Multalin version 5.4.1
Copyright I.N.R.A. France 1989, 1991, 1994, 1996
Published research using this software should cite
Multiple sequence alignment with hierarchical clustering
F. CORPET, 1988, Nucl. Acids Res., 16 (22), 10881-10890
Symbol comparison table: blosum62
Gap weight: 12
Gap length weight: 2
Consensus levels: high=90% low=50%
Consensus symbols:
 ! is anyone of IV
 $ is anyone of LM
 % is anyone of FY
 # is anyone of NDQEBZ

 MSF:   1182    Check:   0         ..
 Name: Human          Len:  1182  Check: 4514  Weight:  0.46
 Name: CHIMP          Len:  1182  Check: 5093  Weight:  0.46
 Name: Pig            Len:  1182  Check: 1085  Weight:  0.55
 Name: Mouse          Len:  1182  Check: 5204  Weight:  0.62
 Name: Chicken        Len:  1182  Check: 4988  Weight:  1.01
 Name: Frog           Len:  1182  Check:  788  Weight:  1.15
 Name: Fugu           Len:  1182  Check: 5941  Weight:  1.38
 Name: Zebrafish      Len:  1182  Check: 4365  Weight:  1.38
 Name: Rat            Len:  1182  Check: 9967  Weight:  1.98
 Name: Consensus      Len:  1182  Check: 8069  Weight:  0.00

//

                      1                                                   50
               Human  .......... ..MAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL
               CHIMP  .......... ..MAFCAKMR SSKKTEVNLE APEPGVEVIF YLSDREPLRL
                 Pig  .......... ..MAFCAKMR SSKKTEVNLE APEPGVEVLF YLSDREPLRL
               Mouse  MQYLNIKEDC NAMAFCAKMR SFKKTEVKQV VPEPGVEVTF YLLDREPLRL
             Chicken  MQYLNVKEDC KAMAFCAKMR STKKSEVNLE AQHQGLEVLF YLQDKSPICY
                Frog  .......... ..MAFCAKMR NSKKLEVDIA AKD.GLEVHF YLPDKTAIYY
                Fugu  MSTQWVMELS WQLCGKMRRS GRKAHLSSPP SPTFGLEIHF YTPYVHQLEY
           Zebrafish  MPELAVMDLG RQLCVKMKKQ .RKAEMTIPT AMK.GLEIHF YLADTHQLEF
                 Rat  .......... .......... .......... .......... ..........
           Consensus  .......... .......k.. ..k....... a...gle..f yl.d...l..

                      51                                                 100
               Human  GSGEYTAEEL CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK
               CHIMP  GSGEYTAEEL CIRAAQACRI SPLCHNLFAL YDENTKLWYA PNRTITVDDK
                 Pig  GGGEYTAEEV CIKAAQECCI SPLCHNLFAL YDESTKLWYA PNRTITVDDK
               Mouse  GSGEYTAEEL CIRAAQECSI SPLCHNLFAL YDESTKLWYA PNRIITVDDK
             Chicken  TSGEFTSEEL CIEAAQKCSI SPLCHNLFAL FDENRRLWYA PNQVFKIDEK
                Frog  PQGEFTAENL CIAAALHCNI SPLCHNLFAL YNERDQIWYS PNHIFKIDSN
                Fugu  LSGCYTAEEL CVEAARKCSI SPLCHNLFAL YDEKDNMWYP PNYEFTVTEE
           Zebrafish  FKACYTAEDL CVEAAKRCRI SPLCHNLFAL YEESQDLWYA PNHVFKVTDE
                 Rat  .......... .......... .......... .......... ..........
           Consensus  ..g.ytae.l c..aa..c.i splchnlfal y.e....wy. pn..f.v...

