmethionine decarboxylase F 2 2 2 100 100 2 2 2 100 100 1.655 0015645 fatty-acid ligase F 0 0 0 0 0 2 2 2 100 100 1.655 0004467 long-chain-fatty-acid-CoA-ligase F 2 2 2 100 100 2 2 2 100 100 1.655 0004019 adenylosuccinate synthase F 2 2 2 100 100 2 2 2 100 100 1.655 0016885 ligase, forming carbon-carbon bonds F 0 0 0 0 0 2 2 3 100 66.7 1.655 0004743 pyruvate kinase F 2 2 2 100 100 2 2 2 100 100 1.655 0005648 importin, beta-subunit C 2 2 2 100 100 2 2 2 100 100 1.655 0004712 protein threonine/tyrosine kinase F 1 1 1 100 100 2 2 2 100 100 1.655 0016514 SWI/SNF complex C 2 2 4 100 50 2 2 4 100 50 1.655 0006354 RNA elongation P 2 2 2 100 100 2 2 2 100 100 1.655 0005889 hydrogen/potassium-exchanging ATPase C 2 2 2 100 100 2 2 2 100 100 1.655 0004673 protein histidine kinase F 2 2 2 100 100 2 2 2 100 100 1.655 0016728 oxidoreductase, acting on CH2 groups, disulfide as acceptor F 0 0 0 0 0 2 2 3 100 66.7 1.655 0008216 spermidine metabolism P 0 0 0 0 0 2 2 2 100 100 1.655 0007020 microtubule nucleation P 1 1 1 100 100 2 2 2 100 100 1.655 0008090 retrograde axon cargo transport P 2 2 2 100 100 2 2 2 100 100 1.655 0005375 copper ion transporter F 0 0 0 0 0 2 2 2 100 100 1.655 0008088 axon cargo transport P 0 0 0 0 0 2 2 2 100 100 1.655 0008610 lipid biosynthesis P 0 0 0 0 0 2 2 4 100 50 1.655 0016582 non-covalent chromatin modification P 0 0 0 0 0 2 2 4 100 50 1.655 0006072 glycerol-3-phosphate metabolism P 2 2 3 100 66.7 2 2 3 100 66.7 1.655 0008295 spermidine biosynthesis P 2 2 2 100 100 2 2 2 100 100 1.655 0006597 spermine biosynthesis P 2 2 2 100 100 2 2 2 100 100 1.655 0006338 chromatin modeling P 2 2 2 100 100 2 2 4 100 50 1.655 0008536 RAN protein binding F 2 2 4 100 50 2 2 4 100 50 1.655 0005498 sterol carrier F 2 2 2 100 100 2 2 2 100 100 1.655 0006725 aromatic compound metabolism P 2 2 2 100 100 2 2 2 100 100 1.655 0007205 protein kinase C activation P 2 2 2 100 100 2 2 2 100 100 1.655 0008430 selenium binding F 2 2 2 100 100 2 2 2 100 100 1.655 0009492 Fe2S2 electron transfer carrier F 2 2 2 100 100 2 2 2 100 100 1.655 0015081 sodium transporter F 0 0 0 0 0 2 2 10 100 20 1.655 0007018 microtubule-based movement P 8 14 18 57.1 77.8 10 16 20 62.5 80 1.645 0003925 small monomeric GTPase F 20 36 42 55.6 85.7 21 38 46 55.3 82.6 1.635 0007010 cytoskeleton organization and biogenesis P 22 53 73 41.5 72.6 58 117 175 49.6 66.9 1.632 0006575 amino acid derivative metabolism P 0 0 0 0 0 11 18 25 61.1 72 1.626 0016766 transferring alkyl or aryl groups, other than methyl groups F 0 0 0 0 0 11 18 21 61.1 85.7 1.626 0016765 transferase, transferring alkyl or aryl (other than methyl) groups F 0 0 0 0 0 11 18 21 61.1 85.7 1.626 0019898 extrinsic membrane protein C 0 0 0 0 0 11 18 26 61.1 69.2 1.626 0019897 extrinsic plasma membrane protein C 1 3 5 33.3 60 11 18 26 61.1 69.2 1.626 0006333 chromatin assembly/disassembly P 4 6 8 66.7 75 12 20 25 60 80 1.614 0006731 coenzymes and prosthetic group metabolism P 0 0 0 0 0 17 30 40 56.7 75 1.608 0008415 acyltransferase F 5 7 8 71.4 87.5 14 24 34 58.3 70.6 1.603 0004407 histone deacetylase F 5 6 9 83.3 66.7 5 7 10 71.4 70 1.566 0006413 protein synthesis initiation P 5 7 10 71.4 70 5 7 10 71.4 70 1.566 0004683 calmodulin regulated protein kinase F 0 1 2 0 0 5 7 8 71.4 87.5 1.566 0005211 plasma glycoprotein F 5 7 7 71.4 100 5 7 7 71.4 100 1.566 0016481 repression of transcription P 1 3 9 33.3 33.3 5 7 19 71.4 36.8 1.566 0008080 N-acetyltransferase F 3 3 4 100 75 5 7 8 71.4 87.5 1.566 0000041 transition metal transport P 0 0 0 0 0 5 7 10 71.4 70 1.566 0006869 lipid transport P 4 6 8 66.7 75 5 7 11 71.4 63.6 1.566 0003743 translation initiation factor F 5 7 10 71.4 70 5 7 10 71.4 70 1.566 0006633 fatty acid biosynthesis P 4 6 9 66.7 66.7 5 7 11 71.4 63.6 1.566 0015630 microtubule cytoskeleton C 1 1 1 100 100 26 49 77 53.1 63.6 1.545 0007498 mesoderm development P 2 2 4 100 50 45 90 111 50 81.1 1.51 0009063 amino acid catabolism P 1 1 1 100 100 6 9 12 66.7 75 1.486 0003714 transcription co-repressor F 6 9 17 66.7 52.9 6 9 17 66.7 52.9 1.486 0016830 carbon-carbon lyase F 0 0 0 0 0 7 11 18 63.6 61.1 1.44 0019200 carbohydrate kinase F 0 0 0 0 0 7 11 11 63.6 100 1.44 0008235 metalloexopeptidase F 2 3 3 66.7 100 7 11 12 63.6 91.7 1.44 0009309 amine biosynthesis P 0 0 0 0 0 7 11 12 63.6 91.7 1.44 0005605 basement lamina C 6 10 10 60 100 7 11 11 63.6 100 1.44 0001558 regulation of cell growth P 6 10 14 60 71.4 7 11 15 63.6 73.3 1.44 0004527 exonuclease F 3 4 7 75 57.1 7 11 15 63.6 73.3 1.44 0005520 insulin-like growth factor binding F 7 11 13 63.6 84.6 7 11 13 63.6 84.6 1.44 0019838 growth factor binding F 0 0 0 0 0 7 11 13 63.6 84.6 1.44 0005635 nuclear membrane C 1 3 4 33.3 75 7 11 18 63.6 61.1 1.44 0005543 phospholipid binding F 1 1 2 100 50 8 13 18 61.5 72.2 1.412 0004672 protein kinase F 75 171 206 43.9 83 122 263 336 46.4 78.3 1.411 0000074 cell cycle control P 52 111 132 46.8 84.1 60 124 146 48.4 84.9 1.41 0008017 microtubule binding F 4 5 6 80 83.3 15 27 50 55.6 54 1.407 0015631 tubulin binding F 0 0 0 0 0 15 27 50 55.6 54 1.407 0005581 collagen C 14 25 31 56 80.6 14 25 31 56 80.6 1.399 0030020 extracellular matrix structural constituent conferring tensile strength F 14 25 31 56 80.6 14 25 31 56 80.6 1.399 0006366 transcription, from Pol II promoter P 3 6 11 50 54.5 14 25 50 56 50 1.399 0007515 lymph gland development P 9 15 17 60 88.2 9 15 17 60 88.2 1.397 0003685 DNA repair protein F 7 16 19 43.8 84.2 13 23 27 56.5 85.2 1.392 0008168 methyltransferase F 1 3 3 33.3 100 10 17 27 58.8 63 1.389 0005874 microtubule C 8 11 13 72.7 84.6 10 17 21 58.8 81 1.389 0009308 amine metabolism P 0 0 0 0 0 10 17 24 58.8 70.8 1.389 0016741 transferase, transferring one-carbon groups F 0 0 0 0 0 11 19 29 57.9 65.5 1.386 0008172 S-methyltransferase F 0 0 0 0 0 3 4 4 75 100 1.328 0009144 purine nucleoside triphosphate metabolism P 0 0 0 0 0 3 4 5 75 80 1.328 0007622 rhythmic behavior P 3 4 5 75 80 3 4 5 75 80 1.328 0006941 striated muscle contraction P 3 4 7 75 57.1 3 4 7 75 57.1 1.328 0005391 sodium/potassium-exchanging ATPase F 3 4 5 75 80 3 4 5 75 80 1.328 0005657 replication fork C 0 0 0 0 0 3 4 4 75 100 1.328 0007507 heart development P 3 4 6 75 66.7 3 4 6 75 66.7 1.328 0005643 nuclear pore C 1 2 5 50 40 3 4 9 75 44.4 1.328 0003995 acyl-CoA dehydrogenase F 3 4 5 75 80 3 4 6 75 66.7 1.328 0005964 phosphorylase kinase C 3 4 4 75 100 3 4 4 75 100 1.328 0003686 DNA repair enzyme F 3 3 4 100 75 3 4 5 75 80 1.328 0009209 pyrimidine ribonucleoside triphosphate biosynthesis P 0 0 0 0 0 3 4 5 75 80 1.328 0004017 adenylate kinase F 3 4 4 75 100 3 4 4 75 100 1.328 0019136 deoxynucleoside kinase F 0 0 0 0 0 3 4 4 75 100 1.328 0004689 phosphorylase kinase F 3 3 3 100 100 3 4 4 75 100 1.328 0006298 mismatch repair P 3 4 5 75 80 3 4 5 75 80 1.328 0000264 heterotrimeric G-protein GTPase, beta-subunit F 3 4 5 75 80 3 4 5 75 80 1.328 0004396 hexokinase F 3 4 4 75 100 3 4 4 75 100 1.328 0045005 maintenance of fidelity during DNA dependent DNA replication P 0 0 0 0 0 3 4 5 75 80 1.328 0006183 GTP biosynthesis P 3 4 5 75 80 3 4 5 75 80 1.328 0009208 pyrimidine ribonucleoside triphosphate metabolism P 0 0 0 0 0 3 4 5 75 80 1.328 0009145 purine nucleoside triphosphate biosynthesis P 0 0 0 0 0 3 4 5 75 80 1.328 0006228 UTP biosynthesis P 3 4 5 75 80 3 4 5 75 80 1.328 0006241 CTP biosynthesis P 3 4 5 75 80 3 4 5 75 80 1.328 0016833 oxo-acid-lyase F 0 0 0 0 0 3 4 4 75 100 1.328 0016284 alanine aminopeptidase F 0 0 0 0 0 3 4 4 75 100 1.328 0016469 hydrogen-transporting two-sector ATPase C 3 3 4 100 75 3 4 6 75 66.7 1.328 0004179 membrane alanyl aminopeptidase F 3 4 4 75 100 3 4 4 75 100 1.328 0004550 nucleoside-diphosphate kinase F 3 4 5 75 80 3 4 5 75 80 1.328 0004194 pepsin A F 3 4 6 75 66.7 3 4 6 75 66.7 1.328 0006733 oxidoreduction coenzyme metabolism P 0 0 0 0 0 3 4 4 75 100 1.328 0019888 protein phosphatase regulator F 0 0 0 0 0 3 4 8 75 50 1.328 0016564 transcriptional repressor F 2 3 13 66.7 23.1 3 4 14 75 28.6 1.328 0016829 lyase F 0 0 1 0 0 20 38 57 52.6 66.7 1.305 0007264 small GTPase mediated signal transduction P 26 48 56 54.2 85.7 31 62 74 50 83.8 1.249 0003819 major histocompatibility complex antigen F 16 30 54 53.3 55.6 16 30 54 53.3 55.6 1.237 0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism P 1 1 2 100 50 331 748 981 44.3 76.2 1.232 0016614 oxidoreductase, CH-OH group of donors F 0 0 0 0 0 23 45 51 51.1 88.2 1.214 0019206 nucleoside kinase F 0 0 0 0 0 4 6 6 66.7 100 1.213 0009126 purine nucleoside monophosphate metabolism P 0 0 0 0 0 4 6 8 66.7 75 1.213 0006417 general regulation of protein biosynthesis P 4 6 6 66.7 100 4 6 6 66.7 100 1.213 0004437 inositol/phosphatidylinositol phosphatase F 3 4 5 75 80 4 6 9 66.7 66.7 1.213 0008360 cell shape control P 4 6 8 66.7 75 4 6 8 66.7 75 1.213 0006879 iron homeostasis P 4 6 11 66.7 54.5 4 6 11 66.7 54.5 1.213 0030006 heavy metal ion homeostasis P 0 0 0 0 0 4 6 11 66.7 54.5 1.213 0006471 protein amino acid ADP-ribosylation P 4 6 6 66.7 100 4 6 6 66.7 100 1.213 0005554 molecular_function unknown F 44 91 230 48.4 39.6 44 91 230 48.4 39.6 1.197 0019941 protein-ligand dependent protein degradation P 0 0 0 0 0 22 43 58 51.2 74.1 1.193 0003712 transcription co-factor F 1 5 8 20 62.5 13 24 39 54.2 61.5 1.188 0008565 protein transporter F 9 17 18 52.9 94.4 13 24 25 54.2 96 1.188 0004230 glutamyl aminopeptidase F 1 1 1 100 100 1 1 1 100 100 1.17 0006892 post Golgi transport P 0 0 0 0 0 1 1 2 100 50 1.17 0006896 Golgi to vacuole transport P 1 1 1 100 100 1 1 1 100 100 1.17 0015757 galactose transport P 1 1 1 100 100 1 1 1 100 100 1.17 0008130 neutrophil collagenase F 1 1 1 100 100 1 1 1 100 100 1.17 0009105 lipoic acid biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0004182 carboxypeptidase A F 1 1 2 100 50 1 1 2 100 50 1.17 0006744 ubiquinone biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0003940 L-iduronidase F 1 1 1 100 100 1 1 1 100 100 1.17 0004192 cathepsin D F 1 1 1 100 100 1 1 1 100 100 1.17 0004193 cathepsin E F 1 1 1 100 100 1 1 1 100 100 1.17 0004195 renin F 1 1 2 100 50 1 1 2 100 50 1.17 0015755 fructose transport P 1 1 1 100 100 1 1 1 100 100 1.17 0008129 actinidain F 1 1 1 100 100 1 1 1 100 100 1.17 0001666 response to hypoxia P 1 1 1 100 100 1 1 1 100 100 1.17 0001609 adenosine receptor, G-protein coupled F 0 0 0 0 0 1 1 1 100 100 1.17 0016802 thioether hydrolase F 0 0 0 0 0 1 1 1 100 100 1.17 0004208 caspase-3 F 1 1 1 100 100 1 1 1 100 100 1.17 0004207 effector caspase F 0 0 0 0 0 1 1 1 100 100 1.17 0004213 cathepsin B F 1 1 1 100 100 1 1 1 100 100 1.17 0008281 sulfonylurea receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0004214 dipeptidyl-peptidase I F 1 1 1 100 100 1 1 1 100 100 1.17 0004251 Xaa-Pro dipeptidase F 1 1 1 100 100 1 1 1 100 100 1.17 0008300 isoprenoid catabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0015988 energy coupled proton transport, against the electrochemical gradient P 0 0 0 0 0 1 1 2 100 50 1.17 0008299 isoprenoid biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0008631 induction of apoptosis by oxidative stress P 1 1 1 100 100 1 1 1 100 100 1.17 0008889 glycerophosphodiester phosphodiesterase F 1 1 1 100 100 1 1 1 100 100 1.17 0008307 structural constituent of muscle F 1 1 1 100 100 1 1 1 100 100 1.17 0005536 glucose binding F 1 1 1 100 100 1 1 1 100 100 1.17 0006909 phagocytosis P 1 1 2 100 50 1 1 3 100 33.3 1.17 0030023 extracellular matrix constituent conferring elasticity F 1 1 1 100 100 1 1 1 100 100 1.17 0007022 chaperonin-mediated tubulin folding P 1 1 1 100 100 1 1 1 100 100 1.17 0004439 phosphatidylinositol-bisphosphatase F 1 1 1 100 100 1 1 1 100 100 1.17 0008195 phosphatidate phosphatase F 1 1 2 100 50 1 1 2 100 50 1.17 0008601 protein phosphatase type 2A, regulator F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0015918 sterol transport P 0 0 0 0 0 1 1 1 100 100 1.17 0030301 cholesterol transport P 1 1 1 100 100 1 1 1 100 100 1.17 0003875 ADP-ribosylarginine hydrolase F 1 1 1 100 100 1 1 1 100 100 1.17 0006651 diacylglycerol biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0004998 transferrin receptor F 1 1 2 100 50 1 1 2 100 50 1.17 0015694 mercury ion transport P 1 1 1 100 100 1 1 1 100 100 1.17 0003905 DNA-3-methyladenine glycosidase II F 1 1 1 100 100 1 1 1 100 100 1.17 0004181 metallocarboxypeptidase F 0 0 0 0 0 1 1 2 100 50 1.17 0030159 receptor signaling complex scaffold protein F 1 1 2 100 50 1 1 4 100 25 1.17 0007021 tubulin folding P 0 0 0 0 0 1 1 1 100 100 1.17 0004013 adenosylhomocysteinase F 1 1 1 100 100 1 1 1 100 100 1.17 0009374 biotin binding F 1 1 1 100 100 1 1 1 100 100 1.17 0005091 guanyl-nucleotide exchange factor adaptor F 1 1 1 100 100 1 1 1 100 100 1.17 0016293 long-chain fatty-acyl-CoA hydrolase F 1 1 1 100 100 1 1 1 100 100 1.17 0030497 fatty acid elongation P 1 1 2 100 50 1 1 2 100 50 1.17 0004423 iduronate-2-sulfatase F 1 1 1 100 100 1 1 1 100 100 1.17 0015991 ATP hydrolysis coupled proton transport P 1 1 2 100 50 1 1 2 100 50 1.17 0004565 beta-galactosidase F 1 1 1 100 100 1 1 1 100 100 1.17 0004296 T-plasminogen activator F 1 1 1 100 100 1 1 1 100 100 1.17 0004935 adrenoceptor F 0 0 0 0 0 1 1 1 100 100 1.17 0006515 degradation of misfolded or incompletely synthesized proteins P 1 1 1 100 100 1 1 1 100 100 1.17 0004749 ribose-phosphate pyrophosphokinase F 1 1 1 100 100 1 1 1 100 100 1.17 0017050 D-erythro-sphingosine kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0004962 endothelin receptor F 0 0 0 0 0 1 1 1 100 100 1.17 0004370 glycerol kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0016305 phosphatidylinositol 3-kinase, class II F 1 1 1 100 100 1 1 1 100 100 1.17 0004137 deoxycytidine kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0004138 deoxyguanosine kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0004864 protein phosphatase