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		Method Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action Maureen E Hillenmeyer, Elke Ericson, Ronald W Davis, Corey Nislow, Daphne Koller, Guri Giaever Genome Biology 2010, 11:R30 (12 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The relationship between co-fitness and co-inhibition of genes in chemicogenomic yeast screens provides insights into gene function and drug target prediction.
		Software Characterizing regulatory path motifs in integrated networks using perturbational data Anagha Joshi, Thomas Van Parys, Yves Peer, Tom Michoel Genome Biology 2010, 11:R32 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Pathicular – a Cytoscape plugin for analysing cellular responses to transcription factor perturbations is presented
		Research Genome-wide functional analysis of human 5' untranslated region introns Can Cenik, Adnan Derti, Joseph C Mellor, Gabriel F Berriz, Frederick P Roth Genome Biology 2010, 11:R29 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genes with short 5'UTR introns have higher expression than genes with no or long 5'UTR introns. Complex evolutionary forces act on these introns.
		Method Detection and correction of false segmental duplications caused by genome mis-assembly David R Kelley, Steven L Salzberg Genome Biology 2010, 11:R28 (10 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A method for determining false segmental duplications in vertebrate genomes, thus correcting mis-assemblies and providing more accurate estimates of duplications.
		Software XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments Morris A Swertz, K Joeri Velde, Bruno M Tesson, Richard A Scheltema, Danny Arends, Gonzalo Vera, Rudi Alberts, Martijn Dijkstra, Paul Schofield, Klaus Schughart, John M Hancock, Damian Smedley, Katy Wolstencroft, Carole Goble, Engbert O de Brock, Andrew R Jones, Helen E Parkinson, members of the Coordination of Mouse Informatics Resources (CASIMIR), Genotype-To-Phenotype (GEN2PHEN) Consortiums, Ritsert C Jansen Genome Biology 2010, 11:R27 (9 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary XGAP, a software platform for the integration and analysis of genotype and phenotype data.
		Research Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates Zhengdong D Zhang, Adam Frankish, Toby Hunt, Jennifer Harrow, Mark Gerstein Genome Biology 2010, 11:R26 (8 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Novel human pseudogenes are identified that had previous functionality and their age is estimated. The rate of loss-of-function occurred uniformly.
		Method A scaling normalization method for differential expression analysis of RNA-seq data Mark D Robinson, Alicia Oshlack Genome Biology 2010, 11:R25 (2 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel and empirical method for normalization of RNA-seq data is presented
		Research High-resolution transcription atlas of the mitotic cell cycle in budding yeast Marina V Granovskaia, Lars J Jensen, Matthew E Ritchie, Joern Toedling, Ye Ning, Peer Bork, Wolfgang Huber, Lars M Steinmetz Genome Biology 2010, 11:R24 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A high resolution strand-specific transcriptional atlas of the budding yeast mitotic cell cycle, including both mRNA and non-coding RNA profiles.
		Method Identification of functional modules that correlate with phenotypic difference: the influence of network topology Jui-Hung Hung, Troy W Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, Charles DeLisi Genome Biology 2010, 11:R23 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A gene set enrichment analysis method for including network topology in the identification of genes involved in phenotypic alterations is described. Classifications: Genome studies, Methods
		Comment Lost in translation Gregory A Petsko Genome Biology 2010, 11:107 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Objections to dividing biomedical research into 'translational' and 'basic' are not just a matter of semantics.
		Research highlight Histone tales: echoes from the past, prospects for the future Chris Murgatroyd, Dietmar Spengler Genome Biology 2010, 11:105 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent studies of the nematode dauer state provide new insights into epigenetic processes that underlie cellular memory.
		Research highlight PRDM9 points the zinc finger at meiotic recombination hotspots Matthew J Neale Genome Biology 2010, 11:104 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent work shows that the histone methyltransferase PRDM9 determines the nonrandom genomic distribution of meiotic recombination hotspots.
		Software ChIA-PET tool for comprehensive chromatin interaction analysis with paired-end tag sequencing Guoliang Li, Melissa J Fullwood, Han Xu, Fabianus Hendriyan Mulawadi, Stoyan Velkov, Vinsensius Vega, Pramila Nuwantha Ariyaratne, Yusoff Bin Mohamed, Hong-Sain Ooi, Chandana Tennakoon, Chia-Lin Wei, Yijun Ruan, Wing-Kin Sung Genome Biology 2010, 11:R22 (25 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary ChIA-PET Tool can be used to process long-range chromatin interaction data. Results are visualized on a user-friendly genome browser.
