Multalin version 5.4.1
Copyright I.N.R.A. France 1989, 1991, 1994, 1996
Published research using this software should cite
Multiple sequence alignment with hierarchical clustering
F. CORPET, 1988, Nucl. Acids Res., 16 (22), 10881-10890
Symbol comparison table: blosum62
Gap weight: 12
Gap length weight: 2
Consensus levels: high=90% low=50%
Consensus symbols:
 ! is anyone of IV
 $ is anyone of LM
 % is anyone of FY
 # is anyone of NDQEBZ

 MSF:   1244    Check:   0         ..
 Name: Human          Len:  1244  Check: 5176  Weight:  0.92
 Name: Fugu           Len:  1244  Check: 6620  Weight:  0.92
 Name: Hopscotch      Len:  1244  Check: 1085  Weight:  1.78
 Name: (1)CionaS      Len:  1244  Check: 2271  Weight:  0.61
 Name: CionaI         Len:  1244  Check:  241  Weight:  0.61
 Name: (2)CionaS      Len:  1244  Check: 2243  Weight:  1.17
 Name: Consensus      Len:  1244  Check: 4132  Weight:  0.00

//

                      1                                                   50
               Human  MGMACLTMTE MEGTSTSSIY QNGDISGNAN SMKQIDPVLQ VYLYHS.LGK
                Fugu  ..MASLAAME TLADACPTVH QNGTAQRESP EARLSVDVLR LHFYRSGQGA
           Hopscotch  MALANGGEDR MDDSSSGRTS LADSASLTNS SLRSGTSSQS IHTNDGTIRV
           (1)CionaS  .......... .......... .......... .......... ..........
              CionaI  .......... .......... .......... .......... ..........
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  ...a...... .......... .......... .......... ..........

                      51                                                 100
               Human  SEADYLTFPS ..GEYVAEEI CIAASKACGI TPVYHNMFAL MSETERIWYP
                Fugu  TDSSFLSYPP ..GNYVAEEL CIDAAKACSI SPLYFSLFGL FRERDCLWFS
           Hopscotch  FNFTTGEFER FHPNMLCEEI CNTMCRQLGI APIAQLLYGI REHSTSRRPS
           (1)CionaS  .......... ..CKILPTYM PLFAMRDAVT GRWVKLRSRL DDHQHAVGLD
              CionaI  .......... ..CKINPTYL NLFALRDSNT GYWVKFRSRL DEHRHSVGLD
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  .......... .......ee. c..a.....i .p.......l ..........

                      101                                                150
               Human  PNHVFHIDES TRHNVLY... RIRFYFPRWY CSGSNRAYRH GISRGAEAPL
                Fugu  PNHTFQLDEF ASEDVFF... RIRYYFPGWY SGGASRAYRY GVAKGSESPV
           Hopscotch  PLVRLDLTWC LPGERLN... CQLVY..... ...CFRMRFR VPELDSQLEL
           (1)CionaS  ENSTAELLEN CNDIKLEFRI RFTFESESQI DGISYEARRY SAQSDVLKPV
              CionaI  RNSTTDLLDA NSDIKLEFRI RFTFKSDSQI DGISCQAHRY SAHSEALKPV
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  pn....l... .....l.... r...y..... .....ra.r. ........p.

                      151                                                200
               Human  LDDFVMSYLF AQWRHDFVHG WIKV.PVTHE TQEECLGMAV LDMMRIAKEN
                Fugu  FDDCVMSYLF SQWRNDFVNG FMKI.PSSHE IQEECLGMAV LDMTRTAKER
           Hopscotch  IDGRSHKFLY RQMRYDMRTE QIPE.IRYPE HKDKSTGLAV MDMLIDDQEQ
           (1)CionaS  MSDLVIEYLF YQWREDFLNT SDKENAQMSD PLGSSLGVAV LDMLRLAREM
              CionaI  MSDQVIEYLF YQCRDDFLNS SEKDTAEMSD PLGASLGVAV LDMLRLAREM
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  .dd.v..ylf .q.r.df... ..k......e .....lg.av ldm.r.a.e.