                      101                                                150
               Human  MSLRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KKIPDATPLL
               CHIMP  MSLRLHYRMR FYFTKH..TD HNKQSGGRHS PKKQKNGYEK KKIPDATPLL
                 Pig  TSVRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KKVPDATPLL
               Mouse  TSLRLHYRMR FYFTNWHGTN DNEQSVWRHS PKKQKNGYEK KRVPEATPLL
             Chicken  TSQRLYYRMR YYFTNWHGTS ENEPSVWRHS PKKSKNSYDK KLAPEGTPIL
                Frog  VSLNLNYRMR FIFTNWHGTN ENEASVWRHY PKK.RDGYDK KQNQEGTPLL
                Fugu  ISLKLHYRMR FYFRNWHGNT EGESSVWRHC ISKLRGSLSP QKIPVGTPLL
           Zebrafish  TSIKLHYRMR FYFTNWHGTS EIESPVWRHT LSKQKSVLNS QKTTEGTPLL
                 Rat  .......... .......... ........HS PKKQKNGYEK KRVPEATPLL
           Consensus  .s..lhyrmr fyftnwhgt. e.e.svwrHs pkKqkngy.k k..pegTPlL

                      151                                                200
               Human  DASSLEYLFA QGQYDLVKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
               CHIMP  DASSLEYLFA QGQYDLVKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
                 Pig  DASSLEYLFA QGQYDLVKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
               Mouse  DASSLEYLFA QGQYDLIKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
             Chicken  DANSLEYIFA QGQYDLVREL APIRDPKNDQ EVHEIENECL GMAVLAISHY
                Frog  DASSLDYLFA QGQYELVKCL APVREPKNDQ EVHEIENECL GMAVLAISHY
                Fugu  DAASLEYLFY QGQHSFHKGL VPVRKSHSDT EQHEIENECL GMAVLAITH.
           Zebrafish  DAASLDYLFA QGQYDFLRGL SPVRPTQTDE EHHEIENECL GMAVLAITHH
                 Rat  DASSLEYLFA QGQYDLIKCL APIRDPKTEQ DGHDIENECL GMAVLAISHY
           Consensus  DAsSL#YlFa QGQydl.kcL aP!Rdpkt#q #.H#IENECL GMAVLAIsHy

                      201                                                250
               Human  AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
               CHIMP  AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
                 Pig  AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
               Mouse  AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
             Chicken  AIKKNVKLPE LPKDISYKHY IPETLNKTIR QRNFLTRIRI NNVFKHFLKE
                Frog  AMKRNIQLHD LPKDIGYKKY IPEMLNRTIK QRNFLTRMRI NNVFKNFLKE
                Fugu  ..TTNVGAPG SH.DISYKRF IPETLNRSIK QRSFLTPIRI NNVFKKFLSE
           Zebrafish  AKSNNLPLSG AGAETSYKRF IPDSLNRTIK QRNFLTRIRI SNVFKNFLNE
                 Rat  AMMKKMQLPE LPKDISYKRY IPETLNKSIR QRNLLTRMRI NNVFKDFLKE
           Consensus  am.kn.qlpe lpk#isYKr% IP#tLNksIr QRnfLTrmRI nNVFK.FLkE

                      251                                                300
               Human  FNNKTICDSS VSTHDLKVKY LATLET..LT KHYGAEIFET SMLLISSENE
               CHIMP  FNNKTICDSS VSTHDLKVKY LATLET..LT KHYGAEIFET SMLLISSENE
                 Pig  FNNKTICDSS VSTHDLKVKY LATLET..LT KHYGAEIFET SMLLISSENE
               Mouse  FNNKTICDSS V..HDLKVKY LATLETSTLT KHYGAEIFET SMLLISSENE
             Chicken  FNNKTICDSS VSPRDLKVKY LSTMET..LT KYYGAEIFET SSLLISSESE
                Frog  FNSKTLCDSS VSPHELKVKY LSTMET..LT TNYGAEIFET NHLIIKSENE
                Fugu  FHQRTVRDSN ITPYDLKIKY LATLEG..LT SGLGSEVFEP ISLIVAQEGE
           Zebrafish  FNSKTIQDSN IGLYDLKVKY LSTLET..LT QGVGREIFKP KNLKVTGESE
                 Rat  FNNKTICDSS VSTHDLKVKY LATLET..LT KHYGAEIFET SMLLISSENE
           Consensus  FnnkTicDSs !s.h#LK!KY LaT$Et..LT k.yGaE!Fet s.Ll!ssEnE