inhibitor F 1 1 2 100 50 1 1 2 100 50 1.17 0004849 uridine kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0004865 type 1 serine/threonine specific protein phosphatase inhibitor F 1 1 2 100 50 1 1 2 100 50 1.17 0019943 RUB1-protein conjugation P 1 1 1 100 100 1 1 1 100 100 1.17 0004385 guanylate kinase F 1 1 1 100 100 1 1 3 100 33.3 1.17 0004284 acrosin F 1 1 1 100 100 1 1 1 100 100 1.17 0008605 casein kinase II, regulator F 1 1 1 100 100 1 1 1 100 100 1.17 0004708 MAP kinase kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0030322 membrane potential stabilization P 1 1 1 100 100 1 1 1 100 100 1.17 0016922 ligand-dependent nuclear receptor interactor F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0004703 G-protein coupled receptor kinase F 1 1 2 100 50 1 1 2 100 50 1.17 0008384 IkB kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0004798 thymidylate kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0006399 tRNA metabolism P 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0001600 endothelin-B receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0000209 polyubiquitylation P 1 1 1 100 100 1 1 1 100 100 1.17 0004031 aldehyde oxidase F 1 1 1 100 100 1 1 1 100 100 1.17 0004676 3-phosphoinositide-dependent protein kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0004936 alpha-adrenergic receptor F 0 0 0 0 0 1 1 1 100 100 1.17 0019942 RUB1-dependent protein degradation P 1 1 1 100 100 1 1 1 100 100 1.17 0016854 racemase and epimerase F 0 0 0 0 0 1 1 3 100 33.3 1.17 0004678 G-protein-coupled receptor phosphorylating protein kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0042080 GPI/GSI anchor synthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0004335 galactokinase F 1 1 1 100 100 1 1 1 100 100 1.17 0030228 lipoprotein receptor F 0 0 0 0 0 1 1 3 100 33.3 1.17 0001611 A2A adenosine receptor, G-protein coupled F 1 1 1 100 100 1 1 1 100 100 1.17 0006502 C-terminal protein prenylation P 1 1 1 100 100 1 1 1 100 100 1.17 0006501 C-terminal fatty acid:protein modification P 0 0 0 0 0 1 1 1 100 100 1.17 0004342 glucosamine-6-phosphate isomerase F 1 1 1 100 100 1 1 1 100 100 1.17 0006506 GPI anchor synthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0004751 ribose-5-phosphate isomerase F 1 1 1 100 100 1 1 1 100 100 1.17 0018342 protein prenylation P 0 0 0 0 0 1 1 1 100 100 1.17 0030371 translation repressor F 1 1 2 100 50 1 1 2 100 50 1.17 0008462 endopeptidase Clp F 1 1 1 100 100 1 1 1 100 100 1.17 0000147 actin cortical patch assembly P 1 1 1 100 100 1 1 1 100 100 1.17 0018410 peptide/protein carboxyl-terminal blocking P 0 0 0 0 0 1 1 3 100 33.3 1.17 0018212 peptidyl-tyrosine modification P 0 0 0 0 0 1 1 1 100 100 1.17 0006507 GPI anchor release P 1 1 1 100 100 1 1 1 100 100 1.17 0016868 intramolecular transferase, phosphotransferases F 0 0 0 0 0 1 1 2 100 50 1.17 0017114 wide-spectrum protease inhibitor F 0 0 0 0 0 1 1 1 100 100 1.17 0016858 racemase and epimerase, acting on other compounds F 0 0 0 0 0 1 1 1 100 100 1.17 0008111 alpha-methylacyl-CoA racemase F 1 1 1 100 100 1 1 1 100 100 1.17 0004991 parathyroid hormone receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0016975 alpha2-macroglobulin F 1 1 1 100 100 1 1 1 100 100 1.17 0004924 oncostatin-M receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0004494 methylmalonyl-CoA mutase F 1 1 1 100 100 1 1 1 100 100 1.17 0009062 fatty acid catabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0004619 phosphoglycerate mutase F 1 1 2 100 50 1 1 2 100 50 1.17 0004082 bisphosphoglycerate mutase F 1 1 1 100 100 1 1 1 100 100 1.17 0008116 prostaglandin-I synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0004937 alpha1-adrenergic receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0004667 prostaglandin-D synthase F 1 1 2 100 50 1 1 2 100 50 1.17 0018108 peptidyl-tyrosine phosphorylation P 1 1 1 100 100 1 1 1 100 100 1.17 0016870 intramolecular transferase, transferring other groups F 0 0 0 0 0 1 1 1 100 100 1.17 0016010 dystrophin-associated glycoprotein complex C 0 0 0 0 0 1 1 1 100 100 1.17 0030218 erythrocyte differentiation P 1 1 1 100 100 1 1 1 100 100 1.17 0000015 enolase C 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0030315 T-tubule C 1 1 1 100 100 1 1 1 100 100 1.17 0005902 microvillus C 1 1 1 100 100 1 1 1 100 100 1.17 0016272 prefoldin C 1 1 2 100 50 1 1 2 100 50 1.17 0030261 chromosome condensation P 1 1 2 100 50 1 1 5 100 20 1.17 0016011 dystroglycan complex C 1 1 1 100 100 1 1 1 100 100 1.17 0000070 mitotic chromosome segregation P 1 1 1 100 100 1 1 1 100 100 1.17 0005888 integral plasma membrane proteoglycan C 1 1 4 100 25 1 1 4 100 25 1.17 0007093 mitotic checkpoint P 0 0 0 0 0 1 1 1 100 100 1.17 0007094 mitotic spindle checkpoint P 1 1 1 100 100 1 1 1 100 100 1.17 0016601 RAC protein signal transduction P 1 1 1 100 100 1 1 1 100 100 1.17 0005770 late endosome C 1 1 1 100 100 1 1 1 100 100 1.17 0005793 ER-Golgi intermediate compartment C 1 1 1 100 100 1 1 1 100 100 1.17 0000075 cell cycle checkpoint P 0 0 0 0 0 1 1 2 100 50 1.17 0015270 dihydropyridine-sensitive calcium channel F 1 1 1 100 100 1 1 1 100 100 1.17 0030615 spindle pole C 0 0 0 0 0 1 1 1 100 100 1.17 0009341 beta-galactosidase C 1 1 1 100 100 1 1 1 100 100 1.17 0009052 pentose-phosphate shunt, non-oxidative branch P 1 1 1 100 100 1 1 1 100 100 1.17 0005819 spindle C 0 0 1 0 0 1 1 2 100 50 1.17 0006047 UDP-N-acetylglucosamine metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0007088 control of mitosis P 0 0 0 0 0 1 1 1 100 100 1.17 0030350 iron-responsive element binding F 1 1 2 100 50 1 1 2 100 50 1.17 0007212 dopamine receptor signaling pathway P 1 1 2 100 50 1 1 2 100 50 1.17 0005838 19S proteasome regulatory particle C 1 1 1 100 100 1 1 1 100 100 1.17 0006275 DNA replication regulation P 1 1 1 100 100 1 1 1 100 100 1.17 0016286 small conductance calcium-activated potassium channel F 1 1 2 100 50 1 1 2 100 50 1.17 0006048 UDP-N-acetylglucosamine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0015269 calcium-activated potassium channel F 0 0 0 0 0 1 1 2 100 50 1.17 0016126 sterol biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0001527 microfibril C 1 1 1 100 100 1 1 1 100 100 1.17 0005337 nucleoside transporter F 1 1 1 100 100 1 1 2 100 50 1.17 0009584 perception of visible light P 0 0 0 0 0 1 1 1 100 100 1.17 0005778 peroxisomal membrane C 1 1 1 100 100 1 1 1 100 100 1.17 0005782 peroxisomal matrix C 1 1 2 100 50 1 1 2 100 50 1.17 0007603 phototransduction, visible light P 1 1 1 100 100 1 1 1 100 100 1.17 0007607 taste P 1 1 2 100 50 1 1 2 100 50 1.17 0005853 eukaryotic translation elongation factor 1 C 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0007157 heterophilic cell adhesion P 1 1 2 100 50 1 1 2 100 50 1.17 0009412 heavy metal response P 0 0 0 0 0 1 1 3 100 33.3 1.17 0005962 isocitrate dehydrogenase (NAD+) C 1 1 1 100 100 1 1 1 100 100 1.17 0015932 nucleobase, nucleoside, nucleotide and nucleic acid transporter F 0 0 0 0 0 1 1 3 100 33.3 1.17 0030062 TCA cycle enzyme complex C 0 0 0 0 0 1 1 1 100 100 1.17 0016565 general transcriptional repressor F 1 1 1 100 100 1 1 1 100 100 1.17 0005750 respiratory chain complex III C 0 0 0 0 0 1 1 1 100 100 1.17 0015008 ubiquinol-cytochrome c reductase C 1 1 1 100 100 1 1 1 100 100 1.17 0030018 Z disc C 1 1 2 100 50 1 1 2 100 50 1.17 0015030 Cajal body C 1 1 2 100 50 1 1 2 100 50 1.17 0000159 protein phosphatase type 2A C 1 1 2 100 50 1 1 2 100 50 1.17 0007213 acetyl choline receptor signaling, muscarinic pathway P 1 1 2 100 50 1 1 2 100 50 1.17 0004883 glucocorticoid receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0005851 eukaryotic translation initiation factor 2B complex C 1 1 1 100 100 1 1 1 100 100 1.17 0017053 transcriptional repressor complex C 1 1 1 100 100 1 1 1 100 100 1.17 0005660 delta-DNA polymerase cofactor C 1 1 1 100 100 1 1 1 100 100 1.17 0009634 heavy metal sensitivity/resistance P 1 1 2 100 50 1 1 3 100 33.3 1.17 0016604 nuclear body C 0 0 0 0 0 1 1 2 100 50 1.17 0016363 nuclear matrix C 1 1 2 100 50 1 1 2 100 50 1.17 0005484 SNAP receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0005665 DNA-directed RNA polymerase II, core C 1 1 2 100 50 1 1 2 100 50 1.17 0015106 bicarbonate transporter F 0 0 0 0 0 1 1 2 100 50 1.17 0006488 oligosaccharide-PP-dolichol assembly P 1 1 1 100 100 1 1 1 100 100 1.17 0005645 RAN-binding protein C 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0005915 zonula adherens C 1 1 1 100 100 1 1 1 100 100 1.17 0005658 alpha DNA polymerase:primase complex C 1 1 1 100 100 1 1 1 100 100 1.17 0005354 galactose transporter F 1 1 1 100 100 1 1 1 100 100 1.17 0003876 AMP deaminase F 1 1 1 100 100 1 1 1 100 100 1.17 0003726 double-stranded RNA adenosine deaminase F 1 1 2 100 50 1 1 2 100 50 1.17 0007340 acrosome reaction P 1 1 2 100 50 1 1 2 100 50 1.17 0004477 methenyltetrahydrofolate cyclohydrolase F 1 1 1 100 100 1 1 1 100 100 1.17 0016822 hydrolase, acting on acid carbon-carbon bonds F 0 0 0 0 0 1 1 1 100 100 1.17 0005360 insulin-responsive hydrogen:glucose transporter F 1 1 1 100 100 1 1 1 100 100 1.17 0004334 fumarylacetoacetase F 1 1 1 100 100 1 1 1 100 100 1.17 0004348 glucosylceramidase F 1 1 1 100 100 1 1 1 100 100 1.17 0005355 glucose transporter F 1 1 2 100 50 1 1 2 100 50 1.17 0007281 germ-cell development P 1 1 1 100 100 1 1 1 100 100 1.17 0008516 hexose uniporter F 0 0 0 0 0 1 1 1 100 100 1.17 0000049 tRNA binding F 1 1 1 100 100 1 1 1 100 100 1.17 0015149 hexose transporter F 0 0 0 0 0 1 1 2 100 50 1.17 0005816 spindle pole body C 1 1 1 100 100 1 1 1 100 100 1.17 0016823 hydrolase, acting on acid carbon-carbon bonds, in ketonic substances F 0 0 0 0 0 1 1 1 100 100 1.17 0007500 mesoderm determination P 1 1 1 100 100 1 1 1 100 100 1.17 0008611 ether lipid biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0004715 non-membrane spanning protein tyrosine kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0030099 myeloid blood cell differentiation P 0 0 2 0 0 1 1 3 100 33.3 1.17 0004165 dodecenoyl-CoA delta-isomerase F 1 1 1 100 100 1 1 1 100 100 1.17 0004621 glycoprotein phospholipase D F 1 1 1 100 100 1 1 1 100 100 1.17 0004465 lipoprotein lipase F 1 1 1 100 100 1 1 1 100 100 1.17 0008418 protein N-terminal asparagine amidohydrolase F 1 1 1 100 100 1 1 1 100 100 1.17 0006003 fructose 2,6-bisphosphate metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0004067 asparaginase F 0 0 1 0 0 1 1 2 100 50 1.17 0015284 fructose uniporter F 1 1 1 100 100 1 1 1 100 100 1.17 0005353 fructose transporter F 0 0 0 0 0 1 1 1 100 100 1.17 0008494 translation activator F 1 1 1 100 100 1 1 1 100 100 1.17 0030539 male genital morphogenesis P 1 1 2 100 50 1 1 2 100 50 1.17 0030538 genital morphogenesis P 0 0 0 0 0 1 1 2 100 50 1.17 0030148 sphingolipid biosynthesis P 1 1 2 100 50 1 1 2 100 50 1.17 0006000 fructose metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0030022 extracellular matrix constituent, adhesive F 1 1 1 100 100 1 1 1 100 100 1.17 0008117 sphinganine-1-phosphate aldolase F 1 1 1 100 100 1 1 1 100 100 1.17 0003796 lysozyme F 1 1 1 100 100 1 1 1 100 100 1.17 0005862 muscle thin filament tropomyosin C 1 1 2 100 50 1 1 2 100 50 1.17 0008510 sodium:bicarbonate cotransporter F 1 1 1 100 100 1 1 1 100 100 1.17 0017072 tubulin folding F 1 1 1 100 100 1 1 1 100 100 1.17 0015145 monosaccharide transporter F 0 0 0 0 0 1 1 2 100 50 1.17 0015295 solute:hydrogen symporter F 0 0 0 0 0 1 1 1 100 100 1.17 0000247 C-8 sterol isomerase F 1 1 1 100 100 1 1 1 100 100 1.17 0015292 uniporter F 0 0 0 0 0 1 1 1 100 100 1.17 0005055 laminin receptor F 1 1 2 100 50 1 1 2 100 50 1.17 0000090 mitotic anaphase P 0 0 0 0 0 1 1 1 100 100 1.17 0007113 endomitotic cell cycle P 1 1 1 100 100 1 1 1 100 100 1.17 0016505 apoptotic protease activator F 1 1 2 100 50 1 1 2 100 50 1.17 0008409 5’-3’ exonuclease F 1 1 1 100 100 1 1 1 100 100 1.17 0003772 cochaperonin F 1 1 1 100 100 1 1 1 100 100 1.17 0005699 kinetochore C 1 1 1 100 100 1 1 1 100 100 1.17 0005403 hydrogen:sugar symporter-transporter F 0 0 0 0 0 1 1 1 100 100 1.17 0005402 cation:sugar symporter F 0 0 0 0 0 1 1 1 100 100 1.17 0016467 hydrogen-translocating F-type ATPase F 1 1 1 100 100 1 1 1 100 100 1.17 0030308 negative regulation of cell growth P 1 1 1 100 100 1 1 1 100 100 1.17 0015433 major histocompatibility peptide transporter F 1 1 1 100 100 1 1 1 100 100 1.17 0005432 calcium:sodium antiporter F 1 1 2 100 50 1 1 2 100 50 1.17 0016228 aldolase F 0 0 0 0 0 1 1 4 100 25 1.17 0015368 calcium:cation antiporter F 0 0 0 0 0 1 1 2 100 50 1.17 0003826 alpha-ketoacid dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0005573 telomerase RNA C 1 1 1 100 100 1 1 1 100 100 1.17 0005697 holotelomerase C 0 0 0 0 0 1 1 1 100 100 1.17 0015097 mercury ion transporter F 1 1 1 100 100 1 1 1 100 100 1.17 0004774 succinate-CoA ligase F 1 1 1 100 100 1 1 1 100 100 1.17 0003987 acetate-CoA ligase F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0006278 RNA dependent DNA replication P 1 1 1 100 100 1 1 1 100 100 1.17 0003923 GPI-anchor transamidase F 1 1 1 100 100 1 1 1 100 100 1.17 0016902 oxidoreductase, acting on the CH-OH group of donors, other acceptors F 0 0 0 0 0 1 1 1 100 100 1.17 0003721 telomeric RNA reverse transcriptase F 1 1 1 100 100 1 1 1 100 100 1.17 0019962 interferon-alpha/beta binding F 0 0 0 0 0 1 1 1 100 100 1.17 0006551 leucine metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004367 glycerol-3-phosphate dehydrogenase (NAD+) F 1 1 1 100 100 1 1 1 100 100 1.17 0004420 hydroxymethylglutaryl-CoA reductase (NADPH) F 1 1 1 100 100 1 1 1 100 100 1.17 0004449 isocitrate dehydrogenase (NAD+) F 1 1 1 100 100 1 1 1 100 100 1.17 0004450 isocitrate dehydrogenase (NADP+) F 1 1 2 100 50 1 1 2 100 50 1.17 0003982 UTP-hexose-1-phosphate uridylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004757 sepiapterin reductase F 1 1 1 100 100 1 1 1 100 100 1.17 0006670 sphingosine metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0006672 ceramide metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0003719 transcription factor, cytoplasmic sequestering F 1 1 1 100 100 1 1 1 100 100 1.17 0003979 UDP-glucose 6-dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0003857 3-hydroxyacyl-CoA dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0008108 UDP-glucose-hexose-1-phosphate uridylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0009065 glutamine family amino acid catabolism P 0 0 0 0 0 1 1 2 100 50 1.17 0006635 fatty acid beta-oxidation P 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0009081 branched chain family amino acid metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0008320 protein carrier F 1 1 1 100 100 1 1 1 100 100 1.17 0008022 protein C-terminus binding F 1 1 1 100 100 1 1 1 100 100 1.17 0004854 xanthine dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0004839 ubiquitin activating enzyme F 1 1 2 100 50 1 1 2 100 50 1.17 0004368 glycerol-3-phosphate dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0016722 oxidoreductase, oxidizing metal ions F 0 0 0 0 0 1 1 2 100 50 1.17 0016724 oxidoreductase, oxidizing metal ions, oxygen as acceptor F 0 0 0 0 0 1 1 2 100 50 1.17 0004322 ferroxidase F 1 1 2 100 50 1 1 2 100 50 1.17 0016899 oxidoreductase, acting on the CH-OH group of donors, oxygen as acceptor F 0 0 0 0 0 1 1 2 100 50 1.17 0004855 xanthine oxidase F 1 1 1 100 100 1 1 1 100 100 1.17 0004473 malate dehydrogenase (oxaloacetate decarboxylating) (NADP+) F 1 1 1 100 100 1 1 1 100 100 1.17 0019781 NEDD8 activating enzyme F 1 1 1 100 100 1 1 1 100 100 1.17 0009093 cysteine catabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0008379 thioredoxin peroxidase F 1 1 1 100 100 1 1 1 100 100 1.17 0019452 L-cysteine catabolism to taurine P 1 1 1 100 100 1 1 1 100 100 1.17 0009487 glutaredoxin F 1 1 1 100 100 1 1 1 100 100 1.17 0019448 L-cysteine catabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004905 interferon-alpha/beta receptor F 1 1 1 100 100 1 1 1 100 100 1.17 0016780 phosphotransferase, for other substituted phosphate groups F 0 0 0 0 0 1 1 1 100 100 1.17 0017172 cysteine dioxygenase F 1 1 1 100 100 1 1 1 100 100 1.17 0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase F 1 1 1 100 100 1 1 1 100 100 1.17 0009132 nucleoside diphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004148 dihydrolipoamide dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0016668 oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor F 0 0 0 0 0 1 1 1 100 100 1.17 0016667 oxidoreductase, acting on sulfur group of donors F 0 0 0 0 0 1 1 1 100 100 1.17 0009186 deoxyribonucleoside diphosphate metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0006528 asparagine metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004466 long-chain acyl-CoA dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0009399 nitrogen fixation P 1 1 1 100 100 1 1 1 100 100 1.17 0015074 DNA integration P 1 1 1 100 100 1 1 1 100 100 1.17 0016646 oxidoreductase, acting on the CH-NH group of donors, NAD or NADP as acceptor F 0 0 0 0 0 1 1 3 100 33.3 1.17 0004486 methylenetetrahydrofolate dehydrogenase F 0 0 0 0 0 1 1 1 100 100 1.17 0004488 methylenetetrahydrofolate dehydrogenase (NADP+) F 1 1 1 100 100 1 1 1 100 100 1.17 0008383 manganese superoxide dismutase F 1 1 1 100 100 1 1 1 100 100 1.17 0004904 interferon receptor F 0 0 0 0 0 1 1 1 100 100 1.17 0003863 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) F 1 1 1 100 100 1 1 1 100 100 1.17 0004085 butyryl-CoA dehydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0016623 oxidoreductase, acting on the aldehyde or oxo group of donors, oxygen as acceptor F 0 0 0 0 0 1 1 1 100 100 1.17 0003998 acylphosphatase F 1 1 1 100 100 1 1 1 100 100 1.17 0005555 blood group antigen F 1 1 1 100 100 1 1 1 100 100 1.17 0009071 serine family amino acid catabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0003720 telomerase F 0 0 0 0 0 1 1 1 100 100 1.17 0003997 acyl-CoA oxidase F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0004084 branched-chain amino acid aminotransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004770 sterol carrier protein X-related thiolase F 1 1 1 100 100 1 1 1 100 100 1.17 0006101 citrate metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0006097 glyoxylate cycle P 1 1 2 100 50 1 1 2 100 50 1.17 0003831 beta-N-acetylglucosaminyl-glycopeptide beta-1,4-galactosyltransferase F 1 1 2 100 50 1 1 2 100 50 1.17 0003946 N-acetyllactosaminide alpha-1,3-galactosyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0006129 protein-disulfide reduction P 1 1 1 100 100 1 1 1 100 100 1.17 0006119 oxidative phosphorylation P 0 0 0 0 0 1 1 7 100 14.3 1.17 0000030 mannosyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0003945 N-acetyllactosamine synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0008120 ceramide glucosyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0006122 complex III (ubiquinone to cytochrome c) P 1 1 1 100 100 1 1 1 100 100 1.17 0003891 delta DNA polymerase F 1 1 1 100 100 1 1 1 100 100 1.17 0006086 acetyl-CoA biosynthesis, from pyruvate P 1 1 2 100 50 1 1 2 100 50 1.17 0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase F 0 0 0 0 0 1 1 1 100 100 1.17 0008781 acylneuraminate cytidylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004105 cholinephosphate cytidylyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0003889 alpha DNA polymerase F 1 1 1 100 100 1 1 1 100 100 1.17 0008119 thiopurine S-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004790 thioether S-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0006085 acetyl-CoA biosynthesis P 0 0 2 0 0 1 1 4 100 25 1.17 0004608 phosphatidylethanolamine N-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004850 uridine phosphorylase F 1 1 1 100 100 1 1 1 100 100 1.17 0004799 thymidylate synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0015067 amidinotransferase F 0 0 0 0 0 1 1 1 100 100 1.17 0015068 glycine amidinotransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0006768 biotin metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0004587 ornithine-oxo-acid aminotransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0030337 DNA polymerase processivity factor F 1 1 1 100 100 1 1 1 100 100 1.17 0003908 methylated-DNA-[protein]-cysteine S-methyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0019961 interferon binding F 0 0 0 0 0 1 1 1 100 100 1.17 0008034 lipoprotein binding F 0 0 0 0 0 1 1 3 100 33.3 1.17 0003985 acetyl-CoA C-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0016453 C-acetyltransferase F 0 0 0 0 0 1 1 1 100 100 1.17 0001561 fatty acid alpha-oxidation P 1 1 1 100 100 1 1 1 100 100 1.17 0004145 diamine N-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004343 glucosamine-phosphate N-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004092 carnitine O-acetyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0016413 O-acetyltransferase F 0 0 0 0 0 1 1 2 100 50 1.17 0030169 low-density lipoprotein binding F 0 0 0 0 0 1 1 3 100 33.3 1.17 0003988 acetyl-CoA C-acyltransferase F 0 0 0 0 0 1 1 1 100 100 1.17 0005041 low-density lipoprotein receptor F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0006743 ubiquinone metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004312 fatty-acid synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0006108 malate metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0004464 leukotriene-C4 synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0003835 beta-galactosamide alpha-2,6-sialyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0003894 zeta DNA polymerase F 1 1 1 100 100 1 1 1 100 100 1.17 0016768 spermine synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0004766 spermidine synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0003790 actin modulating F 1 1 1 100 100 1 1 1 100 100 1.17 0004366 glycerol-3-phosphate acyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004337 geranyltranstransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0004095 carnitine O-palmitoyltransferase F 1 1 2 100 50 1 1 2 100 50 1.17 0006534 cysteine metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004801 transaldolase F 1 1 1 100 100 1 1 1 100 100 1.17 0005523 tropomyosin binding F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0003901 DNA-directed RNA polymerase II F 1 1 2 100 50 1 1 2 100 50 1.17 0016416 O-palmitoyltransferase F 0 0 0 0 0 1 1 2 100 50 1.17 0004471 malate dehydrogenase (decarboxylating) F 1 1 1 100 100 1 1 1 100 100 1.17 0008318 protein prenyltransferase F 1 1 1 100 100 1 1 1 100 100 1.17 0016659 oxidoreductase, acting on NADH or NADPH, other acceptor F 0 0 0 0 0 1 1 2 100 50 1.17 0009212 pyrimidine deoxyribonucleoside triphosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0009211 pyrimidine deoxyribonucleoside triphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0009197 pyrimidine deoxyribonucleoside diphosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0006233 dTDP biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0009176 pyrimidine deoxyribonucleoside monophosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004505 phenylalanine 4-monooxygenase F 1 1 1 100 100 1 1 1 100 100 1.17 0006599 phosphogen metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004506 squalene monooxygenase F 1 1 1 100 100 1 1 1 100 100 1.17 0004511 tyrosine 3-monooxygenase F 1 1 1 100 100 1 1 1 100 100 1.17 0030295 protein kinase activator F 1 1 1 100 100 1 1 1 100 100 1.17 0009177 pyrimidine deoxyribonucleoside monophosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0004325 ferrochelatase F 1 1 1 100 100 1 1 1 100 100 1.17 0006601 creatine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0004018 adenylosuccinate lyase F 1 1 1 100 100 1 1 1 100 100 1.17 0005099 RAS GTPase activator F 1 1 1 100 100 1 1 1 100 100 1.17 0004821 histidine-tRNA ligase F 1 1 1 100 100 1 1 1 100 100 1.17 0005173 stem cell factor receptor ligand F 1 1 1 100 100 1 1 1 100 100 1.17 0006055 CMP-N-acetylneuraminate biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0006529 asparagine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0016884 carbon-nitrogen ligase, with glutamine as amido-N-donor F 0 0 0 0 0 1 1 1 100 100 1.17 0004066 asparagine synthase (glutamine-hydrolyzing) F 1 1 1 100 100 1 1 1 100 100 1.17 0006221 pyrimidine nucleotide biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0006600 creatine metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0003994 aconitate hydratase F 1 1 1 100 100 1 1 1 100 100 1.17 0016842 amidine-lyase F 0 0 0 0 0 1 1 1 100 100 1.17 0004418 hydroxymethylbilane synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0000273 lipoic acid metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004421 hydroxymethylglutaryl-CoA synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0009138 pyrimidine nucleoside diphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0004419 hydroxymethylglutaryl-CoA lyase F 1 1 1 100 100 1 1 1 100 100 1.17 0004108 citrate (SI)-synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0009130 pyrimidine nucleoside monophosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0008124 4a-hydroxytetrahydrobiopterin dehydratase F 1 1 1 100 100 1 1 1 100 100 1.17 0004853 uroporphyrinogen decarboxylase F 1 1 1 100 100 1 1 1 100 100 1.17 0009196 pyrimidine deoxyribonucleoside diphosphate metabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0016832 aldehyde-lyase F 0 0 0 0 0 1 1 4 100 25 1.17 0016850 other lyase F 0 0 0 0 0 1 1 1 100 100 1.17 0017140 lipoic acid synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0009139 pyrimidine nucleoside diphosphate biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0006235 dTTP biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0004333 fumarate hydratase F 1 1 1 100 100 1 1 1 100 100 1.17 0003963 RNA-3’-phosphate cyclase F 1 1 2 100 50 1 1 2 100 50 1.17 0004634 phosphopyruvate hydratase F 1 1 3 100 33.3 1 1 3 100 33.3 1.17 0004730 pseudouridylate synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0003906 DNA-(apurinic or apyrimidinic site) lyase F 1 1 1 100 100 1 1 1 100 100 1.17 0016839 other carbon-oxygen lyase F 0 0 0 0 0 1 1 1 100 100 1.17 0009396 folic acid and derivative biosynthesis P 1 1 2 100 50 1 1 2 100 50 1.17 0019530 taurine metabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0006527 arginine catabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0006552 leucine catabolism P 1 1 1 100 100 1 1 1 100 100 1.17 0019209 kinase activator F 0 0 0 0 0 1 1 1 100 100 1.17 0009083 branched chain family amino acid catabolism P 0 0 0 0 0 1 1 1 100 100 1.17 0008121 ubiquinol-cytochrome c reductase F 1 1 2 100 50 1 1 2 100 50 1.17 0009395 phospholipid catabolism P 1 1 2 100 50 1 1 2 100 50 1.17 0016681 oxidoreductase, acting on diphenols and related substances as donors, cytochrome as acceptor F 0 0 0 0 0 1 1 2 100 50 1.17 0008478 pyridoxal kinase F 1 1 1 100 100 1 1 1 100 100 1.17 0006405 nuclear RNA-nucleus export P 1 1 2 100 50 1 1 3 100 33.3 1.17 0004485 methylcrotonyl-CoA carboxylase F 1 1 1 100 100 1 1 1 100 100 1.17 0006403 RNA localization P 0 0 0 0 0 1 1 3 100 33.3 1.17 0016679 oxidoreductase, acting on diphenols and related substances as donors F 0 0 0 0 0 1 1 2 100 50 1.17 0003957 NAD(P)(+) transhydrogenase (B-specific) F 1 1 1 100 100 1 1 1 100 100 1.17 0008746 NAD(P)(+) transhydrogenase F 1 1 1 100 100 1 1 1 100 100 1.17 0006231 dTMP biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0006656 phosphatidylcholine biosynthesis P 1 1 1 100 100 1 1 