                      201                                                250
               Human  DQTPLAIYNS IS.YKTFLPK C........I RAKIQDY... ...HILTRKR
                Fugu  QLSPLDIYHT MS.YKSFLPK E........I RAQIQDC... ...NFLTRKR
           Hopscotch  SEDQQAMRSI EKLYKLYLPP SLWRAHSFFV GSKIREVFRS LKANSLSVER
           (1)CionaS  DSDLRCIKSL VS.FKKLLPK V........C RANLAKM... ...NLFNRYR
              CionaI  DCDLSCIKSQ VS.FKKLLPR A........C RANLSKM... ...NFCNRYR
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  ......i... .s.yk..lp. .......... ra.i...... ...n.l.r.r

                      251                                                300
               Human  IRYRFRRFIQ QFSQ.CKATA R.NLKLKYLI NLETLQSAFY TEKFEVKEPG
                Fugu  IRFRFKRFIQ QFSQ.CRTTV R.DLKLKYLI SMESLEKAFY TETFQVRELS
           Hopscotch  LKWHYVHQVS HLAP.TYMTE QFTCTVQYLP NEEVARGSGP IGTSLAHSTS
           (1)CionaS  VKRRFMYYLQ HFSPVCRTWL ASQCSPAYFH SKYIRNLELI VG...LKSMG
              CionaI  VERRFMYYLR HFSPVCRTWL ASQCSPAYFY SKYIRNLELI AG...LKSMN
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  ...rf..... .fs..c..t. .......yl. ..e....... ..........

                      301                                                350
               Human  S.GPSGEEIF ATIIITGNGG IQWSRGKHKE SETLTEQDLQ LYCD.FP.NI
                Fugu  R.GQ...... LIILVVADNG IQWCQEKLKD SD....EELQ ILCD.FP.DV
           Hopscotch  TLASSGSTNT LSTLTTNTNS VALGGSGKKA KRRSTSGGID VYVRVFPHDS
           (1)CionaS  VEIYDLLPQT SINDDCDKIS VGADCGIVKY CSGNDYQSVN KWCDFK..EL
              CionaI  LENYDLLPRS STNEDCDKIT VGADCGIVKY SSASDYQSVN KWCDFK..EL
           (2)CionaS  .......... .......... .......... .......... ..........
           Consensus  .......... .......... ........k. .......... ..cd.fp...

                      351                                                400
               Human  IDVSIKQANQ EGSNESRVVT IHKQDG.... .......... ......KNLE
                Fugu  TDISIKQASK EGATESRVVT INKQDG.... .......... ......KNLE
           Hopscotch  LEPGLKVARV TSEATLKWIL VGAVEGIFMI SKINDTSVRL EIVGLPKGYE
           (1)CionaS  TDMNLQVRQN SEAKTTCDVK LSKLDG.... .......... ......TVCN
              CionaI  TDMNLQVRQN SEAETTCIVK LSKLDG.... .......... ......TDCN
           (2)CionaS  .......... ........VK LSKLDG.... .......... ......TVCN
           Consensus  .d...k.a.. ........!. ..k.#G.... .......... ......k..#

                      401                                                450
               Human  IELSSLREAL SFVSLIDGYY RLTADAHHYL CKEVAPPAVL ENIQSNCHGP
                Fugu  LEFPSLSEAL SFVSLIDGYY RLTTDAHHYL CKEVAPPRLV EAITSHCHGP
           Hopscotch  MQFQTEKEMK SFISYLGIYI RLSSKWMQDL CHSYRTPSLE ELSSLHCHGP
           (1)CionaS  LSFKSVIEAE NLASCVDGYY RLHVDAHHYL CKDICSPALV EQLSLNCHGP
              CionaI  LSFKSVVEAE NLASCIDGYY RLHVDPHHYL CKDVCSPSLV EHLALNCHGP
           (2)CionaS  LSFKSVIEAE NLASCVDGYY RLHVDAHHYL CKDICSPALV EQLSLNCHGP
           Consensus  l.f.s..Ea. sf.S..dgYy RL..dahhyL Ck....P.lv E..slnCHGP