                      301                                                350
               Human  MNWFHSNDGG NVLYY..... ......EVMV TGNLGIQWRH KPNVVSVEKE
               CHIMP  MNWFHSNDSG NVLYY..... ......EVMV TGNLGIQWRH KPNVVSVEKE
                 Pig  MSRFHPNDGG NVLY...... ......EVMV TGNLGIQWRQ KPNVVPIEKE
               Mouse  LSRCHSNDSG NVLY...... ......EVMV TGNLGIQWRQ KPNVVPVEKE
             Chicken  INRFNCGDGE IIPLY..... ......EVIV TGNNGIQWRL KPSSVQTEK.
                Frog  QNGFNNGDYD SMHHY..... ......EVSV TGNSGINWRR KPTCTASEKD
                Fugu  LCNGGYYRYF NQNTGQAQSV KTSRDTQVLV TGTTGISWRK KPEMALITS.
           Zebrafish  GSPAQMLPLG DNGMGY.... ......EVQV YGTTGISWRR KPAPNQLIL.
                 Rat  PSRCHSNDSG NVLY...... ......EVMV TGNLGIQWRQ KPNVLPVEKE
           Consensus  .s.....d.g n......... ......#V.V tGn.GIqWR. KP.....ek.

                      351                                                400
               Human  KNKLKRKKLE .NKDKKDEEK NKIREEWNNF SFFPEITHIV IKE.SVVSIN
               CHIMP  KNKLKRKKLE .NKHKKDEEK NKIREEWNNF SYFPEITHIV IKE.SVVSIN
                 Pig  KNKLKRKKLE .SKHKKDEEK NKIREEWNNF SYFPEITHIV IKE.SVVSIN
               Mouse  KNKLKRKKLE YNKHKKDDER NKLREEWNNF SYFPEITHIV IKE.SVVSIN
             Chicken  ......KKKS DGKIKKDEDR YKTRDLWNNF SYFPEITHIV IKE.STVSIN
                Frog  R.KIKWKKTE .SKSKNSDKK GKSKDEWHCF SYFPEITHIV IKE.DTVIIN
                Fugu  KDKSKSKKSK ADGKQQNDRK KEETEGWEVF CDFYEITHAV IKDKTTVTIY
           Zebrafish  KDKPKSKKIK GD.KQWNDKK KDS..GWTLF SDFHEITHIV IKD.CCVTIY
                 Rat  KNKLKRKKLD YIKHKKEDAR NKLREEWNSF SYFPEITHIV IKE.SVVSIN
           Consensus  k.k.k.KK.. ..k.kk.#.k .k.reeWn.F syFpEITHiV IK#.s.VsIn

                      401                                                450
               Human  KQDNKKMELK LSSHEEALSF VSLVDGYFRL TADAHHYLCT DVAPPLIVHN
               CHIMP  KQDNKKMELK LSSHEEALSF VSLVDGYFRL TADAHHYLCT DVAPPLIVHN
                 Pig  KQDNKKMELK LSSHEEALSF VSLIDGYFRL TADAHHYLCT DVAPPLIVHN
               Mouse  KQDNKNMELK LSSREEALSF VSLVDGYFRL TADAHHYLCT DVAPPLIVHN
             Chicken  KQDNKKMELK LSSHDEALSF ASLIDGYFRL TADAHHYLCT DVAPPLIEHN
                Frog  NQDNKSMELK LSTPEEALSF AALIDGYFRL TADAHHYLCS DVAPPLIVNN
                Fugu  RQDNMGMELQ MASRAESLSF VALVDGYFRL TVDAHHYLCK DVAPASVVRN
           Zebrafish  RQDNKTMELD LFYRDAALSF AALVDGYFRL TVDAHHYLCT DVAPSSVVQN
                 Rat  KQDNKNMELK LSSHEGALSF VSLVDGYFRL TADAHHYLCT DVAPPLIVHN
           Consensus  kQDNk.MELk $ss.eeaLSF vsL!DGYFRL TaDAHHYLCt DVAPpl!vhN

