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Genetics of mother-to-child HIV transmission
Mother-to-child HIV transmission in Malawian infants is associated with nine single nucleotide polymorphisms in six genes with roles in pregnancy, development, innate immunity and HIV-protein interaction.
Genome Medicine 2010, 2:17

Wiki-based integration of genomic data
The development of a specialized portal for collaborative annotation and analysis of gene-phenotype networks in congenital heart defects using a Wiki platform highlights this technologys potential for systems biology studies of other complex biological processes.
Genome Medicine 2010, 2:16

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 Welcome to Genome Biology
  Biology for the post-genomic era.

Research    
Pre-initiation complex formation
Albert TK, Grote K, Boeing S, Meisterernst M / 15 March 2010

Genome-wide mapping of the human TFIIB and NC2 transcription factor binding sites reveals insights into the formation of the pre-initiation complex.

Research highlight   
Genome-wide DNA demethylation in mammals
Sanz LA, Kota SK, Feil R / 16 March 2010

New roles for the cytidine deaminase AID and elongator-complex proteins in DNA demethylation.

Research    
Novel prokaryotic structured RNAs
Weinberg Z, Wang JX, Bogue J, Yang J, Corbino K, Moy RH, Breaker RR / 15 March 2010

Novel motifs identified in a comparative genomic analysis of bacterial, archaeal and metagenomic data reveals over 100 candidate structured RNAs.

Research highlight   
Is canalization more than just a beautiful idea?
Sato K, Siomi H / 16 March 2010

The heat-shock protein Hsp90 has been shown to be involved in the repression of de novo transposon-mediated mutagenesis.

Software    
Pathicular
Joshi A, Van Parys T, Van de Peer Y, Michoel T / 15 March 2010

Pathicular a Cytoscape plugin for analysing cellular responses to transcription factor perturbations is presented

Research highlight   
The amazing world of bacterial structured RNAs
Westhof E / 15 March 2010

The discovery of several new structured non-coding RNAs in bacterial and archaeal genomes and metagenomes raises burning questions about their biological and biochemical functions.

Research    
5UTR introns
Cenik C, Derti A, Mellor JC, Berriz GF, Roth FP / 11 March 2010

Genes with short 5UTR introns have higher expression than genes with no or long 5UTR introns. Complex evolutionary forces act on these introns.

The complete issue of Genome Biology Volume 11 Issue 2 is now available.

Comment   
Petsko GA / 26 February 2010
Method    
Hillenmeyer ME, Ericson E, Davis RW, Nislow C, Koller D, Giaever G / 12 March 2010
Research highlight   
Williams D, Gogarten JP, Lapierre P / 16 February 2010
Method    
Kelley DR, Salzberg SL / 10 March 2010
Research highlight   
Elsik CG / 23 February 2010
Research    
Granovskaia MV, Jensen LJ, Ritchie ME, Toedling J, Ning Y, Bork P, Huber W, Steinmetz LM / 01 March 2010
Research highlight   
Murgatroyd C, Spengler D / 26 February 2010
Method    
Robinson MD, Oshlack A / 02 March 2010
Research    
Zhang ZD, Frankish A, Hunt T, Harrow J, Gerstein M / 08 March 2010

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