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	1. 27852 Accesses	Research VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer Georges St Laurent, Dmitry Shtokalo, Biao Dong, Michael R Tackett, Xiaoxuan Fan, Sandra Lazorthes, Estelle Nicolas, Nianli Sang, Timothy J Triche, Timothy A McCaffrey, Weidong Xiao, Philipp Kapranov Genome Biology 2013, 14:R73 (22 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary The expression of vlincRNAs from retroviral promoters is correlated with pluripotency and malignancy
	2. 9035 Accesses	Research A blood based 12-miRNA signature of Alzheimer disease patients Petra Leidinger, Christina Backes, Stephanie Deutscher, Katja Schmitt, Sabine C Muller, Karen Frese, Jan Haas, Klemens Ruprecht, Friedemann Paul, Cord Stahler, Christoph JG Lang, Benjamin Meder, Tamas Bartfai, Eckart Meese, Andreas Keller Genome Biology 2013, 14:R78 (29 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A 12-miRNA signature in blood samples can be used to detect Alzheimer’s disease and other neurological disorders
	3. 5294 Accesses	Comment So, you want to sequence a genome... Derek L Stemple Genome Biology 2013, 14:128 (30 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Derek Stemple discusses lessons learned from the zebrafish genome project
	4. 5255 Accesses	Research highlight DNA methylation, genotype and gene expression: who is driving and who is along for the ride? Meaghan J Jones, Anthony P Fejes, Michael S Kobor Genome Biology 2013, 14:126 (29 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Michael Kobor and colleagues discuss regulatory interactions between DNA methylation, genotype and gene expression
	5. 4474 Accesses	Research highlight MicroRNAs circulate around Alzheimer's disease Thalyana Smith-Vikos, Frank J Slack Genome Biology 2013, 14:125 (29 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Frank Slack and Thalyana Smith-Vikos discuss the blood miRNA signature for Alzheimer's disease reported in this issue of Genome Biology
	6. 3843 Accesses	Research Gene expression changes with age in skin, adipose tissue, blood and brain Daniel Glass, Ana Vinuela, Mathew N Davies, Adaikalavan Ramasamy, Leopold Parts, David Knowles, Andrew A Brown, Asa K Hedman, Kerrin S Small, Alfonso Buil, Elin Grundberg, Alexandra C Nica, Paola Di Meglio, Frank O Nestle, Mina Ryten, The UK Brain Expression consortium, Muther Consortium, Richard Durbin, Mark I McCarthy, Panagiotis Deloukas, Emmanouil T Dermitzakis, Mike E Weale, Veronique Bataille, Tim D Spector Genome Biology 2013, 14:R75 (26 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analysis of microarray experiments in subjects of varying age shows that gene expression in four different tissues changes with time
	7. 3645 Accesses	Correspondence The advantages of SMRT sequencing Richard J Roberts, Mauricio O Carneiro, Michael C Schatz Genome Biology 2013, 14:405 (3 July 2013) Abstract \| Full text \| PDF \| PubMed \| 1 comment \| Editor’s summary Rich Roberts, Mauricio Carneiro and Michael Schatz argue for a greater uptake of the impressive PacBio SMRT sequencing platform
	8. 3395 Accesses	Review Ant genomics sheds light on the molecular regulation of social organization Romain Libbrecht, Peter R Oxley, Daniel JC Kronauer, Laurent Keller Genome Biology 2013, 14:212 (29 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Laurent Keller and colleagues review new insights into insect social organization that have arisen from ant genome sequences and epigenomics research
	9. 3382 Accesses	Research highlight Microbiota's 'little helpers': bacteriophages and antibiotic-associated responses in the gut microbiome Christine L Sun, David A Relman Genome Biology 2013, 14:127 (30 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary David Relman and Christine Sun discuss recent research into how bacteriophage mediate the impact of antibiotics on the gut microbiome
	10. 3271 Accesses	Meeting report Next-generation sequencing for identifying new genes in rare genetic diseases: many challenges and a pinch of luck Amélie Bonnefond, Philippe Froguel Genome Biology 2013, 14:309 (29 July 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A report on the European Society of Human Genetics conference, held in Paris, France, June 8-11, 2013
	11. 3096 Accesses	Method GLiMMPS: Robust statistical model for regulatory variation of alternative splicing using RNA-Seq data Keyan Zhao, Zhi-xiang Lu, Juw Won Park, Qing Zhou, Yi Xing Genome Biology 2013, 14:R74 (22 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary GLiMMPS is a method for detecting QTLs associated with alternative splicing
	12. 2604 Accesses	Research A compact, in vivo screen of all 6-mers reveals drivers of tissue-specific expression and guides synthetic regulatory element design Robin P Smith, Samantha J Riesenfeld, Alisha K Holloway, Qiang Li, Karl K Murphy, Natalie M Feliciano, Lorenzo Orecchia, Nir Oksenberg, Katherine S Pollard, Nadav Ahituv Genome Biology 2013, 14:R72 (18 July 2013) Abstract \| Provisional PDF \| PubMed \| 1 comment \| Editor’s summary All possible 6-mers are incorporated into a compact set of 15-mer synthetic enhancer sequences, which are then screened in zebrafish embryos
	13. 2471 Accesses	Software Ultrafast and memory-efficient alignment of short DNA sequences to the human genome Ben Langmead, Cole Trapnell, Mihai Pop, Steven L Salzberg Genome Biology 2009, 10:R25 (4 March 2009) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Bowtie: a new ultrafast memory-efficient tool for the alignment of short DNA sequence reads to large genomes.