                      451                                                500
               Human  IQNGCHGPIC TEYAINKLRQ EGSEEGMYVL RWSCTDFDNI LMTVTCFEKS
               CHIMP  IQNGCHGPIC TEYAINKLRQ EGSEEGMYVL RWSCTDFDNI LMTVTCFEKS
                 Pig  IQNGCHGPIC TEYAINKLRQ EGSEEGMYVL RWSCTDFDNI LMTVTCFEKS
               Mouse  IQNGCHGPIC TEYAINKLRQ EGSEEGMYVL RWSCTDFDNI LMTVTCFEKS
             Chicken  IKNGCHGPIC TEYAINRLRQ EGNEAGMYVL RWSCTNFNLI LMTVTCLEGP
                Frog  IKNGCHGPIC TEYAINKLRQ EGSDEGMYVL RWSCTDFNNI LMTVACSKMS
                Fugu  ISNSCHGPIS TEYAVHKLRQ EGNEEGTYIL RWSCTDFQYI VITVVCTELD
           Zebrafish  LENGCHGPIC TEYAIHKLRQ EGNEEGTYVL RWSCTEYNFI IMTVVCIELD
                 Rat  IQNGCHGPIC TDIAFNKLRQ EGSEEGMYVL RWSCTDFDNI LIAVSCFEKS
           Consensus  i.NgCHGPIc T#yAinkLRQ EGs#eGmY!L RWSCT#%#nI lmtV.C.e.s

                      501                                                550
               Human  EQVQGAQKQF KNFQIEVQKG RYSLHGSDRS FPSLGDLMSH LKKQILRTDN
               CHIMP  EQVQGAQKQF KNFQIEVQKG RYSLHGSDRS FPSLGDLMSH LKKQILRTDN
                 Pig  E.VLGGQKQF KNFQIEVQKG RYSLHGSDRS FPSLGDLMSH LKKQILRTDN
               Mouse  E.VLGGQKQF KNFQIEVQKG RYSLHGSMDH FPSLRDLMNH LKKQILRTDN
             Chicken  E.MINNSVQY KNFQIEVKKG GYFLHGSNRS FASLKELMDH LKGQILRTDN
                Frog  QYDSKCLKQY KNFQIEVKKG RYSLLGPDLE FDSLKDLMKH LKGQVLKTDD
                Fugu  LKESRPVRQY KNFQIEESSD GFRLYGTDTC RPTLMELLEH LESQSLRTDN
           Zebrafish  LCESRPVPQY KNFQIETSPQ GYRLYGTDTF RPTLKELLEH LQGQLLRTDN
                 Rat  E.VLGNQKQF KNFQIEVQKG RYSLHGSVDH FPSLRDLMNH LKKQILRTDN
           Consensus  e......kQ% KNFQIEv.kg r%sLhGsd.. fpsL.#L$.H Lk.QiLrTD#

                      551                                                600
               Human  ISFMLKRCCQ PKPREISNLL VATK.KAQEW QPVYPMSQLS FDRILKKDLV
               CHIMP  ISFMLKRCCQ PKPREISNLL VATK.KAQEW QPVYPMSQLS FDRILKKDLV
                 Pig  ISFVLKRCCQ PKPREISNLL VATK.KAQEW QPVYTMSQLS FDRILKNDIM
               Mouse  ISFVLKRCCQ PKPREISNLL VATK.KAQEW QPVYSMSQLS FDRILKKDII
             Chicken  ISFTLKRCCQ PKPREISNLL VATK.KAQEC QPAYHLGQLS FHRIRKEEIM
                Frog  VSFTLKKCSP PKPREISNLL VATK.KALEW QPVYHLSQLS FHRILKEEIT
                Fugu  LQFQLLRVCP PQPREISNLL VVTKDRVLTH PSPMPDSQLS FHRILKEDIE
           Zebrafish  LRFQLRRCCP PQPREISNLL VMTTDREPVP QKKTQVSQLS FDRILKEEIV
                 Rat  ISFVLKRCCQ SKPREISNLL VATK.KAQEW QPVYSMSQLS FDRILKKDII
           Consensus  isF.Lkrccq pkPREISNLL VaTk.kaqew qpvy..sQLS FdRIlKe#i.

