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	76.	Minireview Koala retrovirus: a genome invasion in real time Jonathan P Stoye Genome Biology 2006, 7:241 (21 November 2006) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Koalas are currently undergoing a wave of germline retroviral infection, which is spreading throughout Australia.
	77.	Research Genetic diversity in India and the inference of Eurasian population expansion Jinchuan Xing, W Scott Watkins, Ya Hu, Chad D Huff, Aniko Sabo, Donna M Muzny, Michael J Bamshad, Richard A Gibbs, Lynn B Jorde, Fuli Yu Genome Biology 2010, 11:R113 (24 November 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary SNP study demonstrates a high degree of Indian genetic diversity and suggests a significant isolation period between Out-of-Africa and Eurasian expansion.
	78.	Research Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford progeria syndrome cells Ishita S Mehta, Christopher H Eskiw, Halime D Arican, Ian R Kill, Joanna M Bridger Genome Biology 2011, 12:R74 (12 August 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Treating cultured cells from Hutchinson-Gilford progeria patients with farnesyltransferase inhibitors restores wildtype chromosome dynamics
	79.	Research Genetic adaptation to high altitude in the Ethiopian highlands Laura B Scheinfeldt, Sameer Soi, Simon Thompson, Alessia Ranciaro, Dawit Woldemeskel, William Beggs, Charla Lambert, Joseph P Jarvis, Dawit Abate, Gurja Belay, Sarah A Tishkoff Genome Biology 2012, 13:R1 (20 January 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The genetics of hypoxia selection in an Ethiopian high-altitude population are distinct from Andean and Tibetan genotypes, suggestive of convergent evolution
	80.	Research Modeling gene expression using chromatin features in various cellular contexts Xianjun Dong, Melissa C Greven, Anshul Kundaje, Sarah Djebali, James B Brown, Chao Cheng, Thomas R Gingeras, Mark Gerstein, Roderic Guigó, Ewan Birney, Zhiping Weng Genome Biology 2012, 13:R53 (5 September 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Models for linking gene expression with chromatin features vary according to cellular context and RNA measurement method
	81.	Method Analyzing and minimizing PCR amplification bias in Illumina sequencing libraries Daniel Aird, Michael G Ross, Wei-Sheng Chen, Maxwell Danielsson, Timothy Fennell, Carsten Russ, David B Jaffe, Chad Nusbaum, Andreas Gnirke Genome Biology 2011, 12:R18 (21 February 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary The optimization of PCR amplification steps in Illumina libraries significantly reduces sequencing bias
	82.	Meeting report Out of the sequencer and into the wiki as we face new challenges in genome informatics Zemin Ning, Stephen B Montgomery Genome Biology 2010, 11:308 (28 October 2010) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the joint Cold Spring Harbor Laboratory/Wellcome Trust Conference 'Genome Informatics' meeting, 15-19 September 2010, Hinxton, Cambridge, UK.
	83.	Correspondence Genomic information infrastructure after the deluge Julian Parkhill, Ewan Birney, Paul Kersey Genome Biology 2010, 11:402 (26 July 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Maintaining up-to-date annotation on reference genomes is becoming more important, not less, as the ability to rapidly and cheaply resequence genomes expands.
	84.	Research Comparison of solution-based exome capture methods for next generation sequencing Anna-Maija Sulonen, Pekka Ellonen, Henrikki Almusa, Maija Lepistö, Samuli Eldfors, Sari Hannula, Timo Miettinen, Henna Tyynismaa, Perttu Salo, Caroline Heckman, Heikki Joensuu, Taneli Raivio, Anu Suomalainen, Janna Saarela Genome Biology 2011, 12:R94 (28 September 2011) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Roche NimbleGen and Agilent solution-based exome capture kits are compared. NimbleGen kits give more accurate alignments to target regions
	85.	Review Bacterial epidemiology and biology - lessons from genome sequencing Julian Parkhill, Brendan W Wren Genome Biology 2011, 12:230 (24 October 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Brendan Wren and Julian Parkhill on how a new era in microbial genomics has solved ancient controversies and promises to revolutionize our understanding of bacterial pathogens
	86.	Research High levels of RNA-editing site conservation amongst 15 laboratory mouse strains Petr Danecek, Christoffer Nellåker, Rebecca E McIntyre, Jorge E Buendia-Buendia, Suzannah Bumpstead, Chris P Ponting, Jonathan Flint, Richard Durbin, Thomas M Keane, David J Adams Genome Biology 2012, 13:r26 (23 April 2012) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary An extensive, genome-wide analysis of RNA editing in the brain transcriptomes of 15 mouse strains
	87.	Software Genome assembly forensics: finding the elusive mis-assembly Adam M Phillippy, Michael C Schatz, Mihai Pop Genome Biology 2008, 9:R55 (14 March 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A collection of software tools is combined for the first time in an automated pipeline for detecting large-scale genome assembly errors and for validating genome assemblies.
	88.	Research Nucleosome deposition and DNA methylation at coding region boundaries Jung Choi, Jae-Bum Bae, Jaemyun Lyu, Tae-Yoon Kim, Young-Joon Kim Genome Biology 2009, 10:R89 (1 September 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Nucleosomes and methylation have been observed to peak at both ends of protein coding units in a genome-wide survey.