		Research Immunity and other defenses in pea aphids, Acyrthosiphon pisum Nicole M Gerardo, Boran Altincicek, Caroline Anselme, Hagop Atamian, Seth M Barribeau, Martin de Vos, Elizabeth J Duncan, Jay D Evans, Toni Gabaldón, Murad Ghanim, Adelaziz Heddi, Isgouhi Kaloshian, Amparo Latorre, Andres Moya, Atsushi Nakabachi, Benjamin J Parker, Vincente Pérez-Brocal, Miguel Pignatelli, Yvan Rahbé, John S Ramsey, Chelsea J Spragg, Javier Tamames, Daniel Tamarit, Cecilia Tamborindeguy, Caroline Vincent-Monegat, Andreas Vilcinskas Genome Biology 2010, 11:R21 (23 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The genome of the pea aphid Acyrthosiphon pisum lacks genes thought to be crucial in other insects for recognition, signaling and killing of microbes.
		Research highlight The pea aphid genome sequence brings theories of insect defense into question Christine G Elsik Genome Biology 2010, 11:106 (23 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The genome sequence of the pea aphid is the first for a basal hemimetabolous insect and provides insights into developmental plasticity, symbiosis and insect immunity.
		Research Genomic features defining exonic variants that modulate splicing Adam Woolfe, James C Mullikin, Laura Elnitski Genome Biology 2010, 11:R20 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comparative analysis of SNPs and their exonic and intronic environments identifies the features predictive of splice affecting variants.
		Research highlight Filling the gaps in the genomic landscape David Williams, J Peter Gogarten, Pascal Lapierre Genome Biology 2010, 11:103 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sequencing of genomes from many different bacterial and archaeal groups is broadening the picture of the prokaryotic pan-genome.
		Method Evidence-ranked motif identification Stoyan Georgiev, Alan P Boyle, Karthik Jayasurya, Xuan Ding, Sayan Mukherjee, Uwe Ohler Genome Biology 2010, 11:R19 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new computational method for the identification of regulatory motifs from large genomic datasets is presented here
		Method A fuzzy gene expression-based computational approach improves breast cancer prognostication Benjamin Haibe-Kains, Christine Desmedt, Françoise Rothé, Martine Piccart, Christos Sotiriou, Gianluca Bontempi Genome Biology 2010, 11:R18 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A fuzzy computational approach that takes into account several molecular subtypes in order to provide more accurate breast cancer prognosis
		Research 2× genomes - depth does matter Michel C Milinkovitch, Raphaël Helaers, Eric Depiereux, Athanasia C Tzika, Toni Gabaldón Genome Biology 2010, 11:R16 (9 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The use of low coverage genomes in comparative evolutionary analyses skews estimates of gene gains and losses.
		Research Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling Marie JJ Huysman, Cindy Martens, Klaas Vandepoele, Jeroen Gillard, Edda Rayko, Marc Heijde, Chris Bowler, Dirk Inzé, Yves Peer, Lieven De Veylder, Wim Vyverman Genome Biology 2010, 11:R17 (8 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genes controlling the cell cycle in two diatoms have been identified and functionally characterized, revealing environmental regulation of the cell cycle.
		Method A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454 Niall J Lennon, Robert E Lintner, Scott Anderson, Pablo Alvarez, Andrew Barry, William Brockman, Riza Daza, Rachel L Erlich, Georgia Giannoukos, Lisa Green, Andrew Hollinger, Cindi A Hoover, David B Jaffe, Frank Juhn, Danielle McCarthy, Danielle Perrin, Karen Ponchner, Taryn L Powers, Kamran Rizzolo, Dana Robbins, Elizabeth Ryan, Carsten Russ, Todd Sparrow, John Stalker, Scott Steelman, Michael Weiand, Andrew Zimmer, Matthew R Henn, Chad Nusbaum, Robert Nicol et al. Genome Biology 2010, 11:R15 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An automated method for constructing libraries for 454 sequencing significantly reduces the cost and time required.
		Method Gene ontology analysis for RNA-seq: accounting for selection bias Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack Genome Biology 2010, 11:R14 (4 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary GOseq is a method for GO analysis of RNA-seq data that takes into account the length bias inherent in RNA-seq
		Method Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging Kristen Fortney, Max Kotlyar, Igor Jurisica Genome Biology 2010, 11:R13 (3 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An algorithm for determining networks from gene expression data enables the identification of genes potentially linked to aging in worms.
		Research Genomic and small RNA sequencing of Miscanthus × giganteus shows the utility of sorghum as a reference genome sequence for Andropogoneae grasses Kankshita Swaminathan, Magdy S Alabady, Kranthi Varala, Emanuele De Paoli, Isaac Ho, Dan S Rokhsar, Aru K Arumuganathan, Ray Ming, Pamela J Green, Blake C Meyers, Stephen P Moose, Matthew E Hudson Genome Biology 2010, 11:R12 (3 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genomic data together with sequencing of tissue specific small RNA libraries reveals insights into the genome content, small RNA repertoire and evolutionary origins of the grass Miscanthus × giganteus.