                      601                                                650
               Human  QGEHLGRGTR THIYSGTLMD Y.KDDEGTSE EK.K.IKVIL KVLDPSHRDI
               CHIMP  QGEHLGRGTR THIYSGTLMD Y.KDDEGTSE EK.K.IKVIL KVLDPSHRDI
                 Pig  QGEHLGRGTR THIYSGTLMD Y.KDDEGTSE EKRK.IKVIL KVLDPSHRDI
               Mouse  QGEHLGRGTR THIYSGTLLD Y.KDEEGIAE EK.K.IKVIL KVLDPSHRDI
             Chicken  QGEHLGRGTR TQIYSG.ILN Y.KDDENEGY QNEKEIKVLL KVLDPSHRDI
                Frog  QLEHLGRGTR TQIYAGKLNY K.DDNDSESY STEKEIKVIL KVLHPSHRDI
                Fugu  QEEHLGRGTR TNIYSGTLRV KSEEDEDAGY SSFQEVKVVL KLLSYGHRDI
           Zebrafish  QGEHLGRGTR TNIYAGILKP KSDDEDDLGG YS.QEVKVVL KVLGSGHRDI
                 Rat  QGEHLGRGTR THIYSGTLLD Y.KDDEGIAE E..KKIKVIL KVLDPSHRDI
           Consensus  QgEHLGRGTR T.IYsGtl.. y.k###.... ...ke!KViL KvLdpsHRDI

                      651                                                700
               Human  SLA..FFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM
               CHIMP  SLASAFFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM
                 Pig  SLA..FFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM
               Mouse  SLA..FFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM
             Chicken  SLA..FFEAA SMMRQVSHKH IVFLHGVCVR DLENIMVEEF VEFGPLDLFM
                Frog  SLA..FFETA SMMRQVSHKH IVLLHGVCVR DVENIMVEEF VDFGPLDLFM
                Fugu  SLA..FFETA SMMRQVSHKH IVLLYGVCVH HQENIMVEEF VQLGPLDVFM
           Zebrafish  SLA..FFETA SMMRQISHKH TALLYGVCVR HQENIMVEEF VQYGPLDLFM
                 Rat  SLA..FFEAA SMMRQVSHKH IVYLYGVCVR DVENIMVEEF VEGGPLDLFM
           Consensus  SLA..FFEaA SMMRQ!SHKH iv.LyGVCVr dvENIMVEEF V#.GPLDlFM

                      701                                                750
               Human  HRKSDVLTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN LLLAREGID.
               CHIMP  HRKSDVLTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN LLLAREGID.
                 Pig  HRKSDVLTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN LLLAREGID.
               Mouse  HRKSDALTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN LLLAREGID.
             Chicken  HRKSELLTTP WKFNVAKQLA SALSYLEDKD LVHGNVCTKN ILLAREGID.
                Frog  HRKSDVLTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN ILLAREGID.
                Fugu  RRQQSPLSIP WKFQVAKQLA SALSYLEDKK LVHGFVCAKN ILLARDGMGT
           Zebrafish  RRQTTPLSTA WKFQVAKQLA SALSYLEDKK MVHGYVCSKN ILVARDGLD.
                 Rat  HRKSDALTTP WKFKVAKQLA SALSYLEDKD LVHGNVCTKN LLLAREGID.
           Consensus  hRksd.Lttp WKFkVAKQLA SALSYLEDKd $VHGnVCtKN iLlAR#Gid.

