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Software   Open Access Highly Accessed

ggbio: an R package for extending the grammar of graphics for genomic data

Tengfei Yin, Dianne Cook, Michael Lawrence Genome Biology 2012, 13:R77 (31 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A consistent, robust and versatile software tool for visualizing genomic data

Method   Open Access

A computational framework for boosting confidence in high-throughput protein-protein interaction datasets

Raghavendra Hosur, Jian Peng, Arunachalam Vinayagam, Ulrich Stelzl, Jinbo Xu, Norbert Perrimon, Jadwiga Bienkowska, Bonnie Berger Genome Biology 2012, 13:R76 (31 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Coev2Net is a method for assigning confidence to high-throughput protein-protein interaction predictions

Meeting report   Subscription

Turning pipe dreams into reality

Peter Li, Jeremy Goecks, Tin-Lap Lee Genome Biology 2012, 13:318 (30 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The 2012 Galaxy meeting shows how the bioinformatic tools within Galaxy are developing and automating data analysis in the life sciences

Opinion   Subscription Highly Accessed

The tomato genome: implications for plant breeding, genomics and evolution

Aashish Ranjan, Yasunori Ichihashi, Neelima R Sinha Genome Biology 2012, 13:167 (30 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The importance of the tomato genome for plant breeding and the future of crop research

Research   Open Access Highly Accessed

Transcriptional profiling of long non-coding RNAs and novel transcribed regions across a diverse panel of archived human cancers

Alayne L Brunner, Andrew H Beck, Badreddin Edris, Robert T Sweeney, Shirley X Zhu, Rui Li, Kelli Montgomery, Sushama Varma, Thea Gilks, Xiangqian Guo, Joseph W Foley, Daniela M Witten, Craig P Giacomini, Ryan A Flynn, Jonathan R Pollack, Robert Tibshirani, Howard Y Chang, Matt van de Rijn, Robert B West Genome Biology 2012, 13:R75 (28 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Transcript sequencings from 64 solid tumours of 17 diagnostic classes reveals cancer-specific lncRNAs

Research   Open Access

Gene functionalities and genome structure in Bathycoccus prasinos reflect cellular specializations at the base of the green lineage

Hervé Moreau, Bram Verhelst, Arnaud Couloux, Evelyne Derelle, Stephane Rombauts, Nigel Grimsley, Michiel Van Bel, Julie Poulain, Michaël Katinka, Martin F Hohmann-Marriott, Gwenael Piganeau, Pierre Rouzé, Corinne Da Silva, Patrick Wincker, Yves Van de Peer, Klaas Vandepoele Genome Biology 2012, 13:R74 (24 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

The genome sequence of the marine green alga Bathycoccus prasinos, and a phylogenomic comparison with other Mammiellales species

Research   Open Access Highly Accessed

Novel origins of copy number variation in the dog genome

Jonas Berglund, Elisa M Nevalainen, Anna-Maja Molin, Michele Perloski, The LUPA Consortium, Catherine André, Michael C Zody, Ted Sharpe, Christophe Hitte, Kerstin Lindblad-Toh, Hannes Lohi, Matthew T Webster Genome Biology 2012, 13:R73 (23 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

CNVs were analyzed in dogs from 17 breeds, and were found to be associated with different features compared to other mammals

Research   Open Access

Sequencing and characterization of the FVB/NJ mouse genome

Kim Wong, Suzannah Bumpstead, Louise Van Der Weyden, Laura G Reinholdt, Laurens G Wilming, David J Adams, Thomas M Keane Genome Biology 2012, 13:R72 (23 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The genome of the FVB/NJ mouse is sequenced, revealing variants specific to this strain

Research   Open Access Highly Accessed

A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers

Nathan P Palmer, Patrick R Schmid, Bonnie Berger, Isaac S Kohane Genome Biology 2012, 13:R71 (21 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

A comprehensive in silico analysis of mRNA expression profiles in human stem cells, cancers and normal tissues

Research   Open Access

The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite

Andrea H Horakova, J Mauro Calabrese, Christine R McLaughlin, Deanna C Tremblay, Terry Magnuson, Brian P Chadwick Genome Biology 2012, 13:R70 (20 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A characterization of the X-linked homogenous tandem repeat DXZ4 in mouse, and a subsequent analysis of conservation across mammals

Research   Open Access Highly Accessed

Genome-wide distribution of 5-formylcytosine in embryonic stem cells is associated with transcription and depends on thymine DNA glycosylase

Eun-Ang Raiber, Dario Beraldi, Gabriella Ficz, Heather E Burgess, Miguel R Branco, Pierre Murat, David Oxley, Michael J Booth, Wolf Reik, Shankar Balasubramanian Genome Biology 2012, 13:R69 (17 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Genome-wide mapping of 5-formylcytosine in ES cells reveals an enrichment in promoter and exon CpG islands, and an association with transcription

Research   Open Access

Proteogenomic characterization and mapping of nucleosomes decoded by Brd and HP1 proteins

Gary LeRoy, Iouri Chepelev, Peter A DiMaggio, Mario A Blanco, Barry M Zee, Keji Zhao, Benjamin A Garcia Genome Biology 2012, 13:R68 (16 August 2012)

Abstract | Full text | PDF | PubMed | F1000 Biology |  Editor’s summary

A novel proteogenomic strategy links the histone reader proteins Brd3 and Brd4 to HOX gene regulation

Research highlight   Subscription Highly Accessed

Genomes of extremophile crucifers: new platforms for comparative genomics and beyond