1 100 100 1.17 0006585 dopamine biosynthesis, from tyrosine P 1 1 1 100 100 1 1 1 100 100 1.17 0003955 NAD(P)H2 dehydrogenase (quinone) F 1 1 1 100 100 1 1 1 100 100 1.17 0008751 NAD(P)H2 dehydrogenase F 0 0 0 0 0 1 1 1 100 100 1.17 0016553 base conversion/substitution editing P 1 1 1 100 100 1 1 1 100 100 1.17 0019007 N-acetylneuraminic acid phosphate synthase F 1 1 1 100 100 1 1 1 100 100 1.17 0004356 glutamate-ammonia ligase F 1 1 1 100 100 1 1 1 100 100 1.17 0009067 aspartate family amino acid biosynthesis P 0 0 0 0 0 1 1 1 100 100 1.17 0016421 CoA carboxylase F 0 0 0 0 0 1 1 2 100 50 1.17 0004736 pyruvate carboxylase F 1 1 1 100 100 1 1 1 100 100 1.17 0006823 heavy metal ion transport P 2 3 4 66.7 75 5 8 12 62.5 66.7 1.162 0003682 chromatin binding F 5 8 11 62.5 72.7 5 8 11 62.5 72.7 1.162 0006779 porphyrin biosynthesis P 3 6 7 50 85.7 5 8 9 62.5 88.9 1.162 0006783 heme biosynthesis P 5 8 9 62.5 88.9 5 8 9 62.5 88.9 1.162 0006766 vitamin metabolism P 1 1 1 100 100 5 8 10 62.5 80 1.162 0004364 glutathione transferase F 6 10 13 60 76.9 6 10 13 60 76.9 1.14 0003713 transcription co-activator F 6 10 14 60 71.4 6 10 14 60 71.4 1.14 0008757 S-adenosylmethionine-dependent methyltransferase F 2 3 4 66.7 75 6 10 12 60 83.3 1.14 0005544 calcium-dependent phospholipid binding F 6 10 11 60 90.9 6 10 11 60 90.9 1.14 0012502 induction of programmed cell death P 0 0 0 0 0 9 16 24 56.2 66.7 1.138 0006732 coenzyme metabolism P 0 0 0 0 0 9 16 22 56.2 72.7 1.138 0003811 complement component F 9 14 16 64.3 87.5 9 16 19 56.2 84.2 1.138 0006917 induction of apoptosis P 8 13 21 61.5 61.9 9 16 24 56.2 66.7 1.138 0008094 DNA dependent adenosinetriphosphatase F 6 10 11 60 90.9 8 14 16 57.1 87.5 1.132 0006643 membrane lipid metabolism P 0 0 0 0 0 8 14 19 57.1 73.7 1.132 0006334 nucleosome assembly P 8 14 17 57.1 82.4 8 14 17 57.1 82.4 1.132 0006644 phospholipid metabolism P 3 4 4 75 100 8 14 19 57.1 73.7 1.132 0006163 purine nucleotide metabolism P 0 0 0 0 0 7 12 16 58.3 75 1.132 0009108 coenzyme biosynthesis P 0 0 0 0 0 7 12 18 58.3 66.7 1.132 0006512 ubiquitin cycle P 6 11 14 54.5 78.6 7 12 16 58.3 75 1.132 0030154 cell differentiation P 5 7 9 71.4 77.8 7 12 18 58.3 66.7 1.132 0007050 cell cycle arrest P 7 12 12 58.3 100 7 12 12 58.3 100 1.132 0007031 peroxisome organization and biogenesis P 7 12 15 58.3 80 7 12 15 58.3 80 1.132 0009056 catabolism P 1 1 1 100 100 106 232 300 45.7 77.3 1.099 0016746 transferase, transferring acyl groups F 0 0 0 0 0 17 33 43 51.5 76.7 1.085 0003774 motor F 22 40 64 55 62.5 22 44 72 50 61.1 1.05 0005764 lysosome C 22 41 53 53.7 77.4 22 44 57 50 77.2 1.05 0016874 ligase F 0 0 0 0 0 15 29 40 51.7 72.5 1.04 0006511 ubiquitin-dependent protein degradation P 18 39 51 46.2 76.5 21 42 57 50 73.7 1.026 0008289 lipid binding F 13 28 33 46.4 84.8 21 42 51 50 82.4 1.026 0016616 oxidoreductase, acting on the CH-OH group of donors, NAD or NADP as acceptor F 0 0 0 0 0 21 42 47 50 89.4 1.026 0005623 cell C 0 0 0 0 0 1230 2876 4096 42.8 70.2 0.982 0015674 di-, tri-valent inorganic cation transport P 0 0 0 0 0 11 21 28 52.4 75 0.945 0005730 nucleolus C 5 13 19 38.5 68.4 10 19 34 52.6 55.9 0.921 0005604 basement membrane C 8 16 18 50 88.9 9 17 19 52.9 89.5 0.897 0006357 transcription regulation, from Pol II promoter P 5 13 27 38.5 48.1 9 17 38 52.9 44.7 0.897 0005783 endoplasmic reticulum C 45 101 119 44.6 84.9 54 117 141 46.2 83 0.873 0000263 heterotrimeric G-protein GTPase, alpha-subunit F 8 15 16 53.3 93.8 8 15 16 53.3 93.8 0.873 0003773 heat shock protein F 8 15 18 53.3 83.3 8 15 18 53.3 83.3 0.873 0016835 carbon-oxygen lyase F 0 0 0 0 0 8 15 23 53.3 65.2 0.873 0007610 behavior P 0 1 3 0 0 8 15 21 53.3 71.4 0.873 0015405 P-P-bond-hydrolyzis-driven transporter F 0 0 0 0 0 25 52 78 48.1 66.7 0.86 0005945 6-phosphofructokinase C 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0004576 oligosaccharyl transferase F 1 1 1 100 100 2 3 4 66.7 75 0.858 0005172 vascular endothelial growth factor receptor ligand F 2 3 4 66.7 75 2 3 4 66.7 75 0.858 0015027 coreceptor, soluble ligand F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0004862 cAMP-dependent protein kinase inhibitor F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0004859 phospholipase inhibitor F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0001502 cartilage condensation P 2 3 4 66.7 75 2 3 4 66.7 75 0.858 0003956 NAD(P)(+)-arginine ADP-ribosyltransferase F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0006801 superoxide metabolism P 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0007611 learning and memory P 1 1 1 100 100 2 3 4 66.7 75 0.858 0003767 cochaperone F 1 2 2 50 100 2 3 3 66.7 100 0.858 0009451 RNA modification P 0 0 0 0 0 2 3 3 66.7 100 0.858 0006769 nicotinamide metabolism P 0 0 0 0 0 2 3 3 66.7 100 0.858 0003886 DNA (cytosine-5-)-methyltransferase F 2 3 4 66.7 75 2 3 4 66.7 75 0.858 0005736 DNA-directed RNA polymerase I C 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0003900 DNA-directed RNA polymerase I F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0004685 calcium/calmodulin-dependent protein kinase F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0005501 retinoid binding F 2 3 4 66.7 75 2 3 4 66.7 75 0.858 0016506 apoptosis activator F 1 2 3 50 66.7 2 3 5 66.7 60 0.858 0005954 calcium/calmodulin-dependent protein kinase C 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0006584 catecholamine metabolism P 2 3 6 66.7 50 2 3 6 66.7 50 0.858 0019840 isoprenoid binding F 0 0 0 0 0 2 3 4 66.7 75 0.858 0019362 pyridine nucleotide metabolism P 0 0 0 0 0 2 3 3 66.7 100 0.858 0003872 6-phosphofructokinase F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0005890 sodium/potassium-exchanging ATPase C 2 3 4 66.7 75 2 3 4 66.7 75 0.858 0007032 endosome organization and biogenesis P 0 0 0 0 0 2 3 3 66.7 100 0.858 0016624 oxidoreductase, acting on the aldehyde or oxo group of donors, disulfide as acceptor F 2 3 3 66.7 100 2 3 4 66.7 75 0.858 0005452 inorganic anion exchanger F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0016615 malate dehydrogenase F 1 2 2 50 100 2 3 3 66.7 100 0.858 0000002 mitochondrial genome maintenance P 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0008637 apoptotic mitochondrial changes P 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0019239 deaminase F 0 0 0 0 0 2 3 6 66.7 50 0.858 0016805 dipeptidase F 0 0 0 0 0 2 3 3 66.7 100 0.858 0016714 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen F 0 0 0 0 0 2 3 3 66.7 100 0.858 0006740 NADPH regeneration P 0 0 0 0 0 2 3 3 66.7 100 0.858 0016706 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors F 0 0 0 0 0 2 3 4 66.7 75 0.858 0007431 salivary gland development P 0 0 0 0 0 2 3 3 66.7 100 0.858 0007286 spermatid development P 2 3 4 66.7 75 2 3 5 66.7 60 0.858 0015992 proton transport P 0 0 0 0 0 2 3 5 66.7 60 0.858 0004784 superoxide dismutase F 1 1 1 100 100 2 3 3 66.7 100 0.858 0016721 oxidoreductase, acting on superoxide radicals as acceptor F 0 0 0 0 0 2 3 3 66.7 100 0.858 0004029 aldehyde dehydrogenase (NAD+) F 2 3 5 66.7 60 2 3 5 66.7 60 0.858 0016197 endosome transport P 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0006826 iron transport P 2 3 6 66.7 50 2 3 6 66.7 50 0.858 0004656 procollagen-proline,2-oxoglutarate-4-dioxygenase F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0005696 telomere C 1 2 3 50 66.7 2 3 4 66.7 75 0.858 0007435 salivary gland morphogenesis P 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0006739 NADPH metabolism P 0 0 0 0 0 2 3 3 66.7 100 0.858 0008239 dipeptidyl-peptidase F 1 1 1 100 100 2 3 3 66.7 100 0.858 0016655 oxidoreductase, acting on NADH or NADPH, quinone or similar compound as acceptor F 0 0 0 0 0 2 3 12 66.7 25 0.858 0006098 pentose-phosphate shunt P 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0016547 RNA editing P 0 0 0 0 0 2 3 3 66.7 100 0.858 0005080 protein kinase C binding F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0016865 intramolecular isomerase, other intramolecular oxidoreductases F 0 0 0 0 0 2 3 4 66.7 75 0.858 0008199 ferric iron binding F 2 3 5 66.7 60 2 3 5 66.7 60 0.858 0016840 carbon-nitrogen lyase F 0 0 0 0 0 2 3 4 66.7 75 0.858 0015301 anion:anion antiporter F 0 0 0 0 0 2 3 4 66.7 75 0.858 0015380 anion exchanger F 0 0 1 0 0 2 3 4 66.7 75 0.858 0019798 procollagen-proline dioxygenase F 0 0 0 0 0 2 3 3 66.7 100 0.858 0004470 malic enzyme F 2 3 3 66.7 100 2 3 3 66.7 100 0.858 0005506 iron binding F 5 10 12 50 83.3 7 13 17 53.8 76.5 0.85 0016903 oxidoreductase, acting on the aldehyde or oxo group of donors F 0 0 0 0 0 7 13 16 53.8 81.2 0.85 0004702 receptor signaling protein serine/threonine kinase F 3 5 5 60 100 7 13 18 53.8 72.2 0.85 0005718 nucleosome C 6 11 18 54.5 61.1 6 11 18 54.5 61.1 0.829 0016763 transferase, transferring pentosyl groups F 0 0 0 0 0 6 11 13 54.5 84.6 0.829 0004199 caspase F 6 11 11 54.5 100 6 11 11 54.5 100 0.829 0006752 group transfer coenzyme metabolism P 0 0 0 0 0 5 9 14 55.6 64.3 0.811 0008303 caspase C 5 9 9 55.6 100 5 9 9 55.6 100 0.811 0042168 heme metabolism P 0 0 0 0 0 5 9 11 55.6 81.8 0.811 0006778 porphyrin metabolism P 0 0 0 0 0 5 9 11 55.6 81.8 0.811 0009117 nucleotide metabolism P 1 3 3 33.3 100 13 26 35 50 74.3 0.806 0015758 glucose transport P 3 5 6 60 83.3 3 5 6 60 83.3 0.805 0006094 gluconeogenesis P 3 5 7 60 71.4 3 5 7 60 71.4 0.805 0016637 oxidoreductase, acting on the CH-CH group of donors, other acceptors F 0 0 0 0 0 3 5 8 60 62.5 0.805 0008645 hexose transport P 0 0 0 0 0 3 5 6 60 83.3 0.805 0015749 monosaccharide transport P 0 0 0 0 0 3 5 6 60 83.3 0.805 0019208 phosphatase regulator F 0 1 2 0 0 3 5 10 60 50 0.805 0016529 sarcoplasmic reticulum C 3 5 5 60 100 3 5 5 60 100 0.805 0016528 sarcoplasm C 0 0 0 0 0 3 5 5 60 100 0.805 0006885 pH regulation P 3 4 5 75 80 3 5 6 60 83.3 0.805 0006767 water-soluble vitamin metabolism P 0 0 0 0 0 3 5 5 60 100 0.805 0008408 3’-5’ exonuclease F 3 5 6 60 83.3 3 5 7 60 71.4 0.805 0006093 anabolic carbohydrate metabolism P 0 0 0 0 0 3 5 7 60 71.4 0.805 0030004 monovalent inorganic cation homeostasis P 0 0 0 0 0 3 5 7 60 71.4 0.805 0003782 F-actin capping F 3 5 8 60 62.5 3 5 8 60 62.5 0.805 0007015 actin filament organization P 3 5 8 60 62.5 3 5 8 60 62.5 0.805 0007492 endoderm development P 2 3 7 66.7 42.9 3 5 9 60 55.6 0.805 0015297 antiporter F 0 0 0 0 0 3 5 8 60 62.5 0.805 0008443 phosphofructokinase F 0 0 0 0 0 3 5 5 60 100 0.805 0005351 sugar porter F 3 5 6 60 83.3 3 5 6 60 83.3 0.805 0006497 fatty acid:protein modification P 0 0 0 0 0 3 5 6 60 83.3 0.805 0016814 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines F 1 2 2 50 100 3 5 9 60 55.6 0.805 0008290 actin capping protein C 3 5 7 60 71.4 3 5 7 60 71.4 0.805 0000082 G1/S transition of mitotic cell cycle P 3 3 5 100 60 3 5 7 60 71.4 0.805 0019203 carbohydrate phosphatase F 0 0 0 0 0 3 5 5 60 100 0.805 0003916 DNA topoisomerase F 3 5 6 60 83.3 3 5 7 60 71.4 0.805 0016873 other isomerase F 0 0 0 0 0 3 5 7 60 71.4 0.805 0015450 protein translocase F 4 7 7 57.1 100 4 7 7 57.1 100 0.8 0004005 plasma membrane cation-transporting ATPase F 4 7 14 57.1 50 4 7 14 57.1 50 0.8 0015669 gas transport P 0 0 0 0 0 4 7 8 57.1 87.5 0.8 0019829 cation-transporting ATPase F 0 0 0 0 0 4 7 14 57.1 50 0.8 0019936 inositol phospholipid-mediated signaling P 0 0 1 0 0 4 7 14 57.1 50 0.8 0015406 ABC-type uptake permease F 0 0 0 0 0 4 7 14 57.1 50 0.8 0005076 receptor signaling protein serine/threonine kinase signaling protein F 0 0 0 0 0 4 7 10 57.1 70 0.8 0006695 cholesterol biosynthesis P 4 7 8 57.1 87.5 4 7 8 57.1 87.5 0.8 0015076 heavy metal ion transporter F 0 0 1 0 0 4 7 9 57.1 77.8 0.8 0015082 di-, tri-valent inorganic cation transporter F 0 0 0 0 0 4 7 8 57.1 87.5 0.8 0015563 uptake permease F 0 0 0 0 0 4 7 14 57.1 50 0.8 0016651 oxidoreductase, acting on NADH or NADPH F 0 0 0 0 0 4 7 18 57.1 38.9 0.8 0005344 oxygen transporter F 4 7 9 57.1 77.8 4 7 9 57.1 77.8 0.8 0007626 locomotory behavior P 3 4 6 75 66.7 4 7 9 57.1 77.8 0.8 0005373 heavy metal ion porter F 0 0 0 0 0 4 7 8 57.1 87.5 0.8 0006754 ATP biosynthesis P 4 7 11 57.1 63.6 4 7 11 57.1 63.6 0.8 0006305 DNA alkylation P 0 0 1 0 0 4 7 10 57.1 70 0.8 0007200 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) P 1 3 5 33.3 60 4 7 13 57.1 53.8 0.8 0016627 oxidoreductase, acting on the CH-CH group of donors F 0 0 0 0 0 4 7 14 57.1 50 0.8 0007148 cell shape and cell size control P 0 2 2 0 0 4 7 9 57.1 77.8 0.8 0015646 permease F 0 0 0 0 0 4 7 14 57.1 50 0.8 0005160 transforming growth factor-beta receptor ligand F 3 4 4 75 100 4 7 7 57.1 100 0.8 0006306 DNA methylation P 4 7 9 57.1 77.8 4 7 9 57.1 77.8 0.8 0006753 nucleoside phosphate metabolism P 0 0 0 0 0 4 7 11 57.1 63.6 0.8 0040029 epigenetic control of gene expression P 0 0 0 0 0 4 7 9 57.1 77.8 0.8 0005768 endosome C 3 4 5 75 80 4 7 8 57.1 87.5 0.8 0015671 oxygen transport P 4 7 8 57.1 87.5 4 7 8 57.1 87.5 0.8 0006959 humoral immune response P 8 16 55 50 29.1 18 37 79 48.6 46.8 0.795 0003777 microtubule motor F 11 21 40 52.4 52.5 11 22 44 50 50 0.741 0005759 mitochondrial matrix C 2 3 4 66.7 75 11 22 33 50 66.7 0.741 0006951 heat shock response P 11 22 31 50 71 11 22 31 50 71 0.741 0009266 temperature response P 0 0 0 0 0 11 22 31 50 71 0.741 0004197 cysteine-type endopeptidase F 9 18 24 50 75 16 33 41 48.5 80.5 0.732 0016887 ATPase F 1 2 5 50 40 36 78 114 46.2 68.4 0.71 0006956 complement activation P 9 15 16 60 93.8 10 20 23 50 87 0.706 0016042 lipid catabolism P 9 18 24 50 75 10 20 26 50 76.9 0.706 0004722 protein serine/threonine phosphatase F 8 16 19 50 84.2 9 18 27 50 66.7 0.67 0008234 cysteine-type peptidase F 14 30 47 46.7 63.8 18 38 57 47.4 66.7 0.646 0008287 protein serine/threonine phosphatase C 7 15 18 46.7 83.3 8 16 20 50 80 0.631 0000139 Golgi membrane C 8 16 18 50 88.9 8 16 