                      751                                                800
               Human  SECGPFIKLS DPGIPITVLS RQECIERIPW IAPECVEDSK NLSVAADKWS
               CHIMP  SECGPFIKLS DPGIPITVLS RQECIERIPW IAPECVEDSK NLSVAADKWS
                 Pig  SECGPFIKLS DPGIPITVLS RQECIERIPW IAPECVEDSK NLSVAADKWS
               Mouse  SDIGPFIKLS DPGIPVSVLT RQECIERIPW IAPECVEDSK NLSVAADKWS
             Chicken  TEYGPFIKLS DPGIPITVLS RQECVERIPW IAPECVEDSK NLSIAADKWS
                Frog  NDCGPFIKLS DPGIPITVLT RQERVERIPW IAPECVEDSR VLSVAADKWS
                Fugu  DEGGPFIKLS DPGIPITVLT REECVHRIPW IAPECVKNVS ALSVAADKWG
           Zebrafish  GEGGPFIKLS DPGIPITVLS REECVDRIPW IAPECVKDTA NLTIAADKWS
                 Rat  SDIGPFIKLS DLGIPVSVLT RQECIERNPW IAPECVEDSK NLSVAADKWS
           Consensus  .#.GPFIKLS DpGIP!tVLt R#Ec!eRiPW IAPECVe#sk nLs!AADKWs

                      801                                                850
               Human  FGTTLWEICY NGEIPLKDKT LIE.KERFYE SRCRPVTPSC KELADLMTRC
               CHIMP  FGTTLWEICY NGEIPLKDKT LIE.KERFYE SRCRPVTPSC KELADLMTRC
                 Pig  FGTTLWEICY NGEIPLKDKT LIE.KERFYE SRCRPVTPSC KELADLMTRC
               Mouse  FGTTLWEICY NGEIPLKDKT LIE.KERFYE SRCRPVTPSC KELADLMTRC
             Chicken  FGTTLWEICY NGETPLKDKT LAE.KERFYE GHFMLITPSC KELADLMKQC
                Frog  FGTTLWEICF NGEVPLKDRT LAE.KERFYG GCFMLVAPSC KELADLINHC
                Fugu  FGTTLWEICY DGEVPLKEKK LTEQKERFYE TECQLATPDC TELAELMTHC
           Zebrafish  FGTTLWEICY NGEIPLKDKK LSE.KERFYA AQCQLATPDC DELAKLMTHC
                 Rat  FGTTLWEIRY DGEIPLKDKT LIE.KERFYE SRCRPVTPSC KELADLMTRC
           Consensus  FGTTLWEIc% #GEiPLK#kt L.E.KERFYe ..c.lvtPsC kELAdLmt.C

                      851                                                900
               Human  MNYDPNQRPF FRAIMRDINK LEEQNPDIVS RKKNQPTEVD PTHFEKRFLK
               CHIMP  MNYDPNQRPF FRAIMRDINK LEEQNPDIVS EKK.PATEVD PTHFEKRFLK
                 Pig  MNYDPNQRPF FRAIMRDINK LEEQNPDIVS EKK.PATEVD PTHFEKRFLK
               Mouse  MNYDPNQRPF FRAIMRDINK LEEQNPDIVS EKQ.PTTEVD PTHFEKRFLK
             Chicken  MNYDPHQRPF FRAIMRDINK LEEQNPDIVS EKK.PVTEVD PTLFEKRFLK
                Frog  MNYDPNRRPF FRAIMREINK LEEQNPDIVS EKS.PSAEVD PTLFEKRFLK
                Fugu  MNYDPKKRPF FRAIVRDIDM LGEQNPSIKP K...PTAEVD PTVFEKRFLK
           Zebrafish  MTYDPRQRLF FRAIVRDIVM VEKQNPSIQP V...PMLEVD PTVFEKRFLK
                 Rat  MNYDPNQRPF FRAIMRDINK LEEQNPDIVS EKH.PITEVD PTHFEKRFLK
           Consensus  MnYDPnqRpF FRAImR#Ink leeQNPdIvs ek..P.tEVD PT.FEKRFLK

