Multalin version 5.4.1 Copyright I.N.R.A. France 1989, 1991, 1994, 1996 Published research using this software should cite Multiple sequence alignment with hierarchical clustering F. CORPET, 1988, Nucl. Acids Res., 16 (22), 10881-10890 Symbol comparison table: blosum62 Gap weight: 12 Gap length weight: 2 Consensus levels: high=90% low=50% Consensus symbols: ! is anyone of IV $ is anyone of LM % is anyone of FY # is anyone of NDQEBZ MSF: 1215 Check: 0 .. Name: Human Len: 1215 Check: 3928 Weight: 0.63 Name: Pig Len: 1215 Check: 6737 Weight: 0.63 Name: Rat Len: 1215 Check: 9719 Weight: 0.44 Name: Mouse Len: 1215 Check: 7062 Weight: 0.44 Name: Chicken Len: 1215 Check: 2942 Weight: 1.31 Name: Fugu Len: 1215 Check: 8601 Weight: 1.35 Name: Zebrafish Len: 1215 Check: 9263 Weight: 2.19 Name: Consensus Len: 1215 Check: 8147 Weight: 0.00 // 1 50 Human .......MPL RHWGMA.RGS KPVGDGAQPM AAMGGLKVLL HWAGPGGGEP Pig .......MPL CHWGATTRGR KPDGDGAQPT ATTEGLKVLL HWAGPGGGEP Rat .......MPL CGRRAASEDS KADGTEAQPL VPTGRLMVLL HWPGPEGGEP Mouse .......MPL CGRRAILEDS KADGTEAQPL VPTGCLMVLL HWPGPEGGEP Chicken FQYLNVKEDC KAMAFCAKMR STKKSEVNLE AQHQGLEVLF YLQDKSP... Fugu .......... MPRSSFKRSK GNTLPGTAKP PQCQGIHIYL FCTKEGGR.. Zebrafish .......... .......... .......... ...PGVHVFL FWTKDGER.. Consensus .......... .......... .......... ....g.h!.l fwtk.ggr.. 51 100 Human WVTFSESSLT AEEVCIHIAH KVGITPPCFN LFALFDAQAQ VWLPPNHILE Pig WVTFSEVTLT AEEVCIHIAH RVGISPLCLN LFALFDAQAQ VWLPPNHILD Rat WVTFSQPSLT AEEMCIHIAH KVGITPPCLN LFALYDAQAK VWLPPNHVLD Mouse WVTFSQTSLT AEEVCIHIAH KVGITPPCLN LFALYNAQAK VWLPPNHILD Chicken .ICYTSGEFT SEELCIEAAQ KCSISPLCHN LFALFDENRR LWYAPNQVFK Fugu YLSHTSGEIT AEDLCFLAAK AAGITPICHG LFTLFNPLSS CWYSPNHVFT Zebrafish CLSYKKGEVT AEDLTTEAAK AVGITPVCHA LFALYDPASL CWYSPNHNFN Consensus .lsy..ge.T aE#lc.eaAk avgItP.Ch. LFaL%#p.s. cWysPNh.f. 101 150 Human IPRDASLMLY FRIRFYFRNW HGMNPREPAV YRCGPPGTEA SSDQ..TAQG Pig ISGDSSLTLH FRMRFYFRNW HGMNPQEPAV YRCGPPGTE. TSEQ..AEPG Rat TSQDATLRLY FRMRFYFRNW HGMNPQEPAV YRCGFPGAET SSDH..AEQG Mouse TSQD..MNLY FRMRFYFRNW HGMNPQEPAV YRCGFPGAET SSDR..AEQG Chicken IDEKTSQRLY YRMRYYFTNW HGTSENEPSV WRHSPKKSKN SYDKKLAPEG Fugu TEVHSNLVLH YRMRYYFQNW HGLNKNEQSV VRKSLKSKT. ......EEEA Zebrafish AENQSGLLLH FRLRFYFHKW HGLGENAPEV GRYALRTSAG T.....QQAT Consensus .e..s.l.Lh %R$R%YF.nW HGlne#ep.V .R..l..s.. .......... 