	14. 2276 Accesses	Method Differential expression analysis for sequence count data Simon Anders, Wolfgang Huber Genome Biology 2010, 11:R106 (27 October 2010) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| F1000 Biology \| Editor’s summary DEseq allows the determination of differential expression of read count data from RNA-seq or ChIP-seq experiments
	15. 2214 Accesses	Method TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions Daehwan Kim, Geo Pertea, Cole Trapnell, Harold Pimentel, Ryan Kelley, Steven L Salzberg Genome Biology 2013, 14:R36 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary A major update to TopHat, the popular Bowtie-based spliced aligner
	16. 2179 Accesses	Research Experimental characterization of the human non-sequence-specific nucleic acid interactome Gerhard Duernberger, Tilmann Burckstummer, Kilian Huber, Roberto Giambruno, Tobias Doerks, Evren Karayel, Thomas R Burkard, Ines Kaupe, Andre C Muller, Andreas Schonegger, Gerhard F Ecker, Hans Lohninger, Peer Bork, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge Genome Biology 2013, 14:R81 (31 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A mass spectrometry and bioinformatics approach identifies human proteins that bind nucleic acids in a non-sequence-specific manner
	17. 2126 Accesses	Research Transcriptome analysis of human tissues and cell lines reveals one dominant transcript per gene Mar Gonzalez-Porta, Adam Frankish, Johan Rung, Jennifer Harrow, Alvis Brazma Genome Biology 2013, 14:R70 (1 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Analysis of RNA-seq data across different tissues and cell lines reveals that the majority of genes have a single dominant transcript
	18. 2031 Accesses	Review The plant microbiome Thomas R Turner, Euan K James, Philip S Poole Genome Biology 2013, 14:209 (25 June 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| Editor’s summary Philip Poole and colleagues discuss how genomics approaches are unraveling the complex interactions between plant hosts and microbiome communities
	19. 1987 Accesses	Research A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains Michelle M Simon, Simon Greenaway, Jacqueline K White, Helmut Fuchs, Valérie Gailus-Durner, Tania Sorg, Kim Wong, Elodie Bedu, Elizabeth J Cartwright, Romain Dacquin, Sophia Djebali, Jeanne Estabel, Jochen Graw, Neil J Ingham, Ian J Jackson, Andreas Lengeling, Silvia Mandillo, Jacqueline Marvel, Hamid Meziane, Frédéric Preitner, Oliver Puk, Michel Roux, David J Adams, Sarah Atkins, Abdel Ayadi, Lore Becker, Andrew Blake, Debra Brooker, Heather Cater, Marie-France Champy et al. Genome Biology 2013, 14:R82 (31 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary A comprehensive genomic and phenotypic analysis identifies significant differences between the widely used C57BL/6J and C57BL/6N mouse strains
	20. 1955 Accesses	Research Characterizing and measuring bias in sequence data Michael G Ross, Carsten Russ, Maura Costello, Andrew Hollinger, Niall J Lennon, Ryan Hegarty, Chad Nusbaum, David B Jaffe Genome Biology 2013, 14:R51 (29 May 2013) Abstract \| Full text \| PDF \| PubMed \| F1000 Biology \| Editor’s summary A comparison of the bias in sequencing data from four different platforms reveals that some human promoters are completelymissed
	21. 1939 Accesses	Method Quartz-Seq: a highly reproducible and sensitive single-cell RNA sequencing method, reveals non-genetic gene-expression heterogeneity Yohei Sasagawa, Itoshi Nikaido, Tetsutaro Hayashi, Hiroki Danno, Kenichiro D Uno, Takeshi Imai, Hiroki R Ueda Genome Biology 2013, 14:R31 (17 April 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Quartz-Seq is a method for performing single cell RNA-seq which displays high reproducibility
	22. 1708 Accesses	Research Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Jo Vandesompele, Katleen De Preter, Filip Pattyn, Bruce Poppe, Nadine Van Roy, Anne De Paepe, Frank Speleman Genome Biology 2002, 3:research0034-research0034.11 (18 June 2002) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary Using real-time reverse transcription PCR ten housekeeping genes from different abundance and functional classes in various human tissues were evaluated. The conventional use of a single gene for normalization leads to relatively large errors in a significant proportion of samples tested.
	23. 1674 Accesses	Research Variants in exons and in transcription factors affect gene expression in trans Anat Kreimer, Itsik Pe'er Genome Biology 2013, 14:R71 (11 July 2013) Abstract \| Provisional PDF \| PubMed \| Editor’s summary Mapping of eSNPs onto a protein-protein interaction network reveals that SNPs in transcription factors can have a trans effect
	24. 1632 Accesses	Review From pathogen genomes to host plant processes: the power of plant parasitic oomycetes Marina Pais, Joe Win, Kentaro Yoshida, Graham J Etherington, Liliana M Cano, Sylvain Raffaele, Mark J Banfield, Alex Jones, Sophien Kamoun, Diane GO Saunders Genome Biology 2013, 14:211 (28 June 2013) Abstract \| Full text \| PDF \| PubMed \| Editor’s summary Saunders, Kamoun & co review recent genomics insights into plant parasitic oomycete effector function and plant host responses
	25. 1550 Accesses	Editorial Raymond Gosling: the man who crystallized genes Naomi Attar Genome Biology 2013, 14:402 (25 April 2013) Abstract \| Full text \| PDF \| PubMed \| Cited on BioMed Central \| 1 comment \| Editor’s summary "The most wonderful thing!" - Genome Biology meets Raymond Gosling, a key player in the discovery of the double helix