                      901                                                950
               Human  RIRDLGEGHF GKVELCRYDP E.DNTGEQVA VKSLKPESGG NHIADLKKEI
               CHIMP  RIRDLGEGHF GKVELCRYDP EGDNTGEQVA VKSLKPESGG NHIADLKKEI
                 Pig  RIRDLGEGHF GKVELCRYDP EGDNTGEQVA VKSLKPESGG NHIADLKKEI
               Mouse  RIRDLGEGHF GKVELCRYDP EGDNTGEQVA VKSLKPESGG NHIADLKKEI
             Chicken  RIRDLGEGHF GKVELCRYDP EGDNTGEQVA VKSLKPESGG NHIADLKKEI
                Frog  RVRDLGEGHF GKVELCRYDP EGDNTGELVA VKSLKPGTGG SHIADLKKEI
                Fugu  KVRDLGEGHF GKVELCRYDP RGDKTGELVA VKSLKPENQQ EQSTNLSREI
           Zebrafish  KIRDLGEGHF GKVELCRYDP RGDRTGELVA VKSLKPENRE EQSNNLWREI
                 Rat  RIRDLGEGHF GKVELCRYDP EGDNTGEQVA VKSLKPESGG NHIADLKKEI
           Consensus  r!RDLGEGHF GKVELCRYDP eGDnTGEqVA VKSLKPesgg nhia#LkkEI

                      951                                               1000
               Human  EILRNLYHEN IVKYKGICTE DGGNGIKLIM EFLPSGSLKE YLPKNKNKIN
               CHIMP  EILRNLYHEN IVKYKGICTE DGGNGIKLIM EFLPSGSLKE YLPKNKNKIN
                 Pig  EILRNLYHEN IVKYKGICTE DGGNGIKLIM EFLPSGSLKE YLPKNKNKIN
               Mouse  EILRNLYHEN IVKYKGICME DGGNGIKLIM EFLPSGSLKE YLPKNKNKIN
             Chicken  EILRNLYHEN IVKYKGICTE DGGNGIKLIM EFLPSGSLKE YLPRNKNKIN
                Frog  EILRNLYHEN IVKYKGIC.E DGDSGIKLIM EYLPSGSLKE YLPRNVNKIN
                Fugu  DILKALFHEN IVRYKGICQE EGGQAFKLIM EYVPMGSLKD YLPRHKKDTS
           Zebrafish  HILRELYHEN IVKYKGICNE EGGRSIKLIM EFLPAGSLKE YLPRNKAHIN
                 Rat  EILRNLYHEN IVKYKGICME DGGNGIKLIM EFLPSGSLKE YLPKNKNKIN
           Consensus  eILrnL%HEN IVkYKGIC.E #GgngiKLIM E%lPsGSLK# YLPrnknkin

                      1001                                              1050
               Human  LKQQLKYAVQ ICKGMDYLGS RQYVHRDLAA RNVLVESEHQ VKIGDFGLTK
               CHIMP  LKQQLKYAVQ ICKGMDYLGS RQYVHRDLAA RNVLVESEHQ VKIGDFGLTK
                 Pig  LKQQLKYAVQ ICKGMDYLGS RQYVHRDLAA RNVLVESEHQ VKIGDFGLTK
               Mouse  LKQQLKYAIQ ICKGMDYLGS RQYVHRDLAA RNVLVESEHQ VKIGDFGLTK
             Chicken  LKQLLRYAVQ ICKGMDYLGS RQYVHRDLAA RNVLVESENR VKIGDFGLTK
                Frog  LKQQLKYATQ ICKGMDYLGS RQYVHRDLAA RNVLVENEQI IKIGDFGLTK
                Fugu  LATLLSYSVQ ICKGMEYLGS KNYIHRDLAA RNVLVENERM VKIGDFGLTK
           Zebrafish  LKTLHNYSVQ ICQGMDYLGS RNYIHRDLAA RNVLVENEGT VKIGDFGLTK
                 Rat  LKQQLKYAIQ ICKGMDYLG. .......... .......... ..........
           Consensus  LkqqlkYavQ ICkGM#YLGs r.y.hrdlaa rnvlve.e.. vkigdfgltk

