Multalin version 5.4.1
Copyright I.N.R.A. France 1989, 1991, 1994, 1996
Published research using this software should cite
Multiple sequence alignment with hierarchical clustering
F. CORPET, 1988, Nucl. Acids Res., 16 (22), 10881-10890
Symbol comparison table: blosum62
Gap weight: 12
Gap length weight: 2
Consensus levels: high=90% low=50%
Consensus symbols:
 ! is anyone of IV
 $ is anyone of LM
 % is anyone of FY
 # is anyone of NDQEBZ

 MSF:   1133    Check:   0         ..
 Name: Human          Len:  1133  Check: 8455  Weight:  0.57
 Name: Pig            Len:  1133  Check: 9844  Weight:  0.57
 Name: Mouse          Len:  1133  Check: 7209  Weight:  0.49
 Name: Rat            Len:  1133  Check:  713  Weight:  0.49
 Name: Fugu           Len:  1133  Check: 9441  Weight:  1.65
 Name: Chimp          Len:  1133  Check: 6063  Weight:  2.23
 Name: Consensus      Len:  1133  Check: 5146  Weight:  0.00

//

                      1                                                   50
               Human  MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHS.LGK
                 Pig  MGMACLTMTE MEGTSTSPVH QNGDIPGNAN SVKQIDPVLQ VYLYHS.LGK
               Mouse  MGMACLTMTE MEATSTSPVH QNGDIPGSAN SVKQIEPVLQ VYLYHS.LGQ
                 Rat  MGMACLTMTE MEGTSTSPAH QNGDIPGNAN SVKQTEPVLQ VYLYHS.LGQ
                Fugu  ..MASLAAME TLADACPTVH QNGTAQRESP EARLSVDVLR LHFYRSGQGA
               Chimp  MGMACLTMPE MEGTSASSIY QNGDISGNAN SMKQIDPVLQ VYLYHS.LGK
           Consensus  mgMAcLtm.E megts.s.!h QNGdi.g#an s.kqidpVLq vylYhS.lGk

                      51                                                 100
               Human  SEADYLTFPS GEYVAEEICI AASKACGITP VYHNMFALMS ETERIWYPPN
                 Pig  AEGDYLKFPA GEYVAEEICV AASKACGITP VYHSMFALMN ETERIWYPPN
               Mouse  AEGEYLKFPS GEYVAEEICV AASKACGITP VYHNMFALMS ETERIWYPPN
                 Rat  AEGDYLKFPN GEYVAEEICV AASKACGITP VYHNMFALMS ETERIWYPPN
                Fugu  TDSSFLSYPP GNYVAEELCI DAAKACSISP LYFSLFGLFR ERDCLWFSPN
               Chimp  SEADYLTFPS GEYVAEEICI AASKACGITP VYHNMFALMS ETERIWYPPN
           Consensus  .#.d%L.%Ps G#YVAEEiC! aAsKACgItP vYhn$FaLms Et#riW%pPN

                      101                                                150
               Human  HVFHIDESTR HNVLYRIRFY FPRWYCSGSN RAYRHGISRG AEAPLLDDFV
                 Pig  HVFHVDESTR HNVLYRIRFY FPYWYCNGSN RTYRHGISRG AEAPLLDDFV
               Mouse  HVFHIDESTR HDILYRIRFY FPHWYCSGSS RTYRYGVSRG AEAPLLDDFV
                 Rat  HVFHIDESTR HNILYRIRFY FPHWYCSGSN RTYRYGVSRG AEAPLLDDFV
                Fugu  HTFQLDEFAS EDVFFRIRYY FPGWYSGGAS RAYRYGVAKG SESPVFDDCV
               Chimp  HVFHIDESTR HNVLYRIRFY FPRWYCSGSN RAYRHGISRG AEAPLLDDFV
           Consensus  HvFhiDEstr h#!l%RIR%Y FP.WYcsGsn RaYRhG!srG aEaPllDDfV