	89.	Research Assaying the regulatory potential of mammalian conserved non-coding sequences in human cells Catia Attanasio, Alexandre Reymond, Richard Humbert, Robert Lyle, Michael S Kuehn, Shane Neph, Peter J Sabo, Jeff Goldy, Molly Weaver, Andrew Haydock, Kristin Lee, Michael Dorschner, Emmanouil T Dermitzakis, Stylianos E Antonarakis, John A Stamatoyannopoulos Genome Biology 2008, 9:R168 (2 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary The fraction of experimentally active conserved non-coding sequences within any given cell type is low, so classical assays are unlikely to expose their potential.
	90.	Research Comparative genomics of mutualistic viruses of Glyptapanteles parasitic wasps Christopher A Desjardins, Dawn E Gundersen-Rindal, Jessica B Hostetler, Luke J Tallon, Douglas W Fadrosh, Roger W Fuester, Monica J Pedroni, Brian J Haas, Michael C Schatz, Kristine M Jones, Jonathan Crabtree, Heather Forberger, Vishvanath Nene Genome Biology 2008, 9:R183 (30 December 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Comparative genome analysis of two endosymbiotic polydnaviruses from Glyptapanteles parasitic wasps reveals new insights into the evolutionary arms race between host and parasite.
	91.	Method Methods for analyzing deep sequencing expression data: constructing the human and mouse promoterome with deepCAGE data Piotr J Balwierz, Piero Carninci, Carsten O Daub, Jun Kawai, Yoshihide Hayashizaki, Werner Van Belle, Christian Beisel, Erik van Nimwegen Genome Biology 2009, 10:R79 (22 July 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| F1000 Biology \| Editor’s summary A set of methods is presented for normalization, quantification of noise and co-expression analysis for gene expression studies using deep sequencing.
	92.	Software PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes Andreas Ruepp, Andreas Kowarsch, Daniel Schmidl, Felix Buggenthin, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, Fabian J Theis Genome Biology 2010, 11:R6 (20 January 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary PhenomiR is a comprehensive database of 542 studies reporting deregulation of miRNAs allowing large-scale statistical analysis of miRNA expression changes.
	93.	Research Genome-wide functional analysis of human 5' untranslated region introns Can Cenik, Adnan Derti, Joseph C Mellor, Gabriel F Berriz, Frederick P Roth Genome Biology 2010, 11:R29 (11 March 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Genes with short 5'UTR introns have higher expression than genes with no or long 5'UTR introns. Complex evolutionary forces act on these introns.
	94.	Research 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells Hume Stroud, Suhua Feng, Shannon Morey Kinney, Sriharsa Pradhan, Steven E Jacobsen Genome Biology 2011, 12:R54 (20 June 2011) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A genome-wide study in hESCs finds that the modified base 5-hydroxymethylcytosine is enriched in enhancer regions and gene bodies
	95.	Research MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype Cherie Blenkiron, Leonard D Goldstein, Natalie P Thorne, Inmaculada Spiteri, Suet-Feung Chin, Mark J Dunning, Nuno L Barbosa-Morais, Andrew E Teschendorff, Andrew R Green, Ian O Ellis, Simon Tavaré, Carlos Caldas, Eric A Miska Genome Biology 2007, 8:R214 (8 October 2007) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Integrated analysis of miRNA expression and genomic changes in human breast tumors allows the classification of tumor subtypes.
	96.	Method Computational discovery of cis-regulatory modules in Drosophila without prior knowledge of motifs Andra Ivan, Marc S Halfon, Saurabh Sinha Genome Biology 2008, 9:R22 (28 January 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Prediction of cis-regulatory modules ab initio, without any input of relevant motifs, is achieved with two novel methods.
	97.	Opinion Polymorphism in regulatory gene sequences N A Mitchison Genome Biology 2000, 2:comment2001-comment2001.6 (20 December 2000) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary The extensive polymorphism revealed in non-coding gene-regulatory sequences, particularly in the immune system, suggests that this type of genetic variation is functionally and evolutionarily far more important than has been suspected, and provides a lead to new therapeutic strategies.
	98.	Protein family review Fibroblast growth factors David M Ornitz, Nobuyuki Itoh Genome Biology 2001, 2:reviews3005-reviews3005.12 (9 March 2001) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Fibroblast growth factors (FGFs) are a large family of peptide growth factors that require heparan sulfate to activate their tyrosine kinase receptors. They have diverse roles in development, regulating proliferation, migration and differentiation. In adult animals, FGFs are important for homeostasis and tissue repair.
	99.	Method UTILLdb, a Pisum sativum in silico forward and reverse genetics tool Marion Dalmais, Julien Schmidt, Christine Le Signor, Francoise Moussy, Judith Burstin, Vincent Savois, Gregoire Aubert, Veronique Brunaud, Yannick de Oliveira, Cecile Guichard, Richard Thompson, Abdelhafid Bendahmane Genome Biology 2008, 9:R43 (26 February 2008) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary UTILLdb is a database of phenotypic and sequence information on mutant genes from a reference Pisum sativum EMS-mutant population.
	100.	Research Benchmarking ortholog identification methods using functional genomics data Tim Hulsen, Martijn A Huynen, Jacob de Vlieg, Peter MA Groenen Genome Biology 2006, 7:R31 (13 April 2006) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary A benchmarking of the most popular orthologous identification methods using functional genomics data identifies the two best methods.