                      1051                                              1100
               Human  AIETDKEYYT VKDDRDSPVF WYAPECLMQS KFYIASDVWS FGVTLHELLT
               CHIMP  AIETDKEYYT VKDDRDSPVF WYAPECLMQS KFYIASDVWS FGVTLHELLT
                 Pig  AIETDKEYYT VKDDRDSPVF WYAPECLIQC KFYIASDVWS FGVTLHELLT
               Mouse  AIETDKEYYT VKDDRDSPVF WYAPECLIQC KFYIASDVWS FGVTLHELLT
             Chicken  AIETDKEYYT VKDDLDSPVF WYAPECLIQS KFYIASDVWS FGVTLYELLT
                Frog  AIQTDKEYYT VKDDLDSPVF WYAPECLLHC KFYIASDVWS FGVTLYELLT
                Fugu  SIKDNEGYYT VKDENDSPVF WYAPECLTQC KFYLASDVWS FGVTLYELIT
           Zebrafish  SIKDNEGYYT VKDDLDSPVF WYAPECLIHC KFYRASDVWS FGVTMYELLT
                 Rat  .......... .......... .......... .......... ..........
           Consensus  .i.....yyt vkdd.dspvf wyapecl..c kfy.asdvws fgvtlyellt

                      1101                                              1150
               Human  YCDSDSSPMA LFLKMIGPTH GQMTVTRLVN TLKEGKRLPC PPNCPDEVYQ
               CHIMP  YCDSDSSPMA LFLKMIGPTH GQMTVTRLVN TLKEGKRLPC PPNCPDEVYQ
                 Pig  YCDSDSSPMA LFLKMIGPTH GQMTVTRLVN TLKEGKRLPC PPNCPEEVYQ
               Mouse  YCDSDFSPMA LFLKMIGPTH GQMTVTRLVK TLKEGKRLPC PPNCPDEVYQ
             Chicken  YCDSESSPMT EFLKMIGPTQ GQMTVARLVR VLQEEKRLPR PPNCPEEIDQ
                Frog  YCNSEYSPMT MFLKMIGPTQ GQMTVTRLVR VLEEGKRLPI PANCPKQVYQ
                Fugu  YCDSSKSPMT CFLDMIGWTQ GQMTVMRLVK LLNDGRRLPR PDGCPEPVYE
           Zebrafish  YCDASCSPMS VFLKLIGPTH GQMTVTRLVK VLEEGKRLPR PDDCSEQLYN
                 Rat  .......... .......... .......... .......... ..........
           Consensus  ycds..spm. .flkmigpt. gqmtvtrlv. .l.egkrlp. p..cp..vy.

                      1151                           1182
               Human  LMRKCWEFQP SNRTSFQNLI EGFEALLK.. ..
               CHIMP  LMRKCWEFQP SNRTSFQNLI EGFEALLK.. ..
                 Pig  LMRKCWEFQP SNRTTFQNLI EGFEALLK.. ..
               Mouse  LMRKCWEFQP SNRTTFQNLI EGFEALLK.. ..
             Chicken  LMRKCWIFKH DKRTTFHNLI QGFETIMSKM ..
                Frog  LMTKCWEQNP SDRTTFQDLI KGFEAIIITL ..
                Fugu  LMRKCWEQKP DSRITFTGLI KELSNMQQQF QP
           Zebrafish  LMRRCWEATP EKRIDFKSLI ANFQQMLDNL ..
                 Rat  .......... .......... .......... ..
           Consensus  lmrkcwe..p ..r.tf..li ..f....... ..