                      151                                                200
               Human  MSYLFAQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKENDQTPLA
                 Pig  MSYLFAQWRH DFLYGWVKIP VTHETQEECL GMAVLDMMRI AKEKDQTPLD
               Mouse  MSYLFVQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKEKDQTPLA
                 Rat  MSYLFAQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKEKDQTPLA
                Fugu  MSYLFSQWRN DFVNGFMKIP SSHEIQEECL GMAVLDMTRT AKERQLSPLD
               Chimp  MSYLFAQWRH DFVHGWIKVP VTHETQEECL GMAVLDMMRI AKENDQTPLA
           Consensus  MSYLFaQWRh DFVhGwiK!P vtHEtQEECL GMAVLDMmRi AKE.#qtPLa

                      201                                                250
               Human  IYNSISYKTF LPKCIRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN
                 Pig  IYSSVSYKTF LPKCVRAKIQ DYHILTRKRI RYRFRRFIEQ FSHCKATARN
               Mouse  VYNSVSYKTF LPKCVRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN
                 Rat  VYNSISYKTF LPKCVRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN
                Fugu  IYHTMSYKSF LPKEIRAQIQ DCNFLTRKRI RFRFKRFIQQ FSQCRTTVRD
               Chimp  IYNSISYKTF LPKCIRAKIQ DYHILTRKRI RYRFRRFIQQ FSQCKATARN
           Consensus  !YnsiSYKtF LPKc!RAkIQ DyhiLTRKRI R%RFrRFIQQ FSQCkaTaR#

                      251                                                300
               Human  LKLKYLINLE TLQSAFYTEK FEVKEPGSGP SGEEIFATII ITGNGGIQWS
                 Pig  LKLKYLINLE TLQSAFYTEQ FEVKEPGRGP SGEEIFATII ITGNGGIQWS
               Mouse  LKLKYLINLE TLQSAFYTEQ FEVKESARGP SGEEIFATII ITGNGGIQWS
                 Rat  LKLKYLINLE TLQSAFYTEQ FEVKESARGP SGEEIFATII ITGNGGIQWS
                Fugu  LKLKYLISME SLEKAFYTET FQVRELSRGQ ......LIIL VVADNGIQWC
               Chimp  LKLKYLINLE TLQSAFYTEK FEVKEPGSGP SGEEIFATII ITGNGGIQWS
           Consensus  LKLKYLIn$E tL#sAFYTE. F#VkEpgrGp sgeeifatIi !tg#gGIQWs

                      301                                                350
               Human  RGKHKESETL TEQDLQLYCD FPNIIDVSIK QANQEGSNES RVVTIHKQDG
                 Pig  RGKHKESETL TEQDLQLYCD FPDIIDVSIK QANQEGSNES RIVTIHKQDG
               Mouse  RGKHKESETL TEQDVQLYCD FPDIIDVSIK QANQECSNES RIVTVHKQDG
                 Rat  RGKHKESETL TEQDLQLYCD FPDIIDVSIK QANQECSTES RVVTVHKQDG
                Fugu  QEKLKDSD.. ..EELQILCD FPDVTDISIK QASKEGATES RVVTINKQDG
               Chimp  RGKHKESETL TEQDLQLYCD FPNIIDVSIK QANQEGSNES RVVTIHKQDG
           Consensus  rgKhK#S#tl te##LQlyCD FP#!iD!SIK QAnqEgsnES R!VT!hKQDG

                      351                                                400
               Human  KNLEIELSSL REALSFVSLI DGYYRLTADA HHYLCKEVAP PAVLENIQSN
                 Pig  KSLEIELSSL REALSFVSLI DGYYRLTADA HHYLCKEVAP PMVLENIQSN
               Mouse  KVLEIELSSL KEALSFVSLI DGYYRLTADA HHYLCKEVAP PAVLENIHSN
                 Rat  KVLEIELSSL KEALSFVSLI DGYYRLTADA HHYLCKEVAP PAVLENIHSN
                Fugu  KNLELEFPSL SEALSFVSLI DGYYRLTTDA HHYLCKEVAP PRLVEAITSH
               Chimp  KNLEIELSSL REALSFVSLI DGYYRLTADA HHYLCKEVAP PTVLENIQSN
           Consensus  KnLEiElsSL rEALSFVSLI DGYYRLTaDA HHYLCKEVAP P.vlEnIqSn