		Research Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats Tiebing Liang, Mark W Kimpel, Jeanette N McClintick, Ashley R Skillman, Kevin McCall, Howard J Edenberg, Lucinda G Carr Genome Biology 2010, 11:R11 (3 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transcriptional profiling of specific regions of inbred rat brains reveals genes associated with alcohol preference in a known QTL locus on chromosome 4
		Comment Rising in the East Gregory A Petsko Genome Biology 2010, 11:102 (29 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genome sequence of the giant panda using next- generation sequencing marks a watershed in genome sequencing - in more ways than one.
		Editorial Ten years of Genome Biology Clare Garvey Genome Biology 2010, 11:101 (29 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Huge advances in the field of genomics along with the continued rise of open access has made the past ten years an exciting time to be a biologist.
		Method Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data Manuela Marullo, Chiara Zuccato, Caterina Mariotti, Nayana Lahiri, Sarah J Tabrizi, Stefano Di Donato, Elena Cattaneo Genome Biology 2010, 11:R9 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Expressed Alu repeats are a reliable, accurate and universal reference for use in RT-qPCR normalization of human genes
		Research Characterization of X-Linked SNP genotypic variation in globally distributed human populations Amanda M Casto, Jun Z Li, Devin Absher, Richard Myers, Sohini Ramachandran, Marcus W Feldman Genome Biology 2010, 11:R10 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of X-linked genetic variation in human populations provides insights into population structure and demographic patterns.
		Minireview Looking for signatures of sex-specific demography and local adaptation on the X chromosome Evelyne Heyer, Laure Segurel Genome Biology 2010, 11:203 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide study of X chromosome genetic diversity in human populations shows the impact of social organization and local adaptation.
		Minireview Assembling genomes using short-read sequencing technology Shaun D Jackman, İnanç Birol Genome Biology 2010, 11:202 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short-read sequencing technology can bring gigabase genome assemblies in under a million dollars.
		Minireview Targeting viral infection by microRNA inhibition Ashley PE Roberts, Catherine L Jopling Genome Biology 2010, 11:201 (26 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An inhibitor of microRNA-122 reduces viral load in chimpanzees that are chronically infected with hepatitis C virus, suggesting that such an approach might have therapeutic potential in humans.
		Research Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies Shaolin Wang, Eric Peatman, Jason Abernathy, Geoff Waldbieser, Erika Lindquist, Paul Richardson, Susan Lucas, Mei Wang, Ping Li, Jyothi Thimmapuram, Lei Liu, Deepika Vullaganti, Huseyin Kucuktas, Christopher Murdock, Brian C Small, Melanie Wilson, Hong Liu, Yanliang Jiang, Yoona Lee, Fei Chen, Jianguo Lu, Wenqi Wang, Peng Xu, Benjaporn Somridhivej, Puttharat Baoprasertkul, Jonas Quilang, Zhenxia Sha, Baolong Bao, Yaping Wang, Qun Wang et al. Genome Biology 2010, 11:R8 (22 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twelve cDNA libraries from two species of catfish have been sequenced, resulting in the generation of nearly 500,000 ESTs.
		Method Genome-wide prediction of transcription factor binding sites using an integrated model Kyoung-Jae Won, Bing Ren, Wei Wang Genome Biology 2010, 11:R7 (22 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new approach for genome-wide transcription factor binding site prediction is presented that integrates sequence and chromatin modification data.
		Software PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes Andreas Ruepp, Andreas Kowarsch, Daniel Schmidl, Felix Buggenthin, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, Fabian J Theis Genome Biology 2010, 11:R6 (20 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary PhenomiR is a comprehensive database of 542 studies reporting deregulation of miRNAs allowing large-scale statistical analysis of miRNA expression changes.
		Research Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts Ishita S Mehta, Manelle Amira, Amanda J Harvey, Joanna M Bridger Genome Biology 2010, 11:R5 (13 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Nuclear myosin 1β-dependent repositioning of chromosome territories occurs within 15 minutes of serum starvation in human cells.
		Method Substantial deletion overlap among divergent Arabidopsis genomes revealed by intersection of short reads and tiling arrays Luca Santuari, Sylvain Pradervand, Amelia-Maria Amiguet-Vercher, Jerôme Thomas, Eavan Dorcey, Keith Harshman, Ioannis Xenarios, Thomas E Juenger, Christian S Hardtke Genome Biology 2010, 11:R4 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary A new approach to detect deletions in divergentgenomes combines short read sequencing and tilling array data. Its utility is demonstrated on Arabidopsis strains.