151 200 Human MQLLDPASFE YLFEQGKHEF VNDVASLWEL STEEEIHHFK NESLGMAFLH Pig VQLLDPASFE YLFEQGKHEF VNDVASLWEL SSEEEIHHFQ NESLGMAFLH Rat VQLLDSASFE YLFEQGKHEF MNDVVSLRDL SSEEEIHHFK NESLGMAFLH Mouse VQLLDSASFE YLFEQGKHEF MNDVVSLRDL SSEEEIHHFK NESLGMAFLH Chicken TPILDANSLE YIFAQGQYDL VKGLAPIRDP KNDQEVHEIE NECLGMAVLA Fugu LPLFDGNSLD YLFSQAKYEF VNKIVPMEDM KTEEEISCFK NESLGMALLH Zebrafish SHLLELSALE YLFAHAKYDF VNDLVPLNAV SGEEEIGRYQ NECLGMAVLH Consensus ..ll#..sl# YlFaqaky#f vndlvpl.d. s.##E!..f. NEcLGMAvLh 201 250 Human LCHLALRHGI PLEEVAKKTS FKDCIPRSFR RHIRQHSALT RLRLRNVFRR Pig LCQLALRHGV PLEKVAKKIS FKDCIPRSFR RQIRQHNALT RLRLRSIFRK Rat LCHLALNRGV PLEEMAREIS FKNCIPHSFR QHIRQHNVLT RLRLRRVFRR Mouse LCHLALSRGV PLEEMAREIS FKNCIPHSFR QHIRQHNVLT RLRLHRVFRR Chicken ISHYAIKKNV KLPELPKDIS YKHYIPETLN KTIRQRNFLT RIRINNVFKH Fugu MSHQALQTGC TLQAVAKKMS YLDCIPKCFA KHIAKDNFLT KVRIQRMFAD Zebrafish LSYTALQTGS SLQDVAKQTS ..RCIPLSFS RHIAKQNILT RFRIRRVFAH Consensus lsh.Alqtg. .Lq.vak..S ...cIP.sf. .hIak.N.LT r.RirrvFah 251 300 Human FLRDFQ.... .PGRLSQQMV MVKYLATLER LAPRFGTERV PVCHLRLLAQ Pig FLRAFQ.... .PGCLSQQVV MVKYLATLER LAPRFGTERV PVCRLQLLAQ Rat FLQAFQ.... .PGHLSQQVV MVKYLATLER LAPRFGSEHI PVCHLEVLAQ Mouse FLRAFR.... .PGHLSQQVV MVKYLATLER LAPRFGSERI PVCHLEVLAQ Chicken FLKEFNNKTI CDSSVSPRDL KVKYLSTMET LTKYYGAEIF ETSSLLISSE Fugu SVRTFQEHTV DKGRLGMQKT MFKYISTLER LVPSFGVESF YVSHLNLREA Zebrafish FVNTFQQHTV GVGKLGSQEV MYKYLSTLER LAPHFGVETF .......... Consensus fv.tF#.htv ..g.lg.q.v m.KYlsT$Er Lap.%GvE.f .v..l..... 301 350 Human AEGEPCYIRD SGVAPTDPGP ESAAGPPTHE VLVTGTGGIQ WWPVEEEVNK Pig AEGEPCYIRD GGQSSPDPEP QAAPEPTTHE VLVSGTDGIQ WRLVQAEGPS Rat PERDPCYIQN SGQTTGDPGP ELASGPATHE VLVTGTGGIQ WRPLQTQ... Mouse PERDPCYIQN SGQTAGDPGP ELPSGPPTHE VLVTGTGGIQ WHPLQTQ... Chicken SEINRFNCGD GEII...... ......PLYE VIVTGNNGIQ WRL....... Fugu WEESGSLHTH APCED..... ...RAAATHE IMVNGNKGIW WRI....... Zebrafish .......... .......... .......... .......... .......... Consensus .e........ .......... .......the ..v.g..gi. wr........ 351 400 Human EEGSSGSSGR NPQASLFGKK AKAHKAVGQP ADR.PREPLW AYFCDFRDIT Pig GGAGDGSSSR SPHTGHSGKK AKAQERGNQP VDR.PGEALW TYFCNFQDIT Rat .DSERGHSRG NPQGSQSGKK PKAPESGEHL AGS.PQEPPW TYFCDFQDIS Mouse .ESERGNSRG NPHGSRSGKK PKAPKAGEHL TES.PQEPPW TYFCDFQDIS Chicken .......... KPSSVQTEKK KKSDGKIKKD EDRYKTRDLW NNFSYFPEIT Fugu .......... ...SIQTEQA ATQPHK.... ....DTPHKW NVFCDFPEIT Zebrafish .......... .......... .......... .......... .......... Consensus .......... .......... .......... .........w ..fc.f..it 401 450 Human HVVLKEHCVS IHRQDNKCLE LSLPSRAAAL SFVSLVDGYF RLTADSSHYL Pig HVVLKERHVS IHCQD.KCLE LTLPSRATAL SLVALVDGYF RLTADSSHYL Rat HVVLKERRVH IHLQDNKCLL LCLCSQAEAL SFVALVDGYF RLTADSSHYL Mouse HVVLKERRVH IHLQDNKCLL LCLCSQAEAL SFVALVDGYF RLTADSSHYL Chicken HIVIKESTVS INKQDNKKME LKLSSHDEAL SFASLIDGYF RLTADAHHYL Fugu HIVISEANVC ISTQDNHCME VQMSSSQEAR SFISLLDGYY RLTADAHHYL Zebrafish .......... .......... .......... .......... .......... Consensus h.v..e..v. i..qdn.c.e ....s..ea. sf..l.dgy. rltad..hyl 451 500 Human CHEVAPPRLV MSIRDGIHGP LLEPFVQAKL RPED...GLY LIHWSTSHPY Pig CHEVAPPRLV MSIQDGIHGP LLEPFVLAKL RPED...GLY LIHWSTSHLN Rat CHEVAPPRLV TSIQNGIHGP LMDPFVQAKL WPED...GLY LIQWSTSHLH Mouse CHEVAPPRLV TSIQNGIHGP LMDPFVQAKL WPED...GLY LIQWSTSHLH Chicken CTDVAPPLIE HNIKNGCHGP ICTEYAINKL RQEGNEAGMY VLRWSCTNFN Fugu CHDVAPPRVL LNKANGLHGP MHIYFALQKL KKEAAEVKAF LICWSPVNYD Zebrafish .......... .......... .......... .......... .......... Consensus ch.vappr.. ....ng.hgp ....f...kl ..e....... li.ws..... 501 550 Human RLILTVAQRS QAP.DGMQSL RLRKFPIEQQ DGAFVLEGWG RSFPSVRELG Pig RLILTVAQRD QAP..GTKGL RLRKFPIELQ AETVTLEGWG RSFPSVRELR Rat RLILTVAHRN PASRNGPRGL RLRKFPITQQ PGAFVLDGWG RSFDSLGDLR Mouse RLILTVAHRN PAXSNGPRGL RLRKFPITQQ PGAFVLDGWG RSFASLGDLR Chicken HILMTVTCL. EGPEMINNSV QYKNFQIEVK KGGYFLHGSN RSFASLKELM Fugu RLILVVLNKN E....NGQAQ DHKQFQIQHK DSKFCLDGWN REFSSVKELT Zebrafish .......... .......... .......... .......... .......... Consensus rlil.v.... .......... ....f.i... .....l.gw. r.f.s..el. 551 600 Human AALQGCLLRA GDDCFSLRRC CLPQPGETSN LII.MRGARA SPRTLNLSQL Pig AALQGCSLRA GDDCFSLDRC CLPRPGEISN LII.TRGPQA CTRPLNLSHL Rat QALQGCSLRA GDDCFPLHHC CLPRPREISN LVI.MRGSRA HTRPLNLSQL