                      451                                                500
               Human  ISMDFAISKL KKAGN.QTGL YVLRCSPKDF NKYFLTFAVE RENVIEYKHC
                Fugu  ISLEFAINQL QKCGN.KQGL FILQCSPKDF NKYFLTFPVE VYGTVEFKHC
           Hopscotch  IGGAYSLMKL HENGD.KCGS YIVRECDREY NIYYIDINTK IMAKKTDQER
           (1)CionaS  ITSTFAENII KEQQNLENGD CLLRKSQDSY DEYFVNTVLS THPSIVIKNY
              CionaI  ITCSFSEMII NQQADLQTGD CLLRRSQDSY DEYFINTVIN TNPDVIVKNY
           (2)CionaS  ITSTFAENII KEQQNLENGD CLLRKSQDSY DEYFVNTVLS THPSIVIKNY
           Consensus  I...%a...l .e.g#...G. ..lr.s...% #.Y%...... .......k..

                      501                                                550
               Human  LITKNENEEY NLS.GTKKNF SSLKDLLNCY QM..ETVRSD NIIFQFTKCC
                Fugu  QITRSECGQF NLS.GTKRNF SSLHELLSCY KN..ETVRSD SVVFQFSKCC
           Hopscotch  CKTETFRIVR KDS.QWKLSY NNGEHVLNSL HEVAHIIQAD SPDRYRIPAS
           (1)CionaS  KLDRVNGLLG MFGDNASHKY NDLATLLNAC TGMEH..DGQ LIPFNVDRII
              CionaI  KLDRVNGLLG MFGDNASHRY QNLSALLNAC RGNQH..DGQ EIPFNVDRII
           (2)CionaS  KLDRVNGLLG MFGDNASHKY NDLATLLNAC TGMEH..DGQ LIPFNVDRII
           Consensus  ..tr...... ..s...k..% n.l..lLn.. ....h....# .i.f......

                      551                                                600
               Human  PPKPKDKSNL LVFRTNGVSD VPTSPTLQRP THMNQMVFHK IRNEDLIFNE
                Fugu  PPKAKERSCL LVCRTNKGPE VPLSPSTNRH .NISQMVFHK IRKEDLEFNE
           Hopscotch  KYDKPPLLLL LLPKNLKAKK TDLQLSEAEL QRRNPQIFNP .RTDLQWYPD
           (1)CionaS  LPKSKHKTNL LICRCIDTAN QGQSDEFNLL SSPQTLVL.. .KERDYTFEQ
              CionaI  LPKSKQKTNL LIIRCMDASN QGQPMEFNLL SSPQTLVL.. .KERDYTFHQ
           (2)CionaS  LPKSKHKTNL LICRCIDTAN QGQSDEFNLL SSPQTLVL.. .KERDYTFEQ
           Consensus  .pk.k.k.nL L..r...... ...s...n.l ......!f.. .r..d..%.#

                      601                                                650
               Human  SLGQGTFTKI FKGV.RREVG DYGQLHETEV LLKVLDKAHR NYS.ESFFEA
                Fugu  SLGQGTFTKI FKGV.RKELG DYGLMHQTEV VMKVLDQAHR NYS.ESFFEA
           Hopscotch  SISLSDDGMM FT.M.RGDWI QQSPVKDVSV TMKML.KSDG NFM.E.FFRL
           (1)CionaS  HLGFGRFTDV NLHVHRNNPG LKIVLKQVFD VNHRHDLGQK QVIDESFQES
              CionaI  HLGSGRFTDV NLHVHRNNPD LKIVLKQVFD MNQRHDLGQK QVIDESFQES
           (2)CionaS  HLGFGRFTDV NLHVHRNNPG LKIVLKQVFD VNHRHDLGQK QVIDESFQES
           Consensus  slg.g.ft.. f..v.R.#.g ....lk#v.v ..k.ld.... #...EsFfe.