		Method NetPath: a public resource of curated signal transduction pathways Kumaran Kandasamy, S Sujatha Mohan, Rajesh Raju, Shivakumar Keerthikumar, Ghantasala Kumar, Abhilash K Venugopal, Deepthi Telikicherla, J Daniel Navarro, Suresh Mathivanan, Christian Pecquet, Sashi Gollapudi, Sudhir Tattikota, Shyam Mohan, Hariprasad Padhukasahasram, Yashwanth Subbannayya, Renu Goel, Harrys KC Jacob, Jun Zhong, Raja Sekhar, Vishalakshi Nanjappa, Lavanya Balakrishnan, Roopashree Subbaiah, YL Ramachandra, B Abdul Rahiman, TS Keshava Prasad, Jian-Xin Lin, Jon CD Houtman, Stephen Desiderio, Jean-Christophe Renauld, Stefan N Constantinescu et al. Genome Biology 2010, 11:R3 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data.
		Method Integrating phenotype ontologies across multiple species Christopher J Mungall, Georgios V Gkoutos, Cynthia L Smith, Melissa A Haendel, Suzanna E Lewis, Michael Ashburner Genome Biology 2010, 11:R2 (8 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A phenotypic ontology that can be used for the analysis of phenotype-genotype data across multiple species, paving the way for truly cross species translational research.
		Research Genomic characterization of the Yersinia genus Peter E Chen, Christopher Cook, Andrew C Stewart, Niranjan Nagarajan, Dan D Sommer, Mihai Pop, Brendan Thomason, Maureen Thomason, Shannon Lentz, Nichole Nolan, Shanmuga Sozhamannan, Alexander Sulakvelidze, Alfred Mateczun, Lei Du, Michael E Zwick, Timothy D Read Genome Biology 2010, 11:R1 (4 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative Yersinia genomics identifies features responsible for the colonization of specific host habitats and the horizontal transfer of virulence determinants.
		Method Correlating measurements across samples improves accuracy of large-scale expression profile experiments Mariano Alvarez, Pavel Sumazin, Presha Rajbhandari, Andrea Califano Genome Biology 2009, 10:R143 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cleaner is a method for removing uninformative and flawed probes from microarray experiment data, thus improving reproducibility between replicate experiments.
		Comment A harsh climate Gregory A Petsko Genome Biology 2009, 10:115 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We should not be distracted by the debate about whether or not global warming is caused by humans; whatever the answer is, we urgently need to retard or reverse the trend.
		Protein family review The PIN-FORMED (PIN) protein family of auxin transporters Pavel Křeček, Petr Skůpa, Jiří Libus, Satoshi Naramoto, Ricardo Tejos, Jiří Friml, Eva Zažímalová Genome Biology 2009, 10:249 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A review of the PIN auxin-efflux transporters, which have important roles in plant development.
		Protein family review The WUS homeobox-containing (WOX) protein family Eric van der Graaff, Thomas Laux, Stefan A Rensing Genome Biology 2009, 10:248 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The plant-specific WOX family of homeobox proteins have key functions in plant development.
		Method A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data Desmond S Lun, Ashley Sherrid, Brian Weiner, David R Sherman, James E Galagan Genome Biology 2009, 10:R142 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary CSdeconv is a novel method for determining the location of transcription factor binding from ChIP-seq data that discriminates closely-spaced sites.
		Research Characterizing the admixed African ancestry of African Americans Fouad Zakharia, Analabha Basu, Devin Absher, Themistocles L Assimes, Alan S Go, Mark A Hlatky, Carlos Iribarren, Joshua W Knowles, Jun Li, Balasubramanian Narasimhan, Steven Sidney, Audrey Southwick, Richard M Myers, Thomas Quertermous, Neil Risch, Hua Tang Genome Biology 2009, 10:R141 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genome-wide SNP analyses reveal the admixed African genetic ancestry of African Americans.
		Meeting report Unraveling the genomic diversity of small eukaryotes Gilles Fischer, Dawn Thompson, Jennifer Wortman, Cécile Fairhead Genome Biology 2009, 10:318 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the meeting Comparative Genomics of Eukaryotic Microorganisms, 17-22 October 2009, San Feliu de Guixols, Spain.
		Minireview Structural and functional map of a bacterial nucleoid Agustino Martínez-Antonio, Alejandra Medina-Rivera, Julio Collado-Vides Genome Biology 2009, 10:247 (11 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mapping global protein binding in the E. coli genome reveals extended domains of high protein occupancy.
		Method Towards accurate imputation of quantitative genetic interactions Igor Ulitsky, Nevan J Krogan, Ron Shamir Genome Biology 2009, 10:R140 (10 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new method for calculating quantitative genetic interactions allows for the inference of 190,000 new genetic interactions in Saccharomyces cerevisae.

	All
		Method Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action Maureen E Hillenmeyer, Elke Ericson, Ronald W Davis, Corey Nislow, Daphne Koller, Guri Giaever Genome Biology 2010, 11:R30 (12 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The relationship between co-fitness and co-inhibition of genes in chemicogenomic yeast screens provides insights into gene function and drug target prediction.