Mouse LALQGCSLRA GDDCFPLHXC CLPRPREISN LVI.MRGSRA HTRPLNLSQL Chicken DHLKGQILRT DNISFTLKRC CQPKPREISN LLVATKKAQE CQPAYHLGQL Fugu DSLKSLVLIS GSESLTIKKC CLPRHGELSN LLVLRAPLQP LS...NKTQV Zebrafish .......... .......... .......... .......... .......... Consensus ..l....l.. g........c clp...e.sn l......... .....n..q. 601 650 Human SFHRVDQKEI TQLSHLGQGT RTNVYEGRLR VEGSGDPEEG KMDDEDPLVP Pig SFHRVHQEDI TQLSHLGQGT RTNVYEGLLR V.GGGGPEEE KSDGRDPSPS Rat SFHRVHQDEI TQLSHLGQGT RTNVYEGLLS V...GGPNEG KVDSGCPSGP Mouse SFHRVHQDEI TQLSHLGQGT RTNVYEGLLR V...GGPDEG KVDNGCPPEP Chicken SFHRIRKEEI MQGEHLGRGT RTQIYSGILN Y......... ....KDDENE Fugu QVRHIKETEI VQGRHLGCGT KTNIHKGSLQ V......RST EDGDQENEFN Zebrafish .......... .......... .......... .......... .......... Consensus ........ei .q..hlg.gt .tn...g.l. v......... .......... 651 700 Human GRDRGQELRV VLKVLDPSHH DIALA..FYE TASLMSQVSH THLAFVHGVC Pig SGDRGQELRV VLKVLDPSHH DIALA..FYE TASLMSQVSH VHLVFVHGVY Rat DRGSGQQLRV VLKVLDPSHH DIALA..FYE TASLMSQVSH MHLAFLHGVC Mouse GGTSGQQLRV VLKVLDPSHH DIALA..FYE XASLMSQVSH MHLAFLHGVC Chicken GYQNEKEIKV LLKVLDPSHR DISLASAFFE AASMMRQVSH KHIVFLHGVC Fugu NNSSGLDIPV VLKI...PHQ NLEVSLAFIE TVGIMGQLSH SHLVRVHGLS Zebrafish .......... .......... .......... .......... .......... Consensus ....g....v vlk.....h. .......f.e ....m.q.sh .hl...hg.. 701 750 Human VRGPENIMVT EYVEHGPLDV WLRRERGHVP MAWKMVVAQQ LASALSYLEN Pig VHGSENIMVT EYVEHGPLDV WLRRERGHVP LAWKLAVAQQ LASALSYLED Rat VRGSENIIVA EFVEHGPLDV WLRRQRGRVP MPWKMVVAQQ LASALSYLED Mouse VRGSENIIVT EFVEHGPLDV WLRRQRGQVP MTWKMVVAQQ LASALSYLED Chicken VRDLENIMVE EFVEFGPLDL FMHRKSELLT TPWKFNVAKQ LASALSYLED Fugu V..LKHIMVE EWVKFGPLDV FLHREKASVS AHWKLIVAMQ LASALRYQES Zebrafish .......... .......... .......... .......... .......... Consensus v.....imv. e.v..gpldv .l.r....v. ..wk..va.q lasal.y.e. 751 800 Human KNLVHGNVCG RNILLARLGL AEGTSPFIKL SDPGVGLGAL SREERVERIP Pig KSLVHGNVCG RNILLARLGQ AEGTSPFIKL SDPGVGLNAL SREERVERIP Rat KNLVHGNVCG RNILLARLGL EEGTNPFIKL SDPGVGQGAL SREERVERIP Mouse KNLVHGNVCG RNILLARLGL EEGTNPFIKL SDPGVGQGAL SREERVERIP Chicken KDLVHGNVCT KNILLAREGI DTEYGPFIKL SDPGIPITVL SRQECVERIP Fugu KQLVHGNVCL KNILVARHGL EEGCTPCIKL SDPGIAMSVL