Research    

(2 August 2006)

Analysis of primate-specific evolution of the LDL receptor enhancer demonstrates a molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions.

Research    

(2 August 2006)

High-throughput combinatorial RNAi demonstrates that many duplicated genes in C. elegans can retain redundant functions for more than 80 million years

Research    

(2 August 2006)

An analysis of genome-wide histone acetylation data using a few complementary statistical models gives support to a cumulative effect model for global histone acetylation.

Method    

(4 August 2006)

The development and verification of a genomic microarray for ChIP-chip analysis of zebrafish genes is described.

Research    

(10 August 2006)

A proteomic analysis of the tear fluid suggests that an interplay between proteases and protease inhibitors, and between oxidative reactions, is an important feature of the ocular environment.

Software    

(10 August 2006)

UniPep, a database of human N-linked glycosites is presented as a resource for biomarker discovery

Research    

(11 August 2006)

A single population test applied in a genomic context reveals evidence of selection on three biologically interesting genes in the Irish population.

Research    

(14 August 2006)

A codon usage table for 32 nematode species is presented and suggests that total genomic GC content drives codon usage.

Research    

(17 August 2006)

An analysis of the temporal dynamics of metabolite and transcript levels, as well as enzyme activity, of 137 metabolites during diurnal cycles in Arabidopsis leaves

Method    

(17 August 2006)

A software tool for the analysis of high-throughput cell-based assays is presented.

Research    

(17 August 2006)

Investigations of the spacing between TATA box and transcription start site in mouse core promoters reveals a coupling of spacing to tissue specificity.

Research    

(25 August 2006)

A genome-wide microarray analysis of sex-specific expression of alternative transcripts in Drosophila shows sexual dimorphism in transcript abundance for 53% of the genes.

Comment    

(1 September 2006)

The problem with reaching 'senior faculty' status is the feeling that you have nothing much to contribute except experience, but the recently announced Neanderthal Genome Project might put things into perspective.

Opinion    

(30 August 2006)

Various practical challenges involved in controlling living organisms must be surmounted if synthetic biology is to be productive.

Minireview    

(10 August 2006)

A large yeast two-hybrid study shows that some proteins mutated in different spinocerebellar ataxias have interacting protein partners in common.

Minireview    

(30 August 2006)

Separate transcriptional pathways have been delineated for the maintenance of the undifferentiated state and for self-renewal in embryonic stem cells.

Minireview    

(29 August 2006)

A popular method of RNA interference shows levels of toxicity in mice that could limit its therapeutic potential.

Protein family review    

(23 August 2006)

Peptidoglycan recognition proteins (PGRPs) are found in insects, mollusks, echinoderms, and vertebrates, and they protect animals against infections. The four mammalian family members are either bactericidal proteins or amidases that hydrolyze bacterial peptidoglycan.

Meeting report    

(24 August 2006)

A report of the annual meeting of the European Society of Human Genetics, Amsterdam, 6-9 May 2006.

Meeting report    

(24 August 2006)

A report on the Human Genome Organisation (HUGO) 11th Human Genome Meeting, Helsinki, Finland, 31 May-3 June 2006.

Meeting report    

(24 August 2006)

A report on 'The Biology of Genomes' meeting, Cold Spring Harbor, USA, 10-14 May 2006.

Correction    

(23 August 2006)

Correspondence    

(1 September 2006)

A comment on Preferred analysis methods for Affymetrix GeneChips revealed by a wholly defined control dataset by SE Choe, M Boutros, AM Michelson, GM Church and MS Halfon. Genome Biology 2005, 6:R16