		Software Characterizing regulatory path motifs in integrated networks using perturbational data Anagha Joshi, Thomas Van Parys, Yves Peer, Tom Michoel Genome Biology 2010, 11:R32 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Pathicular – a Cytoscape plugin for analysing cellular responses to transcription factor perturbations is presented
		Research Genome-wide functional analysis of human 5' untranslated region introns Can Cenik, Adnan Derti, Joseph C Mellor, Gabriel F Berriz, Frederick P Roth Genome Biology 2010, 11:R29 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genes with short 5'UTR introns have higher expression than genes with no or long 5'UTR introns. Complex evolutionary forces act on these introns.
		Method Detection and correction of false segmental duplications caused by genome mis-assembly David R Kelley, Steven L Salzberg Genome Biology 2010, 11:R28 (10 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A method for determining false segmental duplications in vertebrate genomes, thus correcting mis-assemblies and providing more accurate estimates of duplications.
		Software XGAP: a uniform and extensible data model and software platform for genotype and phenotype experiments Morris A Swertz, K Joeri Velde, Bruno M Tesson, Richard A Scheltema, Danny Arends, Gonzalo Vera, Rudi Alberts, Martijn Dijkstra, Paul Schofield, Klaus Schughart, John M Hancock, Damian Smedley, Katy Wolstencroft, Carole Goble, Engbert O de Brock, Andrew R Jones, Helen E Parkinson, members of the Coordination of Mouse Informatics Resources (CASIMIR), Genotype-To-Phenotype (GEN2PHEN) Consortiums, Ritsert C Jansen Genome Biology 2010, 11:R27 (9 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary XGAP, a software platform for the integration and analysis of genotype and phenotype data.
		Research Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates Zhengdong D Zhang, Adam Frankish, Toby Hunt, Jennifer Harrow, Mark Gerstein Genome Biology 2010, 11:R26 (8 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Novel human pseudogenes are identified that had previous functionality and their age is estimated. The rate of loss-of-function occurred uniformly.
		Method A scaling normalization method for differential expression analysis of RNA-seq data Mark D Robinson, Alicia Oshlack Genome Biology 2010, 11:R25 (2 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A novel and empirical method for normalization of RNA-seq data is presented
		Research High-resolution transcription atlas of the mitotic cell cycle in budding yeast Marina V Granovskaia, Lars J Jensen, Matthew E Ritchie, Joern Toedling, Ye Ning, Peer Bork, Wolfgang Huber, Lars M Steinmetz Genome Biology 2010, 11:R24 (1 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A high resolution strand-specific transcriptional atlas of the budding yeast mitotic cell cycle, including both mRNA and non-coding RNA profiles.
		Method Identification of functional modules that correlate with phenotypic difference: the influence of network topology Jui-Hung Hung, Troy W Whitfield, Tun-Hsiang Yang, Zhenjun Hu, Zhiping Weng, Charles DeLisi Genome Biology 2010, 11:R23 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A gene set enrichment analysis method for including network topology in the identification of genes involved in phenotypic alterations is described. Classifications: Genome studies, Methods
		Comment Lost in translation Gregory A Petsko Genome Biology 2010, 11:107 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Objections to dividing biomedical research into 'translational' and 'basic' are not just a matter of semantics.
		Research highlight Histone tales: echoes from the past, prospects for the future Chris Murgatroyd, Dietmar Spengler Genome Biology 2010, 11:105 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent studies of the nematode dauer state provide new insights into epigenetic processes that underlie cellular memory.
		Research highlight PRDM9 points the zinc finger at meiotic recombination hotspots Matthew J Neale Genome Biology 2010, 11:104 (26 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Recent work shows that the histone methyltransferase PRDM9 determines the nonrandom genomic distribution of meiotic recombination hotspots.
		Software ChIA-PET tool for comprehensive chromatin interaction analysis with paired-end tag sequencing Guoliang Li, Melissa J Fullwood, Han Xu, Fabianus Hendriyan Mulawadi, Stoyan Velkov, Vinsensius Vega, Pramila Nuwantha Ariyaratne, Yusoff Bin Mohamed, Hong-Sain Ooi, Chandana Tennakoon, Chia-Lin Wei, Yijun Ruan, Wing-Kin Sung Genome Biology 2010, 11:R22 (25 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary ChIA-PET Tool can be used to process long-range chromatin interaction data. Results are visualized on a user-friendly genome browser.
		Research Immunity and other defenses in pea aphids, Acyrthosiphon pisum Nicole M Gerardo, Boran Altincicek, Caroline Anselme, Hagop Atamian, Seth M Barribeau, Martin de Vos, Elizabeth J Duncan, Jay D Evans, Toni Gabaldón, Murad Ghanim, Adelaziz Heddi, Isgouhi Kaloshian, Amparo Latorre, Andres Moya, Atsushi Nakabachi, Benjamin J Parker, Vincente Pérez-Brocal, Miguel Pignatelli, Yvan Rahbé, John S Ramsey, Chelsea J Spragg, Javier Tamames, Daniel Tamarit, Cecilia Tamborindeguy, Caroline Vincent-Monegat, Andreas Vilcinskas Genome Biology 2010, 11:R21 (23 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The genome of the pea aphid Acyrthosiphon pisum lacks genes thought to be crucial in other insects for recognition, signaling and killing of microbes.