TREERLERIP Zebrafish .......... .......... .......... .......... .......... Consensus k.lvhgnvc. .nil.ar.g. .eg..p.ikl sdpg.....l .reer.erip 801 850 Human WLAPECLPGG ANSLSTAMDK WGFGATLLEI CFDGEAPLQS RSPSEKEHFY Pig WTAPECLSGG ANSLSTAADK WGFGATLLEI CFDGEAPLQG RGPSEKERFY Rat WTAPECLSGG ANSLGTATDM WGFGATLLEI CFDGEAPLQG RGPSEKERFY Mouse WTAPECLSGG TSSLGTATDM WGFGATLLEI CFDGEAPLQG RGPSEKERFY Chicken WIAPECVEDS KN.LSIAADK WSFGTTLWEI CYNGETPLKD KTLAEKERFY Fugu WIAPECIDGG VS.IRSNPDQ WSFGATFLEI CYNGNLPMST ITLSEKERFY Zebrafish .......... .......... .......... .......... .......... Consensus w.apec..gg ........d. w.fgat.lei c..g..p... ...sekerfy 851 900 Human QRQHRLPEPS CPQLATLTSQ CLTYEPTQRP SFRTILRDLT RLQPHNLADV Pig QKQHKLPEPS CPELATLTSQ CLTYEPAQRP SFRTILRDLT QLQPQNLADV Rat TKKHQLPEPS CPELATLTRQ CLSYEPAQRP SFRTILRDLT RLQPQNLVGT Mouse TKKHQLPEPS SPELATLTRQ CLTYEPAQRP SFRTILRDLT RLQPQNLVGT Chicken EGHFMLITPS CKELADLMKQ CMNYDPHQRP FFRAIMRDIN KLEEQN.PDI Fugu QQKGRLPVLS SKTVSNFINT CLAYDPTERP SFRIELRELS EFMKTT..PD Zebrafish .......... .......... .......... .......... .......... Consensus .....lp..s .......... cl.y.p..rp sfr..lr.l. .......... 901 950 Human LTVNPDSPAS DPTVFHKRYL KKIRDLGEGH FGKVSLYCYD PTNDGTGEMV Pig LSVNPDLPTS DPTIFHKRYL KKIRDLGEGH FGKVSLYCYD PTNDGTGEMV Rat STVNSDSPAS DPTVFHKRYL KRIRDLGEGH FGKVSLYCYD PNNDGTGEMV Mouse SAVNSDSPAS DPTVFHKRYL KKIRDLGEGH FGKVSLYCYD PTNDGTGEMV Chicken VSEKKPVTEV DPTLFEKRFL KRIRDLGEGH FGKVELCRYD PEGDNTGEQV Fugu LSPSETLPYT GHRIFHKRFL KMQQVLGEGN FGKVILYRYD PANDDTGELV Zebrafish .......... .......... .......... .......... .......... Consensus .......p.. ....fhkr.l k....lgeg. fgkv.ly.yd p.nd.tge.v 951 1000 Human AVKALKADCG PQHRSGWKQE IDILRTLYHE HIIKYKGCCE DQGEKSLQLV Pig AVKALKAGCG SQLRTGWRRE IDILRTLYHE HIVKYKGCCE DQGEKSVQLV Rat AVKALKEGCG PQLRSGWQRE IEILRTLYHE HIVKYKGCCE DQGEKSVQLV Mouse AVKALKEGCG PQLRSGWQRE IEILRTLYHE HIVKYKGCCE DQGEKSVQLV Chicken AVKSLKPESG GNHIADLKKE IEILRNLYHE NIVKYKGICT EDEKDPGKCQ Fugu AVKTLKRENG NT..EGWIKE INVLKSLDHR NIVKYKGCCS EGGGQGLLLI Zebrafish .......... .......... .......... .......... .......... Consensus avk.lk...g .....gw..e i..l..l.h. .ivkykgcc. ..g.....l. 1001 1050 Human MEYVPLGSLR