18 50 88.9 0.631 0008015 circulation P 0 1 1 0 0 8 16 17 50 94.1 0.631 0005516 calmodulin binding F 17 36 46 47.2 78.3 17 36 46 47.2 78.3 0.61 0006519 amino acid and derivative metabolism P 0 0 0 0 0 21 45 58 46.7 77.6 0.607 0003676 nucleic acid binding F 71 141 181 50.4 77.9 378 877 1264 43.1 69.4 0.59 0006958 complement activation, classical pathway P 7 14 14 50 100 7 14 14 50 100 0.59 0016836 hydro-lyase F 1 1 1 100 100 7 14 21 50 66.7 0.59 0005489 electron transporter F 3 5 5 60 100 12 25 30 48 83.3 0.587 0016790 thiolester hydrolase F 0 0 0 0 0 6 12 24 50 50 0.547 0006818 hydrogen transport P 4 9 12 44.4 75 6 12 17 50 70.6 0.547 0016860 intramolecular isomerase F 0 0 0 0 0 6 12 13 50 92.3 0.547 0016310 phosphorylation P 0 0 0 0 0 82 186 228 44.1 81.6 0.527 0016064 humoral defense mechanism (sensu Vertebrata) P 0 1 1 0 0 10 21 24 47.6 87.5 0.502 0006800 oxygen and radical metabolism P 1 1 1 100 100 10 21 25 47.6 84 0.502 0008643 carbohydrate transport P 4 7 8 57.1 87.5 5 10 12 50 83.3 0.499 0030097 hemopoiesis P 4 7 9 57.1 77.8 5 10 15 50 66.7 0.499 0016410 N-acyltransferase F 0 1 1 0 0 5 10 11 50 90.9 0.499 0005044 scavenger receptor F 5 10 16 50 62.5 5 10 16 50 62.5 0.499 0008150 biological_process P 0 0 0 0 0 1503 3544 4962 42.4 71.4 0.49 0005386 carrier F 14 46 53 30.4 86.8 58 131 196 44.3 66.8 0.484 0006886 intracellular protein transport P 40 90 113 44.4 79.6 63 143 178 44.1 80.3 0.452 0016459 myosin C 4 8 11 50 72.7 4 8 12 50 66.7 0.446 0009306 protein secretion P 3 5 5 60 100 4 8 12 50 66.7 0.446 0007409 axonogenesis P 1 1 6 100 16.7 4 8 17 50 47.1 0.446 0006468 protein amino acid phosphorylation P 77 174 209 44.3 83.3 81 185 221 43.8 83.7 0.44 0005505 heavy metal binding F 7 12 14 58.3 85.7 27 60 81 45 74.1 0.439 0005875 microtubule associated protein C 9 21 26 42.9 80.8 16 35 60 45.7 58.3 0.42 0007276 gametogenesis P 1 1 2 100 50 12 26 37 46.2 70.3 0.408 0005871 kinesin C 8 17 38 47.1 44.7 8 17 38 47.1 44.7 0.405 0003928 RAB small monomeric GTPase F 8 17 23 47.1 73.9 8 17 23 47.1 73.9 0.405 0016820 hydrolase, acting on acid anhydrides, - catalysing transmembrane movement of substances F 0 0 0 0 0 19 42 67 45.2 62.7 0.398 0006833 water transport P 3 6 9 50 66.7 3 6 9 50 66.7 0.386 0005753 proton-transporting ATP synthase complex C 3 6 9 50 66.7 3 6 9 50 66.7 0.386 0015250 water channel F 3 6 9 50 66.7 3 6 9 50 66.7 0.386 0006839 mitochondrial transport P 3 6 6 50 100 3 6 6 50 100 0.386 0000226 microtubule cytoskeleton organization and biogenesis P 1 2 2 50 100 3 6 7 50 85.7 0.386 0016799 hydrolase, hydrolyzing N-glycosyl compounds F 0 0 0 0 0 3 6 6 50 100 0.386 0042044 fluid transport P 0 0 0 0 0 3 6 9 50 66.7 0.386 0007126 meiosis P 3 6 8 50 75 3 6 9 50 66.7 0.386 0003725 double-stranded RNA binding F 2 5 6 40 83.3 3 6 8 50 75 0.386 0016886 ligase, forming phosphoric ester bonds F 0 0 0 0 0 3 6 8 50 75 0.386 0016831 carboxy-lyase F 0 2 3 0 0 3 6 10 50 60 0.386 0005519 cytoskeletal regulatory protein binding F 3 6 8 50 75 3 6 8 50 75 0.386 0001524 globin F 3 6 7 50 85.7 3 6 7 50 85.7 0.386 0004190 aspartic-type endopeptidase F 3 6 10 50 60 3 6 10 50 60 0.386 0006605 protein targeting P 2 4 6 50 66.7 28 63 75 44.4 84 0.36 0007283 spermatogenesis P 9 21 29 42.9 72.4 11 24 34 45.8 70.6 0.36 0008238 exopeptidase F 0 0 0 0 0 7 15 18 46.7 83.3 0.349 0004002 adenosinetriphosphatase F 0 3 4 0 0 14 31 38 45.2 81.6 0.333 0003707 steroid hormone receptor F 17 38 42 44.7 90.5 17 38 42 44.7 90.5 0.316 0004879 ligand-dependent nuclear receptor F 13 28 32 46.4 87.5 17 38 42 44.7 90.5 0.316 0003706 ligand-regulated transcription factor F 0 0 0 0 0 17 38 42 44.7 90.5 0.316 0006469 protein kinase inhibition P 2 4 4 50 100 2 4 4 50 100 0.315 0007222 frizzled receptor signaling pathway P 2 4 5 50 80 2 4 5 50 80 0.315 0016861 intramolecular isomerase, interconverting aldoses and ketoses F 0 0 0 0 0 2 4 4 50 100 0.315 0004659 prenyltransferase F 1 2 2 50 100 2 4 4 50 100 0.315 0006040 aminosugar metabolism P 0 0 0 0 0 2 4 4 50 100 0.315 0005868 cytoplasmic dynein C 2 4 5 50 80 2 4 5 50 80 0.315 0016811 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amides F 0 0 0 0 0 2 4 9 50 44.4 0.315 0006265 DNA topological change P 2 4 6 50 66.7 2 4 6 50 66.7 0.315 0005881 cytoplasmic microtubule C 0 0 0 0 0 2 4 5 50 80 0.315 0006559 phenylalanine catabolism P 2 4 5 50 80 2 4 5 50 80 0.315 0004032 aldehyde reductase F 2 4 4 50 100 2 4 4 50 100 0.315 0004003 ATP dependent DNA helicase F 2 4 5 50 80 2 4 5 50 80 0.315 0003993 acid phosphatase F 2 4 4 50 100 2 4 4 50 100 0.315 0004691 cAMP-dependent protein kinase F 0 0 0 0 0 2 4 5 50 80 0.315 0016502 nucleotide receptor F 0 0 0 0 0 2 4 4 50 100 0.315 0006558 phenylalanine metabolism P 0 0 0 0 0 2 4 5 50 80 0.315 0042079 GPI/GSI anchor metabolism P 0 0 0 0 0 2 4 5 50 80 0.315 0006919 caspase activation P 2 3 3 66.7 100 2 4 4 50 100 0.315 0004024 alcohol dehydrogenase, zinc-dependent F 2 4 5 50 80 2 4 5 50 80 0.315 0008603 cAMP-dependent protein kinase, regulator F 2 4 5 50 80 2 4 5 50 80 0.315 0006505 GPI anchor metabolism P 0 0 1 0 0 2 4 5 50 80 0.315 0004060 arylamine N-acetyltransferase F 2 4 4 50 100 2 4 4 50 100 0.315 0005079 protein kinase A anchor protein F 2 4 6 50 66.7 2 4 6 50 66.7 0.315 0004602 glutathione peroxidase F 2 4 5 50 80 2 4 5 50 80 0.315 0006974 DNA damage response P 1 2 2 50 100 2 4 5 50 80 0.315 0003964 RNA-directed DNA polymerase F 2 4 4 50 100 2 4 4 50 100 0.315 0000315 organellar large ribosomal subunit C 0 0 0 0 0 6 13 16 46.2 81.2 0.288 0005762 mitochondrial large ribosomal subunit C 6 13 16 46.2 81.2 6 13 16 46.2 81.2 0.288 0015934 large ribosomal subunit C 0 0 0 0 0 6 13 16 46.2 81.2 0.288 0005575 cellular_component C 0 0 0 0 0 1371 3238 4691 42.3 69 0.264 0007243 protein kinase cascade P 4 6 6 66.7 100 9 20 33 45 60.6 0.253 0004239 methionyl aminopeptidase F 1 2 2 50 100 1 2 2 50 100 0.223 0016745 transketolase and transaldolase F 0 0 0 0 0 1 2 2 50 100 0.223 0004372 glycine hydroxymethyltransferase F 1 1 1 100 100 1 2 5 50 40 0.223 0008171 O-methyltransferase F 1 1 1 100 100 1 2 3 50 66.7 0.223 0019970 interleukin-11 binding F 0 0 0 0 0 1 2 2 50 100 0.223 0008629 induction of apoptosis by intracellular signals P 0 0 0 0 0 1 2 2 50 100 0.223 0006776 vitamin A metabolism P 0 0 1 0 0 1 2 4 50 50 0.223 0006775 fat-soluble vitamin metabolism P 0 0 0 0 0 1 2 4 50 50 0.223 0004528 phosphodiesterase I F 1 2 2 50 100 1 2 2 50 100 0.223 0004921 interleukin-11 receptor F 1 2 2 50 100 1 2 2 50 100 0.223 0004237 membrane dipeptidase F 1 2 2 50 100 1 2 2 50 100 0.223 0030318 melanocyte differentiation P 1 2 2 50 100 1 2 2 50 100 0.223 0001523 retinoid metabolism P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0005206 heparin sulfate proteoglycan F 1 2 5 50 40 1 2 5 50 40 0.223 0001568 blood vessel development P 0 0 0 0 0 1 2 2 50 100 0.223 0000103 sulfate assimilation P 1 2 2 50 100 1 2 2 50 100 0.223 0006791 sulfur utilization P 0 0 0 0 0 1 2 2 50 100 0.223 0006790 sulfur metabolism P 0 0 0 0 0 1 2 2 50 100 0.223 0001525 angiogenesis P 1 2 2 50 100 1 2 2 50 100 0.223 0003822 MHC-interacting protein F 1 2 6 50 33.3 1 2 6 50 33.3 0.223 0000096 sulfur amino acid metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.223 0005074 inhibitory SMAD protein F 1 2 2 50 100 1 2 2 50 100 0.223 0004887 thyroid hormone receptor F 1 2 2 50 100 1 2 2 50 100 0.223 0004217 cathepsin L F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0008104 protein localization P 1 2 6 50 33.3 1 2 6 50 33.3 0.223 0009066 aspartate family amino acid metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.223 0015485 cholesterol binding F 1 2 2 50 100 1 2 2 50 100 0.223 0004806 triacylglycerol lipase F 1 2 2 50 100 1 2 2 50 100 0.223 0004287 prolyl oligopeptidase F 1 2 2 50 100 1 2 2 50 100 0.223 0009069 serine family amino acid metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.223 0004630 phospholipase D F 1 2 2 50 100 1 2 2 50 100 0.223 0000163 protein phosphatase type 1 F 0 0 1 0 0 1 2 7 50 28.6 0.223 0015925 galactosidase F 0 0 0 0 0 1 2 2 50 100 0.223 0003969 RNA editase F 0 1 1 0 0 1 2 4 50 50 0.223 0008578 DNA glycosylase F 0 0 0 0 0 1 2 2 50 100 0.223 0006824 cobalt ion transport P 1 2 2 50 100 1 2 2 50 100 0.223 0017018 myosin phosphatase F 0 0 0 0 0 1 2 6 50 33.3 0.223 0016806 dipeptidyl-peptidase and tripeptidyl-peptidase F 0 0 0 0 0 1 2 2 50 100 0.223 0008538 proteasome activator F 1 2 2 50 100 1 2 2 50 100 0.223 0016003 glutamine amidotransferase F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0005548 phospholipid transporter F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0005541 acyl-CoA or acyl binding F 0 0 0 0 0 1 2 3 50 66.7 0.223 0015985 energy coupled proton transport, down the electrochemical gradient P 0 0 0 0 0 1 2 2 50 100 0.223 0015986 ATP synthesis coupled proton transport P 1 2 2 50 100 1 2 2 50 100 0.223 0000062 acyl-CoA binding F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0004461 lactose synthase F 1 2 2 50 100 1 2 2 50 100 0.223 0005532 mannose binding lectin F 1 2 2 50 100 1 2 2 50 100 0.223 0005537 mannose binding F 1 2 2 50 100 1 2 2 50 100 0.223 0008073 ornithine decarboxylase inhibitor F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0006817 phosphate transport P 1 2 2 50 100 1 2 2 50 100 0.223 0017020 myosin phosphatase, regulator F 0 0 0 0 0 1 2 6 50 33.3 0.223 0004499 dimethylaniline monooxygenase (N-oxide forming) F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0016778 diphosphotransferase F 0 0 0 0 0 1 2 4 50 50 0.223 0004781 sulfate adenylyltransferase (ATP) F 1 2 2 50 100 1 2 2 50 100 0.223 0008243 plasminogen activator F 0 0 0 0 0 1 2 2 50 100 0.223 0015701 bicarbonate transport P 1 2 2 50 100 1 2 2 50 100 0.223 0004331 fructose-2,6-bisphosphatase F 1 2 2 50 100 1 2 2 50 100 0.223 0015833 peptide transport P 0 0 0 0 0 1 2 3 50 66.7 0.223 0016744 transferase, transferring aldehyde or ketonic groups F 0 0 0 0 0 1 2 2 50 100 0.223 0006857 oligopeptide transport P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0004062 aryl sulfotransferase F 1 2 2 50 100 1 2 2 50 100 0.223 0006760 folic acid and derivative metabolism P 0 1 1 0 0 1 2 3 50 66.7 0.223 0016504 protease activator F 0 1 1 0 0 1 2 3 50 66.7 0.223 0005545 phosphatidylinositol binding F 0 0 2 0 0 1 2 5 50 40 0.223 0006898 receptor mediated endocytosis P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0006054 N-acetylneuraminate metabolism P 0 1 1 0 0 1 2 2 50 100 0.223 0004779 sulfate adenylyltransferase F 0 0 0 0 0 1 2 2 50 100 0.223 0007219 N receptor signaling pathway P 1 2 6 50 33.3 1 2 6 50 33.3 0.223 0006177 GMP biosynthesis P 1 2 2 50 100 1 2 2 50 100 0.223 0019867 outer membrane C 0 0 0 0 0 1 2 9 50 22.2 0.223 0008537 proteasome activator complex C 1 2 2 50 100 1 2 2 50 100 0.223 0016880 acid-ammonia (or amide) ligase F 0 0 0 0 0 1 2 2 50 100 0.223 0007216 metabotropic glutamate receptor signaling pathway P 1 2 4 50 50 1 2 4 50 50 0.223 0016211 ammonia ligase F 0 1 1 0 0 1 2 2 50 100 0.223 0005952 cAMP-dependent protein kinase C 1 2 2 50 100 1 2 2 50 100 0.223 0005956 casein kinase II C 1 2 2 50 100 1 2 2 50 100 0.223 0015300 solute:solute antiporter F 0 0 0 0 0 1 2 3 50 66.7 0.223 0004785 copper, zinc superoxide dismutase F 1 2 2 50 100 1 2 2 50 100 0.223 0009127 purine nucleoside monophosphate biosynthesis P 0 0 0 0 0 1 2 3 50 66.7 0.223 0007256 activation of JUN kinase kinase P 1 2 2 50 100 1 2 2 50 100 0.223 0009116 nucleoside metabolism P 1 2 4 50 50 1 2 4 50 50 0.223 0007252 phosphorylation of I-kappaB P 1 2 2 50 100 1 2 2 50 100 0.223 0004739 pyruvate dehydrogenase (lipoamide) F 1 2 2 50 100 1 2 2 50 100 0.223 0006381 mRNA editing P 1 2 2 50 100 1 2 2 50 100 0.223 0007059 chromosome segregation P 0 1 1 0 0 1 2 2 50 100 0.223 0004053 arginase F 1 2 2 50 100 1 2 2 50 100 0.223 0006269 DNA replication, priming P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0006518 peptide metabolism P 1 2 2 50 100 1 2 2 50 100 0.223 0016222 procollagen-proline,2-oxoglutarate-4-dioxygenase C 1 2 2 50 100 1 2 2 50 100 0.223 0003910 DNA ligase (ATP) F 1 2 2 50 100 1 2 2 50 100 0.223 0005741 mitochondrial outer membrane C 1 2 9 50 22.2 1 2 9 50 22.2 0.223 0016652 oxidoreductase, acting on NADH or NADPH, NAD or NADP as acceptor F 0 0 0 0 0 1 2 2 50 100 0.223 0005758 mitochondrial intermembrane space C 1 2 2 50 100 1 2 2 50 100 0.223 0015223 vitamin/cofactor transporter F 0 0 0 0 0 1 2 5 50 40 0.223 0008517 folate transporter F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0016841 ammonia-lyase F 0 0 0 0 0 1 2 3 50 66.7 0.223 0015248 sterol transporter F 0 0 0 0 0 1 2 2 50 100 0.223 0003909 DNA ligase F 0 0 0 0 0 1 2 2 50 100 0.223 0007269 neurotransmitter release P 1 1 3 100 33.3 1 2 5 50 40 0.223 0009168 purine ribonucleoside monophosphate biosynthesis P 0 0 0 0 0 1 2 3 50 66.7 0.223 0017127 cholesterol transporter F 1 2 2 50 100 1 2 2 50 100 0.223 0006986 unfolded protein response P 1 2 2 50 100 1 2 2 50 100 0.223 0016351 drug susceptibility/resistance P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0009152 purine ribonucleotide biosynthesis P 0 0 0 0 0 1 2 2 50 100 0.223 0005903 brush border C 1 2 2 50 100 1 2 2 50 100 0.223 0015103 inorganic anion transporter F 0 0 0 0 0 1 2 4 50 50 0.223 0009167 purine ribonucleoside monophosphate metabolism P 0 0 0 0 0 1 2 3 50 66.7 0.223 0005487 nucleocytoplasmic transporter F 1 2 4 50 50 1 2 4 50 50 0.223 0007004 telomere maintenance P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0006979 oxidative stress response P 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0015279 store-operated calcium channel F 1 2 2 50 100 1 2 2 50 100 0.223 0001505 neurotransmitter maintenance P 0 0 1 0 0 1 2 7 50 28.6 0.223 0003873 6-phosphofructo-2-kinase F 1 2 2 50 100 1 2 2 50 100 0.223 0004618 phosphoglycerate kinase