		Research highlight The pea aphid genome sequence brings theories of insect defense into question Christine G Elsik Genome Biology 2010, 11:106 (23 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The genome sequence of the pea aphid is the first for a basal hemimetabolous insect and provides insights into developmental plasticity, symbiosis and insect immunity.
		Research Genomic features defining exonic variants that modulate splicing Adam Woolfe, James C Mullikin, Laura Elnitski Genome Biology 2010, 11:R20 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A comparative analysis of SNPs and their exonic and intronic environments identifies the features predictive of splice affecting variants.
		Research highlight Filling the gaps in the genomic landscape David Williams, J Peter Gogarten, Pascal Lapierre Genome Biology 2010, 11:103 (16 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Sequencing of genomes from many different bacterial and archaeal groups is broadening the picture of the prokaryotic pan-genome.
		Method Evidence-ranked motif identification Stoyan Georgiev, Alan P Boyle, Karthik Jayasurya, Xuan Ding, Sayan Mukherjee, Uwe Ohler Genome Biology 2010, 11:R19 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new computational method for the identification of regulatory motifs from large genomic datasets is presented here
		Method A fuzzy gene expression-based computational approach improves breast cancer prognostication Benjamin Haibe-Kains, Christine Desmedt, Françoise Rothé, Martine Piccart, Christos Sotiriou, Gianluca Bontempi Genome Biology 2010, 11:R18 (15 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A fuzzy computational approach that takes into account several molecular subtypes in order to provide more accurate breast cancer prognosis
		Research 2× genomes - depth does matter Michel C Milinkovitch, Raphaël Helaers, Eric Depiereux, Athanasia C Tzika, Toni Gabaldón Genome Biology 2010, 11:R16 (9 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The use of low coverage genomes in comparative evolutionary analyses skews estimates of gene gains and losses.
		Research Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling Marie JJ Huysman, Cindy Martens, Klaas Vandepoele, Jeroen Gillard, Edda Rayko, Marc Heijde, Chris Bowler, Dirk Inzé, Yves Peer, Lieven De Veylder, Wim Vyverman Genome Biology 2010, 11:R17 (8 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genes controlling the cell cycle in two diatoms have been identified and functionally characterized, revealing environmental regulation of the cell cycle.
		Method A scalable, fully automated process for construction of sequence-ready barcoded libraries for 454 Niall J Lennon, Robert E Lintner, Scott Anderson, Pablo Alvarez, Andrew Barry, William Brockman, Riza Daza, Rachel L Erlich, Georgia Giannoukos, Lisa Green, Andrew Hollinger, Cindi A Hoover, David B Jaffe, Frank Juhn, Danielle McCarthy, Danielle Perrin, Karen Ponchner, Taryn L Powers, Kamran Rizzolo, Dana Robbins, Elizabeth Ryan, Carsten Russ, Todd Sparrow, John Stalker, Scott Steelman, Michael Weiand, Andrew Zimmer, Matthew R Henn, Chad Nusbaum, Robert Nicol et al. Genome Biology 2010, 11:R15 (5 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An automated method for constructing libraries for 454 sequencing significantly reduces the cost and time required.
		Method Gene ontology analysis for RNA-seq: accounting for selection bias Matthew D Young, Matthew J Wakefield, Gordon K Smyth, Alicia Oshlack Genome Biology 2010, 11:R14 (4 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary GOseq is a method for GO analysis of RNA-seq data that takes into account the length bias inherent in RNA-seq
		Method Inferring the functions of longevity genes with modular subnetwork biomarkers of Caenorhabditis elegans aging Kristen Fortney, Max Kotlyar, Igor Jurisica Genome Biology 2010, 11:R13 (3 February 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An algorithm for determining networks from gene expression data enables the identification of genes potentially linked to aging in worms.
		Research Genomic and small RNA sequencing of Miscanthus × giganteus shows the utility of sorghum as a reference genome sequence for Andropogoneae grasses Kankshita Swaminathan, Magdy S Alabady, Kranthi Varala, Emanuele De Paoli, Isaac Ho, Dan S Rokhsar, Aru K Arumuganathan, Ray Ming, Pamela J Green, Blake C Meyers, Stephen P Moose, Matthew E Hudson Genome Biology 2010, 11:R12 (3 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genomic data together with sequencing of tissue specific small RNA libraries reveals insights into the genome content, small RNA repertoire and evolutionary origins of the grass Miscanthus × giganteus.