                      401                                                450
               Human  CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY
                 Pig  CHGPISMDFA ISKLKKAGNQ TGLFVLRCSP KDFNKYFLTF AVERENVTEY
               Mouse  CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY
                 Rat  CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY
                Fugu  CHGPISLEFA INQLQKCGNK QGLFILQCSP KDFNKYFLTF PVEVYGTVEF
               Chimp  CHGPISMDFA ISKLKKAGNQ TGLYVLRCSP KDFNKYFLTF AVERENVIEY
           Consensus  CHGPIS$#FA IskLkKaGNq tGL%!LrCSP KDFNKYFLTF aVErenv!E%

                      451                                                500
               Human  KHCLITKNEN EEYNLSGTKK NFSSLKDLLN CYQMETVRSD NIIFQFTKCC
                 Pig  KHCLITKNEN GEYNLSGTRK NFSNLKDLLN CYQMETVRSD SIIFQFTKCC
               Mouse  KHCLITKNEN GEYNLSGTNR NFSNLKDLLN CYQMETVRSD SIIFQFTKCC
                 Rat  KHCLITKNEN GEYNLSGTKR NFSSLKDLLN CYQMETVRSD SIIFQFTKCC
                Fugu  KHCQITRSEC GQFNLSGTKR NFSSLHELLS CYKNETVRSD SVVFQFSKCC
               Chimp  KHCLITKNEN EEYNLSGTKK NFSSLKDLLN CYQMETVRSD NIIFQFTKCC
           Consensus  KHClITknEn g#%NLSGTkk NFSsLk#LLn CYqmETVRSD s!!FQFtKCC

                      501                                                550
               Human  PPKPKDKSNL LVFRTNGVSD VPTSPTLQRP THMNQMVFHK IRNEDLIFNE
                 Pig  PPKPKDKSNL LVFRTNGISD VPTSPTLQRH NNVNQMVFHK IRNEDLIFNE
               Mouse  PPKPKDKSNL LVFRTNGISD VQISPTLQRH NNVNQMVFHK IRNEDLIFNE
                 Rat  PPKPKDKSNL LVFRTNGVSD VQLSPTLQRH NNVNQMVFHK IRNEDLIFNE
                Fugu  PPKAKERSCL LVCRTNKGPE VPLSPSTNRH .NISQMVFHK IRKEDLEFNE
               Chimp  PPKPKDKSNL LVFRTNGVSD VPTSPTLQRP THMNQMVFHK IRNEDLIFNE
           Consensus  PPKpK#kSnL LVfRTNgvs# VptSPtl#Rh .n.nQMVFHK IRnEDLiFNE

                      551                                                600
               Human  SLGQGTFTKI FKGVRREVGD YGQLHETEVL LKVLDKAHRN YSESFFEAAS
                 Pig  SLGQGTFTKI FKGVRREVGD YGQLHETEVL LKVLDKAHRN YSESFFEAAS
               Mouse  SLGQGTFTKI FKGVRREVGD YGQLHKTEVL LKVLDKAHRN YSESFFEAAS
                 Rat  SLGQGTFTKI FKGVRREVGD YGQLHETEVL LKVLDKAHRN YSESFFEAAS
                Fugu  SLGQGTFTKI FKGVRKELGD YGLMHQTEVV MKVLDQAHRN YSESFFEAAS
               Chimp  SLGQGTFTKI FKGVRREVGD YGQLHETEVL LKVLDKAHRN YSESFFEAAS
           Consensus  SLGQGTFTKI FKGVRrEvGD YGq$H#TEVl $KVLDkAHRN YSESFFEAAS