                      651                                                700
               Human  ASMMSKLSHK HLVLNYGVCV CGDENILVQE FVKFGSLDTY LKKNKNCINI
                Fugu  ASMMTQLSHV HLILNYGVCV CGEENIMVQE YVKFGSLDTY LKKNKNSVNI
           Hopscotch  AQTWSLIQSP QFLKLYGLTL A.DPYTMVME YSRYGPLNKF LHSMPN.VTL
           (1)CionaS  ISLLICLKNV HIVKQMGTL. ...GTQFGLE YVPFRSITNY LQLAVHEERP
              CionaI  ISLLICLKNV HIVKQMGTM. ...GTQIGLE YAPFRSITNY LQLAGNEQGP
           (2)CionaS  ISLLICLKNV HIVKQMGTL. ...GTQFGLE YVPFRSITNY LQLAVHEERP
           Consensus  as....l..v h.vk.yG... .......v.E %v.%gsl..% L....n....

                      701                                                750
               Human  ..LWKLEVAK QLAWAMHFLE ENTLIHGNVC AKNILLIREE DRKTGNPPFI
                Fugu  ..LWKLEVAK QLAQAMNFLE EKNLVHGNVC AKNVLLIRED DWRAGNPPFI
           Hopscotch  ..HCLLDLMH GLVRGMHYLE DNKIIHNYIR CSNLYVTKYD P..NSYVLDA
           (1)CionaS  WPSWFLYALW QLTHACNYLE EMNCAHGNIR GRNVLLWQAL P.....QPFI
              CionaI  WGSWFLYALW QLTHACNYLE EMGCAHGNIR GRNVLLCQAS P.....QPFV
           (2)CionaS  WPSWFLYALW QLTHACNYLE EMNCAHGNIR GRNVLLWQAL P.....QPFI
           Consensus  ...w.L.... qL..amn%LE #....Hgn!r ..Nvll.... p......pfi

                      751                                                800
               Human  KLSDPGISIT VLPKDILQE. .RIPWVPPEC I...EN..PK NLNLATDKWS
                Fugu  KLSDPGISIT VLPKEILVE. .RIPWVPPEC V...ND..PA NLSLAADKWS
           Hopscotch  KISDPGY... ..PRPYRES. .DSPWIPVKY Y...RNLQAA KTDQFAQLWA
           (1)CionaS  KLADPGVRTC QGRNRINEPV LTAPWLAFEF CHVDEDPVTF FPTIDGDKWS
              CionaI  KLGDPGVRTC LGRNRVSEPV LPAPWLAYEF CRIDSEPLSS FPTIDGDKWS
           (2)CionaS  KLADPGVRTC QGRNRINEPV LTAPWLAFEF CHVDEDPVTF FPTIDGDKWS
           Consensus  KlsDPG.... ..p..i.e.. ...PW.p.e. .....#.... ......#kWs

                      801                                                850
               Human  FGTTLWEICS GGDKPLSALD SQR....... ..KLQFYEDR HQLPAPKWAE
                Fugu  FGTTLWEICS GGEKPLASLD NTN....... ..KTLFYEDR HQLPAPKWIE
           Hopscotch  FATTIYEIFS RCKEDLSTLR QEQLLRQKNL DGNILKMLDQ DICPAPIFET
           (1)CionaS  FATTVCEICS WGAPIHPMNA YNLTDEMKNC YKTASVLPIP ELIAANGVDE
              CionaI  YATTVCEICC WGVSPEPFNA YSLSAEMKEK YRTASVIPIP EIIAANGVGE
           (2)CionaS  FATTVCEICS WGAPIHPMNA YNLTDEMKNC YKTASVLPIP ELIASNGVDE
           Consensus  %aTT..EIcs .g...l..l. .......kn. ........d. ...pap...e