		Research Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats Tiebing Liang, Mark W Kimpel, Jeanette N McClintick, Ashley R Skillman, Kevin McCall, Howard J Edenberg, Lucinda G Carr Genome Biology 2010, 11:R11 (3 February 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Transcriptional profiling of specific regions of inbred rat brains reveals genes associated with alcohol preference in a known QTL locus on chromosome 4
		Comment Rising in the East Gregory A Petsko Genome Biology 2010, 11:102 (29 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The genome sequence of the giant panda using next- generation sequencing marks a watershed in genome sequencing - in more ways than one.
		Editorial Ten years of Genome Biology Clare Garvey Genome Biology 2010, 11:101 (29 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Huge advances in the field of genomics along with the continued rise of open access has made the past ten years an exciting time to be a biologist.
		Method Expressed Alu repeats as a novel, reliable tool for normalization of real-time quantitative RT-PCR data Manuela Marullo, Chiara Zuccato, Caterina Mariotti, Nayana Lahiri, Sarah J Tabrizi, Stefano Di Donato, Elena Cattaneo Genome Biology 2010, 11:R9 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Expressed Alu repeats are a reliable, accurate and universal reference for use in RT-qPCR normalization of human genes
		Research Characterization of X-Linked SNP genotypic variation in globally distributed human populations Amanda M Casto, Jun Z Li, Devin Absher, Richard Myers, Sohini Ramachandran, Marcus W Feldman Genome Biology 2010, 11:R10 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An analysis of X-linked genetic variation in human populations provides insights into population structure and demographic patterns.
		Minireview Looking for signatures of sex-specific demography and local adaptation on the X chromosome Evelyne Heyer, Laure Segurel Genome Biology 2010, 11:203 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A genome-wide study of X chromosome genetic diversity in human populations shows the impact of social organization and local adaptation.
		Minireview Assembling genomes using short-read sequencing technology Shaun D Jackman, İnanç Birol Genome Biology 2010, 11:202 (28 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Short-read sequencing technology can bring gigabase genome assemblies in under a million dollars.
		Minireview Targeting viral infection by microRNA inhibition Ashley PE Roberts, Catherine L Jopling Genome Biology 2010, 11:201 (26 January 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary An inhibitor of microRNA-122 reduces viral load in chimpanzees that are chronically infected with hepatitis C virus, suggesting that such an approach might have therapeutic potential in humans.
		Research Assembly of 500,000 inter-specific catfish expressed sequence tags and large scale gene-associated marker development for whole genome association studies Shaolin Wang, Eric Peatman, Jason Abernathy, Geoff Waldbieser, Erika Lindquist, Paul Richardson, Susan Lucas, Mei Wang, Ping Li, Jyothi Thimmapuram, Lei Liu, Deepika Vullaganti, Huseyin Kucuktas, Christopher Murdock, Brian C Small, Melanie Wilson, Hong Liu, Yanliang Jiang, Yoona Lee, Fei Chen, Jianguo Lu, Wenqi Wang, Peng Xu, Benjaporn Somridhivej, Puttharat Baoprasertkul, Jonas Quilang, Zhenxia Sha, Baolong Bao, Yaping Wang, Qun Wang et al. Genome Biology 2010, 11:R8 (22 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Twelve cDNA libraries from two species of catfish have been sequenced, resulting in the generation of nearly 500,000 ESTs.
		Method Genome-wide prediction of transcription factor binding sites using an integrated model Kyoung-Jae Won, Bing Ren, Wei Wang Genome Biology 2010, 11:R7 (22 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new approach for genome-wide transcription factor binding site prediction is presented that integrates sequence and chromatin modification data.
		Software PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes Andreas Ruepp, Andreas Kowarsch, Daniel Schmidl, Felix Buggenthin, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, Fabian J Theis Genome Biology 2010, 11:R6 (20 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary PhenomiR is a comprehensive database of 542 studies reporting deregulation of miRNAs allowing large-scale statistical analysis of miRNA expression changes.
		Research Rapid chromosome territory relocation by nuclear motor activity in response to serum removal in primary human fibroblasts Ishita S Mehta, Manelle Amira, Amanda J Harvey, Joanna M Bridger Genome Biology 2010, 11:R5 (13 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary Nuclear myosin 1β-dependent repositioning of chromosome territories occurs within 15 minutes of serum starvation in human cells.
		Method Substantial deletion overlap among divergent Arabidopsis genomes revealed by intersection of short reads and tiling arrays Luca Santuari, Sylvain Pradervand, Amelia-Maria Amiguet-Vercher, Jerôme Thomas, Eavan Dorcey, Keith Harshman, Ioannis Xenarios, Thomas E Juenger, Christian S Hardtke Genome Biology 2010, 11:R4 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary A new approach to detect deletions in divergentgenomes combines short read sequencing and tilling array data. Its utility is demonstrated on Arabidopsis strains.
