Genome Biology aims to provide the best possible service to authors and readers of primary research articles. The method section publishes peer-reviewed methods in all areas of molecular, cellular, organismal and population biology that are informed by genomics. All method articles are made available free to individuals through the web, and there are no restrictions on article length or on the types of information that can be included. The publication schedule is very fast, using electronic systems for article delivery, proofing and peer-review. For more details about how methods are published in Genome Biology, and for instructions for authors,see 'about refereed research'.

Method    

(18 December 2008)

Singular value decomposition regression can detect the activation of endogenous signaling pathways, allowing the identification of pathway cross-talk.

Method    

(18 December 2008)

A web-based tool for interpretation of experimentally-derived gene lists that provides global models uniting genes from different metabolic pathways.

Method    

(18 December 2008)

A method is presented to computationally identify core promoters in the Plasmodium falciparum genome using only DNA physicochemical properties

Method    

(16 December 2008)

A strategy is presented to prioritize the functional modules that mediate genetic perturbations and their phenotypic effects among candidate modules.

Method    

(16 December 2008)

A method for de novo genome annotation using high-throughput cDNA sequencing data

Method    

(24 November 2008)

New methods for detecting global patterns of gene expression and splicing variation in natural Arabidopsis thaliana populations.

Method    

(30 October 2008)

A method for analysis of microarray data is presented that extracts statistically significant Boolean implication relationships between pairs of genes.

Method    

(13 October 2008)

An automated pipeline for phylogenomic analysis (AMPHORA) is presented that overcomes existing limits to large-scale protein phylogenetic inference.