Genome Biology aims to provide the best possible service to authors and readers of primary research articles. The method section publishes peer-reviewed methods in all areas of molecular, cellular, organismal and population biology that are informed by genomics. All method articles are made available free to individuals through the web, and there are no restrictions on article length or on the types of information that can be included. The publication schedule is very fast, using electronic systems for article delivery, proofing and peer-review. For more details about how methods are published in Genome Biology, and for instructions for authors,see 'about refereed research'.

Method    

(8 April 2008)

So-called Evolutionary potentials for protein structure prediction are derived using a single experimental protein structure and all three-dimensional models of its homologous sequences.

Method    

(7 April 2008)

ModuleMiner detects cis-regulatory modules in a set of co-expressed genes in tissue-specific microarray clusters and in embryonic development datasets.

Method    

(3 April 2008)

A new system based on non-conventional secretion of the luciferase from Gaussia princeps (GLUC) can be used to detect intracellular proteolysis in vivo.

Method    

(3 April 2008)

Extended and validated CRLMM is shown to be more accurate than the Affymetrix default programs, and datasets and methods for validation are presented that can serve as standard benchmarks by which future SNP chip calling algorithms can be measured.

Method    

(22 March 2008)

A novel methodology is presented for detecting and quantifying indirect effects on cancer survival mediated through several target genes of transcription factors in cancer microarray data.

Method    

(18 March 2008)

New computational tools were used to find a robust set of DNA oligomers that can distinguish artificial vector sequences from all available background viral and bacterial genomes.

Method    

(10 March 2008)

A geometric clustering algorithm has been developed to dissect protein fragments based on their relevance to function.

Method    

(1 March 2008)

Inhibitors of the platelet derived growth factor receptor (PDGFR) signaling pathway are isolated using gene expression-based high-throughput screening (GE-HTS), a method that is applicable to other pathways.