                      601                                                650
               Human  MMSKLSHKHL VLNYGVCVCG DENILVQEFV KFGSLDTYLK KNKNCINILW
                 Pig  MMSQLSHKHL VLNYGVCVCG EENILVQEFV KFGSLDTYLK KNKNSINILW
               Mouse  MMSQLSHKHL VLNYGVCVCG EENILVQEFV KFGSLDTYLK KNKNSINILW
                 Rat  MMSQLSHKHL VLNYGVCVCG EENILVQEFV KFGSLDTYLK KNKNSINILW
                Fugu  MMTQLSHVHL ILNYGVCVCG EENIMVQEYV KFGSLDTYLK KNKNSVNILW
               Chimp  MMSKLSHKHL VLNYGVCVCG DENILVQEFV KFGSLDTYLK KNKNCINILW
           Consensus  MMsqLSHkHL !LNYGVCVCG #ENI$VQE%V KFGSLDTYLK KNKNs!NILW

                      651                                                700
               Human  KLEVAKQLAW AMHFLEENTL IHGNVCAKNI LLIREEDRKT GNPPFIKLSD
                 Pig  KLEVAKQLAW AMHFLEEKTL IHGNVCAKNI LLIREEDRKT GNPPFIKLSD
               Mouse  KLGVAKQLAW AMHFLEEKSL IHGNVCAKNI LLIREEDRRT GNPPFIKLSD
                 Rat  KLGVAKQLAW AMHFLEEKSL IHGNVCAKNI LLIREEDRKT GNPPFIKLSD
                Fugu  KLEVAKQLAQ AMNFLEEKNL VHGNVCAKNV LLIREDDWRA GNPPFIKLSD
               Chimp  KLEVAKQLAW AMHFLEENTL IHGNVCAKNI LLIREEDRKT GNPPFIKLSD
           Consensus  KLeVAKQLAw AMhFLEEktL !HGNVCAKN! LLIRE#Drkt GNPPFIKLSD

                      701                                                750
               Human  PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEICSG
                 Pig  PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEICSG
               Mouse  PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEICSG
                 Rat  PGISITVLPK DILQERIPWV PPECIENPKN LTLATDKWSF GTTLWEICSG
                Fugu  PGISITVLPK EILVERIPWV PPECVNDPAN LSLAADKWSF GTTLWEICSG
               Chimp  PGISITVLPK DILQERIPWV PPECIENPKN LNLATDKWSF GTTLWEVCSG
           Consensus  PGISITVLPK #ILqERIPWV PPEC!##PkN LnLAtDKWSF GTTLWE!CSG

                      751                                                800
               Human  GDKPLSALDS QRKLQFYEDR HQLPAPKWAE LANLINNCMD YEPDFRPSFR
                 Pig  GDKPLNALDS QRKLQFYEDR HQLPAPKWTE LANLINNCMD YEPDFRPSFR
               Mouse  GDKPLSALDS QRKLQFYEDK HQLPAPKWTE LANLINNCMD YEPDFRPAFR
                 Rat  GDKPLSALDS QRKLQFYEDK HQLPAPKWTE LANLINTCMD YEPDFRPAFR
                Fugu  GEKPLASLDN TNKTLFYEDR HQLPAPKWIE LANLITSCMD YEPTFRPTFR
               Chimp  GDKPLSALDS QRKLQFYEDR HQLPAPKWAE LANLINNCMD YEPDFRPSFR
           Consensus  G#KPLsaLDs qrKlqFYEDr HQLPAPKW.E LANLInnCMD YEPdFRPsFR

                      801                                                850
               Human  AIIRDLNSLF TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL
                 Pig  AIIRDLNSLF TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL
               Mouse  AVIRDLNSLF TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL
                 Rat  AVIRDLNSLF TPDYELLTEN DMLPNMRIGA LGFSGAFEDR DPTQFEERHL
                Fugu  AIIRDLHSLF TPDYELIVDS DILPNRTACT GWSTGGFDSQ EPAQFEERHL
               Chimp  AIIRDLNSLF TP........ .......... .......... ..........
           Consensus  A!IRDLnSLF TPdyel.... d.lpn..... ....g.f... .p.qfeerhl