Simon M Dittami, Thierry Tonon Genome Biology 2012, 13:166 (16 August 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Research Highlight: the genome sequences of extremophile crucifers provide valuable insights into the underlying mechanisms of stress tolerance in plants

Open letter   Free Highly Accessed

An encyclopedia of mouse DNA elements (Mouse ENCODE)

Mouse ENCODE Consortium, John A Stamatoyannopoulos, Michael Snyder, Ross Hardison, Bing Ren, Thomas Gingeras, David M Gilbert, Mark Groudine, Michael Bender, Rajinder Kaul, Theresa Canfield, Erica Giste, Audra Johnson, Mia Zhang, Gayathri Balasundaram, Rachel Byron, Vaughan Roach, Peter J Sabo, Richard Sandstrom, A Sandra Stehling, Robert E Thurman, Sherman M Weissman, Philip Cayting, Manoj Hariharan, Jin Lian, Yong Cheng, Stephen G Landt, Zhihai Ma, Barbara J Wold, Job Dekker et al. Genome Biology 2012, 13:418 (13 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The Mouse ENCODE Consortium is applying the same experimental pipelines developed for human ENCODE to annotate the mouse genome

Method   Open Access Highly Accessed

Analysis of CLIP and iCLIP methods for nucleotide-resolution studies of protein-RNA interactions

Yoichiro Sugimoto, Julian König, Shobbir Hussain, Blaž Zupan, Tomaž Curk, Michaela Frye, Jernej Ule Genome Biology 2012, 13:R67 (3 August 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

The CLIP and iCLIP methods are compared for their utility in determining RNA binding protein binding sites

Review   Subscription Highly Accessed

Autism genetics: searching for specificity and convergence

Jamee M Berg, Daniel H Geschwind Genome Biology 2012, 13:247 (31 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Daniel Geschwind and Jamee Berg review the genes associated with autism spectrum disorders: how might their functions relate to one another?

Research highlight   Subscription Highly Accessed

The aging epigenome: DNA methylation from the cradle to the grave

Marc Winnefeld, Frank Lyko Genome Biology 2012, 13:165 (30 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

Frank Lyko and Marc Winnefeld highlight a new survey of age-related epigenetic changes in newborn and centenarian methylomes

Research   Open Access

Genome and low-iron response of an oceanic diatom adapted to chronic iron limitation

Markus Lommer, Michael Specht, Alexandra-Sophie Roy, Lars Kraemer, Reidar Andreson, Magdalena A Gutowska, Juliane Wolf, Sonja V Bergner, Markus B Schilhabel, Ulrich C Klostermeier, Robert G Beiko, Philip Rosenstiel, Michael Hippler, Julie LaRoche Genome Biology 2012, 13:R66 (26 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Transcriptomic and proteomic insights into the low-iron tolerance of Thalassoiosira oceanic, an oceanic diatom

Research   Open Access Highly Accessed

Developmental features of DNA methylation during activation of the embryonic zebrafish genome

Ingrid S Andersen, Andrew H Reiner, Håvard Aanes, Peter Aleström, Philippe Collas Genome Biology 2012, 13:R65 (25 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

DNA methylation patterning at developmental genes is assayed before, during and after zygotic genome activation

Research   Open Access Highly Accessed

Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates

Sean Conlan, Lilia A Mijares, NISC Comparative Sequencing Program, Jesse Becker, Robert W Blakesley, Gerard G Bouffard, Shelise Brooks, Holly Coleman, Jyoti Gupta, Natalie Gurson, Morgan Park, Brian Schmidt, Pamela J Thomas, Michael Otto, Heidi H Kong, Patrick R Murray, Julia A Segre Genome Biology 2012, 13:R64 (25 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Comparative genomics of skin commensal and hospital infection-associated isolates uncovers a putative clinical biomarker

Research highlight   Subscription Highly Accessed

piRNAs and siRNAs collaborate in Caenorhabditis elegans genome defense

Allison C Billi, Mallory A Freeberg, John K Kim Genome Biology 2012, 13:164 (20 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

John Kim and colleagues discuss transgenerational genome surveillance and the recognition of non-self by the worm piRNA system

Research   Open Access

RNA processing in the minimal organism Nanoarchaeum equitans

Lennart Randau Genome Biology 2012, 13:R63 (18 July 2012)

Abstract | Full text | PDF | PubMed | Cited on BioMed Central |  Editor’s summary

RNA-seq in the minimal archaeon Nanoarchaeum equitans reveals details of unusual RNA processing such as trans splicing of tRNA molecules

Software   Open Access Highly Accessed

CIDeR: multifactorial interaction networks in human diseases

Martin Lechner, Veit Höhn, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, Gabi Kastenmüller, Brigitte Waegele, Andreas Ruepp Genome Biology 2012, 13:R62 (18 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A database of interactions in neurological and metabolic disorders, with a wide range of search options and graphical outputs

Meeting report   Subscription

Eastern genomics promises

Scott C Edmunds Genome Biology 2012, 13:317 (17 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

A report on the Bio-IT World Asia meeting, Marina Bay Sands, Singapore, 6-8 June 2012.

Research highlight   Subscription Highly Accessed

The greatest catch: big game fishing for mRNA-bound proteins

Christopher R Sibley, Jan Attig, Jernej Ule Genome Biology 2012, 13:163 (17 July 2012)

Abstract | Full text | PDF | PubMed |  Editor’s summary

Jernej Ule and colleagues highlight two recent studies that have identified many novel RNA-binding proteins

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