F 1 2 2 50 100 1 2 2 50 100 0.223 0015298 solute:cation antiporter F 0 0 0 0 0 1 2 3 50 66.7 0.223 0008046 axon guidance receptor F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0016556 mRNA modification P 0 0 0 0 0 1 2 2 50 100 0.223 0004551 nucleotide pyrophosphatase F 1 2 2 50 100 1 2 2 50 100 0.223 0016462 pyrophosphatase F 0 0 0 0 0 1 2 3 50 66.7 0.223 0019238 cyclohydrolase F 0 0 0 0 0 1 2 3 50 66.7 0.223 0004000 adenosine deaminase F 0 1 1 0 0 1 2 4 50 50 0.223 0008606 phosphorylase kinase, catalyst F 1 2 2 50 100 1 2 2 50 100 0.223 0005178 integrin ligand F 1 2 7 50 28.6 1 2 7 50 28.6 0.223 0004797 thymidine kinase F 1 2 2 50 100 1 2 2 50 100 0.223 0005185 neurohypophyseal hormone F 1 2 2 50 100 1 2 2 50 100 0.223 0001664 G-protein coupled receptor ligand F 1 2 2 50 100 1 2 2 50 100 0.223 0004843 ubiquitin-specific protease F 1 2 4 50 50 1 2 4 50 50 0.223 0004345 glucose-6-phosphate 1-dehydrogenase F 1 2 2 50 100 1 2 2 50 100 0.223 0003938 IMP dehydrogenase F 1 2 2 50 100 1 2 2 50 100 0.223 0003845 11-beta-hydroxysteroid dehydrogenase F 1 2 2 50 100 1 2 2 50 100 0.223 0030282 bone mineralization P 1 2 2 50 100 1 2 3 50 66.7 0.223 0004738 pyruvate dehydrogenase F 0 0 0 0 0 1 2 2 50 100 0.223 0004622 lysophospholipase F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0017040 ceramidase F 0 0 1 0 0 1 2 3 50 66.7 0.223 0004680 casein kinase F 0 0 0 0 0 1 2 2 50 100 0.223 0005005 transmembrane-ephrin receptor F 1 2 3 50 66.7 1 2 3 50 66.7 0.223 0016634 oxidoreductase, acting on the CH-CH group of donors, oxygen as acceptor F 0 0 0 0 0 1 2 5 50 40 0.223 0007613 memory P 1 2 2 50 100 1 2 2 50 100 0.223 0007040 lysosome organization and biogenesis P 1 1 1 100 100 1 2 2 50 100 0.223 0015175 neutral amino acid transporter F 1 2 2 50 100 1 2 2 50 100 0.223 0006284 base-excision repair P 1 2 4 50 50 1 2 4 50 50 0.223 0008067 metabotropic glutamate, GABA-B-like receptor F 1 2 4 50 50 1 2 6 50 33.3 0.223 0001633 secretin-like receptor F 0 0 0 0 0 1 2 2 50 100 0.223 0004682 casein kinase II F 0 0 0 0 0 1 2 2 50 100 0.223 0004994 somatostatin receptor F 1 2 2 50 100 1 2 2 50 100 0.223 0008227 amine receptor F 0 0 0 0 0 1 2 3 50 66.7 0.223 0008285 negative control of cell proliferation P 1 2 5 50 40 1 2 5 50 40 0.223 0004840 ubiquitin conjugating enzyme F 5 11 13 45.5 84.6 5 11 13 45.5 84.6 0.218 0016125 sterol metabolism P 0 0 0 0 0 5 11 14 45.5 78.6 0.218 0006112 metabolism of energy reserves P 1 2 2 50 100 5 11 16 45.5 68.8 0.218 0008639 small protein conjugating enzyme F 0 0 0 0 0 5 11 13 45.5 84.6 0.218 0003936 hydrogen-transporting two-sector ATPase F 4 10 14 40 71.4 5 11 16 45.5 68.8 0.218 0015442 hydrogen-/sodium-translocating ATPase F 0 0 0 0 0 5 11 16 45.5 68.8 0.218 0008203 cholesterol metabolism P 2 5 6 40 83.3 5 11 14 45.5 78.6 0.218 0005761 mitochondrial ribosome C 0 0 4 0 0 8 18 27 44.4 66.7 0.192 0008026 ATP dependent helicase F 6 15 18 40 83.3 8 18 23 44.4 78.3 0.192 0000313 organellar ribosome C 0 0 0 0 0 8 18 27 44.4 66.7 0.192 0016792 phosphoric diester hydrolase F 0 0 0 0 0 8 18 32 44.4 56.2 0.192 0007178 transmembrane receptor protein serine/threonine kinase signaling pathway P 4 7 9 57.1 77.8 11 25 31 44 80.6 0.181 0006304 DNA modification P 0 2 2 0 0 4 9 12 44.4 75 0.135 0006730 one-carbon compound metabolism P 4 9 13 44.4 69.2 4 9 13 44.4 69.2 0.135 0016620 oxidoreductase, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor F 0 1 1 0 0 4 9 11 44.4 81.8 0.135 0005024 transforming growth factor-beta receptor F 4 9 9 44.4 100 4 9 9 44.4 100 0.135 0005189 milk protein F 4 9 9 44.4 100 4 9 9 44.4 100 0.135 0007266 RHO protein signal transduction P 4 9 11 44.4 81.8 4 9 11 44.4 81.8 0.135 0005977 glycogen metabolism P 3 6 10 50 60 4 9 14 44.4 64.3 0.135 0005905 coated pit C 4 9 16 44.4 56.2 4 9 16 44.4 56.2 0.135 0008632 apoptotic program P 1 3 3 33.3 100 4 9 9 44.4 100 0.135 0009165 nucleotide biosynthesis P 2 2 3 100 66.7 4 9 13 44.4 69.2 0.135 0006812 cation transport P 16 38 51 42.1 74.5 42 98 135 42.9 72.6 0.13 0004009 ATP-binding cassette (ABC) transporter F 8 22 35 36.4 62.9 13 30 50 43.3 60 0.124 0000003 reproduction P 0 0 0 0 0 13 30 42 43.3 71.4 0.124 0008081 phosphodiesterase F 1 1 2 100 50 7 16 29 43.8 55.2 0.124 0008246 electron transfer flavoprotein F 7 16 19 43.8 84.2 7 16 19 43.8 84.2 0.124 0005057 receptor signaling protein F 1 5 7 20 71.4 36 84 128 42.9 65.6 0.12 0030001 metal ion transport P 0 0 0 0 0 33 77 100 42.9 77 0.115 0006796 phosphate metabolism P 0 0 0 0 0 97 228 278 42.5 82 0.103 0003702 RNA polymerase II transcription factor F 4 7 12 57.1 58.3 21 49 60 42.9 81.7 0.091 0006813 potassium transport P 21 49 60 42.9 81.7 21 49 60 42.9 81.7 0.091 0006118 electron transport P 37 87 106 42.5 82.1 37 87 113 42.5 77 0.059 0005083 small GTPase regulatory/interacting protein F 7 10 18 70 55.6 23 54 78 42.6 69.2 0.056 0006816 calcium ion transport P 6 14 18 42.9 77.8 6 14 18 42.9 77.8 0.049 0006464 protein modification P 9 21 23 42.9 91.3 119 281 336 42.3 83.6 0.046 0004928 frizzled receptor F 3 7 9 42.9 77.8 3 7 9 42.9 77.8 0.034 0004892 B-cell receptor F 0 0 0 0 0 3 7 44 42.9 15.9 0.034 0006665 sphingolipid metabolism P 1 3 3 33.3 100 3 7 9 42.9 77.8 0.034 0003823 antibody F 3 7 44 42.9 15.9 3 7 44 42.9 15.9 0.034 0016718 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous F 0 0 0 0 0 3 7 10 42.9 70 0.034 0008483 transaminase F 1 4 4 25 100 3 7 9 42.9 77.8 0.034 0016769 transferase, transferring nitrogenous groups F 0 0 0 0 0 3 7 9 42.9 77.8 0.034 0005106 ephrin F 3 7 8 42.9 87.5 3 7 8 42.9 87.5 0.034 0009072 aromatic amino acid family metabolism P 2 3 3 66.7 100 3 7 8 42.9 87.5 0.034 0004707 MAP kinase F 3 7 9 42.9 77.8 3 7 9 42.9 77.8 0.034 0008037 cell recognition P 0 0 0 0 0 3 7 11 42.9 63.6 0.034 0015144 carbohydrate transporter F 0 0 0 0 0 3 7 9 42.9 77.8 0.034 0007411 axon guidance P 3 6 10 50 60 3 7 11 42.9 63.6 0.034 0004198 calpain F 3 7 8 42.9 87.5 3 7 8 42.9 87.5 0.034 0008378 galactosyltransferase F 1 1 2 100 50 3 7 11 42.9 63.6 0.034 0007229 integrin-mediated signaling pathway P 11 26 32 42.3 81.2 11 26 32 42.3 81.2 0.009 GO Gene Ontology r 0 0 0 0 0 1931 4574 6697 42.2 68.3 0 0019725 homeostasis P 0 0 0 0 0 8 19 30 42.1 63.3 -0.01 0016789 carboxylic ester hydrolase F 1 6 7 16.7 85.7 8 19 22 42.1 86.4 -0.01 0016329 apoptosis regulator F 8 21 27 38.1 77.8 13 31 43 41.9 72.1 -0.032 0019825 oxygen binding F 0 0 0 0 0 5 12 17 41.7 70.6 -0.039 0006916 anti-apoptosis P 5 12 19 41.7 63.2 5 12 19 41.7 63.2 -0.039 0007167 enzyme linked receptor protein signaling pathway P 1 1 1 100 100 34 81 103 42 78.6 -0.044 0015672 monovalent inorganic cation transport P 0 0 1 0 0 28 67 88 41.8 76.1 -0.071 0006873 ion homeostasis P 0 0 1 0 0 7 17 28 41.2 60.7 -0.087 0030003 cation homeostasis P 0 0 0 0 0 7 17 27 41.2 63 -0.087 0016810 hydrolase, acting on carbon-nitrogen (but not peptide) bonds F 1 2 2 50 100 7 17 28 41.2 60.7 -0.087 0007169 transmembrane receptor protein tyrosine kinase signaling pathway P 14 36 44 38.9 81.8 17 41 52 41.5 78.8 -0.098 0015935 small ribosomal subunit C 0 0 0 0 0 2 5 8 40 62.5 -0.1 0000314 organellar small ribosomal subunit C 0 0 0 0 0 2 5 7 40 71.4 -0.1 0009636 detoxification response P 0 1 1 0 0 2 5 7 40 71.4 -0.1 0005381 iron transporter F 2 5 6 40 83.3 2 5 6 40 83.3 -0.1 0006957 complement activation, alternative pathway P 2 5 7 40 71.4 2 5 7 40 71.4 -0.1 0005763 mitochondrial small ribosomal subunit C 2 5 7 40 71.4 2 5 7 40 71.4 -0.1 0007215 glutamate signaling pathway P 1 3 3 33.3 100 2 5 7 40 71.4 -0.1 0005833 hemoglobin C 2 5 6 40 83.3 2 5 6 40 83.3 -0.1 0004016 adenylate cyclase F 2 5 7 40 71.4 2 5 7 40 71.4 -0.1 0007249 NIK-I-kappaB/NF-kappaB cascade P 1 3 6 33.3 50 2 5 8 40 62.5 -0.1 0016883 other carbon-nitrogen ligase F 0 0 0 0 0 2 5 5 40 100 -0.1 0004028 aldehyde dehydrogenase F 0 2 2 0 0 2 5 7 40 71.4 -0.1 0005558 minor histocompatibility antigen F 2 5 7 40 71.4 2 5 7 40 71.4 -0.1 0005514 calcium storage F 2 5 5 40 100 2 5 5 40 100 -0.1 0006171 cAMP biosynthesis P 2 5 7 40 71.4 2 5 7 40 71.4 -0.1 0003828 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase F 2 5 5 40 100 2 5 5 40 100 -0.1 0008374 O-acyltransferase F 0 2 4 0 0 2 5 11 40 45.5 -0.1 0003727 single-stranded RNA binding F 1 2 4 50 50 2 5 7 40 71.4 -0.1 0006525 arginine metabolism P 1 2 2 50 100 2 5 5 40 100 -0.1 0015026 coreceptor F 0 2 3 0 0 2 5 6 40 83.3 -0.1 0009074 aromatic amino acid family catabolism P 0 0 0 0 0 2 5 6 40 83.3 -0.1 0006582 melanin metabolism P 0 0 1 0 0 2 5 6 40 83.3 -0.1 0007548 sex differentiation P 2 5 5 40 100 2 5 5 40 100 -0.1 0004690 cyclic-nucleotide dependent protein kinase F 0 0 0 0 0 2 5 7 40 71.4 -0.1 0004623 phospholipase A2 F 2 5 6 40 83.3 2 5 6 40 83.3 -0.1 0016568 chromatin modification P 0 1 1 0 0 2 5 8 40 62.5 -0.1 0016863 intramolecular isomerase, transposing C=C bonds F 0 0 0 0 0 2 5 5 40 100 -0.1 0000051 urea cycle intermediate metabolism P 0 0 0 0 0 2 5 5 40 100 -0.1 0004022 alcohol dehydrogenase F 0 1 1 0 0 2 5 6 40 83.3 -0.1 0004212 lysosomal cysteine-type endopeptidase F 0 0 0 0 0 2 5 7 40 71.4 -0.1 0006583 melanin biosynthesis, from tyrosine P 2 5 5 40 100 2 5 5 40 100 -0.1 0007585 respiration P 2 5 8 40 62.5 2 5 8 40 62.5 -0.1 0007160 cell-matrix adhesion P 9 22 23 40.9 95.7 9 22 23 40.9 95.7 -0.124 0004926 non-G-protein coupled 7TM receptor F 0 0 0 0 0 4 10 12 40 83.3 -0.142 0008373 sialyltransferase F 4 8 8 50 100 4 10 10 40 100 -0.142 0006576 biogenic amine metabolism P 0 0 0 0 0 4 10 15 40 66.7 -0.142 0005976 polysaccharide metabolism P 0 0 0 0 0 4 10 15 40 66.7 -0.142 0004860 protein kinase inhibitor F 2 4 4 50 100 4 10 11 40 90.9 -0.142 0004177 aminopeptidase F 2 8 10 25 80 4 10 12 40 83.3 -0.142 0006814 sodium transport P 4 10 16 40 62.5 4 10 16 40 62.5 -0.142 0016764 transferase, transferase, transferring other glycosyl groups F 0 0 0 0 0 4 10 10 40 100 -0.142 0004675 transmembrane receptor protein serine/threonine kinase F 4 10 10 40 100 4 10 10 40 100 -0.142 0004518 nuclease F 3 16 23 18.8 69.6 13 32 50 40.6 64 -0.183 0016337 cell-cell adhesion P 2 4 5 50 80 8 20 30 40 66.7 -0.201 0004868 serpin F 12 30 36 40 83.3 12 30 36 40 83.3 -0.247 0008270 zinc binding F 12 30 40 40 75 12 30 40 40 75 -0.247 0006612 protein-membrane targeting P 0 0 0 0 0 19 47 56 40.4 83.9 -0.25 0006620 post-translational membrane targeting P 19 47 55 40.4 85.5 19 47 55 40.4 85.5 -0.25 0015031 protein transport P 10 19 23 52.6 82.6 66 160 207 41.2 77.3 -0.252 0004714 transmembrane receptor protein tyrosine kinase F 9 21 22 42.9 95.5 14 35 39 40 89.7 -0.267 0008529 endogenous peptide receptor F 0 0 0 0 0 3 8 9 37.5 88.9 -0.27 0003820 class I major histocompatibility complex antigen F 3 8 9 37.5 88.9 3 8 9 37.5 88.9 -0.27 0008189 apoptosis inhibitor F 3 8 13 37.5 61.5 3 8 13 37.5 61.5 -0.27 0006418 amino acid activation P 3 8 11 37.5 72.7 3 8 11 37.5 72.7 -0.27 0016563 transcriptional activator F 3 8 13 37.5 61.5 3 8 13 37.5 61.5 -0.27 0003854 3-beta-hydroxy-delta(5)-steroid dehydrogenase F 3 8 8 37.5 100 3 8 8 37.5 100 -0.27 0016298 lipase F 0 1 1 0 0 5 13 17 38.5 76.5 -0.275 0005496 steroid binding F 4 14 16 28.6 87.5 7 18 20 38.9 90 -0.286 0015933 flavin-containing electron transporter F 0 0 0 0 0 7 18 22 38.9 81.8 -0.286 0007179 TGFbeta receptor signaling pathway P 6 14 16 42.9 87.5 7 18 22 38.9 81.8 -0.286 0016879 ligase, forming carbon-nitrogen bonds F 0 0 0 0 0 7 18 24 38.9 75 -0.286 0016787 hydrolase F 8 16 23 50 69.6 239 574 821 41.6 69.9 -0.3 0005267 potassium channel F 17 44 55 38.6 80 18 45 56 40 80.4 -0.303 0019199 transmembrane receptor protein kinase F 0 0 0 0 0 18 45 49 40 91.8 -0.303 0000151 ubiquitin ligase complex C 1 3 7 33.3 42.9 1 3 7 33.3 42.9 -0.312 0002009 morphogenesis of an epithelium P 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0017085 insecticide response P 0 0 0 0 0 1 3 3 33.3 100 -0.312 0030125 clathrin vesicle coat C 1 3 6 33.3 50 1 3 6 33.3 50 -0.312 0006572 tyrosine catabolism P 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0006487 N-linked glycosylation P 0 2 3 0 0 1 3 4 33.3 75 -0.312 0030137 COPI-coated vesicle C 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0018193 peptidyl-amino acid modification P 0 0 0 0 0 1 3 3 33.3 100 -0.312 0030120 vesicle coat C 0 0 0 0 0 1 3 6 33.3 50 -0.312 0005247 voltage-gated chloride channel F 1 3 8 33.3 37.5 1 3 8 33.3 37.5 -0.312 0004812 tRNA ligase F 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0016876 ligase, forming aminoacyl-tRNA and related compounds F 0 0 0 0 0 1 3 4 33.3 75 -0.312 0007259 JAK-STAT cascade P 1 3 5 33.3 60 1 3 6 33.3 50 -0.312 0045045 secretory pathway P 0 0 0 0 0 1 3 7 33.3 42.9 -0.312 0019221 cytokine and chemokine mediated signaling pathway P 1 3 7 33.3 42.9 1 3 7 33.3 42.9 -0.312 0006268 DNA unwinding P 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0005542 folate binding F 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0016875 ligase, forming carbon-oxygen bonds F 0 0 0 0 0 1 3 4 33.3 75 -0.312 0008452 RNA ligase F 0 0 0 0 0 1 3 4 33.3 75 -0.312 0008484 sulfuric ester hydrolase F 1 3 5 33.3 60 1 3 5 33.3 60 -0.312 0007204 cytosolic calcium ion concentration elevation P 1 3 5 33.3 60 1 3 5 33.3 60 -0.312 0008344 adult locomotory behavior P 1 2 2 50 100 1 3 3 33.3 100 -0.312 0008170 N-methyltransferase F 0 0 1 0 0 1 3 4 33.3 75 -0.312 0016160 amylase F 0 0 0 0 0 1 3 3 33.3 100 -0.312 0004652 polynucleotide adenylyltransferase F 1 3 5 33.3 60 1 3 5 33.3 60 -0.312 0004556 alpha-amylase F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0003953 NAD(+) nucleosidase F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0004035 alkaline phosphatase F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0016356 organophosphosphorous susceptibility/resistance P 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0009405 