                      851                                                900
               Human  KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
                 Pig  KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
               Mouse  KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
                 Rat  KFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHSTE EHLRDFEREI
                Fugu  IFLQQLGKGN FGSVEMCRYD PLQDNTGEVV AVKKLQHGTA EHIRDFEREI
               Chimp  .......... .......... .......... .......... ..........
           Consensus  .flqqlgkgn fgsvemcryd plqdntgevv avkklqh.t. eh.rdferei

                      901                                                950
               Human  EILKSLQHDN IVKYKGVCYS AGRRNLKLIM EYLPYGSLRD YLQKHKERID
                 Pig  EILKSLQHDN IVKYKGVCYS AGRRNLRLIM EYLPYGSLRD YLQKHKERID
               Mouse  EILKSLQHDN IVKYKGVCYS AGRRNLRLIM EYLPYGSLRD YLQKHKERID
                 Rat  EILKSLQHDN IVKYKGVCYS AGRRNLRLIM EYLPYGSLRD YLQKHKERID
                Fugu  EILKSLQHEN IVKYKGVCYS AGRRNLRLVM EYLPFGSLRD YLIKNKERID
               Chimp  .......... .......... .......... .......... ..........
           Consensus  eilkslqh.n ivkykgvcys agrrnlrl.m eylp.gslrd yl.k.kerid

                      951                                               1000
               Human  HIKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK
                 Pig  HKKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK
               Mouse  HKKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK
                 Rat  HKKLLQYTSQ ICKGMEYLGT KRYIHRDLAT RNILVENENR VKIGDFGLTK
                Fugu  HKKLVHYSSQ ICKGMEYLSG KRYIHRDLAT RNILVESESR VKIGDFGLTK
               Chimp  .......... .......... .......... .......... ..........
           Consensus  hkkl..y.sq ickgmeyl.. kryihrdlat rnilve.e.r vkigdfgltk

                      1001                                              1050
               Human  VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT
                 Pig  VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT
               Mouse  VLPQDKEYYK VKEPGESPIF WYAPQSLTES KFSVASDVWS FGVVLYELFT
                 Rat  VLPQDKEYYK VKEPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT
                Fugu  ILPQDKEYYM VREPGESPIF WYAPESLTES KFSVASDVWS FGVVLYELFT
               Chimp  .......... .......... .......... .......... ..........
           Consensus  .lpqdkeyy. v.epgespif wyapesltes kfsvasdvws fgvvlyelft

                      1051                                              1100
               Human  YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI ELLKNNGRLP RPDGCPDEIY
                 Pig  YIEKSKSPPA EFMRMIGNDK QGQMIVFHLI ELLKNNGRLP RPDGCPDEIY
               Mouse  YIEKSKSPPV EFMRMIGNDK QGQMIVFHLI ELLKSNGRLP RPEGCPDEIY
                 Rat  YIEKSKSPPV EFMRMIGNDK QGQMIVFHLI ELLKNNGRLP RPEGCPDEIY
                Fugu  HSSRNSSPPT VFMSMMGNDK QGQLIVYHLI ELLKSGSRLP QPLDCPTEIH
               Chimp  .......... .......... .......... .......... ..........
           Consensus  ......spp. .fm.m.gndk qgq.iv.hli ellk...rlp .p..cp.ei.

                      1101                            1133
               Human  MIMTECWNNN VNQRPSFRDL ALRVDQIRDN MAG
                 Pig  IIMTECWNNN VNQRPSFRDL ALRVDQIRDS MA.
               Mouse  VIMTECWNNN VSQRPSFRDL SFGWIKCGTV ...
                 Rat  VIMTECWNNN VNQRPSFRDL SLRVDQIRDS MAA
                Fugu  EIMEQCWDND PYLRPSFKEL ALSIDLFREH KEF
               Chimp  .......... .......... .......... ...
           Consensus  .im..cw.n. ...rpsf..l .l..d..r.. ...