		Method NetPath: a public resource of curated signal transduction pathways Kumaran Kandasamy, S Sujatha Mohan, Rajesh Raju, Shivakumar Keerthikumar, Ghantasala Kumar, Abhilash K Venugopal, Deepthi Telikicherla, J Daniel Navarro, Suresh Mathivanan, Christian Pecquet, Sashi Gollapudi, Sudhir Tattikota, Shyam Mohan, Hariprasad Padhukasahasram, Yashwanth Subbannayya, Renu Goel, Harrys KC Jacob, Jun Zhong, Raja Sekhar, Vishalakshi Nanjappa, Lavanya Balakrishnan, Roopashree Subbaiah, YL Ramachandra, B Abdul Rahiman, TS Keshava Prasad, Jian-Xin Lin, Jon CD Houtman, Stephen Desiderio, Jean-Christophe Renauld, Stefan N Constantinescu et al. Genome Biology 2010, 11:R3 (12 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data.
		Method Integrating phenotype ontologies across multiple species Christopher J Mungall, Georgios V Gkoutos, Cynthia L Smith, Melissa A Haendel, Suzanna E Lewis, Michael Ashburner Genome Biology 2010, 11:R2 (8 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A phenotypic ontology that can be used for the analysis of phenotype-genotype data across multiple species, paving the way for truly cross species translational research.
		Research Genomic characterization of the Yersinia genus Peter E Chen, Christopher Cook, Andrew C Stewart, Niranjan Nagarajan, Dan D Sommer, Mihai Pop, Brendan Thomason, Maureen Thomason, Shannon Lentz, Nichole Nolan, Shanmuga Sozhamannan, Alexander Sulakvelidze, Alfred Mateczun, Lei Du, Michael E Zwick, Timothy D Read Genome Biology 2010, 11:R1 (4 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative Yersinia genomics identifies features responsible for the colonization of specific host habitats and the horizontal transfer of virulence determinants.
		Method Correlating measurements across samples improves accuracy of large-scale expression profile experiments Mariano Alvarez, Pavel Sumazin, Presha Rajbhandari, Andrea Califano Genome Biology 2009, 10:R143 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Cleaner is a method for removing uninformative and flawed probes from microarray experiment data, thus improving reproducibility between replicate experiments.
		Comment A harsh climate Gregory A Petsko Genome Biology 2009, 10:115 (30 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary We should not be distracted by the debate about whether or not global warming is caused by humans; whatever the answer is, we urgently need to retard or reverse the trend.
		Protein family review The PIN-FORMED (PIN) protein family of auxin transporters Pavel Křeček, Petr Skůpa, Jiří Libus, Satoshi Naramoto, Ricardo Tejos, Jiří Friml, Eva Zažímalová Genome Biology 2009, 10:249 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A review of the PIN auxin-efflux transporters, which have important roles in plant development.
		Protein family review The WUS homeobox-containing (WOX) protein family Eric van der Graaff, Thomas Laux, Stefan A Rensing Genome Biology 2009, 10:248 (29 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The plant-specific WOX family of homeobox proteins have key functions in plant development.
		Method A blind deconvolution approach to high-resolution mapping of transcription factor binding sites from ChIP-seq data Desmond S Lun, Ashley Sherrid, Brian Weiner, David R Sherman, James E Galagan Genome Biology 2009, 10:R142 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary CSdeconv is a novel method for determining the location of transcription factor binding from ChIP-seq data that discriminates closely-spaced sites.
		Research Characterizing the admixed African ancestry of African Americans Fouad Zakharia, Analabha Basu, Devin Absher, Themistocles L Assimes, Alan S Go, Mark A Hlatky, Carlos Iribarren, Joshua W Knowles, Jun Li, Balasubramanian Narasimhan, Steven Sidney, Audrey Southwick, Richard M Myers, Thomas Quertermous, Neil Risch, Hua Tang Genome Biology 2009, 10:R141 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genome-wide SNP analyses reveal the admixed African genetic ancestry of African Americans.
		Meeting report Unraveling the genomic diversity of small eukaryotes Gilles Fischer, Dawn Thompson, Jennifer Wortman, Cécile Fairhead Genome Biology 2009, 10:318 (22 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report of the meeting Comparative Genomics of Eukaryotic Microorganisms, 17-22 October 2009, San Feliu de Guixols, Spain.
		Minireview Structural and functional map of a bacterial nucleoid Agustino Martínez-Antonio, Alejandra Medina-Rivera, Julio Collado-Vides Genome Biology 2009, 10:247 (11 December 2009) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Mapping global protein binding in the E. coli genome reveals extended domains of high protein occupancy.
		Method Towards accurate imputation of quantitative genetic interactions Igor Ulitsky, Nevan J Krogan, Ron Shamir Genome Biology 2009, 10:R140 (10 December 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A new method for calculating quantitative genetic interactions allows for the inference of 190,000 new genetic interactions in Saccharomyces cerevisae.