pathogenesis P 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0005006 epidermal growth factor receptor F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0016645 oxidoreductase, acting on the CH-NH group of donors F 0 0 0 0 0 1 3 6 33.3 50 -0.312 0016352 insecticide susceptibility/resistance P 0 0 0 0 0 1 3 3 33.3 100 -0.312 0004459 L-lactate dehydrogenase F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0030198 extracellular matrix organization and biogenesis P 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0001533 cornified envelope C 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0005027 NGF/TNF (6 C-domain) receptor F 0 0 0 0 0 1 3 5 33.3 60 -0.312 0004457 lactate dehydrogenase F 0 0 0 0 0 1 3 3 33.3 100 -0.312 0005035 death receptor F 0 0 1 0 0 1 3 8 33.3 37.5 -0.312 0005031 tumor necrosis factor receptor F 1 3 5 33.3 60 1 3 5 33.3 60 -0.312 0040014 regulation of body size P 1 2 3 50 66.7 1 3 4 33.3 75 -0.312 0005007 fibroblast growth factor receptor F 1 3 4 33.3 75 1 3 4 33.3 75 -0.312 0016916 inhibin F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0008158 patched receptor F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0005522 profilin binding F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0008366 nerve ensheathment P 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0001614 purinergic nucleotide receptor F 0 0 0 0 0 1 3 3 33.3 100 -0.312 0006570 tyrosine metabolism P 0 0 0 0 0 1 3 4 33.3 75 -0.312 0004931 ATP-gated cation channel F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0040007 growth P 0 0 0 0 0 1 3 4 33.3 75 -0.312 0016774 phosphotransferase, carboxyl group as acceptor F 0 0 0 0 0 1 3 3 33.3 100 -0.312 0004769 steroid delta-isomerase F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0008143 poly(A) binding F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0004064 arylesterase F 1 3 3 33.3 100 1 3 3 33.3 100 -0.312 0005578 extracellular matrix C 11 36 51 30.6 70.6 29 72 94 40.3 76.6 -0.336 0005509 calcium binding F 79 194 266 40.7 72.9 81 198 271 40.9 73.1 -0.381 0001503 ossification P 7 19 20 36.8 95 8 21 24 38.1 87.5 -0.383 0008305 integrin C 6 16 17 37.5 94.1 6 16 17 37.5 94.1 -0.383 0019839 guanyl-nucleotide release factor F 4 11 14 36.4 78.6 4 11 14 36.4 78.6 -0.393 0019210 kinase inhibitor F 0 1 1 0 0 4 11 12 36.4 91.7 -0.393 0003747 translation release factor F 0 0 0 0 0 4 11 14 36.4 78.6 -0.393 0008079 translation termination factor F 0 0 0 0 0 4 11 14 36.4 78.6 -0.393 0006700 C21-steroid hormone biosynthesis P 4 11 13 36.4 84.6 4 11 13 36.4 84.6 -0.393 0003795 antimicrobial peptide F 3 9 22 33.3 40.9 4 11 24 36.4 45.8 -0.393 0008207 C21-steroid metabolism P 0 0 0 0 0 4 11 13 36.4 84.6 -0.393 0006807 nitrogen metabolism P 1 2 2 50 100 4 11 11 36.4 100 -0.393 0005003 ephrin receptor F 4 11 12 36.4 91.7 4 11 13 36.4 84.6 -0.393 0001501 skeletal development P 9 20 22 45 90.9 16 41 47 39 87.2 -0.416 0016757 transferase, transferring glycosyl groups F 0 0 0 0 0 20 51 64 39.2 79.7 -0.436 0007005 mitochondrion organization and biogenesis P 0 0 1 0 0 2 6 7 33.3 85.7 -0.441 0004383 guanylate cyclase F 2 6 6 33.3 100 2 6 6 33.3 100 -0.441 0007193 G-protein signaling, adenylate cyclase inhibiting pathway P 2 6 6 33.3 100 2 6 6 33.3 100 -0.441 0007190 adenylate cyclase activation P 2 6 8 33.3 75 2 6 8 33.3 75 -0.441 0007420 brain development P 2 6 8 33.3 75 2 6 8 33.3 75 -0.441 0005978 glycogen biosynthesis P 2 6 7 33.3 85.7 2 6 7 33.3 85.7 -0.441 0003724 RNA helicase F 2 6 8 33.3 75 2 6 8 33.3 75 -0.441 0004861 cyclin-dependent protein kinase inhibitor F 2 6 7 33.3 85.7 2 6 7 33.3 85.7 -0.441 0030141 secretory granule C 2 6 9 33.3 66.7 2 6 9 33.3 66.7 -0.441 0030286 dynein C 0 0 0 0 0 2 6 8 33.3 75 -0.441 0006691 leukotriene metabolism P 2 6 8 33.3 75 2 6 8 33.3 75 -0.441 0007182 common-partner SMAD protein phosphorylation P 2 6 7 33.3 85.7 2 6 7 33.3 85.7 -0.441 0016791 phosphoric monoester hydrolase F 0 0 0 0 0 31 78 104 39.7 75 -0.446 0016788 hydrolase, acting on ester bonds F 2 3 3 66.7 100 66 163 239 40.5 68.2 -0.454 0016302 phosphatase F 1 5 5 20 100 33 83 108 39.8 76.9 -0.457 0019932 second-messenger-mediated signaling P 0 0 0 0 0 11 29 42 37.9 69 -0.469 0006520 amino acid metabolism P 2 8 9 25 88.9 11 29 36 37.9 80.6 -0.469 0004895 cell adhesion receptor F 6 18 20 33.3 90 7 19 22 36.8 86.4 -0.475 0009593 perception of chemical substance P 0 0 0 0 0 5 14 90 35.7 15.6 -0.493 0016229 steroid dehydrogenase F 0 0 1 0 0 5 14 16 35.7 87.5 -0.493 0005085 guanyl-nucleotide exchange factor F 5 11 15 45.5 73.3 5 14 18 35.7 77.8 -0.493 0007606 chemosensory perception P 0 0 24 0 0 5 14 90 35.7 15.6 -0.493 0030234 enzyme regulator F 0 0 0 0 0 57 142 192 40.1 74 -0.509 0007155 cell adhesion P 65 164 206 39.6 79.6 68 169 216 40.2 78.2 -0.531 0005802 Golgi trans-face C 3 9 15 33.3 60 3 9 15 33.3 60 -0.54 0004869 cysteine protease inhibitor F 3 9 13 33.3 69.2 3 9 13 33.3 69.2 -0.54 0007265 RAS protein signal transduction P 3 9 12 33.3 75 3 9 12 33.3 75 -0.54 0001508 action potential regulation P 1 2 2 50 100 3 9 11 33.3 81.8 -0.54 0008076 voltage-gated potassium channel C 3 9 12 33.3 75 3 9 12 33.3 75 -0.54 0008217 blood pressure regulation P 3 9 10 33.3 90 3 9 10 33.3 90 -0.54 0009064 glutamine family amino acid metabolism P 0 0 0 0 0 3 9 11 33.3 81.8 -0.54 0004842 ubiquitin-protein ligase F 3 9 11 33.3 81.8 3 9 11 33.3 81.8 -0.54 0004620 phospholipase F 1 1 1 100 100 3 9 13 33.3 69.2 -0.54 0007519 myogenesis P 3 7 7 42.9 100 3 9 12 33.3 75 -0.54 0004386 helicase F 7 15 18 46.7 83.3 12 32 57 37.5 56.1 -0.542 0006694 steroid biosynthesis P 8 23 29 34.8 79.3 12 32 42 37.5 76.2 -0.542 0003678 DNA helicase F 12 32 55 37.5 58.2 12 32 55 37.5 58.2 -0.542 0016023 cytoplasmic vesicle C 4 5 9 80 55.6 10 27 45 37 60 -0.547 0006486 protein amino acid glycosylation P 5 12 14 41.7 85.7 6 17 20 35.3 85 -0.579 0009101 glycoprotein biosynthesis P 0 0 0 0 0 6 17 20 35.3 85 -0.579 0019538 protein metabolism P 0 0 1 0 0 6 17 22 35.3 77.3 -0.579 0009100 glycoprotein metabolism P 0 0 0 0 0 6 17 21 35.3 81 -0.579 0005194 cell adhesion molecule F 14 34 43 41.2 79.1 27 70 91 38.6 76.9 -0.622 0009653 morphogenesis P 0 3 3 0 0 4 12 15 33.3 80 -0.624 0030005 di-, tri-valent inorganic cation homeostasis P 0 0 0 0 0 4 12 20 33.3 60 -0.624 0006875 metal ion homeostasis P 0 0 0 0 0 4 12 21 33.3 57.1 -0.624 0005096 GTPase activator F 8 23 34 34.8 67.6 9 25 38 36 65.8 -0.631 0016311 dephosphorylation P 0 0 0 0 0 16 43 50 37.2 86 -0.668 0006470 protein amino acid dephosphorylation P 16 43 50 37.2 86 16 43 50 37.2 86 -0.668 0006508 proteolysis and peptidolysis P 45 126 155 35.7 81.3 67 169 215 39.6 78.6 -0.69 0009566 fertilization P 0 0 0 0 0 1 4 5 25 80 -0.697 0030118 clathrin coat C 0 0 0 0 0 1 4 7 25 57.1 -0.697 0008375 acetylglucosaminyltransferase F 1 2 2 50 100 1 4 5 25 80 -0.697 0006541 glutamine metabolism P 1 3 4 33.3 75 1 4 5 25 80 -0.697 0030117 membrane coat C 0 0 0 0 0 1 4 7 25 57.1 -0.697 0007605 hearing P 1 4 7 25 57.1 1 4 7 25 57.1 -0.697 0004091 carboxylesterase F 1 3 4 33.3 75 1 4 5 25 80 -0.697 0004303 estradiol 17 beta-dehydrogenase F 1 4 5 25 80 1 4 5 25 80 -0.697 0005075 pathway-specific SMAD protein F 1 4 4 25 100 1 4 4 25 100 -0.697 0015023 syndecan F 1 4 4 25 100 1 4 4 25 100 -0.697 0007183 SMAD protein heteromerization P 1 4 4 25 100 1 4 4 25 100 -0.697 0007254 JNK cascade P 0 1 5 0 0 1 4 9 25 44.4 -0.697 0007338 fertilization (sensu Animalia) P 0 2 2 0 0 1 4 5 25 80 -0.697 0000165 MAPKKK cascade P 1 3 7 33.3 42.9 1 4 8 25 50 -0.697 0000050 urea cycle P 1 4 4 25 100 1 4 4 25 100 -0.697 0005070 SH3/SH2 adaptor protein F 1 4 8 25 50 1 4 8 25 50 -0.697 0015070 toxin F 1 4 4 25 100 1 4 4 25 100 -0.697 0005786 signal recognition particle C 1 4 5 25 80 1 4 5 25 80 -0.697 0016288 cytokinesis P 1 4 6 25 66.7 1 4 6 25 66.7 -0.697 0005891 voltage-gated calcium channel C 1 4 6 25 66.7 1 4 6 25 66.7 -0.697 0003794 acute-phase response protein F 1 4 4 25 100 1 4 4 25 100 -0.697 0009592 perception of sound P 0 0 0 0 0 1 4 7 25 57.1 -0.697 0004653 polypeptide N-acetylgalactosaminyltransferase F 1 4 4 25 100 1 4 4 25 100 -0.697 0008376 acetylgalactosaminyltransferase F 0 0 0 0 0 1 4 5 25 80 -0.697 0005320 apolipoprotein F 1 4 5 25 80 1 4 6 25 66.7 -0.697 0009314 radiation response P 0 0 0 0 0 5 15 21 33.3 71.4 -0.698 0009583 perception of light P 0 0 0 0 0 5 15 21 33.3 71.4 -0.698 0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway P 5 15 20 33.3 75 5 15 20 33.3 75 -0.698 0009416 light response P 0 0 0 0 0 5 15 21 33.3 71.4 -0.698 0007156 homophilic cell adhesion P 5 15 22 33.3 68.2 5 15 22 33.3 68.2 -0.698 0016849 phosphorus-oxygen lyase F 0 0 0 0 0 2 7 9 28.6 77.8 -0.731 0006693 prostaglandin metabolism P 2 7 8 28.6 87.5 2 7 8 28.6 87.5 -0.731 0007272 ionic insulation of neurons by glial cells P 2 7 9 28.6 77.8 2 7 9 28.6 77.8 -0.731 0005540 hyaluronic acid binding F 2 7 8 28.6 87.5 2 7 8 28.6 87.5 -0.731 0009190 cyclic nucleotide biosynthesis P 0 0 0 0 0 2 7 9 28.6 77.8 -0.731 0004759 serine esterase F 2 7 10 28.6 70 2 7 10 28.6 70 -0.731 0009187 cyclic nucleotide metabolism P 0 0 0 0 0 2 7 9 28.6 77.8 -0.731 0005478 intracellular transporter F 0 4 5 0 0 2 7 10 28.6 70 -0.731 0004293 tissue kallikrein F 2 7 12 28.6 58.3 2 7 12 28.6 58.3 -0.731 0006692 prostanoid metabolism P 0 0 0 0 0 2 7 8 28.6 87.5 -0.731 0004089 carbonate dehydratase F 2 7 11 28.6 63.6 2 7 11 28.6 63.6 -0.731 0008202 steroid metabolism P 2 5 7 40 71.4 15 41 53 36.6 77.4 -0.733 0030163 protein degradation P 1 2 3 50 66.7 67 170 217 39.4 78.3 -0.755 0008509 anion transporter F 0 0 1 0 0 3 10 16 30 62.5 -0.783 0015171 amino acid transporter F 0 0 0 0 0 3 10 13 30 76.9 -0.783 0016881 acid-D-amino acid ligase F 0 0 0 0 0 3 10 16 30 62.5 -0.783 0004222 metalloendopeptidase F 14 40 55 35 72.7 16 44 61 36.4 72.1 -0.79 0009057 macromolecule catabolism P 0 0 0 0 0 67 171 219 39.2 78.1 -0.819 0030054 cell junction C 0 0 0 0 0 12 34 48 35.3 70.8 -0.82 0019933 cAMP-mediated signaling P 1 2 2 50 100 7 21 26 33.3 80.8 -0.826 0005249 voltage-sensitive potassium channel F 4 10 12 40 83.3 7 21 25 33.3 84 -0.826 0007608 olfaction P 4 13 64 30.8 20.3 4 13 64 30.8 20.3 -0.837 0006690 eicosanoid metabolism P 0 0 0 0 0 4 13 16 30.8 81.2 -0.837 0016798 hydrolase, acting on glycosyl bonds F 0 0 0 0 0 8 24 32 33.3 75 -0.883 0004519 endonuclease F 8 24 30 33.3 80 8 24 33 33.3 72.7 -0.883 0008014 calcium-dependent cell adhesion molecule F 5 16 21 31.2 76.2 5 16 21 31.2 76.2 -0.89 0003677 DNA binding F 268 662 933 40.5 71 301 739 1069 40.7 69.1 -0.893 0016265 death P 0 0 0 0 0 41 108 138 38 78.3 -0.906 0004175 endopeptidase F 2 4 5 50 80 16 45 63 35.6 71.4 -0.909 0007188 G-protein signaling, coupled to cAMP nucleotide second messenger P 0 2 2 0 0 6 19 24 31.6 79.2 -0.941 0008047 enzyme activator F 0 3 3 0 0 12 35 49 34.3 71.4 -0.954 0004221 ubiquitin C-terminal hydrolase F 2 8 14 25 57.1 2 8 14 25 57.1 -0.987 0008146 sulfotransferase F 2 6 10 33.3 60 2 8 14 25 57.1 -0.987 0016782 transferase, transferring sulfur-containing groups F 0 0 0 0 0 2 8 16 25 50 -0.987 0004114 3’,5’-cyclic-nucleotide phosphodiesterase F 2 8 13 25 61.5 2 8 18 25 44.4 -0.987 0015203 polyamine transporter F 0 0 0 0 0 2 8 9 25 88.9 -0.987 0005279 amino acid-polyamine transporter F 2 8 9 25 88.9 2 8 9 25 88.9 -0.987 0008514 organic anion transporter F 1 2 3 50 66.7 2 8 11 25 72.7 -0.987 0004289 subtilase F 2 8 8 25 100 2 8 8 25 100 -0.987 0009628 response to abiotic stimulus P 0 0 0 0 0 29 79 192 36.7 41.1 -1 0007417 central nervous system development P 1 6 8 16.7 75 3 11 15 27.3 73.3 -1.005 0005923 tight junction C 3 11 15 27.3 73.3 3 11 15 27.3 73.3 -1.005 0006804 peroxidase reaction P 3 11 14 27.3 78.6 3 11 14 27.3 78.6 -1.005 0016684 oxidoreductase, acting on peroxide as acceptor F 0 0 0 0 0 3 11 13 27.3 84.6 -1.005 0004601 peroxidase F 0 6 6 0 0 3 11 12 27.3 91.7 -1.005 0007601 vision P 3 10 13 30 76.9 3 11 14 27.3 78.6 -1.005 0004428 inositol/phosphatidylinositol kinase F 2 6 8 33.3 75 3 11 14 27.3 78.6 -1.005 0007602 phototransduction P 2 9 14 22.2 64.3 3 11 16 27.3 68.8 -1.005 0005242 inward rectifier potassium channel F 3 11 13 27.3 84.6 3 11 13 27.3 84.6 -1.005 0006835 dicarboxylic acid transport P 1 5 6 20 83.3 1 5 6 20 83.3 -1.006 0008513 organic cation porter F 0 0 0 0 0 1 5 6 20 83.3 -1.006 0016071 mRNA metabolism P 1 1 1 100 100 1 5 5 20 100 -1.006 0005245 voltage-sensitive calcium channel F 1 5 6 20 83.3 1 5 7 20 71.4 -1.006 0004180 carboxypeptidase F 1 5 8 20 62.5 1 5 8 20 62.5 -1.006 0005311 sodium:dicarboxylate/tricarboxylate cotransporter F 1 5 5 20 100 1 5 5 20 100 -1.006 0016638 oxidoreductase, acting on the CH-NH2 group of donors F 1 2 2 50 100 1 5 11 20 45.5 -1.006 0015034 cytochrome P450 F 0 0 0 0 0 1 5 8 20 62.5 -1.006 0005310 dicarboxylic acid transporter F 0 0 0 0 0 1 5 6 20 83.3 -1.006 0015142 tricarboxylic acid transporter F 0 0 0 0 0 1 5 5 20 100 -1.006 0015101 organic cation transporter F 0 0 0 0 0 1 5 6 20 83.3 -1.006 0005069 transmembrane receptor protein tyrosine kinase docking protein F 0 1 1 0 0 1 5 9 20 55.6 -1.006 0005507 copper binding F 1 5 10 20 50 1 5 10 20 50 -1.006 0015354 polyspecific organic cation transporter F 0 0 0 0 0 1 5 5 20 100 -1.006 0007242 intracellular signaling cascade P 41 123 142 33.3 86.6 88 226 282 38.9 80.1 -1.023 0004713 protein tyrosine kinase F 37 99 114 37.4 86.8 38 102 118 37.3 86.4 -1.026 0007189 G-protein signaling, adenylate cyclase activating pathway P 2 6 8 33.3 75 4 14 19 28.6 73.7 -1.035 0004721 protein phosphatase F 7 24 27 29.2 88.9 21 59 79 35.6 74.7 -1.037 0007582 physiological processes P 6 8 12 75 66.7 21 59 75 35.6 78.7 -1.037 0016327 apicolateral plasma membrane C 0 0 0 0 0 11 33 45 33.3 73.3 -1.037 0008009 chemokine F 8 25 32 32 78.1 8 25 32 32 78.1 -1.037 0009410 xenobiotic response P 0 