DYLPRHS... ..IGLAQLLL FAQQICEGMA YLHSQHYIHR Pig MEYVPLGSLR DYLPRQN... ..VGLAQLLL FAQQICEGMA YLHAQHYVHR Rat MEYVPLGSLR DYLPRHS... ..VGLAQLLL FAQQICEGMA YLHAQHYIHR Mouse MEYVPLGSLR DYLPRHC... ..VGLAQLLL FAQQICEGMA YLHAQHYIHR Chicken QDLPWKTGME DYCRKKGMLG SEVGRKTLMR FLFLLLQGMD YLGSRQYVHR Fugu MEFLPLGSLL KYLPKNK... ..LNLSQLMI FAQQICEGME YLHSKRYIHR Zebrafish .......... .......... .......... .......... .......... Consensus me..plgsl. .ylp...... ....l.ql.. faqqicegm. ylh...y.hr 1051 1100 Human DLAARNVLLD NDRLVKIGDF GLAKAVPEGH EYYRVREDGD SPVFWYAPEC Pig DLAARNVLLD NNRLVKIGDF GLAKAVPEGH DYYCVREDGD SPVFWYAPEC Rat DLAARNVLLD NDRLVKIGDF GLAKAVPEGH EYYRVREDGD SPVFWYAPEC Mouse DLAARNVLLD NDRLVKIGDF GLAKAVPEGH EYYRVREDGD SPVFWYAPEC Chicken DLAARNVLVE SENRVKIGDF GLTKAIETDK EYYTVKDDLD SPVFWYAPEC Fugu DLATRNVLLD RDRLVKIGDF GLTKHIPTGE LYYRVSENGE NPVFWFAVEC Zebrafish .......... .......... .......... .......... .......... Consensus dla.rnvlld ..rlvkigdf gl.k..p.g. .yy.v.e.g. .pvfw.a.ec 1101 1150 Human LKEYKFYYAS DVWSFGVTLY ELLTHCDSSQ SPPTKFLELI GIAQGQMTVL Pig LKECKFYYAS DVWSFGVTMY ELLTYCDSSQ SPPSKFIELI GLTQGQMTVL Rat LKECKFYYAS DVWSFGVTLY ELLTYCDSSQ SPPTKFIELI GVTQGQMTVL Mouse LKECKFYYAS DVWSFGVTLY ELLTYCDSNQ SPHMKFTELI GHTQGQMTVL Chicken LIQSKFYIAS DVWSFGVTLY ELLTYCDSES SPMTEFLKMI GPTQGQMTVA Fugu LKENKFSFAS DVWSFGVTLY EILTHCDPKQ SPRKKFEEML EP.KSLINQV Zebrafish .......... .......... .......... .......... .......... Consensus lke.kf..as dvwsfgvtly e.lt.cd..q sp..kf.e.. .......... 1151 1200 Human RLTELLERGE RLPRPDKCPC EVYHLMKNCW ETEASFRPTF ENLIPILKTV Pig RLTELLEQGE RLPQPEKCPH EIYRLMKNCW EAKASFRPTF QNLVPILKTI Rat RLTELLERGE RLPRPDRCPC EIYHLMKNCW ESEASFRPTF QNLVPILKTA Mouse RLTELLERGE RLPRPDRCPC EIYHLMKNCW ETEASFRPTF QNLVPILQTA Chicken RLVRVLQEEK RLPRPPNCPE EIDQLMRKCW IFKHDKRTTF HNLIQGFETI Fugu PLIELLEKKM RLPCPKNCPQ EVRIIMEQCW AAEPKQRPSF RSLIEKFQEM Zebrafish .......... .......... .......... .......... .......... Consensus .l.elle... rlp.p..cp. e....m..cw ......rp.f ..l....... 1201 1215 Human HEKYQGQAPS VFSVC Pig QEKYQGQAPS VFSVC Rat QEKYQGQVPS VFSVC Mouse QEKYQGQVPS VFSVC Chicken MSKM...... ..... Fugu CHGEKFS... ..... Zebrafish .......... ..... Consensus .......... .....