                      851                                                900
               Human  LANLINNCMD YEPDFRPSF. ..RAIIRDLN SLFTPDYELL T....ENDML
                Fugu  LANLITSCMD YEPTFRPTF. ..RAIIRDLH SLFTPDYELI V....DSDIL
           Hopscotch  IMDGWSDDET KRFSHHDIFS RLNTIKAEIL PNYMPPPEIA TNGTGDETVI
           (1)CionaS  LSSLLKQCWD PLPRKRPPF. ..KQILRELG TVLSSDYILP S..IAPSSSN
              CionaI  LGALLRQCWN PYPPKRPPF. ..KQILRELG TVLSSDYILP S..VSPSNGN
           (2)CionaS  LSSLLKQCWD PLPRKRPPF. ..KQILRELG TVLSSDYILP S..IAPSSSN
           Consensus  l..l...c.d ..p..rp.F. ....I.r#l. ....pdyel. ......s...

                      901                                                950
               Human  PNMRIGALGF SGAFEDRDPT QFEERHLKFL QQ..LGKGNF GSVEMCRYD.
                Fugu  PNRTACTGWS TGGFDSQEPA QFEERHLIFL QQ..LGKGNF GSVEMCRYD.
           Hopscotch  DRSDIPFLPF PRSNMLMVIP LTSECRVIYN MENMIGRGHY GTVYKGHLEF
           (1)CionaS  NRSTTQTIDN VISGNMPDLR KYRDDNLTFV RQ..LGDGHF GHVDLYHHD.
              CionaI  SRGESRNITN IIGASMPDLR KYRDDNLTFV KQ..LGEGHF GHVDLYHHD.
           (2)CionaS  NRSTTQTIDN VISGNMPDLR KYRDDNLTFV RQ..LGDGHF GHVDLYHHD.
           Consensus  .rs....... ..s....d.. ...#..l.%. .#..lG.Gh% G.V...h.#.

                      951                                               1000
               Human  PLQDNTGEVV AVKKLQHSTE ..EHLRDFER EIEILKSLQH DNIVKYKGVC
                Fugu  PLQDNTGEVV AVKKLQHGTA ..EHIRDFER EIEILKSLQH ENIVKYKGVC
           Hopscotch  NDKDQPREQV AIKML..NTM ..QVSTDFHR EIGIMRTLSH PNIVKFK...
           (1)CionaS  MQRNGQFERV AVKSLRRSMQ NPQSRSDFRN EIETMRRIEH RYIVKLNG..
              CionaI  IQRNGQFERV AIKSLRRSMN NPQSRSDFRN EIETMRRIDH KYIVKLNG..
           (2)CionaS  MQRNGQFERV AVKSLRRSMQ NPQSRSDFRN EIETMRRIEH RYIVKLNG..
           Consensus  ...#...E.V A!K.L..st. ..#...DF.r EIei$r.l.H .nIVK.kg..

                      1001                                              1050
               Human  YSAGRRNLKL IMEYLPYGSL RDYLQKHKER IDHIK..... LLQYTSQICK
                Fugu  YSAGRRNLRL VMEYLPFGSL RDYLIKNKER IDHKK..... LVHYSSQICK
           Hopscotch  YWAEKSHC.I IMEYLQSGSF DIYLRFTAPN LNNPR..... LVSFALDIAN
           (1)CionaS  ..VAEPSLRI VMEYLPYGPL SKFLRGQRES GSAVQQLPGL LLRFSFQIAQ
              CionaI  ..VAEPSLRI VMEYLPYGSL SHFLRGQRDS GIALQQLSGL LLRFSFQIAQ
           (2)CionaS  ..VAEPSLRI VMEYLPYGPL SKFLRGQRES GSAVQQLPGL LLRFSFQIAQ
           Consensus  y.a....lri !MEYLpyGsl ..%Lr...e. .......... Ll.%s.#Ia.