0 0 0 0 8 25 43 32 58.1 -1.037 0015291 porter F 0 0 0 0 0 14 41 56 34.1 73.2 -1.051 0008219 cell death P 1 2 2 50 100 39 105 135 37.1 77.8 -1.065 0005262 calcium channel F 5 17 26 29.4 65.4 5 17 26 29.4 65.4 -1.071 0005319 lipid transporter F 5 16 21 31.2 76.2 6 20 27 30 74.1 -1.109 0008237 metallopeptidase F 6 31 46 19.4 67.4 18 52 74 34.6 70.3 -1.116 0016758 transferase, transferring hexosyl groups F 1 3 4 33.3 75 10 31 42 32.3 73.8 -1.126 0019935 cyclic-nucleotide-mediated signaling P 0 0 0 0 0 7 23 29 30.4 79.3 -1.147 0015290 electrochemical potential-driven transporter F 0 1 1 0 0 14 42 57 33.3 73.7 -1.171 0012501 programmed cell death P 0 0 0 0 0 38 104 134 36.5 77.6 -1.186 0006915 apoptosis P 31 88 109 35.2 80.7 38 104 134 36.5 77.6 -1.186 0003793 defense/immunity protein F 4 13 27 30.8 48.1 20 58 114 34.5 50.9 -1.2 0007423 sensory organ development P 3 12 17 25 70.6 3 12 17 25 70.6 -1.209 0006310 DNA recombination P 3 12 12 25 100 3 12 13 25 92.3 -1.209 0004725 protein tyrosine phosphatase F 12 37 47 32.4 78.7 12 37 47 32.4 78.7 -1.21 0005208 amyloid protein F 2 9 9 22.2 100 2 9 9 22.2 100 -1.216 0005539 glycosaminoglycan binding F 0 0 0 0 0 2 9 11 22.2 81.8 -1.216 0004112 cyclic-nucleotide phosphodiesterase F 0 0 0 0 0 2 9 19 22.2 47.4 -1.216 0005275 amine/polyamine transporter F 0 0 0 0 0 2 9 11 22.2 81.8 -1.216 0008138 protein tyrosine/serine/threonine phosphatase F 2 9 10 22.2 90 2 9 10 22.2 90 -1.216 0006865 amino acid transport P 2 9 9 22.2 100 2 9 10 22.2 90 -1.216 0016171 cell surface antigen F 2 9 11 22.2 81.8 2 9 11 22.2 81.8 -1.216 0005615 extracellular space C 4 15 19 26.7 78.9 4 15 19 26.7 78.9 -1.221 0007422 peripheral nervous system development P 1 3 3 33.3 100 4 15 20 26.7 75 -1.221 0005207 extracellular matrix glycoprotein F 4 15 16 26.7 93.8 4 15 16 26.7 93.8 -1.221 0016701 oxidoreductase, acting on single donors with incorporation of molecular oxygen F 0 0 0 0 0 9 29 38 31 76.3 -1.223 0016051 carbohydrate biosynthesis P 1 1 1 100 100 5 18 24 27.8 75 -1.243 0004553 hydrolase, hydrolyzing O-glycosyl compounds F 1 3 5 33.3 60 5 18 26 27.8 69.2 -1.243 0009582 perception of abiotic stimulus P 0 0 0 0 0 10 32 117 31.2 27.4 -1.26 0009581 perception of external stimulus P 0 0 0 0 0 29 82 197 35.4 41.6 -1.267 0015711 organic anion transport P 0 0 0 0 0 1 6 7 16.7 85.7 -1.268 0008222 tumor antigen F 1 6 12 16.7 50 1 6 12 16.7 50 -1.268 0016709 oxidoreductase, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD or NADH as one donor, and incorporation of one atom of oxygen F 0 0 0 0 0 1 6 7 16.7 85.7 -1.268 0008533 astacin F 1 6 6 16.7 100 1 6 6 16.7 100 -1.268 0016932 glycosyltransferase F 1 6 6 16.7 100 1 6 6 16.7 100 -1.268 0008652 amino acid biosynthesis P 0 1 1 0 0 1 6 7 16.7 85.7 -1.268 0016477 cell migration P 1 2 3 50 66.7 1 6 7 16.7 85.7 -1.268 0005550 pheromone binding F 1 6 6 16.7 100 1 6 6 16.7 100 -1.268 0005066 transmembrane receptor protein tyrosine kinase signaling protein F 0 2 5 0 0 1 6 14 16.7 42.9 -1.268 0016813 hydrolase, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines F 0 0 0 0 0 1 6 7 16.7 85.7 -1.268 0016303 phosphatidylinositol 3-kinase F 0 5 7 0 0 1 6 8 16.7 75 -1.268 0003930 RAS small monomeric GTPase F 1 6 7 16.7 85.7 1 6 7 16.7 85.7 -1.268 0007187 G-protein signaling, coupled to cyclic nucleotide second messenger P 0 0 0 0 0 6 21 27 28.6 77.8 -1.269 0006805 xenobiotic metabolism P 5 18 33 27.8 54.5 6 21 36 28.6 58.3 -1.269 0016192 vesicle-mediated transport P 6 15 24 40 62.5 11 35 55 31.4 63.6 -1.297 0005794 Golgi apparatus C 29 87 108 33.3 80.6 37 103 133 35.9 77.4 -1.308 0004896 hematopoeitin/interferon-class (D200-domain) cytokine receptor F 9 28 29 32.1 96.6 12 38 42 31.6 90.5 -1.333 0005212 structural constituent of eye lens F 3 13 19 23.1 68.4 3 13 19 23.1 68.4 -1.399 0006953 acute-phase response P 3 13 13 23.1 100 3 13 13 23.1 100 -1.399 0004984 olfactory receptor F 2 10 61 20 16.4 2 10 61 20 16.4 -1.424 0005181 glycopeptide hormone F 2 10 10 20 100 2 10 10 20 100 -1.424 0004857 enzyme inhibitor F 1 2 3 50 66.7 29 84 108 34.5 77.8 -1.441 0004867 serine protease inhibitor F 13 45 56 28.9 80.4 16 50 65 32 76.9 -1.471 0006289 nucleotide-excision repair P 1 7 7 14.3 100 1 7 8 14.3 87.5 -1.497 0006928 cell motility P 2 2 4 100 50 23 69 89 33.3 77.5 -1.505 0006810 transport P 56 159 193 35.2 82.4 182 468 627 38.9 74.6 -1.538 0006350 transcription P 8 12 15 66.7 80 222 566 743 39.2 76.2 -1.541 0007218 neuropeptide signaling pathway P 5 20 27 25 74.1 5 20 27 25 74.1 -1.562 0005162 fibroblast growth factor receptor ligand F 4 17 18 23.5 94.4 4 17 18 23.5 94.4 -1.563 0030135 coated vesicle C 0 0 0 0 0 4 17 27 23.5 63 -1.563 0015293 symporter F 0 0 0 0 0 3 14 21 21.4 66.7 -1.577 0030136 clathrin-coated vesicle C 0 0 0 0 0 3 14 24 21.4 58.3 -1.577 0008021 synaptic vesicle C 2 11 18 18.2 61.1 2 11 18 18.2 61.1 -1.616 0005164 tumor necrosis factor receptor ligand F 2 11 13 18.2 84.6 2 11 13 18.2 84.6 -1.616 0007600 sensory perception P 0 2 4 0 0 9 32 116 28.1 27.6 -1.619 0006351 transcription, DNA-dependent P 1 1 3 100 33.3 217 558 732 38.9 76.2 -1.698 0016892 endoribonuclease, producing other than 5’-phosphomonoesters F 0 0 0 0 0 1 8 9 12.5 88.9 -1.703 0016702 oxidoreductase, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen F 0 0 0 0 0 1 8 10 12.5 80 -1.703 0005530 lectin F 0 6 18 0 0 1 8 21 12.5 38.1 -1.703 0005549 odorant binding F 0 2 4 0 0 1 8 10 12.5 80 -1.703 0004522 pancreatic ribonuclease F 1 8 9 12.5 88.9 1 8 9 12.5 88.9 -1.703 0015294 solute:cation symporter F 0 0 0 0 0 1 8 14 12.5 57.1 -1.703 0045111 intermediate filament cytoskeleton C 0 0 0 0 0 13 44 55 29.5 80 -1.71 0005882 intermediate filament C 13 44 55 29.5 80 13 44 55 29.5 80 -1.71 0006355 transcription regulation P 207 539 686 38.4 78.6 214 551 719 38.8 76.6 -1.712 0004907 interleukin receptor F 5 20 24 25 83.3 5 21 25 23.8 84 -1.712 0019965 interleukin binding F 0 0 0 0 0 5 21 25 23.8 84 -1.712 0005254 chloride channel F 0 0 0 0 0 7 27 38 25.9 71.1 -1.719 0006897 endocytosis P 1 11 17 9.1 64.7 3 15 24 20 62.5 -1.745 0006968 cellular defense response P 3 12 37 25 32.4 3 15 43 20 34.9 -1.745 0008233 peptidase F 23 43 52 53.5 82.7 76 210 308 36.2 68.2 -1.81 0007596 blood coagulation P 6 25 28 24 89.3 6 25 28 24 89.3 -1.849 0005253 anion channel F 0 0 0 0 0 7 28 41 25 68.3 -1.85 0006950 stress response P 2 6 13 33.3 46.2 46 134 236 34.3 56.8 -1.876 0004866 endopeptidase inhibitor F 2 9 11 22.2 81.8 20 65 86 30.8 75.6 -1.882 0030414 protease inhibitor F 0 0 0 0 0 20 65 86 30.8 75.6 -1.882 0008133 collagenase F 0 8 11 0 0 1 9 12 11.1 75 -1.891 0004521 endoribonuclease F 0 0 0 0 0 1 9 12 11.1 75 -1.891 0005184 neuropeptide hormone F 0 5 8 0 0 1 9 13 11.1 69.2 -1.891 0004540 ribonuclease F 0 0 4 0 0 1 9 17 11.1 52.9 -1.891 0006811 ion transport P 24 88 115 27.3 76.5 54 155 215 34.8 72.1 -1.892 0008066 glutamate receptor F 0 0 0 0 0 3 16 21 18.8 76.2 -1.904 0005911 intercellular junction C 0 1 2 0 0 7 29 39 24.1 74.4 -1.977 0007599 hemostasis P 0 1 2 0 0 6 26 29 23.1 89.7 -1.981 0005261 cation channel F 11 29 34 37.9 85.3 28 88 114 31.8 77.2 -1.994 0007275 developmental processes P 25 80 98 31.2 81.6 132 355 471 37.2 75.4 -1.999 0005244 voltage-gated ion channel F 10 39 55 25.6 70.9 11 41 57 26.8 71.9 -2.004 0015285 connexon channel F 2 14 14 14.3 100 2 14 14 14.3 100 -2.119 0015256 monocarboxylate channel F 0 0 0 0 0 2 14 15 14.3 93.3 -2.119 0005922 connexon C 2 14 14 14.3 100 2 14 14 14.3 100 -2.119 0004970 ionotropic glutamate receptor F 2 12 12 16.7 100 2 14 15 14.3 93.3 -2.119 0005234 glutamate-gated ion channel F 2 10 10 20 100 2 14 15 14.3 93.3 -2.119 0005243 gap-junction forming channel F 2 14 16 14.3 87.5 2 14 16 14.3 87.5 -2.119 0003801 blood coagulation factor F 2 10 10 20 100 2 14 14 14.3 100 -2.119 0015259 glutamate channel F 0 0 0 0 0 2 14 15 14.3 93.3 -2.119 0007397 histogenesis and organogenesis P 21 90 110 23.3 81.8 81 229 301 35.4 76.1 -2.152 0005231 excitatory extracellular ligand-gated ion channel F 0 0 0 0 0 3 18 21 16.7 85.7 -2.199 0008083 growth factor F 6 25 30 24 83.3 6 28 34 21.4 82.4 -2.234 0008369 obsolete F 0 0 0 0 0 51 153 201 33.3 76.1 -2.263 0005921 gap junction C 2 15 17 13.3 88.2 2 15 17 13.3 88.2 -2.268 0015698 inorganic anion transport P 0 0 0 0 0 4 22 33 18.2 66.7 -2.288 0006820 anion transport P 3 7 9 42.9 77.8 8 35 49 22.9 71.4 -2.328 0016055 Wnt receptor signaling pathway P 1 2 4 50 50 3 19 24 15.8 79.2 -2.337 0005180 peptide hormone F 6 23 27 26.1 85.2 9 39 47 23.1 83 -2.43 0007345 embryogenesis and morphogenesis P 9 34 46 26.5 73.9 92 263 349 35 75.4 -2.447 0007214 gamma-amino butyric acid signaling pathway P 1 13 17 7.7 76.5 1 13 17 7.7 76.5 -2.524 0005792 microsome C 11 46 55 23.9 83.6 11 46 55 23.9 83.6 -2.526 0007398 ectoderm development P 0 0 0 0 0 22 78 110 28.2 70.9 -2.527 0006821 chloride transport P 2 17 26 11.8 65.4 2 17 26 11.8 65.4 -2.547 0005624 membrane fraction C 10 30 48 33.3 62.5 21 76 106 27.6 71.7 -2.596 0000267 cell fraction C 0 0 0 0 0 21 76 107 27.6 71 -2.596 0005237 inhibitory extracellular ligand-gated ion channel F 0 0 0 0 0 3 21 26 14.3 80.8 -2.597 0004890 GABA-A receptor F 3 21 26 14.3 80.8 3 21 26 14.3 80.8 -2.597 0016917 GABA receptor F 0 0 0 0 0 3 21 26 14.3 80.8 -2.597 0004263 chymotrypsin F 10 44 51 22.7 86.3 10 44 51 22.7 86.3 -2.63 0005215 transporter F 24 76 84 31.6 90.5 144 400 554 36 72.2 -2.635 0007223 frizzled-2 receptor signaling pathway P 1 14 17 7.1 82.4 1 14 17 7.1 82.4 -2.661 0007399 neurogenesis P 9 41 54 22 75.9 20 74 105 27 70.5 -2.667 0005654 nucleoplasm C 3 4 7 75 57.1 86 252 329 34.1 76.6 -2.675 0009613 response to pest/pathogen/parasite P 0 0 1 0 0 28 97 179 28.9 54.2 -2.691 0030594 neurotransmitter receptor F 0 0 0 0 0 3 22 29 13.6 75.9 -2.72 0042165 neurotransmitter binding F 0 0 0 0 0 3 22 29 13.6 75.9 -2.72 0006836 neurotransmitter transport P 1 15 18 6.7 83.3 1 15 18 6.7 83.3 -2.792 0004497 monooxygenase F 12 51 74 23.5 68.9 12 52 75 23.1 69.3 -2.81 0004295 trypsin F 11 49 58 22.4 84.5 11 49 58 22.4 84.5 -2.816 0015276 ligand-gated ion channel F 0 0 0 0 0 10 46 58 21.7 79.3 -2.826 0007389 pattern specification P 8 40 49 20 81.6 8 40 49 20 81.6 -2.857 0019955 cytokine binding F 0 1 1 0 0 7 37 43 18.9 86 -2.881 0005216 ion channel F 31 112 148 27.7 75.7 38 128 174 29.7 73.6 -2.911 0019956 chemokine binding F 0 0 0 0 0 1 16 18 6.2 88.9 -2.918 0004950 chemokine receptor F 1 13 14 7.7 92.9 1 16 18 6.2 88.9 -2.918 0001637 G-protein chemoattractant receptor F 0 0 0 0 0 1 16 18 6.2 88.9 -2.918 0030528 transcription regulator F 0 0 2 0 0 144 407 544 35.4 74.8 -2.925 0045087 innate immune response P 0 0 0 0 0 9 45 55 20 81.8 -3.032 0006954 inflammatory response P 9 44 54 20.5 81.5 9 45 55 20 81.8 -3.032 0003700 transcription factor F 127 369 474 34.4 77.8 134 386 507 34.7 76.1 -3.118 0005557 lymphocyte antigen F 13 59 64 22 92.2 13 59 64 22 92.2 -3.159 0005179 hormone F 5 25 29 20 86.2 11 53 62 20.8 85.5 -3.182 0008236 serine-type peptidase F 2 4 8 50 50 21 84 123 25 68.3 -3.224 0005126 hematopoeitin/interferon-class (D200-domain) cytokine receptor ligand F 2 13 15 15.4 86.7 2 23 27 8.7 85.2 -3.263 0003674 molecular_function F 0 0 0 0 0 1652 3999 5846 41.3 68.4 -3.273 0030246 carbohydrate binding F 0 0 0 0 0 7 41 60 17.1 68.3 -3.274 0005529 sugar binding F 6 34 40 17.6 85 7 41 60 17.1 68.3 -3.274 0015268 alpha-type channel F 0 0 0 0 0 43 148 200 29.1 74 -3.296 0015267 channel/pore class transporter F 0 0 0 0 0 43 148 200 29.1 74 -3.296 0004252 serine-type endopeptidase F 20 77 114 26 67.5 20 82 120 24.4 68.3 -3.298 0005887 integral plasma membrane protein C 76 244 412 31.1 59.2 88 271 449 32.5 60.4 -3.348 0005576 extracellular C 46 162 213 28.4 76.1 78 245 321 31.8 76.3 -3.381 0005230 extracellular ligand-gated ion channel F 3 21 25 14.3 84 6 39 47 15.4 83 -3.407 0012505 endomembrane system C 0 0 0 0 0 183 520 819 35.2 63.5 -3.445 0019226 transmission of nerve impulse P 0 0 0 0 0 13 64 84 20.3 76.2 -3.573 0005667 transcription factor complex C 72 234 303 30.8 77.2 73 236 306 30.9 77.1 -3.604 0007268 synaptic transmission P 9 51 64 17.6 79.7 10 55 73 18.2 75.3 -3.63 0008528 peptide receptor, G-protein coupled F 0 2 3 0 0 3 31 35 9.7 88.6 -3.68 0006935 chemotaxis P 6 42 50 14.3 84 6 42 50 14.3 84 -3.682 0009611 response to wounding P 0 0 1 0 0 10 56 95 17.9 58.9 -3.713 0006955 immune response P 25 95 118 26.3 80.5 48 170 268 28.2 63.4 -3.761 0005125 cytokine F 24 98 118 24.5 83.1 35 134 163 26.1 82.2 -3.829 0005886 plasma membrane C 53 162 242 32.7 66.9 165 489 775 33.7 63.1 -4.015 0007186 G-protein coupled receptor protein signaling pathway P 62 206 306 30.1 67.3 73 249 370 29.3 67.3 -4.238 0001584 rhodopsin-like receptor F 0 0 0 0 0 6 49 107 12.2 45.8 -4.27 0016020 membrane C 182 555 690 32.8 80.4 452 1234 1771 36.6 69.7 -4.651 0009607 response to biotic stimulus P 0 0 0 0 0 83 288 428 28.8 67.3 -4.755 0009605 response to external stimulus P 0 0 1 0 0 109 360 602 30.3 59.8 -4.778 0007267 cell-cell signaling P 4 30 35 13.3 85.7 17 94 119 18.1 79 -4.786 0007166 cell surface receptor linked signal transduction P 6 35 44 17.1 79.5 128 414 586 30.9 70.6 -4.88 0006952 defense response P 39 131 172 29.8 76.2 79 280 414 28.2 67.6 -4.896 0005102 ligand F 1 18 26 5.6 69.2 52 210 267 24.8 78.7 -5.243 0007165 signal transduction P 48 146 182 32.9 80.2 225 688 922 32.7 74.6 -5.481 0004872 receptor F 15 42 73 35.7 57.5 135 449 694 30.1 64.7 -5.488 0004930 G-protein coupled receptor F 35 160 205 21.9 78 37 175 276 21.1 63.4 -5.755 0016021 integral membrane protein C 340 986 1245 34.5 79.2 372 1079 1479 34.5 73 -5.889 0004888 transmembrane receptor F 7 21 35 33.3 60 102 369 577 27.6 64 -5.911 0007154 cell communication P 3 18 19 16.7 94.7 389 1160 1631 33.5 71.1 -6.929 0004871 signal transducer F 27 74 98 36.5 75.5 237 779 1132 30.4 68.8 -7.316