                      1051                                              1100
               Human  GMEYLGTKRY IHRDLATRNI LVENENR... .VKIGDFGLT KVLPQDKEYY
                Fugu  GMEYLSGKRY IHRDLATRNI LVESESR... .VKIGDFGLT KILPQDKEYY
           Hopscotch  GMKYLSDMGL IHRDLAARNI LVDHNGDGDC .VKISDFGLA QFANSDG.YY
           (1)CionaS  GMLYLKEKRV IHRDLALRNI LLDKEGSNCY NIKIADFGLS RVLGEERDYY
              CionaI  GMLYLQEKRV IHRDLALRNI LLDKEGSNCW NIKISDFGLS RILSEDRDYY
           (2)CionaS  GMLYLKEKRV IHRDLALRNI LLDKEGSNCY NIKIADFGLS RVLGEERDYY
           Consensus  GM.YL..kr. IHRDLA.RNI Lv#.#g.... .!KI.DFGL. ..l..#..YY

                      1101                                              1150
               Human  KVKEPGESPI FWYAPESLTE S...KFSVAS DVWSFGVVLY ELFTYIEKSK
                Fugu  MVREPGESPI FWYAPESLTE S...KFSVAS DVWSFGVVLY ELFTHSSRNS
           Hopscotch  YAKSKRDIPI RWYSPEAIST C...RFSSYS DVWSYGVTLF EMFSRGEEPN
           (1)CionaS  .AGNPDEFPV QWYAPECLRQ DGRRTFHFES DIWSYGVTLW EMFSYGARPM
              CionaI  .TGNPDEFPA QWYAPECLRL DGRRTFHFES DVWSYGVTLW EMFSYGARPT
           (2)CionaS  .AGNPDEFPV QWYAPECLRQ DGRRTFHFES DIWSYGVTLW EMFSYGARPM
           Consensus  .a..p.#.Pi .WYaPE.l.. .....Fs..S D!WS%GVtL. E$Fsyg.rp.

                      1151                                              1200
               Human  SPPAEFMRMI GNDKQGQMIV FHLIELLKNN GRLPRPDGCP DEIYMIMTEC
                Fugu  SPPTVFMSMM GNDKQGQLIV YHLIELLKSG SRLPQPLDCP TEIHEIMEQC
           Hopscotch  LVPI...... ......QTSQ EDFLNRLQSG ERLNRPASCP DFIYDLMQLC
           (1)CionaS  YESLPNIT.. ......VRNL IQLQELLKNN VRLGKPEQCP DHVYALIQRC
              CionaI  YEPLPNIT.. ......LRQL TQLQELLKDN VRLSQPEHCP NEVFHLISRC
           (2)CionaS  YESLPNIT.. ......VRNL IQLQELLKNN VRLGKPEQCP DHVYALIQRC
           Consensus  ..p....... ......q... ..l.#lLk.n .RL..P..CP d.!y.lmq.C

                      1201                                        1244
               Human  WNNNVNQRPS FRDLALRVDQ IRDNMAG... .......... ....
                Fugu  WDNDPYLRPS FKELALSIDL FREHKEF... .......... ....
           Hopscotch  WHATPRSRPS FATIVDIITR EVATKVTHPT DGHQSPPNQP TDAE
           (1)CionaS  WEYQPQNRIK FDELCREFGR LRN....... .......... ....
              CionaI  WEYEPQQRVK FDELCREFDR LRN....... .......... ....
           (2)CionaS  WEYQPQNRIK FDELCREFGR L......... .......... ....
           Consensus  W...p..Rps F.el.....r .r........ .......... ....